leucinol has been researched along with sirolimus in 3 studies
| Studies (leucinol) | Trials (leucinol) | Recent Studies (post-2010) (leucinol) | Studies (sirolimus) | Trials (sirolimus) | Recent Studies (post-2010) (sirolimus) |
|---|---|---|---|---|---|
| 17 | 0 | 9 | 20,711 | 2,368 | 11,516 |
| Protein | Taxonomy | leucinol (IC50) | sirolimus (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 10 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 1.25 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 2 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 2 | |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | Mus musculus (house mouse) | 0.001 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 4 | |
| Serine/threonine-protein kinase mTOR | Homo sapiens (human) | 0.0897 | |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | Homo sapiens (human) | 0.0042 | |
| Regulatory-associated protein of mTOR | Homo sapiens (human) | 0.225 | |
| Target of rapamycin complex subunit LST8 | Homo sapiens (human) | 0.225 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 1.9 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 1.1 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jeong, SJ; Kim, C; Kim, JH; Kim, S; Kim, SE; Koh, Y; Lee, J; Yoon, I; Yoon, S | 1 |
| Ann, J; Cho, D; Kim, JH; Kim, S; Kim, SE; Kim, WK; Lee, J; Lee, S; Yoon, I; Yoon, S; Zuo, D | 1 |
| Fox, HL; Heydrick, SJ; Jefferson, LS; Kimball, SR; Lynch, CJ; Pham, PT | 1 |
3 other study(ies) available for leucinol and sirolimus
| Article | Year |
|---|---|
Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor.
Topics: Antineoplastic Agents; Cell Line, Tumor; HEK293 Cells; Humans; Isoleucine-tRNA Ligase; Leucine; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Oxazolidinones; Phosphorylation; Ribosomal Protein S6 Kinases; Sirolimus; Stereoisomerism; TOR Serine-Threonine Kinases | 2016 |
Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.
Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Leucine; Leucine-tRNA Ligase; Mechanistic Target of Rapamycin Complex 1; Molecular Structure; Structure-Activity Relationship | 2018 |
Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes.
Topics: Adenosine Diphosphate Ribose; Adipocytes; Aluminum; Amino Acids; Animals; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Fluorine; GTP-Binding Protein alpha Subunits, Gi-Go; Histidinol; Insulin; Intracellular Signaling Peptides and Proteins; Leucine; Male; Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Staurosporine; TOR Serine-Threonine Kinases; Virulence Factors, Bordetella | 2000 |