leucine methyl ester has been researched along with leucine in 99 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (42.42) | 18.7374 |
| 1990's | 38 (38.38) | 18.2507 |
| 2000's | 12 (12.12) | 29.6817 |
| 2010's | 6 (6.06) | 24.3611 |
| 2020's | 1 (1.01) | 2.80 |
| Authors | Studies |
|---|---|
| Bottazzo, GF; Davenport, C; Todd, I | 1 |
| Corrigall, V; Linardopoulos, S; Panayi, GS | 1 |
| Simon, P; Townsend, RM | 1 |
| David, B; Oskeritzian, C; Prouvost-Danon, A | 1 |
| Coombs, GH; Hunter, CA; Lockwood, BC | 1 |
| Dubois-Dalcq, M; Friedman, E; Gilbert, D; Ronnett, G; Sharpless, N; Vandercam, B; Verdin, E; Zhou, JM | 1 |
| Ennen, J; Ernst, M; Fetting, R; Flad, HD; Jaźwiec, B; Lange, A; Moniewska, A | 1 |
| Ager, A; Dissen, E; Fossum, S; Rolstad, B; Vaage, JT | 1 |
| Mizutani, Y; Nio, Y; Yoshida, O | 1 |
| Lipsky, PE; Thiele, DL | 4 |
| Brookes, RH; Oxley, JD; Rayfield, LS; Shepherd, PS | 1 |
| Burke, JF; Jaksic, T; Wagner, DA; Young, VR | 1 |
| Amadori, A; Barelli, A; Borri, A; Chieco-Bianchi, L; Mazza, MR; Panozzo, M; Veronese, ML; Zamarchi, R | 1 |
| Antoni, F; Csuka, I; Lapis, K; Szende, B; Timar, J | 1 |
| Bogitsh, BJ; Davenport, GR | 1 |
| Alfieri, SC; Galvao-Quintao, L; Rabinovitch, M; Ryter, A | 1 |
| Edalji, R; Egan, DA; Fesik, SW; Gampe, RT; Helfrich, R; Holzman, TF; Kishore, V; Luly, JR; Rich, DH; Simmer, R | 1 |
| Hoyer, M; Lewis, W; Meineke, T; Rinehart, J; Zwilling, B | 1 |
| Antoni, F; Csuka, I; Hrabák, A; Lapis, K; Szende, B; Temesi, A | 1 |
| Aquino, S; Young, ME; Young, MR | 1 |
| Duncan, CJ; Shamsadeen, N | 1 |
| Ballow, M; Rubinstien, E | 1 |
| Alfieri, SC; Rabinovitch, M; Shaw, E; Zilberfarb, V | 1 |
| Antoine, JC; Jouanne, C; Ryter, A | 1 |
| Bowers, WE; Goodell, EM; Ruhoff, MS; Stoltenborg, JK | 1 |
| Herberman, RB; Hiserodt, JC; Sarneva, M; Van den Brink, MR; Vujanovic, NL | 1 |
| Hariguchi, S; Morita, H; Nakamura, Y; Nishimura, T; Suzuki, H; Tada, K; Takeda, M | 1 |
| Newby, M; Wepsic, HT; Young, MR | 1 |
| Ellis, NK; Wepsic, HT; Young, ME; Young, MR | 1 |
| Balch, CM; Itoh, K; Platsoucas, CD; Pollock, RE; Tilden, AB | 1 |
| Abbas, AK; Burakoff, SJ; Ferrara, JL; Hamberg, SD; Reynolds, DS; Wall, DA | 1 |
| Borrebaeck, CA; Danielsson, L; Möller, SA | 2 |
| Alfieri, SC; Antoine, JC; Juliano, L; Quintao, LG; Rabinovitch, M; Ramazeilles, C; Ryter, A; Shaw, E; Zilberfarb, V | 1 |
| Herberman, RB; Hiserodt, JC; Maghazachi, AA; Vujanovic, NL | 1 |
| Alfieri, SC; Rabinovitch, M | 1 |
| Rabinovitch, M; Zilberfarb, V | 1 |
| Alfieri, SC; Galpin, I; Norman, SE; Rabinovitch, M; Ramazeilles, C; Zilberfarb, V | 1 |
| Agah, R; Mazumder, A; Shau, H | 1 |
| Alfieri, SC; Rabinovitch, M; Zilberfarb, V | 1 |
| Golub, SH; Lindemann, RA; Park, NH | 1 |
| Pouchelet, M; Rabinovitch, M; Zilberfarb, V | 1 |
| Golub, SH; Shau, H | 1 |
| Cashaw, JL; Flagge, FP; Laughter, AH; Orson, FM; Rossen, RD; Sumaya, CV | 1 |
| Bakouche, O; Gerlier, D | 1 |
| Rabinovitch, M; Ramazeilles, C; Zilberfarb, V | 1 |
| Bennardini, F; Dini, G; Franconi, F; Giotti, A; Matucci, R; Stendardi, I | 1 |
| Hedeskov, CJ; Knudsen, P; Kofod, H; Lernmark, A | 1 |
| Chua, BH; Lautensack, N; Long, WM; Morgan, HE | 1 |
| Clem, LW; Cuchens, MA; Lobb, CJ; Miller, NW; Sizemore, RC | 1 |
| Decker, RS; Fuseler, JF | 1 |
| Kurosaka, M; Lipsky, PE; Thiele, DL | 1 |
| Ransom, JT; Reeves, JP | 1 |
| Reames, T; Reeves, JP | 1 |
| Crie, JS; Decker, RS; Reeves, JP; Wildenthal, K | 1 |
| Bazin, H; Bombil, F; Havaux, X; Kints, JP; Latinne, D; Scheiff, JM | 1 |
| Antoni, F; Bánfalvi, G; Csuka, I; Solymossy, M; Temesi, A | 1 |
| Blomberg, J; Desgranges, C; Ebersold, A; Fraisier, C | 1 |
| Szende, B | 1 |
| Antoni, F; Csuka, I; Solymossy, M; Temesi, A | 1 |
| Babst, R; Filgueira, L; Harder, F; Heberer, M; Hörig, H; Juretic, A; Lüscher, U; Spagnoli, GC; von Bremen, K | 1 |
| Egawa, K; Seo, N | 1 |
| Aubry, A; Bayeul, D; Boesten, WH; Bonora, GM; Crisma, M; Dautant, A; Formaggio, F; Pantano, M; Schoemaker, HE; Toniolo, C | 1 |
| Downie, PA; Goldberg, A; Goodell, WR; LeBeau, MM; McCabe, NR; Miley, D; Morgan, R; Raimondi, SC; Sklar, J; Zhang, LQ | 1 |
| David, B; Oskéritzian, C; Peronet, R; Prouvost-Danon, A | 1 |
| Ashby, JM; Eremin, O; Li, Y | 1 |
| Kabelitz, D; Pechhold, K | 1 |
| Brown, DR; Kretzschmar, HA; Schmidt, B | 1 |
| Bogitsh, BJ; Carter, CE; Ribeiro-Rodrigues, R | 1 |
| Andreesen, R; Konur, A; Krause, SW; Kreutz, M; Rehli, M | 1 |
| Böhles, H; Brendel, L; Förster, H; Georgieff, M; Träger, K; Vogt, J | 1 |
| Kozlov, VA; Samarin, DM; Seledtsov, VI; Seledtsova, GV; Taraban, VIa | 1 |
| Brown, DR; Feldmann, C; Giese, A; Groschup, MH; Haist, I; Kretzschmar, HA | 1 |
| Langley, D; Pearce, B | 1 |
| Brown, DR | 1 |
| Furusho, K; Heike, T; Iio, J; Katamura, K; Kiyomasu, T; Ohmura, K; Ueno, H | 1 |
| Hashimoto, S; Inoue, T; Ito, K; Iwata, M; Nagai, T; Nishioka, Y; Sato, T; Sawada, T; Tohma, S; Yamamoto, K | 1 |
| Antoine, JC; Courret, N; Frehel, C; Lang, T; Prina, E | 1 |
| Hayashi, H; Hirotsu, K; Kagamiyama, H; Okada, K | 1 |
| Casartelli, M; Fiandra, L; Giordana, B; Leonardi, MG; Parenti, P | 1 |
| Casartelli, M; Forcella, M; Giordana, B; Hanozet, GM; Leonardi, MG; Parenti, P; Pugliese, A | 1 |
| HEIN, GE; JONES, JB; NIEMANN, C | 1 |
| Andrews, NW; Huynh, C | 1 |
| Morris, BD; Nojima, S; Robbins, PS; Roelofs, WL; Salsbury, GA; Villani, MG | 1 |
| Hamby, ME; Hewett, JA; Hewett, SJ; Uliasz, TF | 1 |
| Birdsall, HH; Porter, WJ; Rossen, RD; Trial, J | 1 |
| Cool, SM; Nurcombe, V | 1 |
| Adade, CM; De Castro, SL; Figueiredo, RC; Soares, MJ | 1 |
| Aarstad, HJ; Heimdal, JH; Kross, KW; Olofson, J; Olsnes, C | 1 |
| Ejgenberg, M; Mastai, Y | 1 |
| Hamby, ME; Hewett, JA; Hewett, SJ; Jackman, NA; Uliasz, TF | 1 |
| Marius Clore, G; Tugarinov, V; Venditti, V | 1 |
| Jebelli, J; Piers, T; Pocock, J | 1 |
| Britton, R; Campeau, LC; DiRocco, DA; Halperin, SD; Holmes, M; Kwon, D; Regalado, EL | 1 |
| Chen, G; Chen, SF; Feng, BM; Lu, XJ; Pei, YH; Wang, HF; Zhao, D | 1 |
| Kotake, Y; Miyara, M; Sanoh, S; Takao, S; Umeda-Miyara, K; Yabuki, A | 1 |
1 review(s) available for leucine methyl ester and leucine
| Article | Year |
|---|---|
From lysosomes to cells, from cells to Leishmania: amino acid esters as potential chemotherapeutic agents.
Topics: Animals; Dipeptides; Leishmania mexicana; Leucine; Lysosomes; Protease Inhibitors | 1987 |
98 other study(ies) available for leucine methyl ester and leucine
| Article | Year |
|---|---|
Stimulation of human B cells specific for Candida albicans for monoclonal antibody production.
Topics: Antibodies, Monoclonal; B-Lymphocytes; Candida albicans; Cell Line; Dipeptides; Herpesvirus 4, Human; Humans; Immunization; Interleukin-2; Interleukin-4; Interleukin-6; Leucine; Lymphocyte Activation | 1992 |
Activation of HLA-DR and interleukin-6 gene transcription in resting T cells via the CD2 molecule: relevance to chronic immune-mediated inflammation.
Topics: Antigens, Differentiation, T-Lymphocyte; CD2 Antigens; Cells, Cultured; Flow Cytometry; Gene Expression Regulation; HLA-DR Antigens; Humans; Immunity, Cellular; Inflammation; Interleukin-6; Leucine; Lymphocyte Activation; Phytohemagglutinins; Receptors, Immunologic; Receptors, Interleukin-2; RNA, Messenger; Rosette Formation; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic; Up-Regulation | 1992 |
The preferential expansion of functional CD4+ lymphocyte populations in vitro.
Topics: CD4-Positive T-Lymphocytes; Cell Division; Cells, Cultured; Dipeptides; HIV Infections; Humans; Immunophenotyping; Leucine; Lymphocyte Activation; Mitogens; T-Lymphocytes, Regulatory | 1992 |
Effects of L-leucine methyl ester (Leu-OMe) on mouse peritoneal mast cells: characterization of histamine release versus cytotoxicity.
Topics: Animals; Antibodies; Cytotoxicity, Immunologic; Dose-Response Relationship, Drug; Histamine Release; Immunoglobulin E; Leucine; Mast Cells; Mice; Mice, Inbred CBA; Peritoneum; Temperature | 1992 |
Hydrolysis of L-leucine methyl ester by Leishmania mexicana mexicana amastigote cysteine proteinases.
Topics: Animals; Cysteine Endopeptidases; Hydrolysis; Leishmania mexicana; Leucine | 1992 |
The restricted nature of HIV-1 tropism for cultured neural cells.
Topics: AIDS Dementia Complex; Astrocytes; Brain; Cell Differentiation; Cells, Cultured; DNA, Viral; HIV Core Protein p24; HIV-1; Humans; Immunohistochemistry; Leucine; Oligodendroglia; Polymerase Chain Reaction; Proviruses; Tissue Distribution; Transcription, Genetic; Virus Replication | 1992 |
Augmentation of interleukin 2-activated cytotoxicity after treatment of cells with inhibitors of interferon production.
Topics: Cells, Cultured; Cytotoxicity, Immunologic; Humans; Interferons; Interleukin-2; Killer Cells, Natural; Leucine; Lymphocytes; Recombinant Proteins | 1991 |
Allospecific recognition of hemic cells in vitro by natural killer cells from athymic rats: evidence that allodeterminants coded for by single major histocompatibility complex haplotypes are recognized.
Topics: Animals; Antibody-Dependent Cell Cytotoxicity; Bone Marrow; Cross Reactions; Crosses, Genetic; Cytotoxicity Tests, Immunologic; Dose-Response Relationship, Immunologic; Epitopes; Flow Cytometry; Haplotypes; Immunophenotyping; In Vitro Techniques; Interleukin-2; Killer Cells, Natural; Leucine; Lymphocytes; Major Histocompatibility Complex; Rats; Rats, Nude; Spleen | 1991 |
Modulation by cis-diamminedichloroplatinum (II) of the susceptibilities of human T24 lined and freshly separated autologous urinary bladder transitional carcinoma cells to peripheral blood lymphocytes and lymphokine activated killer cells.
Topics: Aged; Aged, 80 and over; Carcinoma, Transitional Cell; Cell Line; Chloroquine; Cisplatin; Cytotoxicity, Immunologic; Female; Humans; Killer Cells, Lymphokine-Activated; Leucine; Lymphocytes; Male; Middle Aged; Mitomycin; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1992 |
Spectrum of toxicities of amino acid methyl esters for myeloid cells is determined by distinct metabolic pathways.
Topics: Adult; Ammonium Chloride; Cathepsin C; Cell Death; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Esterases; Glutamates; Granulocytes; Humans; Killer Cells, Natural; Leucine; Leukemia, Myeloid; Leukocytes, Mononuclear; Neutrophils; Phagocytes; Phenylalanine; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured | 1992 |
Human T cell responses to beta-galactosidase.
Topics: Adjuvants, Immunologic; Antigens; B-Lymphocytes; beta-Galactosidase; Cell Division; Cell Line, Transformed; Herpesvirus 4, Human; Humans; Leucine; T-Lymphocytes | 1991 |
Proline metabolism in adult male burned patients and healthy control subjects.
Topics: Adult; Burns; Carbon Isotopes; Deuterium; Humans; Kinetics; Leucine; Male; Oxidation-Reduction; Proline | 1991 |
B-cell activation during HIV-1 infection. III. Down-regulating effect of mitogens.
Topics: Antigens, Differentiation, T-Lymphocyte; B-Lymphocytes; CD8 Antigens; Cell Separation; Cells, Cultured; Cytotoxicity Tests, Immunologic; Down-Regulation; HIV Antibodies; HIV Infections; Humans; Immunoglobulins; Kinetics; Leucine; Lymphocyte Activation; Pokeweed Mitogens; T-Lymphocytes | 1991 |
Morphological studies on the effect of L-leucine methyl ester on mouse peritoneal macrophages in vitro.
Topics: Animals; Cell Membrane; Cell Nucleus; Cells, Cultured; Cytoplasm; Formaldehyde; Leucine; Lysosomes; Macrophages; Male; Mice; Microscopy, Electron; Organelles; Peritoneal Cavity; Time Factors | 1991 |
The in vitro effects of various lysosomotropic agents on the gut of Schistosoma mansoni schistosomula.
Topics: Acridine Orange; Alanine; Amino Acids; Ammonium Chloride; Animals; Chloroquine; Dipeptides; Esters; Hydrogen-Ion Concentration; Leucine; Microscopy, Electron; Microscopy, Fluorescence; Schistosoma mansoni; Tryptophan | 1991 |
Intracellular differentiation of Leishmania amazonensis promastigotes to amastigotes: presence of megasomes, cysteine proteinase activity and susceptibility to leucine-methyl ester.
Topics: Animals; Cells, Cultured; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Female; Leishmania; Leishmaniasis; Leucine; Macrophages; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron | 1990 |
Isotope-edited NMR of cyclosporin A bound to cyclophilin: evidence for a trans 9,10 amide bond.
Topics: Amides; Amino Acid Isomerases; Carbon Isotopes; Carrier Proteins; Cyclosporins; Escherichia coli; Humans; Leucine; Magnetic Resonance Spectroscopy; Peptidylprolyl Isomerase; Phenylalanine; Protein Binding; Protein Conformation; Recombinant Proteins; Tryptophan | 1990 |
Characterization and modulation of human lymphokine (interleukin 2) activated killer cell induction.
Topics: Cytotoxicity, Immunologic; Humans; Interferons; Interleukin-1; Interleukin-2; Killer Cells, Natural; Kinetics; Leucine; Monocytes; Phenylalanine; Thymidine; Tritium | 1986 |
The effect of L-leucine methyl ester on the phagocytosis and amino acid incorporation of murine peritoneal cells.
Topics: Animals; Biological Transport, Active; Cell Adhesion; Cell Membrane; In Vitro Techniques; Leucine; Macrophages; Male; Mice; Peritoneal Cavity; Phagocytosis; Protein Biosynthesis; Rabbits; Temperature; Valine | 1989 |
Differential induction of hematopoiesis and immune suppressor cells in the bone marrow versus in the spleen by Lewis lung carcinoma variants.
Topics: Animals; Antibodies, Anti-Idiotypic; Bone Marrow; Cell Adhesion; Cell Division; Hematopoiesis; Indomethacin; Leucine; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Spleen; T-Lymphocytes, Regulatory | 1989 |
Cytotoxic action of the lysosomotropic agent L-leucine methyl ester on mammalian skeletal muscle. The role of the sarcoplasmic reticulum in producing myofilament damage.
Topics: Animals; Cell Survival; Diaphragm; Leucine; Lysosomes; Mice; Mice, Inbred BALB C; Microscopy, Electron; Muscles; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum | 1989 |
Isolation of monocyte-depleted and monocyte-rich fractions from human mononuclear cells.
Topics: Adult; Antibody Formation; Antigen-Presenting Cells; B-Lymphocytes; Cell Separation; Cells, Cultured; Cold Temperature; Humans; Leucine; Leukocytes, Mononuclear; Pokeweed Mitogens | 1989 |
Leishmania amazonensis: involvement of cysteine proteinases in the killing of isolated amastigotes by L-leucine methyl ester.
Topics: Animals; Cysteine Endopeptidases; Diazomethane; Electrophoresis, Polyacrylamide Gel; Leishmania mexicana; Leucine; Macrophages; Mice; Protease Inhibitors; Substrate Specificity | 1989 |
Megasomes as the targets of leucine methyl ester in Leishmania amazonensis amastigotes.
Topics: Acid Phosphatase; Animals; Dinitrobenzenes; Female; Histocytochemistry; Hydrogen-Ion Concentration; Leishmania; Leucine; Lysosomes; Mice; Mice, Inbred BALB C; Microscopy, Electron; Protease Inhibitors | 1989 |
The effect of silica treatment on accessory cell-dependent rat T lymphocyte proliferation.
Topics: Animals; Antigen-Presenting Cells; Dendritic Cells; Female; In Vitro Techniques; Leucine; Lymphocyte Activation; Macrophages; Male; Rats; Rats, Inbred Lew; Silicon Dioxide; T-Lymphocytes | 1988 |
Lymphokine-activated killer cells in rats: generation of natural killer cells and lymphokine-activated killer cells from bone marrow progenitor cells.
Topics: Animals; Antigens, Differentiation; Bone Marrow Cells; Cell Differentiation; Fluorouracil; G(M1) Ganglioside; Glycosphingolipids; Killer Cells, Natural; Leucine; Lymphocyte Activation; Lymphokines; Rats; Rats, Inbred F344 | 1989 |
Lysosome instability in aged rat brain.
Topics: Aging; Animals; Brain; Cathepsin D; Cytosol; Glucuronidase; Leucine; Lysosomes; Rats; Rats, Inbred Strains | 1989 |
Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors.
Topics: Animals; Bone Marrow; Cell Adhesion; Cells, Cultured; Colony-Stimulating Factors; Complement System Proteins; Hematopoiesis; Hematopoietic Stem Cells; Immune Tolerance; Indomethacin; Isoantibodies; Leucine; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; T-Lymphocytes, Regulatory | 1987 |
Stimulation of hematopoiesis and bone marrow suppressor cells by the subcutaneous injection of linoleic acid.
Topics: Animals; Bone Marrow Cells; Colony-Forming Units Assay; Colony-Stimulating Factors; Concanavalin A; Hematopoiesis; Histocompatibility Antigens Class II; Immune Tolerance; Indomethacin; Injections, Subcutaneous; Leucine; Linoleic Acid; Linoleic Acids; Male; Mice; Mice, Inbred C57BL; Spleen; T-Lymphocytes, Regulatory | 1987 |
Lysis of fresh solid tumor targets in the presence of Con A is mediated primarily by Leu 7+ peripheral blood T lymphocytes: blocking by the anti-CD3 monoclonal antibody and comparison with recombinant interleukin 2-induced lysis by natural killer cells.
Topics: Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Concanavalin A; Cytotoxicity, Immunologic; Humans; Immunity, Cellular; Interleukin-2; Killer Cells, Natural; Leucine; Neoplasms; Phytohemagglutinins; T-Lymphocytes | 1987 |
Immunodeficiency in graft-versus-host disease. I. Mechanism of immune suppression.
Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Bone Marrow; Bone Marrow Transplantation; Cell Differentiation; Graft vs Host Disease; Immune Tolerance; Interferon-gamma; Leucine; Lymphocyte Activation; Mice; Mitogens; Radiation Chimera; T-Lymphocytes; Time Factors | 1988 |
Human monoclonal antibodies produced by primary in vitro immunization of peripheral blood lymphocytes.
Topics: Antibodies, Monoclonal; B-Lymphocytes; Cell Separation; Digoxin; Hemocyanins; Humans; Immunization; In Vitro Techniques; Interferon-gamma; Interleukin-2; Leucine; Lymphocytes; Lysosomes; Monocytes; T-Lymphocytes | 1988 |
Leishmanicidal activity of amino acid and peptide esters: an update.
Topics: Animals; Dipeptides; Leishmania; Leishmaniasis; Leucine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Structure-Activity Relationship | 1988 |
Lymphokine-activated killer cells in rats. IV. Developmental relationships among large agranular lymphocytes, large granular lymphocytes, and lymphokine-activated killer cells.
Topics: Animals; Cell Differentiation; Cytotoxicity, Immunologic; Interleukin-2; Killer Cells, Natural; Leucine; Lymphocyte Activation; Lymphocytes; Male; Rats; Rats, Inbred F344; Recombinant Proteins; Spleen | 1988 |
Lymphokine-activated killer cell activity.
Topics: Animals; Humans; In Vitro Techniques; Killer Cells, Natural; Leucine; Lymphokines; T-Lymphocytes, Cytotoxic | 1988 |
Destruction of intracellular and isolated Leishmania mexicana amazonensis amastigotes by amino acid amides.
Topics: Amides; Amino Acids; Animals; Esters; Leishmania mexicana; Leishmaniasis; Leucine; Macrophages; Mice; Mice, Inbred BALB C; Time Factors | 1988 |
Proteinase inhibitors protect Leishmania amazonensis amastigotes from destruction by amino acid esters.
Topics: Amino Acids; Animals; Antipain; Chymotrypsin; Esters; Female; Hydrogen-Ion Concentration; Hydrolysis; Leishmania; Leucine; Macrophages; Mice; Oligopeptides; Protease Inhibitors | 1988 |
Human monoclonal antibodies produced from L-leucine methyl ester-treated and in vitro immunized peripheral blood lymphocytes.
Topics: Antibodies, Monoclonal; Antigens, Differentiation; Humans; Immunization; In Vitro Techniques; Leucine; Lymphocytes; Monocytes; T-Lymphocytes | 1987 |
Lysosome rich cells contain the lytic activity of lymphokine-activated killer cell populations.
Topics: Animals; Cell Separation; Cytotoxicity, Immunologic; Female; Killer Cells, Natural; Leucine; Lymphocytes; Lysosomes; Mice; Neoplasms, Experimental; Quinacrine | 1987 |
Destruction of Leishmania mexicana amazonensis amastigotes by leucine methyl ester: protection by other amino acid esters.
Topics: Amino Acids; Animals; Esters; Isoleucine; Leishmania mexicana; Leucine; Macrophages | 1987 |
HSV-1 infected oral epithelial cells are targets for natural killer cells.
Topics: Antibodies, Monoclonal; Cells, Cultured; Cytotoxicity, Immunologic; Epithelium; Humans; Immunity, Cellular; Immunity, Innate; Killer Cells, Natural; Leucine; Mouth Mucosa; Stomatitis, Herpetic | 1987 |
Leishmania mexicana: destruction of isolated amastigotes by amino acid esters.
Topics: Amino Acids; Animals; Antiprotozoal Agents; Female; Leishmania mexicana; Leucine; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests | 1987 |
Regulation of cellular function by products of lysosomal enzyme activity: elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes.
Topics: Dipeptides; Humans; In Vitro Techniques; Killer Cells, Natural; Leucine; Lysosomes; Monocytes; Neutrophils | 1985 |
Depletion of NK cells with the lysosomotropic agent L-leucine methyl ester and the in vitro generation of NK activity from NK precursor cells.
Topics: Cell Separation; Cell Survival; Cytotoxicity, Immunologic; Hematopoietic Stem Cells; Humans; Killer Cells, Natural; Leucine; Lymphocyte Activation; Lysosomes; T-Lymphocytes | 1985 |
Human peripheral blood monocytes release a 30,000 dalton factor (30 KD MF) that stimulates immunoglobulin production by activated B cells.
Topics: Adult; B-Lymphocytes; Cell Line; Growth Substances; Hemolytic Plaque Technique; Humans; Immunoglobulin A; Interferon-gamma; Interleukin-2; Interleukin-4; Kinetics; Leucine; Lymphocyte Activation; Lymphocyte Depletion; Lymphokines; Molecular Weight; Monocytes; T-Lymphocytes; Trypsin | 1985 |
Presentation of an MuLV-related tumour antigen in liposomes as a potent tertiary immunogen after adoptive transfer.
Topics: AKR murine leukemia virus; Animals; Antibodies, Neoplasm; Antibodies, Viral; Antigens, Neoplasm; Antigens, Surface; Antigens, Viral; Dose-Response Relationship, Immunologic; Immunization, Passive; Immunologic Memory; In Vitro Techniques; Kinetics; Leucine; Liposomes; Lymphoma; Macrophages; Rats; Rats, Inbred Strains; Spleen | 1986 |
Destruction of Leishmania mexicana amazonensis amastigotes within macrophages by lysosomotropic amino acid esters.
Topics: Amino Acids; Animals; Dose-Response Relationship, Drug; Female; Hydrogen-Ion Concentration; In Vitro Techniques; Leishmaniasis; Leucine; Lysosomes; Macrophages; Male; Mice; Stereoisomerism; Structure-Activity Relationship; Temperature | 1986 |
Modulation of human natural killer cell function by L-leucine methyl ester: monocyte-dependent depletion from human peripheral blood mononuclear cells.
Topics: Adult; Cell Survival; Cells, Cultured; Cytotoxicity, Immunologic; Drug Resistance; Humans; Immunosuppressive Agents; Killer Cells, Natural; Leucine; Lysosomes; Macrophages; Monocytes; Time Factors | 1985 |
Effects of leucine methylester on guinea-pig atria.
Topics: Acid Phosphatase; Animals; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Leucine; Lysosomes; Male; Mitochondria, Heart; Proteins | 1985 |
L-leucine methyl ester stimulates insulin secretion and islet glutamate dehydrogenase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Glucagon; Glucose; Glutamate Dehydrogenase; Glutamine; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Leucine; Male; Mice; Mice, Inbred Strains; Norepinephrine; Pancreatic Neoplasms; Rats | 1983 |
Effects of amino acid methyl esters on cardiac lysosomes and protein degradation.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Glucose; Heart; Insulin; Leucine; Lysosomes; Male; Methionine; Myocardium; Phenylalanine; Proteins; Rats; Rats, Inbred Strains | 1983 |
Phylogeny of lymphocyte heterogeneity: the cellular requirements for in vitro mitogenic responses of channel catfish leukocytes.
Topics: Animals; Cell Separation; Concanavalin A; Fishes; Immunosuppressive Agents; Leucine; Leukocytes; Lipopolysaccharides; Lymphocyte Activation; Phylogeny | 1984 |
Methylated amino acids and lysosomal function in cultured heart cells.
Topics: Ammonium Chloride; Animals; Cathepsin B; Cathepsins; Cells, Cultured; Chloroquine; Heart; Leucine; Lysosomes; Methionine; Myocardium; Proteins; Rats | 1984 |
Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic agent, L-leucine methyl ester.
Topics: Adult; B-Lymphocytes; Cell Count; Humans; Interleukin-1; Leucine; Lymphocyte Activation; Lymphocyte Cooperation; Lysosomes; Macrophages; Mitogens; Phenotype; T-Lymphocytes | 1983 |
Accumulation of amino acids within intracellular lysosomes of rat polymorphonuclear leukocytes incubated with amino acid methyl esters. Evidence for the internal acidification of azurophilic granules.
Topics: Amino Acids; Animals; Chloroquine; Cytoplasmic Granules; Leucine; Lysosomes; Methionine; Neutrophils; Rats; Temperature | 1983 |
ATP stimulates amino acid accumulation by lysosomes incubated with amino acid methyl esters. Evidence for a lysosomal proton pump.
Topics: Adenosine Triphosphate; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Hydrogen-Ion Concentration; Leucine; Liver; Lysosomes; Male; Nigericin; Potassium Chloride; Rats; Sucrose; Valinomycin | 1981 |
Intracellular disruption of rat heart lysosomes by leucine methyl ester: effects on protein degradation.
Topics: Animals; Cathepsins; Heart; Leucine; Lysosomes; Male; Microscopy, Electron; Myocardium; Osmolar Concentration; Peptide Hydrolases; Phenylalanine; Rats | 1981 |
A rat monoclonal anti-(human CD2) and L-leucine methyl ester impacts on human/SCID mouse graft and B lymphoproliferative syndrome.
Topics: Animals; Antibodies, Monoclonal; B-Lymphocytes; Blood Component Transfusion; CD2 Antigens; Chimera; Humans; Leucine; Leukocytes, Mononuclear; Lymphoproliferative Disorders; Mice; Mice, SCID; Phenotype; T-Lymphocytes; Transplantation Chimera | 1995 |
Formation of leucyl-leucine-O-methylester in leucine-O-methylester treated cells.
Topics: Animals; Cells, Cultured; Chromatography, Thin Layer; Dipeptides; Hydrolysis; Immunosuppressive Agents; Leucine; Macrophages; Mice; Neutrophils; Swine | 1994 |
Primary in vitro immunization with multimeric synthetic peptides of HIV-1 envelope glycoproteins: generation of neutralizing human monoclonal antibodies.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Enzyme-Linked Immunosorbent Assay; HIV Antibodies; HIV Envelope Protein gp120; HIV Envelope Protein gp41; HIV-1; Humans; Immunization; Immunoglobulin Isotypes; Immunoglobulin M; In Vitro Techniques; Leucine; Lymphocytes; Molecular Sequence Data; Neutralization Tests; Peptides | 1994 |
The effect of amino acids and amino acid derivatives on cell proliferation.
Topics: Amino Acids; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Cell Death; Cell Division; Cells, Cultured; Doxorubicin; Drug Therapy, Combination; Leucine; Lymphoma; Lysine; Macrophages; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Rats, Wistar; Sarcoma, Experimental; Sarcoma, Yoshida; Tumor Cells, Cultured | 1993 |
In vitro effect of leucine-O-methylester on polymorphonuclear and mononuclear cells.
Topics: Animals; Chemotaxis, Leukocyte; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dipeptides; Exocytosis; In Vitro Techniques; Leucine; Leukocytes, Mononuclear; Macrophages, Peritoneal; Neutrophils; Swine | 1993 |
Generation of lymphokine-activated killer activity in rodents but not in humans is nitric oxide dependent.
Topics: Animals; Arginine; Cells, Cultured; Female; Hemoglobins; Humans; In Vitro Techniques; Killer Cells, Lymphokine-Activated; Leucine; Lysosomes; Mice; Mice, Inbred C57BL; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Inbred F344; Time Factors | 1994 |
Utilization of leucine methyl ester for the generation of hybridomas producing monoclonal antibodies specific to tumor-associated antigens.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Cells, Cultured; Hybridomas; Leucine; Male; Mice; Mice, Inbred C3H; T-Lymphocytes, Cytotoxic | 1994 |
Onset of the fully extended conformation in (alpha Me)Leu derivatives and short peptides.
Topics: Amino Acid Sequence; Crystallography, X-Ray; Leucine; Magnetic Resonance Spectroscopy; Methylation; Models, Molecular; Molecular Sequence Data; Molecular Structure; Oligopeptides; Protein Conformation; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared | 1994 |
Establishment of cell lines from B-cell precursor acute lymphoblastic leukemia.
Topics: Adolescent; Adult; Cell Division; Child; Child, Preschool; Female; Gene Rearrangement, B-Lymphocyte; Humans; Immunophenotyping; Karyotyping; Leucine; Leukocytes, Mononuclear; Male; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1993 |
In vivo assessment of mast cell functional alteration induced by L-leucine methyl ester, using the passive cutaneous anaphylaxis technique.
Topics: Allergens; Animals; Antibodies, Anti-Idiotypic; Cytotoxicity, Immunologic; Immunoglobulin E; Injections, Intradermal; Leucine; Mast Cells; Mice; Passive Cutaneous Anaphylaxis; Pollen; Rats; Stereoisomerism | 1993 |
In vitro primary immunization of B lymphocytes for producing human monoclonal antibodies against tumor-associated antigens.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Antigen-Presenting Cells; Antigens, Neoplasm; Axilla; B-Lymphocyte Subsets; Breast Neoplasms; Cell Fusion; Cell Line; Dipeptides; Humans; Interferon-gamma; Interleukin-2; Leucine; Lymph Nodes; Macrophages; Mice; Pokeweed Mitogens; Recombinant Proteins | 1993 |
Human peripheral blood gamma delta T cells are uniformly sensitive to destruction by the lysosomotropic agents leucine methyl ester and leucyl leucine methyl ester.
Topics: Blood; Cells, Cultured; Cytotoxicity, Immunologic; Dipeptides; Flow Cytometry; Fluorescent Antibody Technique; Humans; Immunosuppressive Agents; Leucine; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocyte Subsets; T-Lymphocytes | 1993 |
Role of microglia and host prion protein in neurotoxicity of a prion protein fragment.
Topics: Amino Acid Sequence; Animals; Cell Survival; Cells, Cultured; Cerebellum; Coculture Techniques; Leucine; Mice; Mice, Inbred C57BL; Microglia; Molecular Sequence Data; Neurotoxins; Oxidative Stress; Peptide Fragments; Prions; PrPC Proteins | 1996 |
An ultrastructure study of the in vitro effects of L-leucine methyl ester and ammonium chloride on Trypanosoma cruzi epimastigotes.
Topics: Ammonium Chloride; Animals; Cysteine Proteinase Inhibitors; Diazomethane; Leucine; Lysosomes; Microscopy, Electron; Organelles; Trypanosoma cruzi | 1996 |
Human monocytes induce a carcinoma cell line to secrete high amounts of nitric oxide.
Topics: Arginine; Carcinoma, Transitional Cell; Coculture Techniques; Drug Combinations; Humans; Interleukin-1; Kidney Medulla; Leucine; Macrophage Activation; Monocytes; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Solubility; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Urinary Bladder Neoplasms | 1996 |
The effect of human growth hormone therapy on L-(methyl-2H3)-leucine turnover and urinary pseudouridine concentration in patients with Ullrich-Turner syndrome.
Topics: Adolescent; Adult; Age Determination by Skeleton; Amino Acids, Branched-Chain; Child; Female; Follow-Up Studies; Growth Hormone; Humans; Leucine; Pseudouridine; Sexual Maturation; Tritium; Turner Syndrome | 1996 |
[Suppressor effect of immature erythroid cells on B-cell proliferation].
Topics: Animals; B-Lymphocytes; Cells, Cultured; Erythroid Precursor Cells; Immune Tolerance; Leucine; Lymphocyte Activation; Mice; Phenylhydrazines; Spleen | 1997 |
Role of microglia in neuronal cell death in prion disease.
Topics: Animals; Animals, Newborn; Apoptosis; Cells, Cultured; Cerebellum; Cricetinae; Dose-Response Relationship, Drug; Female; Immunoenzyme Techniques; Leucine; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Microglia; Neurons; PrPC Proteins; PrPSc Proteins; Scrapie; Time Factors | 1998 |
Pyrimidine nucleotide-stimulated thromboxane A2 release from cultured glia.
Topics: Aminobenzoates; Animals; Animals, Newborn; Calcium; Cells, Cultured; Cerebral Cortex; Chlorobenzoates; Cinnamates; Culture Media, Serum-Free; Cytidine Triphosphate; Drug Interactions; Ionomycin; Ionophores; Leucine; Neuroglia; ortho-Aminobenzoates; Phospholipases A; Phospholipases A2; Rats; Thromboxane A2; Thymine Nucleotides; Uridine Diphosphate; Uridine Triphosphate | 1998 |
Prion protein-overexpressing cells show altered response to a neurotoxic prion protein peptide.
Topics: Animals; Astrocytes; Blotting, Western; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; Coculture Techniques; Formazans; Gene Expression; Leucine; Mice; Mice, Transgenic; Microglia; Neurons; Nitroblue Tetrazolium; Peptide Fragments; Prions; PrPC Proteins; Superoxides; Tetrazolium Salts | 1998 |
Hypomethylation of the proximal and intronic regulatory regions of the IFN-gamma gene is not essential for its transcription by naive CD4+ T cells cultured with IL-4.
Topics: CD4-Positive T-Lymphocytes; Cell Differentiation; Cells, Cultured; DNA; DNA Methylation; Fetal Blood; Gene Expression Regulation; Humans; Interferon-gamma; Interleukin-4; Introns; Ionomycin; Leucine; Recombinant Proteins; Regulatory Sequences, Nucleic Acid; TATA Box; Tetradecanoylphorbol Acetate; Th1 Cells; Transcription Factors; Transcription, Genetic | 1999 |
Inhibition of L-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Cell Death; Dipeptides; Growth Inhibitors; Humans; Hydrogen-Ion Concentration; Leucine; Lysosomes; Monocytes; Phenylmethylsulfonyl Fluoride; Sulfonamides; Tumor Cells, Cultured; U937 Cells | 2000 |
Kinetics of the intracellular differentiation of Leishmania amazonensis and internalization of host MHC molecules by the intermediate parasite stages.
Topics: Animals; Blotting, Western; Cathepsin B; Cathepsin L; Cathepsins; Cells, Cultured; Cysteine Endopeptidases; Down-Regulation; Endopeptidases; Female; Fluorescent Antibody Technique, Indirect; Histocompatibility Antigens Class II; Host-Parasite Interactions; Kinetics; Leishmania; Leishmaniasis; Leucine; Macrophages; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Immunoelectron; Phagocytosis; Time Factors | 2001 |
Structures of Escherichia coli branched-chain amino acid aminotransferase and its complexes with 4-methylvalerate and 2-methylleucine: induced fit and substrate recognition of the enzyme.
Topics: Bacillus; Binding Sites; Computer Simulation; Conserved Sequence; Crystallography, X-Ray; D-Alanine Transaminase; Escherichia coli; Imines; Keto Acids; Leucine; Ligands; Models, Molecular; Protein Conformation; Protein Structure, Tertiary; Structure-Activity Relationship; Substrate Specificity; Transaminases | 2001 |
Role of specific activators of intestinal amino acid transport in Bombyx mori larval growth and nutrition.
Topics: Amino Acid Transport Systems, Basic; Animals; Arginine; Bombyx; Intestinal Absorption; Leucine; Lysine; Microvilli | 2001 |
Leucine methyl ester is a powerful allosteric activator of the neutral amino acid cotransport system in Bombyx mori larval midgut.
Topics: Allosteric Regulation; Amino Acid Transport Systems, Neutral; Animals; Bombyx; Digestive System; Hydrogen-Ion Concentration; Kinetics; Larva; Leucine; Microvilli; Potassium | 2002 |
The kinetics of the alpha-chymotrypsin-catalyzed hydrolysis of acetyl-L-leucine methyl ester.
Topics: Chymotrypsin; Hydrolysis; Kinetics; Leucine | 1962 |
Leishmania amazonensis Rab7 promotes toxicity of the amino acid ester Leu-OMe in amastigote megasomes.
Topics: Animals; Kinetics; Leishmania mexicana; Leucine; Mutagenesis; Protozoan Proteins; rab GTP-Binding Proteins; rab7 GTP-Binding Proteins | 2003 |
L-leucine methyl ester: the female-produced sex pheromone of the scarab beetle, Phyllophaga lanceolata.
Topics: Animals; Coleoptera; Female; Leucine; Male; Movement; Sex Attractants | 2003 |
Characterization of an improved procedure for the removal of microglia from confluent monolayers of primary astrocytes.
Topics: Animals; Antimetabolites, Antineoplastic; Astrocytes; Cell Separation; Cells, Cultured; Cyclooxygenase 2; Cytarabine; Leucine; Mice; Mice, Inbred Strains; Microglia; Mitosis; Nitric Oxide Synthase Type II | 2006 |
Monocytes stimulated by 110-kDa fibronectin fragments suppress proliferation of anti-CD3-activated T cells.
Topics: CD3 Complex; Fibronectins; Humans; Immune Tolerance; Leucine; Lipopolysaccharide Receptors; Lymphocyte Activation; Monocytes; Peptide Fragments; T-Lymphocytes | 2005 |
Substrate induction of osteogenesis from marrow-derived mesenchymal precursors.
Topics: Alkaline Phosphatase; Animals; Bone Marrow; Cell Adhesion; Cell Line; Cell Proliferation; Collagen Type I; Culture Media; Fibronectins; Laminin; Leucine; Mesenchymal Stem Cells; Mice; Osteogenesis; Phenotype; Polymerase Chain Reaction | 2005 |
Effect of L-leucine methyl ester on growth and ultrastructure of Trypanosoma cruzi.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Dose-Response Relationship, Drug; Flow Cytometry; Inhibitory Concentration 50; Leucine; Macrophages, Peritoneal; Mice; Microscopy, Confocal; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Trypanosoma cruzi | 2007 |
Tumour-associated macrophages secrete IL-6 and MCP-1 in head and neck squamous cell carcinoma tissue.
Topics: Carcinoma, Squamous Cell; Cell Division; Chemokine CCL2; Enzyme-Linked Immunosorbent Assay; Humans; Immunoenzyme Techniques; Interleukin-6; Leucine; Macrophages; Organ Culture Techniques; Otorhinolaryngologic Neoplasms; Spheroids, Cellular; Tumor Cells, Cultured | 2007 |
Conglomerate crystallization on self-assembled monolayers.
Topics: Calorimetry, Differential Scanning; Caproates; Crystallization; Glutamic Acid; Gold; Leucine; Spectrum Analysis, Raman; X-Ray Diffraction | 2011 |
Generation of primary astrocyte cultures devoid of contaminating microglia.
Topics: Astrocytes; Cell Culture Techniques; Cytarabine; Leucine; Microglia; Receptor, Macrophage Colony-Stimulating Factor | 2012 |
A NMR experiment for simultaneous correlations of valine and leucine/isoleucine methyls with carbonyl chemical shifts in proteins.
Topics: Isoleucine; Leucine; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Proteins; Valine | 2014 |
Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester.
Topics: Animals; Apoptosis; Cell Communication; Cell Culture Techniques; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Leucine; Microglia; Neurons; Rats | 2015 |
Development of a Direct Photocatalytic C-H Fluorination for the Preparative Synthesis of Odanacatib.
Topics: Biphenyl Compounds; Cathepsin K; Esters; Halogenation; Leucine; Molecular Structure; Sulfonamides | 2015 |
Three new amino acid derivatives from edible mushroom Pleurotus ostreatus.
Topics: Agaricales; Antioxidants; Candida albicans; Flavins; Leucine; Microbial Sensitivity Tests; Molecular Structure; Phenylalanine; Pleurotus | 2017 |
MiT/TFE family members suppress L-leucyl-L-leucine methyl ester-induced cell death.
Topics: Active Transport, Cell Nucleus; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Death; Gene Expression; HeLa Cells; Humans; Hydrolases; Leucine; Lysosomal Membrane Proteins; Lysosomes; Microphthalmia-Associated Transcription Factor; Organelle Biogenesis; RNA, Messenger | 2021 |