leukotriene-b4 and 4-nitrosodimethylaniline

leukotriene-b4 has been researched along with 4-nitrosodimethylaniline* in 1 studies

Other Studies

1 other study(ies) available for leukotriene-b4 and 4-nitrosodimethylaniline

Article	Year
3-alkyl- and 3-aryl-(7-oxo-7H-furo[3, 2-g]chromen-5-yl)alkanoic acids as inhibitors of leukotriene B4 biosynthesis. Archiv der Pharmazie, 2003, Volume: 336, Issue:6-7 The synthesis and biological properties of 3-alkyl-and 3-aryl-(7-oxo-7H-furo [3, 2-g]chromen-5-yl)alkanoic acids are described. The compounds were evaluated for their ability to inhibit soybean 15-lipoxygenase (15-LO) and the production of leukotriene B(4) (LTB(4)) in bovine polymorphonuclear leukocytes. The furocoumarins were further investigated for their lipophilicity and their capacity to photobleach N, N-dimethyl-p-nitrosoaniline (RNO) after irradiation with UVA light. The synthesised furocoumarins showed only a moderate ability to inhibit the 15-LO and the production of LT B(4). The 3-alkyl substituted furocoumarins had a higher capacity to photobleach RNO than then the 3-aryl substituted furocoumarinso. The inhibitory activity of the newcompounds was quite modest in comparison to other known inhibitors of 15-LO and LTB(4) production. Nevertheless, they may provide the basis for the development of more potent antiinflammatory potential photoreactive furocoumarins. Topics: Animals; Anti-Inflammatory Agents; Cattle; Drug Design; Furocoumarins; Glycine max; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Neutrophils; Nitroso Compounds; Photosensitizing Agents; Ultraviolet Rays	2003

Article

Year

3-alkyl- and 3-aryl-(7-oxo-7H-furo[3, 2-g]chromen-5-yl)alkanoic acids as inhibitors of leukotriene B4 biosynthesis.

Archiv der Pharmazie, 2003, Volume: 336, Issue:6-7

The synthesis and biological properties of 3-alkyl-and 3-aryl-(7-oxo-7H-furo [3, 2-g]chromen-5-yl)alkanoic acids are described. The compounds were evaluated for their ability to inhibit soybean 15-lipoxygenase (15-LO) and the production of leukotriene B(4) (LTB(4)) in bovine polymorphonuclear leukocytes. The furocoumarins were further investigated for their lipophilicity and their capacity to photobleach N, N-dimethyl-p-nitrosoaniline (RNO) after irradiation with UVA light. The synthesised furocoumarins showed only a moderate ability to inhibit the 15-LO and the production of LT B(4). The 3-alkyl substituted furocoumarins had a higher capacity to photobleach RNO than then the 3-aryl substituted furocoumarinso. The inhibitory activity of the newcompounds was quite modest in comparison to other known inhibitors of 15-LO and LTB(4) production. Nevertheless, they may provide the basis for the development of more potent antiinflammatory potential photoreactive furocoumarins.

Topics: Animals; Anti-Inflammatory Agents; Cattle; Drug Design; Furocoumarins; Glycine max; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Magnetic Resonance Spectroscopy; Neutrophils; Nitroso Compounds; Photosensitizing Agents; Ultraviolet Rays

2003