leucine thiorphan has been researched along with thiorphan in 6 studies
*Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms. [MeSH]
*Thiorphan: A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms. [MeSH]
| Studies (leucine thiorphan) | Trials (leucine thiorphan) | Recent Studies (post-2010) (leucine thiorphan) | Studies (thiorphan) | Trials (thiorphan) | Recent Studies (post-2010) (thiorphan) |
|---|---|---|---|---|---|
| 6 | 0 | 0 | 665 | 50 | 82 |
| Protein | Taxonomy | leucine thiorphan (IC50) | thiorphan (IC50) |
|---|---|---|---|
| Thermolysin | Bacillus thermoproteolyticus | 9.5 | |
| Neprilysin | Rattus norvegicus (Norway rat) | 0.0058 | |
| Neprilysin | Oryctolagus cuniculus (rabbit) | 0.0085 | |
| Neprilysin | Homo sapiens (human) | 0.0024 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.2281 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 0.42 | |
| Neprilysin | Sus scrofa (pig) | 0.0062 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Borson, DB; Di Maria, GU; Katayama, M; Nadel, JA | 1 |
| Borson, DB; Nadel, JA; Sekizawa, K; Tamaoki, J | 1 |
| Borson, DB; Graf, PD; Kohrogi, H; Nadel, JA; Sekizawa, K | 1 |
| Borson, DB; Djokic, TD; Nadel, JA; Sekizawa, K | 1 |
| Borson, DB; Djokic, TD; Dusser, DJ; Graf, PD; Nadel, JA; Sekizawa, K | 1 |
| Borson, DB; Dusser, DJ; Graf, PD; Nadel, JA; Sekizawa, K | 1 |
6 other study(ies) available for leucine thiorphan and thiorphan
| Article | Year |
|---|---|
Neutral endopeptidase modulates endothelin-1-induced airway smooth muscle contraction in guinea-pig trachea.
Topics: Animals; Drug Interactions; Endothelins; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neprilysin; Recombinant Proteins; Thiorphan; Trachea | 1992 |
Enkephalinase inhibitor potentiates substance P- and electrically induced contraction in ferret trachea.
Topics: Airway Resistance; Amino Acids, Sulfur; Animals; Electric Stimulation; Ferrets; In Vitro Techniques; Metalloendopeptidases; Neprilysin; Substance P; Thiorphan; Tiopronin; Trachea | 1987 |
Neutral endopeptidase inhibitors potentiate substance P- and capsaicin-induced cough in awake guinea pigs.
Topics: Animals; Capsaicin; Cough; Drug Synergism; Glycopeptides; Guinea Pigs; Male; Neprilysin; Substance P; Thiorphan | 1988 |
Neutral endopeptidase inhibitors potentiate substance P-induced contraction in gut smooth muscle.
Topics: Animals; Drug Synergism; Duodenum; Endopeptidases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Ferrets; Glycopeptides; Ileum; Intestines; Male; Muscle Contraction; Protease Inhibitors; Rats; Substance P; Thiorphan | 1989 |
Inhibitors of neutral endopeptidase potentiate electrically and capsaicin-induced noncholinergic contraction in guinea pig bronchi.
Topics: Animals; Bronchi; Capsaicin; Electric Stimulation; Glycopeptides; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Neprilysin; Substance P; Thiorphan | 1989 |
Neutral endopeptidase and angiotensin converting enzyme inhibitors potentiate kinin-induced contraction of ferret trachea.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dose-Response Relationship, Drug; Drug Synergism; Ferrets; Glycopeptides; Kinins; Male; Metalloendopeptidases; Muscle Contraction; Neprilysin; Thiorphan; Tiopronin; Trachea | 1988 |