letrozole and tamoxifen

letrozole has been researched along with tamoxifen in 492 studies

Research

Studies (492)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's16 (3.25)18.2507
2000's264 (53.66)29.6817
2010's181 (36.79)24.3611
2020's31 (6.30)2.80

Authors

AuthorsStudies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brodie, A; Savinov, A; Wang, J; Yue, W1
Enomoto, K1
Buzdar, AU; Roseman, BJ; Singletary, SE1
Dickson, RB; El-Ashry, D; Hannum, RS; Kern, FG; Kharbanda, S; Lopez, CA; Lorant, LA; McLeskey, SW; Tobias, CA; Trock, BJ; Zhang, L1
Brodie, A; Liu, Y; Long, B; Lu, Q; Wang, JP; Yue, W1
Colussi, DM; Lefèvre, GY; Parisot, CY1
Brodie, A; Liu, Y; Lu, Q; Wang, J; Yue, W1
Brodie, A; Liu, Y; Long, B; Lu, Q; Wang, J; Yue, W1
Hamilton, A; Piccart, M1
Dowsett, M; Ingle, JN; Johnson, PA; Jordan, VC; Krook, JE; Loprinzi, CL; Mailliard, JA; Perez, EA; Suman, VJ; Wheeler, RH1
Dowsett, M; Gundacker, H; Houston, SJ; Johnston, SR; Miles, DW; Pfister, C; Sioufi, A; Smith, IE; Verbeek, JA1
Brodie, A; Gimbel, M; Grigoryev, D; Liu, Y; Long, BJ; Lu, Q1
Brodie, AM; Njar, VC1
Dowsett, M1
Bellamy, C; Cameron, DA; Dixon, JM; Leonard, RC; Love, CD; Miller, WR; Renshaw, L1
Dowsett, M; Ingle, JN; Jordan, VC; Suman, VJ1
Harvey, HA; Santen, RJ1
Mokbel, K1
Apffelstaedt, J; Bapsy, PP; Becquart, D; Boni, C; Chaudri-Ross, HA; Dank, M; Dugan, M; Gershanovich, M; Jänicke, F; Lassus, M; Monnier, A; Mouridsen, H; Pérez-Carrión, R; Pluzanska, A; Salminen, E; Sleeboom, HP; Smith, R; Snyder, R; Staffler, B; Sun, Y; Verbeek, JA1
Tominaga, T1
Pritchard, KI1
Borgs, M; Brady, C; Coop, A; Dugan, M; Ellis, MJ; Evans, DB; Jänicke, F; Llombert-Cussac, A; Mauriac, L; Miller, WR; Quebe-Fehling, E; Singh, B1
Lønning, PE2
Murray, R1
Nabholtz, JM; Reese, DM1
Buzdar, AU6
Fenaroli, P; Labianca, R; Tondini, C1
Appfelstaedt, J; Borgs, M; Chaudri-Ross, HA; Dugan, M; Eiermann, W; Ellis, M; Eremin, J; Lassus, M; Llombart-Cussac, A; Mauriac, L; Paepke, S; Vinholes, J1
Blankenstein, MA; Blijham, GH; Brodie, AM; Chen, T; DeJong, PC; Elbers, JR; Fulton, A; Long, BJ; Lu, Q; Macpherson, N; Nortier, JW; Schipper, ME; Slee, PH; Thijssen, JH; van de Ven, J; van Gorp, JM1
Anderson, TJ; Cameron, DA; Dixon, JM; Miller, WR1
Chen, G; Cohen, MH; Johnson, JR; Li, N; Pazdur, R1
Timms, B1
Goss, PE5
Illiger, HJ1
Jones, SE1
Benedetto, C; De Nicola, B; Ferraris, F; Genta, F; Piccinno, R; Porpiglia, M; Vicelli, R1
Alba, E; Colla, F; Farina, C; Mazzoleni, A; Ragonesi, G1
Ingle, JN4
Brodie, AM; Jelovac, D; Long, BJ; Thiantanawat, A1
Bettuzzi, S; Filippi, S; Forti, G; Granchi, S; Ledda, F; Luconi, M; Maggi, M; Tozzi, P; Vignozzi, L1
Atalay, G; Cardoso, F; Piccart, MJ1
Anderson, TJ; Dixon, JM; Miller, WR1
Robertson, JF1
Crescioli, C; Ferruzzi, P; Forti, G; Granchi, S; Luconi, M; Maggi, M; Mancina, R; Muratori, M; Serio, M; Vannelli, GB1
Martín de Vidales, C; Pérez-Torrubia, A; Zapatero, A1
Jones, T; Karnon, J1
Ali, SM; Brady, C; Carney, W; Chaudri-Ross, HA; Demers, L; Harvey, HA; Leitzel, K; Lipton, A; Wyld, P1
Anderson, TJ; Cameron, D; Dixon, JM; Macfarlane, L; Miller, WR1
Apffelstaedt, J; Bapsy, PP; Becquart, D; Bhatnagar, A; Boni, C; Chaudri-Ross, H; Dank, M; Gershanovich, M; Jaenicke, F; Lang, R; Monnier, A; Mouridsen, H; Perez-Carrion, R; Pluzanska, A; Salminen, E; Sleeboom, HP; Smith, R; Snyder, R; Sun, Y; Wyld, P1
Berstein, LM; Harada, H; Lykkesfeldt, AE; Naftolin, F; Santen, RJ; Shanabrough, M; Wang, JP; Yue, W; Zheng, H1
Dranitsaris, G; Trudeau, M; Verma, S1
Höffken, K; Sayer, HG1
Rose, C1
Brodie, AH; Mouridsen, HT1
Dowsett, M; Ellis, MJ1
Thomas, R1
Dixon, JM; Jackson, J; Miller, WR1
Bryant, J; Wolmark, N1
Burstein, HJ1
Abrams, JS; Castiglione, M; Davidson, NE; Goss, PE; Ingle, JN; Livingston, RB; Martino, S; Muss, HB; Norton, L; Palmer, MJ; Pater, JL; Perez, EA; Piccart, MJ; Pritchard, KI; Robert, NJ; Shepherd, LE; Therasse, P; Tu, D1
Chaudri-Ross, HA; Coop, A; Ellis, MJ; Evans, DB; Jänicke, F; Llombart-Cussac, A; Mauriac, L; Miller, WR; Quebe-Fehling, E; Singh, B; Tao, Y1
Glendenning, A; Johnston, SR; Jones, T; Karnon, J1
Hobson, K1
Brodie, AH; Jelovac, D; Long, B1
Smith, IE3
Dixon, JM; Jackson, J; Miller, WR; Renshaw, L1
Dressman, H; Ellis, MJ; Marks, J; Rosen, E1
Jones, J; Kirma, N; Luthra, R; Tekmal, RR1
Twombly, R1
Brodie, AH; Mouridsen, HT; Rose, C; Smith, IE1
Filippi, S; Forti, G; Gelmini, S; Granchi, S; Ledda, F; Luconi, M; Maggi, M; Mancina, R; Marini, M; Morelli, A; Orlando, C; Vannelli, GB; Vignozzi, L1
DeGrendele, H1
Shahab, N1
Harris, SR1
Hellman, D; Hellman, S1
Domont, J; Khayat, D; Namer, M; Spano, JP1
Kawakami, M; Saji, S; Toi, M1
Ellis, MJ1
Dixon, JM2
Brodie, AM; Goloubeva, OG; Handratta, V; Jelovac, D; Long, BJ; MacPherson, N; Ragaz, J; Thiantanawat, A1
Campos, SM1
Armeanu, S; Fersis, N; Friedrich, M; Gagulic, E; Pantic, L; Relakis, K; Smyczek-Gargya, B; Wallwiener, D1
Altundag, K; Oyan, B; Ozisik, Y1
Arora, A; Potter, JF1
Chaudri-Ross, HA; Mouridsen, HT1
Clemons, M; Coleman, RE; Verma, S1
Sainsbury, R1
Ellis, M1
Aglietta, M; Cirillo, S; Gatti, M; Martincich, L; Montemurro, F; Regge, D; Russo, F1
Aebi, S; Baumann, ChK1
Tobias, JS1
Barrett, JC; Berrigan, D; Brodie, A; Hursting, SD; Jelovac, D; Macedo, L; Núñez, NP; Perkins, SN1
Altundag, K; Buzdar, AU; Hortobagyi, G; Morandi, P; Rouzier, R; Theriault, RL1
Becquart, D; Chaudri-Ross, HA; Gershanovich, M; Lang, R; Mouridsen, H; Perez-Carrion, R; Sun, Y1
Chaudri-Ross, HA; Mouridsen, H1
Ameye, L; Carbonez, A; Christiaens, MR; Morales, L; Neven, P; Paridaens, R; Timmerman, D; Van Huffel, S; Van Limbergen, E; Vergote, I1
Davis, GJ; Ravdin, PM1
Caruggi, M; Colombo, G; Marchetti, M1
Brodie, AM; Goloubeva, OG; Handratta, V; Ingle, JN; Jelovac, D; Long, BJ; Macedo, L1
de Cremoux, P; Diéras, V; Fourquet, A; Magdelénat, H; Pierga, JY; Poupon, MF; Sigal-Zafrani, B1
Harwood, KV1
Fentiman, IS1
Clemons, MJ; Freedman, OC; Verma, S1
Henderson, IC1
Fricker, J2
Kondo, M; Miki, S; Ochiai, T; Okubo, I; Toi, M1
Kahán, Z1
Deangelis, D; Goss, PE; Heath, M; Ingle, JN; Liu, S; Palmer, MJ; Perez, EA; Pritchard, PH; Shepherd, L; Tu, D; Wasan, KM1
Akar, M; Buyuk, E; Libertella, N; Oktay, K; Rosenwaks, Z1
Liu, H; Mi, Y; Tang, X; Zeng, W; Zhang, C1
Chen, S; Itoh, T; Karlsberg, K; Kijima, I; Smith, D; Ye, J; Yuan, YC1
Dodwell, D; Vergote, I1
Oktay, K1
Carpi, A; Nicolini, A1
Kaufmann, M; Rody, A2
Ingle, JN; Suman, VJ1
Cole, B; Gard, C; Glendenning, GA; Irish, W; Mouridsen, H; Sherrill, B1
Ali, SM; Carney, W; Chaudri-Ross, HA; Demers, L; Evans, D; Hackl, W; Hamer, P; Harvey, HA; Lang, R; Leitzel, K; Lipton, A1
Brodie, AM; Goloubeva, OG; Jelovac, D; Long, BJ; Macedo, L; Sabnis, G1
Brodie, AM; Goloubeva, OG; Handratta, V; Jelovac, D; Macedo, L1
Brodie, A; Goloubeva, O; Jelovac, D; Long, B; Macedo, L; Sabnis, G1
Senn, HJ; Thürlimann, B1
Hamilton, AL; Nordman, IC; Spillane, AJ1
Bae, K; Ellis, M; Klause, A; Tao, Y; Vickers, A1
Anderson, TJ; Dixon, JM; Evans, D; Krause, A; Larionov, A; Miller, WR; Murray, J; White, S1
Gradishar, WJ1
Johnson, JR; Kelly, R; Mann, BS; Pazdur, R; Sridhara, R; Williams, G1
Abrams, JS; Cameron, DA; Castiglione, M; Davidson, NE; Goss, PE; Ingle, JN; Livingston, RB; Martino, S; Muss, HB; Norton, L; Palmer, MJ; Pater, JL; Perez, EA; Piccart, MJ; Pritchard, KI; Robert, NJ; Shepherd, LE; Tu, D5
Goss, PE; Ingle, JN; Liu, S; Martino, S; Muss, HB; Palmer, M; Pater, JL; Pritchard, K; Robert, NJ; Shepherd, LE; Tu, D; Whelan, TJ1
Oktay, KH1
Chen, S; Itoh, T; Kijima, I1
Dörken, B; Kretzschmar, A; Lindner, T; Mrozek, A; Pink, D; Reichardt, P; Thuss-Patience, PC1
Koeberle, D; Thuerlimann, B2
Castiglione-Gertsch, M; Coates, AS; Forbes, JF; Gelber, RD; Goldhirsch, A; Keshaviah, A; Mauriac, L; Mouridsen, H; Paridaens, R; Price, KN; Rabaglio, M; Smith, I; Thürlimann, B; Wardley, A; Wardly, A1
Swain, SM1
Davis, WA; Dokras, A; Moss, V; Ryan, GL; Sparks, AE; Van Voorhis, BJ1
Fodor, J1
Brandman, J; Delea, T; Goss, PE; Johnston, SR; Karnon, J; Smith, R; Sung, J1
Gltick, S1
Keam, SJ; Scott, LJ1
Higa, GM1
Hargis, JB; Nakajima, ST1
Abrial, C; Cabrespine, A; Chollet, P; Cure, H; Durando, X; Ferriere, JP; Kwiatkowski, F; Leheurteur, M; Mouret-Reynier, MA; Penault-Llorca, F1
Wardley, AM2
Baum, M; Buzdar, AU; Cuzick, J1
Erban, JK1
Chlebowski, RT1
Grana, G1
Dunn, C; Keam, SJ1
Forbes, JF1
Dowsett, M; Hayes, D; Lønning, PE; Santen, RJ; Smith, IE; Walsh, G; Yap, YS1
Canorea, F; Del Castillo, A; Gil, JM; González, P; Rubio-Terrés, C1
Duffy, MJ1
Tsukagoshi, S1
Brown, MM; Manquez, ME; Shields, CL; Shields, JA1
Brandman, J; Delea, T; El Ouagari, K; Karnon, J; Talbot, W1
Findlay, BP; Goss, PE; Ingle, JN; Josse, RG; Liu, S; Martino, S; Palmer, MJ; Perez, EA; Pritchard, KI; Shenkier, TN; Shepherd, LE; Tozer, RG; Tu, D1
Brandman, J; Delea, TE; Gross, PE; Johnston, SR; Karnon, J; Smith, RE; Sung, JC1
Vakaet, L1
Brodie, AM; Nnane, IP; Tao, X1
Goss, PE; Ingle, JN; Moy, B; Pater, JL; Shepherd, LE; Tu, D; Whelan, TJ1
Crane, J; Gaya, A; Stebbing, J1
Bryce, C; Chia, SK; Gelmon, KA; Kennecke, HF; Norris, B; Olivotto, IA; Speers, C1
Borenstein, MR; Canney, DJ; Nnane, IP; Piao, H; Tao, X1
Ali, SM; Carney, W; Chaudri-Ross, HA; Demers, L; Evans, DB; Hackl, W; Hamer, P; Leitzel, K; Lipton, A; Souder, C1
DiLeonardo, M; Gibbons, G; Resnik, KS1
Brodie, A; Jelovac, D; Sabnis, G1
Beresford, MJ; Makris, A; Ravichandran, D1
Goss, PE; Gottardt, H; Ingle, JN; Olson, JE; Scott, CG; Suman, VJ; Vachon, CM1
Barash, NIu; Bershteĭn, LM; Gamaiunova, VB; Ivanov, VG; Kovalenko, IG; Malysheva, SA; Poroshina, TE; Semiglazov, VF; Shcherbakova, EB; Tsyrlina, EV; Zhil'tsova, EK1
Castiglione-Gertsch, M; Chirgwin, J; Coates, AS; Colleoni, M; Del Mastro, L; Forbes, JF; Gelber, RD; Goldhirsch, A; Jakobsen, EH; Keshaviah, A; Láng, I; Mauriac, L; Mouridsen, H; Nogaret, JM; Paridaens, R; Pienkowski, T; Price, KN; Smith, I; Thürlimann, B; Wardley, A1
Dewar, R; Rayson, D; Skedgel, C; Younis, T1
Costantino, J; Cronin, W; Geyer, C; Harkins, B; Jeong, JH; Lembersky, B; Mamounas, EP; Paik, S; Wickerham, DL; Wolmark, N1
Imai, H; Kuroi, K; Ohsumi, S; Ono, M; Shimozuma, K1
Castiglione-Gertsch, M; Coates, AS; Debled, M; Forbes, JF; Gelber, RD; Goldhirsch, A; Keshaviah, A; Láng, I; Mauriac, L; Monnier, A; Mouridsen, H; Nogaret, JM; Paridaens, R; Price, KN; Rabaglio, M; Smith, I; Thürlimann, B; Viale, G; Wardley, A; Zabaznyi, N1
Nortier, JW; Seynaeve, C; van de Velde, CJ; van Nes, JG1
Mouridsen, HT2
Konkle, AT; McCarthy, MM; Schwarz, JM; Shiroor, C; Speert, DB; Taylor, ME; Zup, SL1
Angeli, A; Ardine, M; Berruti, A; Bertoldo, F; Dogliotti, L; Mosca, A; Tucci, M; Vana, F1
Lian, ZQ; Yang, MT1
Aapro, M; Cannon, H; Georgiou, V; Leto di Priolo, S; Wengström, Y1
Brodie, A; Goloubeva, O; Jelovac, D; Sabnis, G; Schayowitz, A1
Monnier, AM1
Kafy, S; Tulandi, T1
Barghout, V; Delea, TE; Karnon, J; Papo, NL; Sofrygin, O; Thomas, SK1
Barghout, V; Delea, T; Karnon, J1
Carroll, C; De Nigris, E; Hind, D; Simpson, E; Ward, S; Wyld, L1
Delea, TE; El-Ouagari, K; Karnon, J; Sofrygin, O1
Braye, S; Castiglione-Gertsch, M; Coates, AS; Dell'Orto, P; Gelber, RD; Goldhirsch, A; Gusterson, BA; Maiorano, E; Mastropasqua, MG; Neven, P; Ohlschlegel, C; Orosz, Z; Price, KN; Raffoul, J; Rasmussen, BB; Regan, MM; Thürlimann, B; Viale, G1
Abreu, P; Banke-Bochita, J; Goss, PE; Hadji, P; Subar, M; Thomsen, T1
Cao, A; Zhang, C1
Kamby, C; Lindberg, H; Nielsen, DL; Tuxen, M1
Cufer, T1
Fabian, CJ1
Bhatnagar, AS1
Ellis, MJ; Ma, C1
O'Shaughnessy, J1
Perez, EA1
Haidinger, R; Harbeck, N1
Jahanzeb, M1
Atabekoglu, C; Sonmezer, M1
Castiglione-Gertsch, M; Coates, AS; Colleoni, M; Forbes, JF; Gelber, RD; Goldhirsch, A; Keshaviah, A; Mauriac, L; Mouridsen, H; Paridaens, R; Price, KN; Rabaglio, M; Smith, I; Sun, Z; Thürlimann, B1
Dodwell, D; Williamson, D1
Altermatt, HJ; Braye, S; Castiglione-Gertsch, M; Coates, AS; Del Curto, B; Dell'Orto, P; Gelber, RD; Goldhirsch, A; Gusterson, BA; Henriksen, KL; Lacroix-Triki, M; Lykkesfeldt, AE; Mastropasqua, MG; Méry, E; Price, KN; Rasmussen, BB; Regan, MM; Thürlimann, B; Viale, G1
Botti, G; D'Aiuto, G; D'Aiuto, M; De Maio, E; de Matteis, A; Di Rella, F; Esposito, G; Gallo, C; Gravina, A; Labonia, V; Landi, G; Morabito, A; Nuzzo, F; Pacilio, C; Perrone, F; Piccirillo, MC; Rinaldo, M; Rossi, E1
Eisen, A; Messersmith, H; Pritchard, KI; Shelley, W; Trudeau, M1
Collingridge, D1
Blackwell, KL; Herold, CI2
Doughty, JC2
Carpenter, R1
Braat, S; Gerhard, D; Hothorn, LA1
Castiglione-Gertsch, M; Chirgwin, JH; Coates, AS; Colleoni, M; Crivellari, D; Del Mastro, L; Forbes, JF; Gelber, RD; Gladieff, L; Goldhirsch, A; Láng, I; Mauriac, L; Mouridsen, H; Paridaens, RJ; Price, KN; Rabaglio, M; Smith, IE; Sun, Z; Thürlimann, B1
Goss, PE; He, Z; Ingle, JN; Martino, S; Muss, HB; Palmer, MJ; Pater, JL; Piccart, MJ; Pritchard, KI; Robert, NJ; Shepherd, LE; Tu, D; Whelan, TJ1
Aapro, M1
Pennery, E1
A'Hern, RP; Cameron, DA; Dixon, JM; Dowsett, M; Folkerd, E; Macaskill, EJ; McHugh, M; Murray, J; Renshaw, L; Young, O1
Marshall, C; Thomas, R; Walker, L; Williams, M1
Ali, SM; Brown-Shimer, S; Carney, W; Chaudri-Ross, HA; Demers, L; Evans, DB; Gaur, V; Hamer, P; Leitzel, K; Lipton, A; Pierce, K1
Adrover, E; Barnadas, A; Calvo, L; de la Haba, J; Estevez, LG; Gil, M; Llombart, A; Sánchez-Rovira, P1
Fields, MM; Mellington, TE1
Gligorov, J; Nabholtz, JM1
Chen, S; Lui, K; Mori, T; Tamura, T; Zhou, D1
Paydas, S1
Vaidya, JS1
Nagykálnai, T1
A'Hern, R; Bhatnagar, AS; Chaudri Ross, HA; Dowsett, M; Eiermann, W; Ellis, MJ; Evans, DB; Luo, J; Miller, WR; Smith, I; Tao, Y; von Kameke, A1
Chaudri Ross, HA; Ellis, MJ; Evans, DB; Miki, Y; Miller, WR; Sasano, H; Suzuki, T; Tao, Y1
Harbeck, N1
Braye, SG; Castiglione-Gertsch, M; Coates, AS; Dell'Orto, P; Gelber, RD; Giobbie-Hurder, A; Goldhirsch, A; Gusterson, BA; Knox, F; MacGrogan, G; Maiorano, E; Mastropasqua, MG; Neven, P; Ohlschlegel, C; Olszewski, WP; Orosz, Z; Price, KN; Regan, MM; Thürlimann, B; Viale, G1
Dos Reis, FJ; Ferriani, RA; Filho, FM; Martins, WP; Nastri, CO1
Cianfrocca, M1
Ejlertsen, B; Henriksen, KL; Lykkesfeldt, AE; Mouridsen, HT; Møller, S; Rasmussen, BB1
Alberts, S; Dentchev, T; Hines, SL; Johnson, DB; Kahanic, S; Liu, H; Loprinzi, CL; Mazurczak, MA; Mincey, B; Nikcevich, DA; Perez, EA; Schaefer, PL; Sloan, JA1
Campbell, I; Colleoni, M; Gelber, RD; Goldhirsch, A; Price, KN; Ravaioli, A; Simoncini, E; Sun, Z; Towler, M1
Azria, D; Belkacémi, Y; Gligorov, J; Jacot, W; Ozsahin, M; Romieu, G; Zaman, K1
Aliev, DA; Azizov, VA; Musaev, IN; Sadygova, TA; Zeĭnalov, RS1
Botti, G; Chiodini, P; D'Aiuto, G; De Feo, G; De Maio, E; de Matteis, A; Di Maio, M; Di Rella, F; Esposito, G; Gallo, C; Gravina, A; Labonia, V; Landi, G; Morabito, A; Nuzzo, F; Pacilio, C; Perrone, F; Piccirillo, MC; Rossi, E1
Sun, L; Wang, Z; Zha, J1
Campone, M; Castiglione-Gertsch, M; Coates, AS; Colleoni, M; Forbes, JF; Gelber, RD; Goldhirsch, A; Hawle, H; Láng, I; Mouridsen, H; Nogaret, JM; Paridaens, RJ; Pienkowski, T; Price, KN; Rabaglio, M; Smith, I; Sun, Z; Thürlimann, B1
Gelber, RD; Giobbie-Hurder, A; Price, KN1
Fischgräbe, J; Götte, M; Kiesel, L; Radke, I; Smollich, M; Wülfing, P1
Ejlertsen, B; Evans, DB; Henriksen, KL; Lykkesfeldt, AE; Mouridsen, HT; Møller, S; Rasmussen, BB; Sasano, H1
Calado, RT; Kajigaya, S; Regal, JA; Stratakis, CA; Wilkerson, KL; Yewdell, WT; Young, NS1
Anderson, J; Chen, YY; Chin, K; DeVries, S; Esserman, LJ; Hwang, ES; Lessing, J; Shim, V; Swain, R; Waldman, FM1
Coates, AS; Forbes, J; Gelber, RD; Giobbie-Hurder, A; Goldhirsch, A; Mauriac, L; Mouridsen, H; Paridaens, R; Price, KN; Regan, MM; Smith, I; Thürlimann, B1
Amakye, D; Bauerfeind, I; Buzdar, A; Chia, S; Chlebowski, R; Cutuli, B; Cuzick, J; Hadji, P; Linforth, R; Maass, N; Noguchi, S; Robidoux, A; Verma, S1
Glück, S1
Lazarus, P; Sun, D1
Chen, S; Masri, S; Phung, S; Wang, X1
Joerger, M; Thürlimann, B1
Dixon, JM; Hannon, R; Macaskill, EJ; McCaig, FM; McHugh, M; Murray, J; Renshaw, L; Williams, L; Young, O1
Aogi, K; Hara, F; Kiyoto, S; Osumi, S; Takabatake, D; Takashima, S1
Chetty, U; Wishart, GC1
Fu, Z; Jin, Y; Liu, W; Qian, H; Shao, X; Sun, L; Wen, L1
Recht, A1
Morimoto, N; Shibaki, T1
Bernhard, J; Cardoso, F; Coates, AS; Gelber, RD; Goldhirsch, A; Harvey, V; Pagani, O; Phillips, KA; Price, KN; Ribi, K; Stephens, A; Sun, Z; Thompson, A; Thürlimann, B1
Dowsett, M; Evans, AH; Evans, DB; Farmer, I; Johnston, SR; Martin, LA; Pancholi, S; Thornhill, A1
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Bandos, H; Brufsky, AM; Chia, SK; Dakhil, SR; Fehrenbacher, L; Geyer, CE; Graham, ML; Jeong, JH; Lembersky, BC; Mamounas, EP; McCarron, EC; Paik, S; Rastogi, P; Seay, TE; Soori, GS; Swain, SM; Wade, JL; Walshe, JM; Wickerham, DL; Wolmark, N1
Åvall-Lundqvist, E; Bagge, E; Beiron, U; Malander, S; Rosenberg, P1
Dong, S; Feng, F; Qi, L; Sun, C; Tian, J; Wang, X; Yao, Y; Zhang, T; Zhou, C1
Clark, BL; Gersch, CL; Gregory, BJ; Hayes, DF; Henry, NL; Hertz, DL; Kamdem, LK; Kidwell, KM; Rae, JM; Stearns, V; Storniolo, AM; Xi, J1
Baker, GM; Brown, M; Colleoni, M; Hazra, A; Heng, YJ; Kammler, R; Kensler, KH; Pyle, ME; Regan, MM; Schnitt, SJ; Tamimi, RM; Thürlimann, B; Viale, G1
Birzniece, V; Ho, KKY; McLean, M; Reddy, N1
Shao, ZM; Yu, KD1
Regan, MM; Ruhstaller, T1
Arenare, L; Barni, S; Cinieri, S; Daniele, G; De Laurentiis, M; De Maio, E; de Matteis, A; De Placido, S; Del Mastro, L; Di Rella, F; Fabbri, A; Forestieri, V; Gallo, C; Gori, S; Gravina, A; Ibrahim, T; Iodice, G; Landi, G; Lauria, R; Mosconi, AM; Normanno, N; Nuzzo, F; Orditura, M; Pacilio, C; Perrone, F; Piccirillo, MC; Putzu, C; Ribecco, AS; Riccardi, F; Rossi, E; Simeon, V; Tinessa, V1
Dempsey, JM; Desta, Z; Gersch, CL; Hayes, DF; Henry, NL; Hertz, DL; Kidwell, KM; Pesch, AM; Rae, JM; Skaar, TC; Stearns, V; Storniolo, AM1
Aktas, B; Barry, WT; Carey, LA; Carrasco, E; Casas, M; Cirrincione, CT; De la Haba-Rodríguez, J; Dickler, MN; Furlanetto, J; Garcia-Saenz, JA; Guerrero-Zotano, A; Hahn, O; Hudis, C; Hyslop, T; Loibl, S; Martín, M; Martinez-Jañez, N; Mehta, K; Morales, S; Partridge, A; Rodriguez-Martin, C; Winer, E1
Yardley, DA1
Chen, J; Fan, Y; He, T; Huang, Q; Li, P; Lv, Q; Wu, Y; Xiang, M; Yang, D; Yang, W; Zhang, X; Zhou, R1
Carpi, A; Ferrari, P; Morganti, R; Nicolini, A; Rossi, G1
Abdelhamid, T; El Desouky, ED; Khaled, H; Nassar, H; Omran, MA; Rashad, N; Shouman, SA1
Ames, MM; Bruinsma, ES; Buhrow, SA; Carter, JM; Cheng, J; Goetz, MP; Hawse, JR; Hoskin, TL; Hou, X; Ingle, JN; Jayaraman, S; Kalari, KR; Kuffel, MJ; McGovern, RM; Monroe, DG; Reid, JM; Reinicke, KE; Safgren, SL; Suman, VJ; Tang, X; Walden, CA; Zeldenrust, MA1
Bartlett, JMS; Blok, EJ; Duijm-de Carpentier, M; Hasenburg, A; Hozumi, Y; Kroep, JR; Liefers, GJ; Markopoulos, CJ; Meershoek-Klein Kranenbarg, E; Noordhoek, I; Paridaens, R; Portielje, JEA; Putter, H; Rea, DW; Rutgers, EJT; Seynaeve, C; van de Velde, CJH; Vannetzel, JM1
Bergqvist, M; Bethune, A; Bidard, FC; Brain, E; Cabel, L; Cottu, P; Donnadieu, A; Kiavue, N; Lerebours, F; Loirat, D; Pierga, JY; Rodrigues, M; Rosenblum, D; Tanguy, ML1
Bonnefoi, H; Castiglione, M; Coates, AS; Colleoni, M; Ejlertsen, B; Gelber, RD; Giobbie-Hurder, A; Goldhirsch, A; Harvey, VJ; Láng, I; Maibach, R; Neven, P; Rabaglio, M; Regan, MM; Ruepp, B; Sun, Z; Thürlimann, B; Wardley, A1
Bonnefoi, H; Coates, AS; Cole, BF; Colleoni, M; Di Leo, A; Ejlertsen, B; Gelber, RD; Giobbie-Hurder, A; Goldhirsch, A; Harvey, VJ; Láng, I; Leone, JP; Lin, NU; Neven, P; Rabaglio, M; Regan, MM; Thürlimann, B; Vaz-Luis, I; Wardley, A1
Ahn, JH; Cheon, J; Jeong, JH; Jung, KH; Kim, GM; Kim, JE; Kim, SB; Koh, SJ; Lee, KS; Park, IH; Sim, SH; Sohn, J1
Almog, B; Azem, F; Cohen, Y; Fouks, Y; Kalma, Y; Shulman, Y1
Agostinetto, E; de Azambuja, E; Debien, V; Lambertini, M; Marta, GN; Piccart-Gebhart, M1
Blomqvist, C; Faltinová, M; Haanpää, M; Hämäläinen, E; Lyytinen, H; Mattson, J; Tiitinen, A; Vehmanen, L1
Cedars, MI; Chien, AJ; Dolezal, M; Juarez-Hernandez, F; Letourneau, J; McCulloch, CE; Mok-Lin, E; Ribeiro, S; Rosen, M; Wald, K; Wang, A1
Abdi, E; Aebi, S; Burstein, HJ; Chirgwin, J; Coates, AS; Colleoni, M; Courtois, A; Farah, S; Gavilá, J; Gelber, RD; Goldhirsch, A; Gombos, A; Graas, MP; Hitre, E; Jerusalem, G; Kamby, C; Karlsson, P; Kuroi, K; Loi, S; Loibl, S; Marth, C; Müller, B; Neven, P; O'Reilly, S; Rabaglio, M; Regan, MM; Ribi, K; Ruepp, B; Ruhstaller, T; Simoncini, E; Thompson, A; Viale, G1
Amaducci, L; Arpino, G; Ballestrero, A; Barone, C; Bighin, C; Bisagni, G; Bruzzi, P; Campadelli, E; Cognetti, F; De Placido, S; Del Mastro, L; Durando, A; Fabi, A; Frassoldati, A; Garrone, O; Gori, S; Lambertini, M; Mansutti, M; Michelotti, A; Montemurro, F; Moretti, G; Mura, S; Poggio, F; Ponzone, R; Puglisi, F; Sanna, G; Tamberi, S; Urracci, Y1
Chang, LT; Chen, CH; Chen, CN; Tam, KW1
Gong, S; Hong, K; Liang, JJ; Liu, TY; Qin, KM; Xie, BH; Yan, JJ; Yang, L; Yin, YP; Yu, WL; Zhou, HB1
Ng, BP; Park, C; Park, SK; Woo, A1
Lu, X; Qian, C1
Elancheran, R; Maruthanila, VL; Mirunalini, S1
Andersson, M; Buch-Larsen, K; Gillberg, L; Marina, D; Rasmussen, ÅK; Schwarz, P1
Balkenende, EME; Beerendonk, CCM; Bos, AME; Cantineau, AEP; Dahhan, T; de Bruin, JP; Fleischer, K; Goddijn, M; Lambalk, CB; Linn, SC; Louwé, LA; Schats, R; Smeenk, JMJ; Stoop, D; van der Veen, F; van Wely, M1
Abel, MK; Juarez-Hernandez, F; Letourneau, JM; Mok-Lin, E; Rosen, MP; Wang, A1
Acconcia, F1
Flaws, JA; Furth, PA; Kang, K; Keegan, G; Muralidaran, V; Rooney, BL; Wang, W; Zou, X1
Han, S; Heo, JH; Mehta, S; Park, C; Spencer, JC1
Bhaskaran, R; Louis, DM; Nair, LM; Narmadha, MP; Vallonthaiel, AG; Vijaykumar, DK; Yesodharan, J1
Choupo, A; Fotsing, SI; Ngo Pambe, JC; Njamen, D; Pieme, CA; Silihe, KK; Yembeau, NL; Zingue, S1
Bandos, H; Brufsky, AM; Chia, SK; Dakhil, SR; Fehrenbacher, L; Geyer, CE; Jeong, JH; Lembersky, BC; Mamounas, EP; McCarron, EC; Rastogi, P; Soori, GS; Swain, SM; Wade, JL; Walshe, JM; Wolmark, N1
Al Hussein Al Awamlh, B; Barocas, DA; Chang, SS; Cortese, BD; Dusetzina, SB; Luckenbaugh, AN; Penson, DF; Stimson, CJ; Talwar, R1
Davidson, NE; Symonds, LK1

Reviews

126 review(s) available for letrozole and tamoxifen

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[New drugs in metastatic breast cancer--1997].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:13

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Aromatase Inhibitors; Breast Neoplasms; Bridged-Ring Compounds; Camptothecin; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cyclophosphamide; Diphosphonates; Drug Resistance, Multiple; Female; Humans; Ibandronic Acid; Imidazoles; Letrozole; Nitriles; Tamoxifen; Taxoids; Triazoles; Zoledronic Acid

1997
Use of aromatase inhibitors in postmenopausal women with advanced breast cancer.
    Journal of surgical oncology, 1997, Volume: 66, Issue:3

    Topics: Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Tamoxifen; Triazoles

1997
The third-generation non-steroidal aromatase inhibitors: a review of their clinical benefits in the second-line hormonal treatment of advanced breast cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:4

    Topics: Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Belgium; Breast Neoplasms; Clinical Trials as Topic; Disease Progression; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Postmenopause; Severity of Illness Index; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles

1999
Aromatase inhibitors and their application in breast cancer treatment*.
    Steroids, 2000, Volume: 65, Issue:4

    Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Mice; Nitriles; Tamoxifen; Triazoles

2000
Drug and hormone interactions of aromatase inhibitors.
    Endocrine-related cancer, 1999, Volume: 6, Issue:2

    Topics: Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Interactions; Enzyme Inhibitors; Estrogens; Fadrozole; Female; Humans; Letrozole; Male; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Premenopause; Sensitivity and Specificity; Tamoxifen; Triazoles

1999
Lessons from the use of aromatase inhibitors in the neoadjuvant setting.
    Endocrine-related cancer, 1999, Volume: 6, Issue:2

    Topics: Aged; Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Receptors, Estrogen; Tamoxifen; Triazoles

1999
Combination hormonal therapy involving aromatase inhibitors in the management of women with breast cancer.
    Endocrine-related cancer, 1999, Volume: 6, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

1999
Use of aromatase inhibitors in breast carcinoma.
    Endocrine-related cancer, 1999, Volume: 6, Issue:1

    Topics: Adult; Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Drug Design; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Middle Aged; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Premenopause; Tamoxifen; Triazoles

1999
[Developments of hormonal agents for breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2001, Volume: 28, Issue:7

    Topics: Adult; Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; Middle Aged; Nitriles; Tamoxifen; Triazoles

2001
Role of anti-aromatase agents in postmenopausal advanced breast cancer.
    Cancer chemotherapy and pharmacology, 2001, Volume: 48, Issue:4

    Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Phytogenic; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Tamoxifen; Triazoles

2001
Third-generation aromatase inhibitors in the treatment of advanced breast cancer.
    Breast cancer (Tokyo, Japan), 2001, Volume: 8, Issue:4

    Topics: Adult; Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Mastectomy; Middle Aged; Neoplasm Staging; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles

2001
A summary of second-line randomized studies of aromatase inhibitors.
    The Journal of steroid biochemistry and molecular biology, 2001, Volume: 79, Issue:1-5

    Topics: Aminoglutethimide; Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Drug Tolerance; Enzyme Inhibitors; Estrogen Receptor Modulators; Fadrozole; Female; Humans; Letrozole; Megestrol Acetate; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2001
Preliminary data from ongoing adjuvant aromatase inhibitor trials.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:12 Suppl

    Topics: Anastrozole; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Tamoxifen; Triazoles

2001
Antiaromatase agents: evolving role in adjuvant therapy.
    Clinical breast cancer, 2002, Volume: 3, Issue:1

    Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2002
[The role of aromatase inhibitors in the treatment of breast neoplasms. An evaluation of clinical efficacy and the tolerability profile].
    Minerva ginecologica, 2002, Volume: 54, Issue:2

    Topics: Adult; Aminoglutethimide; Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Enzyme Inhibitors; Female; Follow-Up Studies; Forecasting; Humans; Letrozole; Middle Aged; Nitriles; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Time Factors; Triazoles

2002
[Antiestrogen therapy in the treatment of breast neoplasms].
    Minerva ginecologica, 2002, Volume: 54, Issue:3

    Topics: Adult; Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Enzyme Inhibitors; Estrogen Antagonists; Female; Forecasting; Humans; Indoles; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Osteoporosis; Postmenopause; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen; Toremifene; Triazoles

2002
Anti-tumor effects of letrozole.
    Cancer investigation, 2002, Volume: 20 Suppl 2

    Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Enzyme Inhibitors; Estrogen Receptor Modulators; Estrogens; Female; Humans; Letrozole; Mastectomy, Segmental; Neoadjuvant Therapy; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Salvage Therapy; Tamoxifen; Treatment Outcome; Triazoles

2002
[Present and future of adjuvant hormone therapy in breast cancer: clinical evidence and clinical trials].
    Revista clinica espanola, 2003, Volume: 203, Issue:4

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2003
A comparison of the efficacy of aromatase inhibitors in second-line treatment of metastatic breast cancer.
    American journal of clinical oncology, 2003, Volume: 26, Issue:4

    Topics: Aminoglutethimide; Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Megestrol Acetate; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Receptors, Estrogen; Tamoxifen; Triazoles

2003
Applicability of the intratumor aromatase preclinical model to predict clinical trial results with endocrine therapy.
    American journal of clinical oncology, 2003, Volume: 26, Issue:4

    Topics: Anastrozole; Androstadienes; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Estrogen Antagonists; Humans; Letrozole; Neoplasm Metastasis; Nitriles; Tamoxifen; Triazoles; Xenograft Model Antitumor Assays

2003
Emerging role of aromatase inhibitors in the adjuvant setting.
    American journal of clinical oncology, 2003, Volume: 26, Issue:4

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Bone Remodeling; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Enzyme Inhibitors; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Quality of Life; Tamoxifen; Triazoles

2003
Safety issues surrounding the use of aromatase inhibitors in breast cancer.
    Expert opinion on drug safety, 2003, Volume: 2, Issue:1

    Topics: Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Metabolism; Nitriles; Patient Satisfaction; Quality of Life; Safety; Tamoxifen; Triazoles

2003
Should aromatase inhibitors replace tamoxifen?
    Drug and therapeutics bulletin, 2003, Volume: 41, Issue:8

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2003
Neoadjuvant tamoxifen and aromatase inhibitors: comparisons and clinical outcomes.
    The Journal of steroid biochemistry and molecular biology, 2003, Volume: 86, Issue:3-5

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Nitriles; Randomized Controlled Trials as Topic; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles

2003
Neoadjuvant comparisons of aromatase inhibitors and tamoxifen: pretreatment determinants of response and on-treatment effect.
    The Journal of steroid biochemistry and molecular biology, 2003, Volume: 86, Issue:3-5

    Topics: Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Letrozole; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Tamoxifen; Treatment Outcome; Triazoles

2003
Challenges in the endocrine management of breast cancer.
    Breast (Edinburgh, Scotland), 2003, Volume: 12 Suppl 2

    Topics: Adult; Aged; Anastrozole; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Letrozole; Mastectomy, Segmental; Mice; Middle Aged; Nitriles; Prognosis; Randomized Controlled Trials as Topic; Receptors, Estrogen; Risk Assessment; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles; United Kingdom

2003
[Neoadjuvant endocrine therapy for breast cancer: an overview].
    Bulletin du cancer, 2004, Volume: 91, Issue:1

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Breast Neoplasms; Clinical Trials as Topic; Estrogen Antagonists; Female; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Tamoxifen; Triazoles

2004
[Controversies in endocrine therapy for breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2004, Volume: 31, Issue:2

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Enzyme Inhibitors; Estrogen Replacement Therapy; Female; Humans; Letrozole; Mastectomy, Segmental; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Receptors, Estrogen; Receptors, Progesterone; Risk Factors; Tamoxifen; Triazoles

2004
Importance of correlative science in advancing hormonal therapy and a new clinical paradigm for neoadjuvant therapy.
    Annals of surgical oncology, 2004, Volume: 11, Issue:1 Suppl

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Disease Progression; Female; Gene Expression Profiling; Humans; Letrozole; Nitriles; Oligonucleotide Array Sequence Analysis; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2004
Aromatase inhibitors for breast cancer in postmenopausal women.
    The oncologist, 2004, Volume: 9, Issue:2

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Enzyme Inhibitors; Female; Humans; Letrozole; Megestrol Acetate; Nitriles; Postmenopause; Receptors, Estrogen; Tamoxifen; Triazoles

2004
Aromatase inhibitors: current indications and future prospects for treatment of postmenopausal breast cancer.
    Journal of the American Geriatrics Society, 2004, Volume: 52, Issue:4

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Drug Approval; Drug Interactions; Economics, Pharmaceutical; Female; Forecasting; Geriatrics; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Patient Selection; Postmenopause; Practice Patterns, Physicians'; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome; Triazoles; United States; United States Food and Drug Administration

2004
Aromatase inhibitors in the adjuvant setting: bringing the gold to a standard?
    Cancer treatment reviews, 2004, Volume: 30, Issue:4

    Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles

2004
Aromatase inhibition in the treatment of advanced breast cancer: is there a relationship between potency and clinical efficacy?
    British journal of cancer, 2004, May-04, Volume: 90, Issue:9

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2004
Overcoming endocrine therapy resistance by signal transduction inhibition.
    The oncologist, 2004, Volume: 9 Suppl 3

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Resistance, Neoplasm; Farnesyltranstransferase; Humans; Immunosuppressive Agents; Letrozole; Nitriles; Receptor, ErbB-2; Receptors, Estrogen; Sirolimus; Tamoxifen; Triazoles

2004
[Aromatase inhibitors in the adjuvant therapy of breast carcinomas].
    Therapeutische Umschau. Revue therapeutique, 2004, Volume: 61, Issue:6

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Patient Care Management; Practice Guidelines as Topic; Practice Patterns, Physicians'; Tamoxifen; Treatment Outcome; Triazoles

2004
Endocrine approaches for the treatment of early and advanced breast cancer in postmenopausal women.
    The international journal of biochemistry & cell biology, 2004, Volume: 36, Issue:11

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase; Breast Neoplasms; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; Nitriles; Postmenopause; Tamoxifen; Triazoles

2004
Current developments in hormonal therapy of breast cancer.
    Clinical breast cancer, 2004, Volume: 5 Suppl 1

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2004
The role of aromatase inhibitors in the adjuvant treatment of breast carcinoma: the M. D. Anderson Cancer Center evidence-based approach.
    Cancer, 2004, Oct-01, Volume: 101, Issue:7

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Enzyme Inhibitors; Evidence-Based Medicine; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Prospective Studies; Tamoxifen; Triazoles

2004
[Tamoxifen and aromatase inhibitors in the treatment of breast cancer in menopausal women: pharmacological and clinical aspects].
    Bulletin du cancer, 2004, Volume: 91, Issue:12

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Estrogen Antagonists; Female; Humans; Letrozole; Menopause; Neoplasms, Hormone-Dependent; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2004
Advances in endocrine therapy for breast cancer: considering efficacy, safety, and quality of life.
    Clinical journal of oncology nursing, 2004, Volume: 8, Issue:6

    Topics: Algorithms; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Decision Trees; Drug Administration Schedule; Drug Monitoring; Estradiol; Female; Fulvestrant; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Nurse's Role; Oncology Nursing; Patient Education as Topic; Patient Selection; Postmenopause; Quality of Life; Safety; Selective Estrogen Receptor Modulators; Social Support; Tamoxifen; Treatment Outcome; Triazoles

2004
Aromatase inhibitors and breast cancer: time for a change?
    International journal of clinical practice, 2004, Volume: 58, Issue:12

    Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Cost-Benefit Analysis; Female; Humans; Letrozole; Multicenter Studies as Topic; Nitriles; Randomized Controlled Trials as Topic; Risk Factors; Tamoxifen; Treatment Outcome; Triazoles

2004
Using aromatase inhibitors in the neoadjuvant setting: evolution or revolution?
    Cancer treatment reviews, 2005, Volume: 31, Issue:1

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Evidence-Based Medicine; Female; Humans; Letrozole; Mastectomy, Segmental; Neoadjuvant Therapy; Nitriles; Randomized Controlled Trials as Topic; Receptors, Estrogen; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles

2005
Changing clinical practice: extending the benefits of adjuvant endocrine therapy in breast cancer.
    Seminars in oncology, 2004, Volume: 31, Issue:6 Suppl 12

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Female; Humans; Letrozole; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2004
Aromatase inhibitors in the management of early breast cancer: optimizing the clinical benefit.
    Seminars in oncology, 2004, Volume: 31, Issue:6 Suppl 12

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Bone Resorption; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2004
Cost-effectiveness of letrozole versus tamoxifen as first-line hormonal therapy in treating postmenopausal women with advanced breast cancer in Japan.
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:3

    Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cost-Benefit Analysis; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; National Health Programs; Nitriles; Postmenopause; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2005
A comparison of fulvestrant and the third-generation aromatase inhibitors in the second-line treatment of postmenopausal women with advanced breast cancer.
    Cancer treatment reviews, 2005, Volume: 31, Issue:4

    Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Drug Resistance, Neoplasm; Estradiol; Female; Fulvestrant; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Tamoxifen; Triazoles

2005
Long-term risk of breast cancer recurrence: the need for extended adjuvant therapy.
    Journal of cancer research and clinical oncology, 2005, Volume: 131, Issue:8

    Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Resistance; Estrogen Receptor Modulators; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Risk Assessment; Tamoxifen; Time Factors; Triazoles

2005
Aromatase inhibitors for therapy of advanced breast cancer.
    The Journal of steroid biochemistry and molecular biology, 2005, Volume: 95, Issue:1-5

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Drug Evaluation; Female; Humans; Letrozole; Megestrol Acetate; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles

2005
[Consensus Meeting of the 9th International Conference on Primary Therapy of Early Breast Cancer (St. Gall, January 26-29, 2005)].
    Gynakologisch-geburtshilfliche Rundschau, 2005, Volume: 45, Issue:3

    Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Disease-Free Survival; Female; Humans; Letrozole; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Tamoxifen; Triazoles

2005
The aromatase inhibitors in early breast cancer: who, when, and why?
    The Medical journal of Australia, 2005, Jul-04, Volume: 183, Issue:1

    Topics: Anastrozole; Aromatase Inhibitors; Breast Neoplasms; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Letrozole; Nitriles; Patient Selection; Selective Estrogen Receptor Modulators; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles

2005
Clinical and biomarker endpoint analysis in neoadjuvant endocrine therapy trials.
    The Journal of steroid biochemistry and molecular biology, 2005, Volume: 95, Issue:1-5

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Clinical Trials as Topic; Endpoint Determination; Female; Humans; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Nitriles; Tamoxifen; Treatment Outcome; Triazoles

2005
Safety considerations of adjuvant therapy in early breast cancer in postmenopausal women.
    Oncology, 2005, Volume: 69, Issue:1

    Topics: Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Controlled Clinical Trials as Topic; Estrogen Receptor Modulators; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles

2005
Letrozole as adjuvant endocrine therapy in postmenopausal women with breast cancer.
    Expert review of anticancer therapy, 2006, Volume: 6, Issue:1

    Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2006
[Interactions between radiation and hormonal therapy in breast cancer: simultaneous or sequential treatment].
    Orvosi hetilap, 2006, Jan-22, Volume: 147, Issue:3

    Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Disease Models, Animal; Drug Administration Schedule; Female; Humans; Letrozole; Nitriles; Radiation-Sensitizing Agents; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2006
Letrozole : in postmenopausal hormone-responsive early-stage breast cancer.
    Drugs, 2006, Volume: 66, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Humans; Letrozole; Male; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Thromboembolism; Triazoles; Venous Thrombosis

2006
Emerging data on optimal adjuvant endocrine therapy: Breast International Group trial 1-98/MA.17.
    Clinical breast cancer, 2006, Volume: 6 Suppl 2

    Topics: Aged; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles

2006
Extended breast cancer treatment with an aromatase inhibitor (Letrozole) after tamoxifen: why, who and how long?
    European journal of obstetrics, gynecology, and reproductive biology, 2006, Jun-01, Volume: 126, Issue:2

    Topics: Aromatase Inhibitors; Breast Neoplasms; Drug Administration Schedule; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2006
Adjuvant aromatase inhibitor therapy for early breast cancer: A review of the most recent data.
    Journal of surgical oncology, 2006, Jun-01, Volume: 93, Issue:7

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Female; Humans; Letrozole; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2006
Letrozole: a pharmacoeconomic review of its use in postmenopausal women with breast cancer.
    PharmacoEconomics, 2006, Volume: 24, Issue:5

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Drug Costs; Female; Humans; Letrozole; Neoplasm Staging; Nitriles; Postmenopause; Quality-Adjusted Life Years; Tamoxifen; Treatment Outcome; Triazoles

2006
Extended adjuvant therapy with letrozole: reducing the risk of recurrence.
    Expert review of anticancer therapy, 2006, Volume: 6, Issue:6

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Letrozole; Lymphatic Metastasis; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Triazoles

2006
[Introduction of new drug: letrozole, a new non-steroidal aromatase inhibitor for the treatment of postmenopausal women with breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:6

    Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Female; Humans; Letrozole; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Survival Rate; Tamoxifen; Triazoles

2006
Breast cancer (metastatic).
    Clinical evidence, 2006, Issue:15

    Topics: Antibodies, Monoclonal; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Bone Neoplasms; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Progestins; Tamoxifen; Taxoids; Triazoles

2006
Bone safety of aromatase inhibitors versus tamoxifen.
    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2006, Volume: 16 Suppl 2

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bone Density; Breast Neoplasms; Female; Fractures, Bone; Humans; Letrozole; Nitriles; Postmenopause; Tamoxifen; Triazoles

2006
Neoadjuvant endocrine therapy in breast cancer.
    Cancer treatment reviews, 2007, Volume: 33, Issue:1

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Goserelin; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Patient Selection; Tamoxifen; Triazoles

2007
Economic evaluation of the prevention and treatment of breast cancer--present status and open issues.
    Breast cancer (Tokyo, Japan), 2007, Volume: 14, Issue:1

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Quality-Adjusted Life Years; Tamoxifen; Triazoles

2007
[Optimal adjuvant hormone therapy in postmenopausal women with hormone-sensitive mammary carcinoma: tamoxifen and the aromatase inhibitors anastrozole, exemestane and letrozole].
    Nederlands tijdschrift voor geneeskunde, 2006, Dec-30, Volume: 150, Issue:52

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles

2006
[Advancement in endocrine therapy for breast cancer].
    Ai zheng = Aizheng = Chinese journal of cancer, 2007, Volume: 26, Issue:4

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2007
The Breast International Group 1-98 trial: big results for women with hormone-sensitive early breast cancer.
    Expert review of anticancer therapy, 2007, Volume: 7, Issue:5

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2007
New advances in ovulation induction.
    Current opinion in obstetrics & gynecology, 2007, Volume: 19, Issue:3

    Topics: Anastrozole; Aromatase Inhibitors; Clomiphene; Estrogen Antagonists; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female; Letrozole; Nitriles; Ovary; Ovulation Induction; Pregnancy; Pregnancy Rate; Tamoxifen; Treatment Outcome; Triazoles

2007
Hormonal therapies for early breast cancer: systematic review and economic evaluation.
    Health technology assessment (Winchester, England), 2007, Volume: 11, Issue:26

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Drug Administration Schedule; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Quality-Adjusted Life Years; Survival Analysis; Tamoxifen; Time Factors; Triazoles

2007
[Antiestrogen treatment in postmenopausal patients with metastatic breast cancer].
    Ugeskrift for laeger, 2007, Sep-10, Volume: 169, Issue:37

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; Nitriles; Postmenopause; Prognosis; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome; Triazoles

2007
Reducing the risk of late recurrence in hormone-responsive breast cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18 Suppl 8

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease-Free Survival; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Risk Factors; Tamoxifen; Triazoles

2007
The what, why and how of aromatase inhibitors: hormonal agents for treatment and prevention of breast cancer.
    International journal of clinical practice, 2007, Volume: 61, Issue:12

    Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Cardiovascular Diseases; Chemotherapy, Adjuvant; Drug Resistance; Female; Humans; Letrozole; Musculoskeletal Diseases; Nitriles; Postmenopause; Premenopause; Tamoxifen; Thromboembolism; Triazoles

2007
The discovery and mechanism of action of letrozole.
    Breast cancer research and treatment, 2007, Volume: 105 Suppl 1

    Topics: Aged; Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Female; Humans; Letrozole; Middle Aged; Molecular Structure; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen; Treatment Outcome; Triazoles

2007
Safety of aromatase inhibitors in the adjuvant setting.
    Breast cancer research and treatment, 2007, Volume: 105 Suppl 1

    Topics: Anastrozole; Androstadienes; Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cardiovascular Diseases; Causality; Chemotherapy, Adjuvant; Comorbidity; Estrogen Receptor Modulators; Female; Hot Flashes; Humans; Incidence; Letrozole; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Neoplasms, Second Primary; Nitriles; Osteoporosis; Rats; Survival Analysis; Tamoxifen; Triazoles

2007
The patient experience.
    Breast cancer research and treatment, 2007, Volume: 105 Suppl 1

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Patient Education as Topic; Postmenopause; Quality of Life; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2007
Reducing the risk for breast cancer recurrence after completion of tamoxifen treatment in postmenopausal women.
    Clinical therapeutics, 2007, Volume: 29, Issue:8

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Letrozole; Nitriles; Postmenopause; Practice Guidelines as Topic; Quality of Life; Risk Assessment; Secondary Prevention; Tamoxifen; Treatment Outcome; Triazoles

2007
Assisted reproduction and breast cancer.
    Minerva ginecologica, 2007, Volume: 59, Issue:4

    Topics: Algorithms; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cryopreservation; Embryo Transfer; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Ovulation Induction; Pregnancy; Primary Ovarian Insufficiency; Quality of Life; Reproductive Techniques, Assisted; Tamoxifen; Triazoles

2007
Beyond tamoxifen: extended and late extended endocrine therapy in postmenopausal early breast cancer.
    Cancer treatment reviews, 2008, Volume: 34, Issue:2

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Survival Analysis; Tamoxifen; Time Factors; Triazoles

2008
Aromatase inhibitors in adjuvant therapy for hormone receptor positive breast cancer: a systematic review.
    Cancer treatment reviews, 2008, Volume: 34, Issue:2

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Survival Analysis; Tamoxifen; Time Factors; Treatment Outcome; Triazoles

2008
The impact of adjuvant endocrine therapy on reducing the risk of distant metastases in hormone-responsive breast cancer.
    Breast (Edinburgh, Scotland), 2008, Volume: 17 Suppl 1

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Disease-Free Survival; Evidence-Based Medicine; Letrozole; Neoplasm Metastasis; Neoplasm Staging; Nitriles; Quality of Life; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles

2008
A review of the BIG results: the Breast International Group 1-98 trial analyses.
    Breast (Edinburgh, Scotland), 2008, Volume: 17 Suppl 1

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Disease-Free Survival; Female; Humans; Letrozole; Neoplasm Metastasis; Neoplasm Staging; Nitriles; Quality of Life; Tamoxifen; Treatment Outcome; Triazoles; United States

2008
Choosing early adjuvant therapy for postmenopausal women with hormone-sensitive breast cancer: aromatase inhibitors versus tamoxifen.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2008, Volume: 34, Issue:7

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Tamoxifen; Triazoles

2008
The role of endocrine therapies in reducing risk of recurrence in postmenopausal women with hormone receptor-positive breast cancer.
    European journal of oncology nursing : the official journal of European Oncology Nursing Society, 2008, Volume: 12, Issue:3

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Nurse Clinicians; Nurse Practitioners; Nurse's Role; Oncology Nursing; Patient Education as Topic; Patient Selection; Postmenopause; Receptors, Estrogen; Risk Factors; Tamoxifen; Time Factors; Treatment Outcome; Triazoles

2008
Neoadjuvant endocrine therapy for breast cancer: past, present and future.
    Anti-cancer drugs, 2008, Volume: 19, Issue:4

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Forecasting; Humans; Letrozole; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Patient Selection; Postmenopause; Tamoxifen; Triazoles

2008
Targeting breast cancer with hormonal treatment options.
    The Nurse practitioner, 2008, Volume: 33, Issue:5

    Topics: Aftercare; Ambulatory Care; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Estrogen Receptor Modulators; Humans; Information Services; Internet; Letrozole; Nitriles; Nurse Practitioners; Patient Selection; Postmenopause; Practice Guidelines as Topic; Receptors, Estrogen; Tamoxifen; Treatment Outcome; Triazoles

2008
The emerging role of aromatase inhibitors in the adjuvant management of breast cancer.
    Reviews on recent clinical trials, 2006, Volume: 1, Issue:3

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Therapy, Combination; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles

2006
Aromatase inhibitors for breast cancer: proven efficacy across the spectrum of disease.
    Clinical breast cancer, 2008, Volume: 8, Issue:1

    Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Tamoxifen; Treatment Outcome; Triazoles

2008
[Adjuvant endocrine therapy in postmenopausal hormone-sensitive breast cancer: to start, to switch or to extend?].
    Magyar onkologia, 2008, Volume: 52, Issue:2

    Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Administration Schedule; Drug Resistance, Neoplasm; Estrogen Receptor Modulators; Female; Humans; Letrozole; Lymphatic Metastasis; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality of Life; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome; Triazoles

2008
Never too late: reducing late breast cancer relapse risk.
    Current medical research and opinion, 2008, Volume: 24, Issue:12

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Europe; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Risk Factors; Tamoxifen; Time Factors; Triazoles

2008
Overcoming recurrence risk: extended adjuvant endocrine therapy.
    Clinical breast cancer, 2008, Volume: 8, Issue:6

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Lymphatic Metastasis; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Tamoxifen; Triazoles

2008
Understanding the BIG results: Insights from the BIG 1-98 trial analyses.
    Advances in therapy, 2008, Volume: 25, Issue:12

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Receptors, Estrogen; Research Design; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2008
[Adjuvant breast cancer treatment with hormono-radiotherapy].
    Bulletin du cancer, 2009, Volume: 96, Issue:3

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2009
Clinical perspectives on the utility of aromatase inhibitors for the adjuvant treatment of breast cancer.
    Breast (Edinburgh, Scotland), 2009, Volume: 18 Suppl 2

    Topics: Adult; Aged; Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Postmenopause; Secondary Prevention; Survival Analysis; Tamoxifen; Triazoles; Women's Health

2009
Exemestane as first-line therapy in postmenopausal women with recurrent or metastatic breast cancer.
    American journal of clinical oncology, 2010, Volume: 33, Issue:3

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Celecoxib; Estrogens; Female; Humans; Letrozole; Middle Aged; Multicenter Studies as Topic; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Pyrazoles; Randomized Controlled Trials as Topic; Recurrence; Salvage Therapy; Sulfonamides; Tamoxifen; Triazoles

2010
Fertility preservation in women with breast cancer.
    Clinical obstetrics and gynecology, 2010, Volume: 53, Issue:4

    Topics: Aromatase Inhibitors; Breast Neoplasms; Counseling; Cryopreservation; Embryo, Mammalian; Female; Fertility; Gonadotropins; Heterozygote; Humans; Infertility, Female; Letrozole; Nitriles; Oocytes; Ovulation Induction; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2010
Women and bone health: maximizing the benefits of aromatase inhibitor therapy.
    Oncology, 2010, Volume: 79, Issue:1-2

    Topics: Anastrozole; Androstadienes; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Breast Neoplasms; Colorectal Neoplasms; Denosumab; Diphosphonates; Female; Humans; Imidazoles; Letrozole; Nitriles; Osteoporosis; Osteoporosis, Postmenopausal; Randomized Controlled Trials as Topic; RANK Ligand; Secondary Prevention; Tamoxifen; Triazoles; Zoledronic Acid

2010
When to start an aromatase inhibitor: now or later?
    Journal of surgical oncology, 2011, Jun-01, Volume: 103, Issue:7

    Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Cost-Benefit Analysis; Drug Administration Schedule; Female; Humans; Letrozole; Neoadjuvant Therapy; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nitriles; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2011
Overview of adjuvant trials of aromatase inhibitors in early breast cancer.
    Steroids, 2011, Volume: 76, Issue:8

    Topics: Anastrozole; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Receptors, Estrogen; Tamoxifen; Triazoles

2011
Interpreting Breast International Group (BIG) 1-98: a randomized, double-blind, phase III trial comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive, early breast cancer.
    Breast cancer research : BCR, 2011, May-26, Volume: 13, Issue:3

    Topics: Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Double-Blind Method; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles

2011
An overview of letrozole in postmenopausal women with hormone-responsive breast cancer.
    Advances in therapy, 2011, Volume: 28, Issue:12

    Topics: Androgens; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Bone and Bones; Breast Neoplasms; Clinical Trials as Topic; Cytochrome P-450 Enzyme System; Estrogen Receptor Modulators; Female; Humans; Letrozole; Lipids; Nitriles; Postmenopause; Tamoxifen; Triazoles

2011
Approval summary: letrozole (Femara® tablets) for adjuvant and extended adjuvant postmenopausal breast cancer treatment: conversion of accelerated to full approval.
    The oncologist, 2011, Volume: 16, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Approval; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles; United States; United States Food and Drug Administration

2011
[Progress of molecularly targeted therapy for breast cancer].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2012, Volume: 53, Issue:4

    Topics: Ado-Trastuzumab Emtansine; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Denosumab; Drug Design; Drug Therapy, Combination; Everolimus; Humans; Lapatinib; Letrozole; Maytansine; Molecular Targeted Therapy; Nitriles; Quinazolines; Receptor, ErbB-2; Sirolimus; Tamoxifen; Trastuzumab; Triazoles

2012
Extended adjuvant endocrine therapy in hormone dependent breast cancer: the paradigm of the NCIC-CTG MA.17/BIG 1-97 trial.
    Critical reviews in oncology/hematology, 2013, Volume: 86, Issue:1

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2013
Pharmacogenomics of endocrine therapy in breast cancer.
    Journal of human genetics, 2013, Volume: 58, Issue:6

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Genome-Wide Association Study; Humans; Japan; Letrozole; Musculoskeletal Physiological Phenomena; Nitriles; Pharmacogenetics; Phenotype; Postmenopause; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2013
Impact of metabolizing enzymes on drug response of endocrine therapy in breast cancer.
    Expert review of molecular diagnostics, 2013, Volume: 13, Issue:4

    Topics: Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Pharmacological; Breast Neoplasms; Cytochrome P-450 CYP2D6; Female; Humans; Letrozole; Nitriles; Receptors, Estrogen; Tamoxifen; Triazoles

2013
Extended adjuvant endocrine therapy in hormone-receptor positive breast cancer.
    Breast (Edinburgh, Scotland), 2013, Volume: 22 Suppl 2

    Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Letrozole; Long-Term Care; Mastectomy, Segmental; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Premenopause; Prognosis; Randomized Controlled Trials as Topic; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles

2013
Postmenopausal women with hormone receptor-positive breast cancer: balancing benefit and toxicity from aromatase inhibitors.
    Breast (Edinburgh, Scotland), 2013, Volume: 22 Suppl 2

    Topics: Aged; Aged, 80 and over; Aromatase Inhibitors; Breast Neoplasms; Cardiovascular Diseases; Chemotherapy, Adjuvant; Drug-Related Side Effects and Adverse Reactions; Estrogen Antagonists; Female; Follow-Up Studies; Fractures, Bone; Humans; Letrozole; Mastectomy, Segmental; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles

2013
Personalized adjuvant therapies: lessons from the past: the opening address by the St. Gallen 2013 award recipient.
    Breast (Edinburgh, Scotland), 2013, Volume: 22 Suppl 2

    Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Awards and Prizes; Breast Neoplasms; Chemotherapy, Adjuvant; Consensus Development Conferences as Topic; Disease-Free Survival; Female; Genes, erbB-2; Humans; Letrozole; Mastectomy; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Precision Medicine; Premenopause; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Switzerland; Tamoxifen; Treatment Outcome; Triazoles

2013
Obesity and endocrine therapy: host factors and breast cancer outcome.
    Breast (Edinburgh, Scotland), 2013, Volume: 22 Suppl 2

    Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Body Mass Index; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Kaplan-Meier Estimate; Letrozole; Middle Aged; Nitriles; Obesity; Postmenopause; Predictive Value of Tests; Premenopause; Prognosis; Proportional Hazards Models; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles

2013
Co-targeting estrogen receptor and HER2 pathways in breast cancer.
    Breast (Edinburgh, Scotland), 2014, Volume: 23, Issue:1

    Topics: Anastrozole; Androstadienes; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Everolimus; Female; Fulvestrant; Gefitinib; Humans; Lapatinib; Letrozole; Molecular Targeted Therapy; Nitriles; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Signal Transduction; Sirolimus; Tamoxifen; Trastuzumab; Triazoles

2014
Tamoxifen or letrozole versus standard methods for women with estrogen-receptor positive breast cancer undergoing oocyte or embryo cryopreservation in assisted reproduction.
    The Cochrane database of systematic reviews, 2013, Nov-08, Issue:11

    Topics: Breast Neoplasms; Cryopreservation; Embryo, Mammalian; Female; Humans; Letrozole; Nitriles; Oocytes; Pregnancy; Receptors, Estrogen; Reproductive Techniques, Assisted; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2013
The optimal duration and selection of adjuvant endocrine therapy for breast cancer: how long is enough?
    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2014

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Humans; Letrozole; Nitriles; Recurrence; Risk Factors; Tamoxifen; Time Factors; Triazoles

2014
Neoadjuvant chemotherapy in breast cancer: review of literature.
    Journal of the Indian Medical Association, 2013, Volume: 111, Issue:9

    Topics: Anthracyclines; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Patient Selection; Tamoxifen; Taxoids; Trastuzumab; Triazoles

2013
Extended adjuvant endocrine therapy in hormone-receptor positive early breast cancer: current and future evidence.
    Cancer treatment reviews, 2015, Volume: 41, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles

2015
Endocrine therapy for hormone treatment-naïve advanced breast cancer.
    Breast (Edinburgh, Scotland), 2016, Volume: 28

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Breast Neoplasms; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Estradiol; Female; Fulvestrant; Humans; Letrozole; Nitriles; Piperazines; Pyridines; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2016
Extended adjuvant endocrine therapy in hormone-receptor-positive early breast cancer.
    Current opinion in oncology, 2016, Volume: 28, Issue:6

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Receptors, Estrogen; Tamoxifen; Triazoles

2016
Identification of miRNAs as biomarkers for acquired endocrine resistance in breast cancer.
    Molecular and cellular endocrinology, 2017, Nov-15, Volume: 456

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Exosomes; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; MicroRNAs; Neoplasm Invasiveness; Neoplasm Metastasis; Nitriles; Signal Transduction; Tamoxifen; Triazoles

2017
ADJUVANT (HORMONAL) THERAPY AS A CAUSE OF BONE LOSS IN PATIENTS WITH BREAST CANCER (REVIEW OF LITERATURE).
    Georgian medical news, 2017, Issue:262

    Topics: Anastrozole; Androstadienes; Aromatase Inhibitors; Bone Density; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Estrogen Antagonists; Female; Humans; Letrozole; Nitriles; Osteoporosis; Postmenopause; Premenopause; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2017
Efficacy and safety of endocrine monotherapy as first-line treatment for hormone-sensitive advanced breast cancer: A network meta-analysis.
    Medicine, 2017, Volume: 96, Issue:33

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Breast Neoplasms; Disease-Free Survival; Estradiol; Female; Fulvestrant; Humans; Letrozole; Neoplasms, Hormone-Dependent; Network Meta-Analysis; Nitriles; Receptor, ErbB-2; Tamoxifen; Triazoles

2017
Efficacy and acceptability of neoadjuvant endocrine therapy in patients with hormone receptor-positive breast cancer: A network meta-analysis.
    Journal of cellular physiology, 2019, Volume: 234, Issue:8

    Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Letrozole; Neoadjuvant Therapy; Network Meta-Analysis; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Zoledronic Acid

2019
Comparative effectiveness of tamoxifen, toremifene, letrozole, anastrozole, and exemestane on lipid profiles in breast cancer patients: A network meta-analysis.
    Medicine, 2020, Volume: 99, Issue:2

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Humans; Letrozole; Lipids; Network Meta-Analysis; Research Design; Tamoxifen; Toremifene

2020
CDK4/6 and PI3K inhibitors: A new promise for patients with HER2-positive breast cancer.
    European journal of clinical investigation, 2021, Volume: 51, Issue:7

    Topics: Aminopyridines; Anastrozole; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Immunological; Benzimidazoles; Breast Neoplasms; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Female; Fulvestrant; Humans; Letrozole; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Protein Kinase Inhibitors; Purines; Pyridines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Trastuzumab

2021
Fertility preservation for women with breast cancer before chemotherapy: a systematic review and meta-analysis.
    Reproductive biomedicine online, 2022, Volume: 44, Issue:2

    Topics: Breast Neoplasms; Cryopreservation; Female; Fertility Preservation; Humans; Letrozole; Oocytes; Ovulation Induction; Tamoxifen

2022
Influence of the anti-oestrogens tamoxifen and letrozole on thyroid function in women with early and advanced breast cancer: A systematic review.
    Cancer medicine, 2023, Volume: 12, Issue:2

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Estrogens; Female; Humans; Hypothyroidism; Letrozole; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Triazoles

2023

Trials

127 trial(s) available for letrozole and tamoxifen

ArticleYear
Evaluation of tamoxifen plus letrozole with assessment of pharmacokinetic interaction in postmenopausal women with metastatic breast cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Interactions; Endocrinology; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles

1999
Impact of tamoxifen on the pharmacokinetics and endocrine effects of the aromatase inhibitor letrozole in postmenopausal women with breast cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Tamoxifen; Triazoles

1999
Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, May-15, Volume: 19, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Double-Blind Method; Female; Humans; Letrozole; Logistic Models; Middle Aged; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles

2001
Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Sep-15, Volume: 19, Issue:18

    Topics: Antineoplastic Agents; Breast Neoplasms; Disease Progression; Double-Blind Method; ErbB Receptors; Estrogen Antagonists; Female; Humans; Letrozole; Logistic Models; Neoadjuvant Therapy; Nitriles; Odds Ratio; Postmenopause; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Prostaglandin; Tamoxifen; Treatment Outcome; Triazoles

2001
Preoperative treatment of postmenopausal breast cancer patients with letrozole: A randomized double-blind multicenter study.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2001, Volume: 12, Issue:11

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Preoperative Care; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Treatment Outcome; Triazoles

2001
[Superiority of letrozole compared with tamoxifen as first line therapy of postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group].
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2002, Volume: 178, Issue:2

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Palliative Care; Postmenopause; Survival Rate; Tamoxifen; Triazoles

2002
Serum HER-2/neu and response to the aromatase inhibitor letrozole versus tamoxifen.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, May-15, Volume: 21, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Estrogen Antagonists; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Receptor, ErbB-2; Switzerland; Tamoxifen; Treatment Outcome; Triazoles; United States

2003
Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Jun-01, Volume: 21, Issue:11

    Topics: Antineoplastic Agents; Breast Neoplasms; Cross-Over Studies; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Nitriles; Postmenopause; Proportional Hazards Models; Survival Rate; Tamoxifen; Triazoles

2003
A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer.
    The New England journal of medicine, 2003, Nov-06, Volume: 349, Issue:19

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality of Life; Survival Analysis; Tamoxifen; Triazoles

2003
Letrozole inhibits tumor proliferation more effectively than tamoxifen independent of HER1/2 expression status.
    Cancer research, 2003, Oct-01, Volume: 63, Issue:19

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Division; Double-Blind Method; ErbB Receptors; Female; Humans; Immunohistochemistry; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Nitriles; Protein Biosynthesis; Proteins; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Trefoil Factor-1; Triazoles; Tumor Suppressor Proteins

2003
A trial-based cost-effectiveness analysis of letrozole followed by tamoxifen versus tamoxifen followed by letrozole for postmenopausal advanced breast cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Volume: 14, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cost-Benefit Analysis; Cross-Over Studies; Drug Costs; Female; Humans; Letrozole; Life Tables; Nitriles; Postmenopause; Quality-Adjusted Life Years; Survival Analysis; Tamoxifen; Triazoles; United States

2003
Letrozole versus tamoxifen in the treatment of advanced breast cancer and as neoadjuvant therapy.
    The Journal of steroid biochemistry and molecular biology, 2003, Volume: 86, Issue:3-5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles

2003
Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the international letrozole breast cancer group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Aug-01, Volume: 22, Issue:15

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cross-Over Studies; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2004
The role of aromatase inhibitors in the adjuvant treatment of breast carcinoma: the M. D. Anderson Cancer Center evidence-based approach.
    Cancer, 2004, Oct-01, Volume: 101, Issue:7

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Enzyme Inhibitors; Evidence-Based Medicine; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Prospective Studies; Tamoxifen; Triazoles

2004
Superiority of letrozole to tamoxifen in the first-line treatment of advanced breast cancer: evidence from metastatic subgroups and a test of functional ability.
    The oncologist, 2004, Volume: 9, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Double-Blind Method; Female; Humans; Karnofsky Performance Status; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles

2004
Efficacy of first-line letrozole versus tamoxifen as a function of age in postmenopausal women with advanced breast cancer.
    The oncologist, 2004, Volume: 9, Issue:5

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease Progression; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Prognosis; Tamoxifen; Treatment Outcome; Triazoles

2004
Acute effects of tamoxifen and third-generation aromatase inhibitors on menopausal symptoms of breast cancer patients.
    Anti-cancer drugs, 2004, Volume: 15, Issue:8

    Topics: Anastrozole; Aromatase Inhibitors; Belgium; Body Mass Index; Breast Neoplasms; Data Interpretation, Statistical; Demography; Dyspareunia; Female; Hot Flashes; Humans; Letrozole; Logistic Models; Memory Disorders; Menopause; Middle Aged; Musculoskeletal Diseases; Nitriles; Pain; Patient Selection; Prospective Studies; Randomized Controlled Trials as Topic; Surveys and Questionnaires; Tamoxifen; Time Factors; Triazoles; Urination Disorders; Vaginal Diseases; Withholding Treatment

2004
The influence of letrozole on serum lipid concentrations in postmenopausal women with primary breast cancer who have completed 5 years of adjuvant tamoxifen (NCIC CTG MA.17L).
    Annals of oncology : official journal of the European Society for Medical Oncology, 2005, Volume: 16, Issue:5

    Topics: Aged; Aromatase Inhibitors; Biological Availability; Breast Neoplasms; Chemotherapy, Adjuvant; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Postmenopause; Probability; Reference Values; Risk Assessment; Statistics, Nonparametric; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles

2005
Fertility preservation in breast cancer patients: a prospective controlled comparison of ovarian stimulation with tamoxifen and letrozole for embryo cryopreservation.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Jul-01, Volume: 23, Issue:19

    Topics: Adult; Breast Neoplasms; Cryopreservation; Embryo, Mammalian; Female; Fertility; Humans; Letrozole; Nitriles; Ovulation Induction; Tamoxifen; Triazoles

2005
Letrozole improves disease-free survival vs tamoxifen in adjuvant treatment of early breast cancer.
    Oncology (Williston Park, N.Y.), 2005, Volume: 19, Issue:3

    Topics: Aged; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Treatment Outcome; Triazoles

2005
Beta-interferon and interleukin-2 prolong more than three times the survival of 26 consecutive endocrine dependent breast cancer patients with distant metastases: an exploratory trial.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2005, Volume: 59, Issue:5

    Topics: Breast Neoplasms; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Immunotherapy; Interferon-beta; Interleukin-2; Letrozole; Multivariate Analysis; Neoplasm Metastasis; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Toremifene; Triazoles

2005
Quality-adjusted survival in a crossover trial of letrozole versus tamoxifen in postmenopausal women with advanced breast cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2005, Volume: 16, Issue:9

    Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Cross-Over Studies; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Quality of Life; Survival Analysis; Tamoxifen; Triazoles

2005
Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17.
    Journal of the National Cancer Institute, 2005, Sep-07, Volume: 97, Issue:17

    Topics: Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Incidence; Letrozole; Lymphatic Metastasis; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles

2005
Assessment of quality of life in MA.17: a randomized, placebo-controlled trial of letrozole after 5 years of tamoxifen in postmenopausal women.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Oct-01, Volume: 23, Issue:28

    Topics: Administration, Oral; Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Drug Administration Schedule; Female; Health Status; Humans; Letrozole; Middle Aged; Nitriles; Pain; Placebos; Postmenopause; Quality of Life; Tamoxifen; Treatment Outcome; Triazoles

2005
A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer.
    The New England journal of medicine, 2005, Dec-29, Volume: 353, Issue:26

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Neoplasms, Second Primary; Nitriles; Postmenopause; Proportional Hazards Models; Receptors, Estrogen; Receptors, Progesterone; Secondary Prevention; Survival Rate; Tamoxifen; Triazoles

2005
Cost effectiveness of extended adjuvant letrozole in postmenopausal women after adjuvant tamoxifen therapy: the UK perspective.
    PharmacoEconomics, 2006, Volume: 24, Issue:3

    Topics: Aged; Anticarcinogenic Agents; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Female; Humans; Letrozole; Markov Chains; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2006
Duration of letrozole treatment and outcomes in the placebo-controlled NCIC CTG MA.17 extended adjuvant therapy trial.
    Breast cancer research and treatment, 2006, Volume: 99, Issue:3

    Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Proportional Hazards Models; Receptors, Estrogen; Receptors, Progesterone; Selective Estrogen Receptor Modulators; Survival Analysis; Tamoxifen; Time Factors; Treatment Outcome; Triazoles

2006
The use of early adjuvant aromatase inhibitor therapy: contributions from the BIG 1-98 letrozole trial.
    Seminars in oncology, 2006, Volume: 33, Issue:2 Suppl 7

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles

2006
Preventing relapse beyond 5 years: the MA.17 extended adjuvant trial.
    Seminars in oncology, 2006, Volume: 33, Issue:2 Suppl 7

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles

2006
Effect of letrozole versus placebo on bone mineral density in women with primary breast cancer completing 5 or more years of adjuvant tamoxifen: a companion study to NCIC CTG MA.17.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Aug-01, Volume: 24, Issue:22

    Topics: Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers; Bone Density; Breast Neoplasms; Canada; Chemotherapy, Adjuvant; Collagen Type I; Estrogen Receptor Modulators; Female; Humans; Letrozole; Middle Aged; Nitriles; Peptides; Tamoxifen; Treatment Outcome; Triazoles

2006
Clinical outcomes of ethnic minority women in MA.17: a trial of letrozole after 5 years of tamoxifen in postmenopausal women with early stage breast cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2006, Volume: 17, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Comorbidity; Disease-Free Survival; Ethnicity; Female; Humans; Letrozole; Mental Health; Middle Aged; Minority Groups; Nitriles; Pain; Patient Compliance; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles; White People

2006
Serum epidermal growth factor receptor/HER-2 predicts poor survival in patients with metastatic breast cancer.
    Cancer, 2006, Nov-15, Volume: 107, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Double-Blind Method; ErbB Receptors; Female; Humans; Letrozole; Middle Aged; Multivariate Analysis; Neoplasm Metastasis; Nitriles; Prognosis; Receptor, ErbB-2; Survival Analysis; Tamoxifen; Triazoles

2006
Pilot study of the impact of letrozole vs. placebo on breast density in women completing 5 years of tamoxifen.
    Breast (Edinburgh, Scotland), 2007, Volume: 16, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aromatase Inhibitors; Breast Neoplasms; Drug Administration Schedule; Female; Humans; Letrozole; Mammography; Middle Aged; Nitriles; Pilot Projects; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome; Triazoles

2007
Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1-98.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Feb-10, Volume: 25, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Estrogen Antagonists; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Proportional Hazards Models; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Time Factors; Treatment Outcome; Triazoles

2007
NSABP B-42: a clinical trial to determine the efficacy of five years of letrozole compared with placebo in patients completing five years of hormonal therapy consisting of an aromatase inhibitor (AI) or tamoxifen followed by an AI in prolonging disease-fr
    Clinical breast cancer, 2006, Volume: 7, Issue:5

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Letrozole; Neoplasm Staging; Nitriles; Patient Selection; Postmenopause; Tamoxifen; Triazoles

2006
Predictors of early relapse in postmenopausal women with hormone receptor-positive breast cancer in the BIG 1-98 trial.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18, Issue:5

    Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Prognosis; Tamoxifen; Time Factors; Treatment Outcome; Triazoles

2007
Letrozole in advanced breast cancer: the PO25 trial.
    Breast cancer research and treatment, 2007, Volume: 105 Suppl 1

    Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cost-Benefit Analysis; Cross-Over Studies; Disease Progression; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Postmenopause; Prognosis; Quality of Life; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles

2007
Efficacy of letrozole extended adjuvant therapy according to estrogen receptor and progesterone receptor status of the primary tumor: National Cancer Institute of Canada Clinical Trials Group MA.17.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, May-20, Volume: 25, Issue:15

    Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Canada; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Nitriles; Placebos; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles

2007
Cost-effectiveness of letrozole versus tamoxifen as initial adjuvant therapy in postmenopausal women with hormone-receptor positive early breast cancer from a Canadian perspective.
    Breast cancer research and treatment, 2008, Volume: 108, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Canada; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Drug Costs; Female; Humans; Letrozole; Markov Chains; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality-Adjusted Life Years; Tamoxifen; Triazoles

2008
Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Sep-01, Volume: 25, Issue:25

    Topics: Adult; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Female; Humans; Immunohistochemistry; Letrozole; Nitriles; Postmenopause; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles

2007
Effects of steroidal and nonsteroidal aromatase inhibitors on markers of bone turnover in healthy postmenopausal women.
    Breast cancer research : BCR, 2007, Volume: 9, Issue:4

    Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers; Bone Density; Bone Remodeling; Bone Resorption; Breast Neoplasms; Estrogens; Female; Humans; Letrozole; Lipids; Menopause; Middle Aged; Nitriles; Peptide Fragments; Placebos; Procollagen; Single-Blind Method; Tamoxifen; Triazoles

2007
Letrozole in the neoadjuvant setting: the P024 trial.
    Breast cancer research and treatment, 2007, Volume: 105 Suppl 1

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Double-Blind Method; Female; Humans; Immunohistochemistry; Letrozole; Mastectomy, Segmental; Middle Aged; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Survival Analysis; Tamoxifen; Triazoles

2007
Letrozole in the extended adjuvant setting: MA.17.
    Breast cancer research and treatment, 2007, Volume: 105 Suppl 1

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cross-Over Studies; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Quality of Life; Receptors, Estrogen; Tamoxifen; Treatment Outcome; Triazoles

2007
Letrozole as upfront endocrine therapy for postmenopausal women with hormone-sensitive breast cancer: BIG 1-98.
    Breast cancer research and treatment, 2007, Volume: 105 Suppl 1

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Europe; Female; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles; United States

2007
A decade of letrozole: FACE.
    Breast cancer research and treatment, 2007, Volume: 105 Suppl 1

    Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Disease-Free Survival; Estrogen Receptor Modulators; Female; Humans; Letrozole; Lymphatic Metastasis; Middle Aged; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Receptors, Estrogen; Tamoxifen; Triazoles

2007
Cardiovascular adverse events during adjuvant endocrine therapy for early breast cancer using letrozole or tamoxifen: safety analysis of BIG 1-98 trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Dec-20, Volume: 25, Issue:36

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cardiovascular Diseases; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Middle Aged; Nitriles; Tamoxifen; Triazoles

2007
Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: supplementary results from the BIG 1-98 randomised trial.
    The Lancet. Oncology, 2008, Volume: 9, Issue:1

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Female; Follow-Up Studies; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Letrozole; Nitriles; Postmenopause; Receptors, Estrogen; Tamoxifen; Triazoles

2008
Endocrine effects of adjuvant letrozole + triptorelin compared with tamoxifen + triptorelin in premenopausal patients with early breast cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Jan-10, Volume: 26, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Gonadal Hormones; Humans; Letrozole; Middle Aged; Nitriles; Premenopause; Prospective Studies; Statistics, Nonparametric; Tamoxifen; Treatment Outcome; Triazoles; Triptorelin Pamoate

2008
Intent-to-treat analysis of the placebo-controlled trial of letrozole for extended adjuvant therapy in early breast cancer: NCIC CTG MA.17.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:5

    Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Estrogens; Humans; Kaplan-Meier Estimate; Letrozole; Lymphatic Metastasis; Neoplasms, Hormone-Dependent; Neoplasms, Second Primary; Nitriles; Patient Acceptance of Health Care; Placebos; Postmenopause; Progesterone; Proportional Hazards Models; Recurrence; Tamoxifen; Triazoles

2008
Letrozole compared with tamoxifen for elderly patients with endocrine-responsive early breast cancer: the BIG 1-98 trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Apr-20, Volume: 26, Issue:12

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cardiovascular Diseases; Double-Blind Method; Female; Fractures, Bone; Humans; Letrozole; Middle Aged; Nitriles; Patient Compliance; Postmenopause; Tamoxifen; Triazoles

2008
Efficacy, toxicity, and quality of life in older women with early-stage breast cancer treated with letrozole or placebo after 5 years of tamoxifen: NCIC CTG intergroup trial MA.17.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Apr-20, Volume: 26, Issue:12

    Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Placebos; Quality of Life; Tamoxifen; Triazoles

2008
Late extended adjuvant treatment with letrozole improves outcome in women with early-stage breast cancer who complete 5 years of tamoxifen.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Apr-20, Volume: 26, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Placebos; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles

2008
Letrozole suppresses plasma estradiol and estrone sulphate more completely than anastrozole in postmenopausal women with breast cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Apr-01, Volume: 26, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Cross-Over Studies; Estradiol; Estrone; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Radioimmunoassay; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome; Triazoles

2008
Switching to letrozole or exemestane improves hot flushes, mood and quality of life in tamoxifen intolerant women.
    British journal of cancer, 2008, May-06, Volume: 98, Issue:9

    Topics: Affect; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Chemotherapy, Adjuvant; Cross-Over Studies; Estrogen Receptor Modulators; Female; Hot Flashes; Humans; Letrozole; Middle Aged; Nitriles; Patient Participation; Patient Selection; Postmenopause; Prospective Studies; Quality of Life; Research Design; Sample Size; Surveys and Questionnaires; Tamoxifen; Triazoles

2008
Serum TIMP-1 and response to the aromatase inhibitor letrozole versus tamoxifen in metastatic breast cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Jun-01, Volume: 26, Issue:16

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Tamoxifen; Tissue Inhibitor of Metalloproteinase-1; Triazoles

2008
Aromatase expression and outcomes in the P024 neoadjuvant endocrine therapy trial.
    Breast cancer research and treatment, 2009, Volume: 116, Issue:2

    Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase; Biomarkers, Tumor; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Nitriles; Prognosis; Receptors, Estrogen; Tamoxifen; Treatment Outcome; Triazoles

2009
Prognostic and predictive value of centrally reviewed Ki-67 labeling index in postmenopausal women with endocrine-responsive breast cancer: results from Breast International Group Trial 1-98 comparing adjuvant tamoxifen with letrozole.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Dec-01, Volume: 26, Issue:34

    Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Endocrine System; Female; Humans; Ki-67 Antigen; Letrozole; Nitriles; Postmenopause; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Tamoxifen; Triazoles

2008
Immediate versus delayed zoledronic acid for prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen-N03CC.
    Breast cancer research and treatment, 2009, Volume: 117, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Diphosphonates; Drug Administration Schedule; Female; Humans; Imidazoles; Letrozole; Middle Aged; Nitriles; Osteoporosis, Postmenopausal; Tamoxifen; Triazoles; Zoledronic Acid

2009
Bone Quality Test (BQT) scores of fingernails in postmenopausal patients treated with adjuvant letrozole or tamoxifen for early breast cancer.
    Breast (Edinburgh, Scotland), 2009, Volume: 18, Issue:2

    Topics: Aged; Antineoplastic Agents, Hormonal; Bone Density; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nails; Nitriles; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles

2009
[Lipid metabolism disorders at the breast cancer patients receiving hormonotherapy].
    Georgian medical news, 2009, Issue:168

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cholesterol, LDL; Dyslipidemias; Estrogen Antagonists; Female; Humans; Letrozole; Lipid Metabolism Disorders; Nitriles; Tamoxifen; Time Factors; Toremifene; Triazoles; Triglycerides

2009
Endocrine effects of adjuvant letrozole compared with tamoxifen in hormone-responsive postmenopausal patients with early breast cancer: the HOBOE trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Jul-01, Volume: 27, Issue:19

    Topics: Aged; Antineoplastic Agents; Bone Density Conservation Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Dehydroepiandrosterone Sulfate; Diphosphonates; Estradiol; Female; Follicle Stimulating Hormone; Humans; Hydrocortisone; Imidazoles; Letrozole; Luteinizing Hormone; Middle Aged; Nitriles; Postmenopause; Progesterone; Receptors, Estrogen; Tamoxifen; Testosterone; Triazoles; Zoledronic Acid

2009
Bone fractures among postmenopausal patients with endocrine-responsive early breast cancer treated with 5 years of letrozole or tamoxifen in the BIG 1-98 trial.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2009, Volume: 20, Issue:9

    Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Double-Blind Method; Female; Fractures, Bone; Humans; Incidence; Letrozole; Middle Aged; Nitriles; Postmenopause; Risk Factors; Tamoxifen; Triazoles

2009
Design, conduct, and analyses of Breast International Group (BIG) 1-98: a randomized, double-blind, phase-III study comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with receptor-positive, early breast cancer.
    Clinical trials (London, England), 2009, Volume: 6, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Double-Blind Method; Drug Therapy, Combination; Estrogen Antagonists; Female; Humans; Letrozole; Nitriles; Postmenopause; Receptors, Estrogen; Research Design; Tamoxifen; Treatment Outcome; Triazoles

2009
In situ aromatase expression in primary tumor is associated with estrogen receptor expression but is not predictive of response to endocrine therapy in advanced breast cancer.
    BMC cancer, 2009, Jun-16, Volume: 9

    Topics: Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Carcinoma in Situ; Cyclooxygenase 2; Female; Humans; Immunohistochemistry; Letrozole; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Tamoxifen; Tissue Array Analysis; Triazoles

2009
Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situ.
    BMC cancer, 2009, Aug-18, Volume: 9

    Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Ductal; Cohort Studies; Estrogen Antagonists; Female; Gene Expression Regulation, Neoplastic; Hormone Replacement Therapy; Humans; Letrozole; Middle Aged; Nitriles; Receptors, Estrogen; Tamoxifen; Triazoles

2009
Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer.
    The New England journal of medicine, 2009, Aug-20, Volume: 361, Issue:8

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Fractures, Bone; Humans; Incidence; Kaplan-Meier Estimate; Letrozole; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Proportional Hazards Models; Tamoxifen; Triazoles

2009
Update of the BIG 1-98 Trial: where do we stand?
    Breast (Edinburgh, Scotland), 2009, Volume: 18 Suppl 3

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Letrozole; Nitriles; Postmenopause; Proportional Hazards Models; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles

2009
A study of the effects of the aromatase inhibitors anastrozole and letrozole on bone metabolism in postmenopausal women with estrogen receptor-positive breast cancer.
    Breast cancer research and treatment, 2010, Volume: 119, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Aromatase Inhibitors; Bone and Bones; Bone Resorption; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2010
Cognitive function in postmenopausal women receiving adjuvant letrozole or tamoxifen for breast cancer in the BIG 1-98 randomized trial.
    Breast (Edinburgh, Scotland), 2010, Volume: 19, Issue:5

    Topics: Aged; Analysis of Variance; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cognition; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Statistics, Nonparametric; Tamoxifen; Triazoles

2010
Anastrozole and letrozole: an investigation and comparison of quality of life and tolerability.
    Breast cancer research and treatment, 2011, Volume: 125, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cross-Over Studies; Endocrine System; Humans; Letrozole; Middle Aged; Nitriles; Quality of Life; Tamoxifen; Treatment Outcome; Triazoles

2011
Cognitive function in postmenopausal breast cancer patients one year after completing adjuvant endocrine therapy with letrozole and/or tamoxifen in the BIG 1-98 trial.
    Breast cancer research and treatment, 2011, Volume: 126, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cognition; Cross-Sectional Studies; Female; Humans; International Agencies; Letrozole; Longitudinal Studies; Menopause; Nitriles; Prognosis; Survival Rate; Tamoxifen; Triazoles

2011
Analyses adjusting for selective crossover show improved overall survival with adjuvant letrozole compared with tamoxifen in the BIG 1-98 study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Mar-20, Volume: 29, Issue:9

    Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cross-Over Studies; Double-Blind Method; Female; Follow-Up Studies; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles

2011
Which patients benefit most from adjuvant aromatase inhibitors? Results using a composite measure of prognostic risk in the BIG 1-98 randomized trial.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2011, Volume: 22, Issue:10

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Double-Blind Method; Drug Administration Schedule; ErbB Receptors; Female; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Nitriles; Prognosis; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles

2011
The advantage of letrozole over tamoxifen in the BIG 1-98 trial is consistent in younger postmenopausal women and in those with chemotherapy-induced menopause.
    Breast cancer research and treatment, 2012, Volume: 131, Issue:1

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Menopause; Middle Aged; Nitriles; Postmenopause; Tamoxifen; Triazoles

2012
[Letrozole vs. tamoxifen as neoadjuvant therapy for postmenopausal patients with hormone-dependent locally-advanced breast cancer].
    Ginecologia y obstetricia de Mexico, 2011, Volume: 79, Issue:9

    Topics: Aged; Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma, Ductal, Breast; Combined Modality Therapy; Double-Blind Method; Estrogens; Female; Humans; Letrozole; Mastectomy, Radical; Middle Aged; Neoadjuvant Therapy; Neoplasms, Hormone-Dependent; Nitriles; Palliative Care; Postmenopause; Progesterone; Prospective Studies; Remission Induction; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome; Triazoles; Ultrasonography

2011
Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8·1 years median follow-up.
    The Lancet. Oncology, 2011, Volume: 12, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Australia; Biomarkers, Tumor; Breast Neoplasms; Cross-Over Studies; Disease-Free Survival; Double-Blind Method; Europe; Female; Humans; Kaplan-Meier Estimate; Letrozole; Neoplasm Recurrence, Local; Neoplasms, Second Primary; New Zealand; Nitriles; North America; Postmenopause; Proportional Hazards Models; Receptors, Steroid; Risk Factors; Selective Estrogen Receptor Modulators; South Africa; South America; Tamoxifen; Time Factors; Treatment Outcome; Triazoles

2011
Longer-term outcomes of letrozole versus placebo after 5 years of tamoxifen in the NCIC CTG MA.17 trial: analyses adjusting for treatment crossover.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Mar-01, Volume: 30, Issue:7

    Topics: Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Nitriles; Placebos; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles

2012
The protective effect of zoledronic acid on bone loss in postmenopausal women with early breast cancer treated with sequential tamoxifen and letrozole: a prospective, randomized, phase II trial.
    Oncology, 2011, Volume: 81, Issue:5-6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Diphosphonates; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Imidazoles; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Osteoporosis, Postmenopausal; Prospective Studies; Tamoxifen; Triazoles; Zoledronic Acid

2011
Comparison of changes in the lipid profile of postmenopausal women with early stage breast cancer treated with exemestane or letrozole.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Lipids; Middle Aged; Nitriles; Postmenopause; Tamoxifen; Triazoles

2012
CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the breast international group 1-98 trial.
    Journal of the National Cancer Institute, 2012, Mar-21, Volume: 104, Issue:6

    Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cytochrome P-450 CYP2D6; Disease-Free Survival; Drug Administration Schedule; Female; Genotype; Humans; International Cooperation; Kaplan-Meier Estimate; Letrozole; Middle Aged; Nitriles; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles

2012
Bone effect of adjuvant tamoxifen, letrozole or letrozole plus zoledronic acid in early-stage breast cancer: the randomized phase 3 HOBOE study.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Diphosphonates; Estradiol; Female; Humans; Imidazoles; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Tamoxifen; Triazoles; Zoledronic Acid

2012
Subjective cognitive complaints one year after ceasing adjuvant endocrine treatment for early-stage breast cancer.
    British journal of cancer, 2012, May-08, Volume: 106, Issue:10

    Topics: Aromatase Inhibitors; Breast Neoplasms; Cognition; Estrogen Antagonists; Female; Humans; Letrozole; Neoplasm Staging; Nitriles; Quality of Life; Tamoxifen; Triazoles

2012
A randomized controlled trial comparing primary tumour resection plus systemic therapy with systemic therapy alone in metastatic breast cancer (PRIM-BC): Japan Clinical Oncology Group Study JCOG1017.
    Japanese journal of clinical oncology, 2012, Volume: 42, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Letrozole; Mastectomy; Middle Aged; Neoplasm Staging; Nitriles; Paclitaxel; Prognosis; Prospective Studies; Survival Rate; Tamoxifen; Trastuzumab; Triazoles; Young Adult

2012
Activated HER-receptors in predicting outcome of ER-positive breast cancer patients treated with adjuvant endocrine therapy.
    Breast (Edinburgh, Scotland), 2012, Volume: 21, Issue:5

    Topics: Aged; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; ErbB Receptors; Female; Follow-Up Studies; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Letrozole; Mastectomy; Middle Aged; Nitriles; Phosphorylation; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Tamoxifen; Treatment Outcome; Triazoles

2012
A new look at tamoxifen: co-administration with letrozole in intrauterine insemination cycles.
    Archives of gynecology and obstetrics, 2013, Volume: 287, Issue:2

    Topics: Adult; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; Infertility; Insemination, Artificial; Letrozole; Menotropins; Nitriles; Ovulation Induction; Pregnancy; Prospective Studies; Tamoxifen; Treatment Outcome; Triazoles

2013
Impact of premenopausal status at breast cancer diagnosis in women entered on the placebo-controlled NCIC CTG MA17 trial of extended adjuvant letrozole.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2013, Volume: 24, Issue:2

    Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Nitriles; Placebos; Postmenopause; Premenopause; Quality of Life; Survival; Tamoxifen; Treatment Outcome; Triazoles

2013
Obesity and risk of recurrence or death after adjuvant endocrine therapy with letrozole or tamoxifen in the breast international group 1-98 trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Nov-10, Volume: 30, Issue:32

    Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Body Mass Index; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Estrogen Receptor Modulators; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Obesity; Odds Ratio; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Risk Assessment; Risk Factors; Tamoxifen; Treatment Outcome; Triazoles

2012
Lipid concentrations in postmenopausal women on letrozole after 5 years of tamoxifen: an NCIC CTG MA.17 sub-study.
    Breast cancer research and treatment, 2012, Volume: 136, Issue:3

    Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cholesterol; Cholesterol, HDL; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Letrozole; Lipids; Lipoprotein(a); Middle Aged; Nitriles; Postmenopause; Tamoxifen; Time Factors; Triazoles

2012
Bone mineral density and circulating biomarkers in the BIG 1-98 trial comparing adjuvant letrozole, tamoxifen and their sequences.
    Breast cancer research and treatment, 2014, Volume: 144, Issue:2

    Topics: Aged; Alkaline Phosphatase; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Bone Density; Breast Neoplasms; Chemotherapy, Adjuvant; Collagen Type I; Double-Blind Method; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Nitriles; Osteocalcin; Osteoporosis, Postmenopausal; Peptides; Postmenopause; Prospective Studies; Tamoxifen; Triazoles

2014
Extended therapy with letrozole and ovarian suppression in premenopausal patients with breast cancer after tamoxifen.
    Clinical breast cancer, 2014, Volume: 14, Issue:6

    Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Feasibility Studies; Female; Follow-Up Studies; Gonadotropin-Releasing Hormone; Humans; Letrozole; Middle Aged; Neoplasm Grading; Neoplasm Staging; Nitriles; Ovariectomy; Premenopause; Prognosis; Survival Rate; Tamoxifen; Triazoles

2014
Does patient education work in breast cancer? Final results from the global CARIATIDE study.
    Future oncology (London, England), 2015, Volume: 11, Issue:2

    Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Nitriles; Patient Compliance; Patient Education as Topic; Tamoxifen; Triazoles

2015
5-year follow-up of a randomized controlled trial of immediate versus delayed zoledronic acid for the prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen: N03CC (Alliance) trial.
    Cancer, 2015, Aug-01, Volume: 121, Issue:15

    Topics: Aged; Antineoplastic Agents; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Breast Neoplasms, Male; Chemotherapy, Adjuvant; Diphosphonates; Disease Progression; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Imidazoles; Letrozole; Male; Middle Aged; Nitriles; Osteoporosis, Postmenopausal; Postmenopause; Tamoxifen; Triazoles; Zoledronic Acid

2015
A phase III randomized multicenter trial evaluating cognition in post-menopausal breast cancer patients receiving adjuvant hormonotherapy.
    Breast cancer research and treatment, 2015, Volume: 152, Issue:3

    Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cognition Disorders; Female; Humans; Letrozole; Memory; Middle Aged; Nitriles; Postmenopause; Psychomotor Performance; Quality of Life; Tamoxifen; Triazoles

2015
Relative Effectiveness of Letrozole Compared With Tamoxifen for Patients With Lobular Carcinoma in the BIG 1-98 Trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Sep-01, Volume: 33, Issue:25

    Topics: Adult; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Ki-67 Antigen; Letrozole; Middle Aged; Nitriles; Receptor, ErbB-2; Tamoxifen; Treatment Outcome; Triazoles

2015
Outcomes of special histotypes of breast cancer after adjuvant endocrine therapy with letrozole or tamoxifen in the monotherapy cohort of the BIG 1-98 trial.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2015, Volume: 26, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Cohort Studies; Disease-Free Survival; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Treatment Outcome; Triazoles

2015
Identifying treatment effect heterogeneity in clinical trials using subpopulations of events: STEPP.
    Clinical trials (London, England), 2016, Volume: 13, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Data Interpretation, Statistical; Double-Blind Method; Female; Humans; Letrozole; Nitriles; Outcome Assessment, Health Care; Research Design; Tamoxifen; Treatment Outcome; Triazoles

2016
ESR1 and ESR2 polymorphisms in the BIG 1-98 trial comparing adjuvant letrozole versus tamoxifen or their sequence for early breast cancer.
    Breast cancer research and treatment, 2015, Volume: 154, Issue:3

    Topics: Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Double-Blind Method; Early Detection of Cancer; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Hot Flashes; Humans; Letrozole; Middle Aged; Nitriles; Polymorphism, Single Nucleotide; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles

2015
Observation versus late reintroduction of letrozole as adjuvant endocrine therapy for hormone receptor-positive breast cancer (ANZ0501 LATER): an open-label randomised, controlled trial.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2016, Volume: 27, Issue:5

    Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Australia; Breast Neoplasms; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Treatment Outcome; Triazoles

2016
New onset vasomotor symptoms but not musculoskeletal symptoms associate with clinical outcomes on extended adjuvant letrozole - Analyses from NCIC CTG MA.17.
    Breast (Edinburgh, Scotland), 2016, Volume: 27

    Topics: Aged; Antineoplastic Agents; Autonomic Nervous System Diseases; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Multivariate Analysis; Musculoskeletal Diseases; Nitriles; Proportional Hazards Models; Tamoxifen; Time Factors; Treatment Outcome; Triazoles; Vasomotor System

2016
Treatment Adherence and Its Impact on Disease-Free Survival in the Breast International Group 1-98 Trial of Tamoxifen and Letrozole, Alone and in Sequence.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016, 07-20, Volume: 34, Issue:21

    Topics: Aged; Breast Neoplasms; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Medication Adherence; Middle Aged; Nitriles; Tamoxifen; Triazoles

2016
Chemosensitivity and Endocrine Sensitivity in Clinical Luminal Breast Cancer Patients in the Prospective Neoadjuvant Breast Registry Symphony Trial (NBRST) Predicted by Molecular Subtyping.
    Annals of surgical oncology, 2017, Volume: 24, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Bridged-Ring Compounds; Chemotherapy, Adjuvant; Clinical Decision-Making; Cyclophosphamide; Docetaxel; Doxorubicin; Female; Gene Expression Profiling; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Letrozole; Mastectomy, Segmental; Middle Aged; Molecular Typing; Neoadjuvant Therapy; Nitriles; Prospective Studies; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Registries; Tamoxifen; Taxoids; Treatment Outcome; Triazoles; Young Adult

2017
Cholesterol, Cholesterol-Lowering Medication Use, and Breast Cancer Outcome in the BIG 1-98 Study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017, Apr-10, Volume: 35, Issue:11

    Topics: Aged; Anticholesteremic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cholesterol; Disease-Free Survival; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Letrozole; Mastectomy, Segmental; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Proportional Hazards Models; Radiotherapy, Adjuvant; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles

2017
Stimulation of the ovaries in women with breast cancer undergoing fertility preservation: Alternative versus standard stimulation protocols; the study protocol of the STIM-trial.
    Contemporary clinical trials, 2017, Volume: 61

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents; Body Mass Index; Breast Neoplasms; Estrogens; Female; Fertility Preservation; Follicle Stimulating Hormone; Humans; Letrozole; Nitriles; Oocytes; Ovulation Induction; Research Design; Socioeconomic Factors; Tamoxifen; Triazoles; Young Adult

2017
Prognostic and predictive importance of the estrogen receptor coactivator AIB1 in a randomized trial comparing adjuvant letrozole and tamoxifen therapy in postmenopausal breast cancer: the Danish cohort of BIG 1-98.
    Breast cancer research and treatment, 2017, Volume: 166, Issue:2

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Double-Blind Method; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Neoplasm Grading; Nitriles; Nuclear Receptor Coactivator 3; Postmenopause; Prognosis; Tamoxifen; Tissue Array Analysis; Treatment Outcome; Triazoles; Up-Regulation

2017
Optimal Duration of Extended Adjuvant Endocrine Therapy for Early Breast Cancer; Results of the IDEAL Trial (BOOG 2006-05).
    Journal of the National Cancer Institute, 2018, 01-01, Volume: 110, Issue:1

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Follow-Up Studies; Humans; Letrozole; Mastectomy, Segmental; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Survival Rate; Tamoxifen; Time Factors; Triazoles

2018
Aurora kinase A as a possible marker for endocrine resistance in early estrogen receptor positive breast cancer.
    Acta oncologica (Stockholm, Sweden), 2018, Volume: 57, Issue:1

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Aurora Kinase A; Biomarkers; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Denmark; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Immunohistochemistry; Letrozole; Nitriles; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Tamoxifen; Triazoles

2018
Adjuvant anastrozole versus exemestane versus letrozole, upfront or after 2 years of tamoxifen, in endocrine-sensitive breast cancer (FATA-GIM3): a randomised, phase 3 trial.
    The Lancet. Oncology, 2018, Volume: 19, Issue:4

    Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen

2018
Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): a randomised phase 3 trial.
    The Lancet. Oncology, 2018, Volume: 19, Issue:7

    Topics: Administration, Oral; Adult; Aminopyridines; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease-Free Survival; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Humans; Internationality; Kaplan-Meier Estimate; Letrozole; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Premenopause; Prognosis; Proportional Hazards Models; Purines; Survival Analysis; Tamoxifen; Treatment Outcome; Young Adult

2018
Association of Somatic Driver Alterations With Prognosis in Postmenopausal, Hormone Receptor-Positive, HER2-Negative Early Breast Cancer: A Secondary Analysis of the BIG 1-98 Randomized Clinical Trial.
    JAMA oncology, 2018, 10-01, Volume: 4, Issue:10

    Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Middle Aged; Mutation; Neoplasm Recurrence, Local; Postmenopause; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Tamoxifen

2018
Pharmacokinetic Effects and Safety of Olaparib Administered with Endocrine Therapy: A Phase I Study in Patients with Advanced Solid Tumours.
    Advances in therapy, 2018, Volume: 35, Issue:11

    Topics: Adult; Aged; Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Letrozole; Male; Middle Aged; Neoplasm Staging; Neoplasms; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Tamoxifen; Treatment Outcome

2018
Adjuvant Letrozole and Tamoxifen Alone or Sequentially for Postmenopausal Women With Hormone Receptor-Positive Breast Cancer: Long-Term Follow-Up of the BIG 1-98 Trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019, 01-10, Volume: 37, Issue:2

    Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen

2019
Use of letrozole after aromatase inhibitor-based therapy in postmenopausal breast cancer (NRG Oncology/NSABP B-42): a randomised, double-blind, placebo-controlled, phase 3 trial.
    The Lancet. Oncology, 2019, Volume: 20, Issue:1

    Topics: Aged; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Female; Humans; Intention to Treat Analysis; Letrozole; Middle Aged; Multivariate Analysis; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen

2019
Prognostic and predictive value of androgen receptor expression in postmenopausal women with estrogen receptor-positive breast cancer: results from the Breast International Group Trial 1-98.
    Breast cancer research : BCR, 2019, 02-22, Volume: 21, Issue:1

    Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Estrogen Antagonists; Female; Humans; Kaplan-Meier Estimate; Letrozole; Mastectomy; Middle Aged; Postmenopause; Prognosis; Receptors, Androgen; Receptors, Estrogen; Retrospective Studies; Tamoxifen

2019
Adjuvant zoledronic acid and letrozole plus ovarian function suppression in premenopausal breast cancer: HOBOE phase 3 randomised trial.
    European journal of cancer (Oxford, England : 1990), 2019, Volume: 118

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Bone Density Conservation Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Disease Progression; Disease-Free Survival; Estrogen Antagonists; Female; Humans; Italy; Letrozole; Middle Aged; Ovary; Premenopause; Tamoxifen; Time Factors; Triptorelin Pamoate; Zoledronic Acid

2019
Effects of
    Pharmacogenomics, 2019, Volume: 20, Issue:8

    Topics: Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Estrogen Receptor alpha; Estrogens; Female; Genotype; Humans; Letrozole; Liver-Specific Organic Anion Transporter 1; Middle Aged; Pharmacogenetics; Polymorphism, Genetic; Tamoxifen

2019
Evaluating the addition of bevacizumab to endocrine therapy as first-line treatment for hormone receptor-positive metastatic breast cancer: a pooled analysis from the LEA (GEICAM/2006-11_GBG51) and CALGB 40503 (Alliance) trials.
    European journal of cancer (Oxford, England : 1990), 2019, Volume: 117

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Bone Neoplasms; Breast Neoplasms; Evaluation Studies as Topic; Female; Follow-Up Studies; Fulvestrant; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Receptors, Estrogen; Receptors, Progesterone; Soft Tissue Neoplasms; Survival Rate; Tamoxifen

2019
MONALEESA clinical program: a review of ribociclib use in different clinical settings.
    Future oncology (London, England), 2019, Volume: 15, Issue:23

    Topics: Adolescent; Adult; Aminopyridines; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Estrogens; Female; Fulvestrant; Humans; Letrozole; Middle Aged; Postmenopause; Progression-Free Survival; Purines; Receptor, ErbB-2; Tamoxifen; Young Adult

2019
Capecitabine-Based Chemoendocrine Combination as First-Line Treatment for Metastatic Hormone-Positive Metastatic Breast Cancer: Phase 2 Study.
    Clinical breast cancer, 2020, Volume: 20, Issue:3

    Topics: Abdominal Pain; Adult; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Capecitabine; Constipation; Diarrhea; Female; Hand-Foot Syndrome; Humans; Letrozole; Middle Aged; Progression-Free Survival; Prospective Studies; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen

2020
Cumulative incidence of cardiovascular events under tamoxifen and letrozole alone and in sequence: a report from the BIG 1-98 trial.
    Breast cancer research and treatment, 2021, Volume: 185, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cardiovascular Diseases; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Incidence; Letrozole; Nitriles; Postmenopause; Tamoxifen; Triazoles

2021
Leuprorelin combined with letrozole with/without everolimus in ovarian-suppressed premenopausal women with hormone receptor-positive, HER2-negative metastatic breast cancer: The LEO study.
    European journal of cancer (Oxford, England : 1990), 2021, Volume: 144

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Everolimus; Female; Follow-Up Studies; Gonadotropin-Releasing Hormone; Humans; Letrozole; Leuprolide; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Premenopause; Primary Ovarian Insufficiency; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Survival Rate; Tamoxifen; Young Adult

2021
Monitoring serum estradiol levels in breast cancer patients during extended adjuvant letrozole treatment after five years of tamoxifen: a prospective trial.
    Breast cancer research and treatment, 2021, Volume: 187, Issue:3

    Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Chromatography, Liquid; Estradiol; Female; Humans; Letrozole; Nitriles; Prospective Studies; Tamoxifen; Tandem Mass Spectrometry

2021
Concomitant tamoxifen or letrozole for optimal oocyte yield during fertility preservation for breast cancer: the TAmoxifen or Letrozole in Estrogen Sensitive tumors (TALES) randomized clinical trial.
    Journal of assisted reproduction and genetics, 2021, Volume: 38, Issue:9

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cryopreservation; Dose-Response Relationship, Drug; Drug Therapy, Combination; Embryo, Mammalian; Female; Fertility Preservation; Gonadotropins; Humans; Infertility, Female; Letrozole; Oocytes; Ovulation Induction; Tamoxifen; Young Adult

2021
Continuous versus intermittent extended adjuvant letrozole for breast cancer: final results of randomized phase III SOLE (Study of Letrozole Extension) and SOLE Estrogen Substudy.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2021, Volume: 32, Issue:10

    Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Estrogens; Female; Humans; Letrozole; Nitriles; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles

2021
Extended therapy with letrozole as adjuvant treatment of postmenopausal patients with early-stage breast cancer: a multicentre, open-label, randomised, phase 3 trial.
    The Lancet. Oncology, 2021, Volume: 22, Issue:10

    Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Italy; Letrozole; Mastectomy; Middle Aged; Neoplasm Staging; Postmenopause; Selective Estrogen Receptor Modulators; Tamoxifen; Time Factors

2021
Fertility preservation for women with breast cancer: a multicentre randomized controlled trial on various ovarian stimulation protocols.
    Human reproduction (Oxford, England), 2022, 07-30, Volume: 37, Issue:8

    Topics: Breast Neoplasms; Female; Fertility Preservation; Fertilization in Vitro; Gonadotropin-Releasing Hormone; Humans; Letrozole; Multicenter Studies as Topic; Ovulation Induction; Pregnancy; Pregnancy Rate; Randomized Controlled Trials as Topic; Sperm Injections, Intracytoplasmic; Tamoxifen

2022
Hormone concentrations of dominant follicles in the TALES randomized controlled trial comparing letrozole with tamoxifen.
    Journal of assisted reproduction and genetics, 2022, Volume: 39, Issue:11

    Topics: Estradiol; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Letrozole; Ovarian Follicle; Tamoxifen

2022
Ten-year update: NRG Oncology/National Surgical Adjuvant Breast and Bowel Project B-42 randomized trial: extended letrozole therapy in early-stage breast cancer.
    Journal of the National Cancer Institute, 2023, Nov-08, Volume: 115, Issue:11

    Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Double-Blind Method; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Treatment Outcome; Triazoles

2023

Other Studies

240 other study(ies) available for letrozole and tamoxifen

ArticleYear
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Effect of aromatase inhibitors on growth of mammary tumors in a nude mouse model.
    Cancer research, 1995, Jul-15, Volume: 55, Issue:14

    Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase Inhibitors; Cell Division; Fadrozole; Female; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Organ Size; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles; Uterus

1995
Tamoxifen-resistant fibroblast growth factor-transfected MCF-7 cells are cross-resistant in vivo to the antiestrogen ICI 182,780 and two aromatase inhibitors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:3

    Topics: Androstenedione; Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cell Division; Cell Line; Chloramphenicol O-Acetyltransferase; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fibroblast Growth Factors; Fulvestrant; Humans; Letrozole; Luciferases; Mice; Mice, Nude; Nitriles; Ovariectomy; Polymerase Chain Reaction; Receptors, Progesterone; Recombinant Fusion Proteins; RNA, Messenger; Tamoxifen; Transcription, Genetic; Transfection; Transplantation, Heterologous; Triazoles; Tumor Cells, Cultured

1998
Preclinical studies using the intratumoral aromatase model for postmenopausal breast cancer.
    Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:3 Suppl 5

    Topics: Anastrozole; Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Drug Screening Assays, Antitumor; Endometrial Neoplasms; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasms, Hormone-Dependent; Nitriles; Organ Size; Postmenopause; Tamoxifen; Treatment Outcome; Triazoles; Tumor Cells, Cultured; Uterus

1998
Plasma protein binding of letrozole, a new nonsteroidal aromatase enzyme inhibitor.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:8

    Topics: Animals; Aromatase Inhibitors; Blood Proteins; Dialysis; Dogs; Enzyme Inhibitors; Erythrocytes; Estrogen Antagonists; Humans; Indicators and Reagents; Letrozole; Mice; Nitriles; Plasma; Protein Binding; Rabbits; Rats; Tamoxifen; Triazoles; Ultrafiltration

1998
Intratumoral aromatase model: the effects of letrozole (CGS 20267).
    Breast cancer research and treatment, 1998, Volume: 49 Suppl 1

    Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Mice; Mice, Inbred BALB C; Neoplasms, Hormone-Dependent; Nitriles; Tamoxifen; Triazoles; Tumor Cells, Cultured

1998
The effects of aromatase inhibitors and antiestrogens in the nude mouse model.
    Breast cancer research and treatment, 1998, Volume: 50, Issue:1

    Topics: Anastrozole; Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Nitriles; Tamoxifen; Triazoles; Tumor Cells, Cultured

1998
The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer.
    Breast cancer research and treatment, 1999, Volume: 57, Issue:2

    Topics: Analysis of Variance; Anastrozole; Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Tamoxifen; Time Factors; Triazoles; Tumor Cells, Cultured

1999
The Twenty-third Annual San Antonio Breast Cancer Symposium.
    Current medical research and opinion, 2001, Volume: 16, Issue:4

    Topics: Anastrozole; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Capecitabine; Combined Modality Therapy; Deoxycytidine; Estradiol; Estrogen Antagonists; Female; Fluorouracil; Fulvestrant; Humans; Letrozole; Male; Mastectomy; Nitriles; Prognosis; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles

2001
Use of ErbB-1 and ErbB-2 to select endocrine therapy for breast cancer: will it play in Peoria?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, Sep-15, Volume: 19, Issue:18

    Topics: Antineoplastic Agents; Breast Neoplasms; ErbB Receptors; Estrogen Antagonists; Female; Humans; Letrozole; Neoadjuvant Therapy; Nitriles; Predictive Value of Tests; Receptor, ErbB-2; Tamoxifen; Triazoles

2001
Aromatase inhibitors and inactivators in breast cancer.
    BMJ (Clinical research ed.), 2001, Oct-20, Volume: 323, Issue:7318

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogen Antagonists; Estrogens; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2001
Superior efficacy of letrozole versus tamoxifen as first-line therapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Feb-01, Volume: 20, Issue:3

    Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Postmenopause; Tamoxifen; Triazoles

2002
Pre-operative endocrine therapy for postmenopausal women: when and why?
    Annals of oncology : official journal of the European Society for Medical Oncology, 2001, Volume: 12, Issue:11

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Postmenopause; Preoperative Care; Randomized Controlled Trials as Topic; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Treatment Outcome; Triazoles

2001
Aromatase and COX-2 expression in human breast cancers.
    The Journal of steroid biochemistry and molecular biology, 2001, Volume: 79, Issue:1-5

    Topics: Adipocytes; Adult; Aged; Aged, 80 and over; Animals; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cyclooxygenase 2; Dinoprostone; Endothelium; Enzyme Inhibitors; Epithelial Cells; Estrogen Receptor Modulators; Estrogens; Female; Humans; Immunohistochemistry; Isoenzymes; Letrozole; Mammary Neoplasms, Experimental; Membrane Proteins; Mice; Mice, Inbred BALB C; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Prostaglandin-Endoperoxide Synthases; Stromal Cells; Tamoxifen; Triazoles

2001
Biological and clinical effects of aromatase inhibitors in neoadjuvant therapy.
    The Journal of steroid biochemistry and molecular biology, 2001, Volume: 79, Issue:1-5

    Topics: Anastrozole; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Enzyme Inhibitors; Estrogen Receptor Modulators; Female; Humans; Immunohistochemistry; Ki-67 Antigen; Letrozole; Menopause; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles

2001
Approval summary: letrozole in the treatment of postmenopausal women with advanced breast cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:3

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Approval; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles; United States; United States Food and Drug Administration

2002
Breast cancer studies challenge tamoxifen therapy.
    The Lancet. Oncology, 2000, Volume: 1

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2000
New breast cancer drugs expand treatment options.
    Harvard women's health watch, 2002, Volume: 9, Issue:8

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2002
Estrogen as therapy for breast cancer.
    Breast cancer research : BCR, 2002, Volume: 4, Issue:4

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Breast Neoplasms; Clinical Trials, Phase II as Topic; Diethylstilbestrol; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Estrogens; Female; Humans; Letrozole; Megestrol Acetate; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Salvage Therapy; Tamoxifen; Treatment Outcome; Triazoles

2002
Promising results for Arimidex and Femara.
    Expert review of anticancer therapy, 2001, Volume: 1, Issue:4

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Clinical Trials, Phase III as Topic; Disease Progression; Double-Blind Method; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2001
The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: long-term studies using the intratumoral aromatase postmenopausal breast cancer model.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:7

    Topics: Animals; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; In Vitro Techniques; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Tamoxifen; Triazoles; Tumor Cells, Cultured

2002
Estrogens, but not androgens, regulate expression and functional activity of oxytocin receptor in rabbit epididymis.
    Endocrinology, 2002, Volume: 143, Issue:11

    Topics: Androgens; Animals; Aromatase Inhibitors; Blotting, Northern; Blotting, Western; Enzyme Inhibitors; Epididymis; Estradiol; Estrogen Antagonists; Estrogens; Gene Expression Regulation; Hypogonadism; Letrozole; Male; Nitriles; Oxytocin; Rabbits; Receptors, Oxytocin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tamoxifen; Testosterone; Triazoles; Triptorelin Pamoate

2002
Letrozole's superiority over progestins and tamoxifen challenges standards of care in endocrine therapy for metastatic breast cancer.
    European journal of cancer (Oxford, England : 1990), 2002, Volume: 38 Suppl 6

    Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasm Metastasis; Nitriles; Progestins; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles

2002
Current role of endocrine therapy in the management of breast cancer.
    Breast cancer (Tokyo, Japan), 2002, Volume: 9, Issue:4

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Estrogen Receptor Modulators; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2002
Expression of functional estrogen receptors in human fetal male external genitalia.
    The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:4

    Topics: Aromatase Inhibitors; Blotting, Western; Cell Division; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Genitalia, Male; Gestational Age; Humans; Immunohistochemistry; Letrozole; Male; Metribolone; Muscle, Smooth; Nitriles; Penis; Polymerase Chain Reaction; Receptors, Androgen; Receptors, Estrogen; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; Tamoxifen; Testosterone; Testosterone Congeners; Triazoles

2003
A stochastic economic evaluation of letrozole versus tamoxifen as a first-line hormonal therapy: for advanced breast cancer in postmenopausal patients.
    PharmacoEconomics, 2003, Volume: 21, Issue:7

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Cost-Benefit Analysis; Female; Humans; Letrozole; Markov Chains; Models, Biological; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Stochastic Processes; Tamoxifen; Triazoles

2003
Pathological features of breast cancer response following neoadjuvant treatment with either letrozole or tamoxifen.
    European journal of cancer (Oxford, England : 1990), 2003, Volume: 39, Issue:4

    Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Apoptosis; Breast Neoplasms; Cell Division; Chemotherapy, Adjuvant; Female; Humans; Ki-67 Antigen; Letrozole; Nitriles; Postmenopause; Tamoxifen; Triazoles

2003
New approaches to the understanding of tamoxifen action and resistance.
    Endocrine-related cancer, 2003, Volume: 10, Issue:2

    Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Drug Resistance, Neoplasm; Estradiol; Farnesol; Female; Humans; Immunoenzyme Techniques; Letrozole; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; Nitriles; Receptors, Estrogen; Salicylates; Tamoxifen; Triazoles; Tumor Cells, Cultured

2003
Cost utility analysis of first-line hormonal therapy in advanced breast cancer: comparison of two aromatase inhibitors to tamoxifen.
    American journal of clinical oncology, 2003, Volume: 26, Issue:3

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Canada; Cost-Benefit Analysis; Decision Support Techniques; Enzyme Inhibitors; Humans; Letrozole; Meta-Analysis as Topic; Nitriles; Quality of Life; Tamoxifen; Triazoles

2003
[Hormone therapy, chemotherapy and immunotherapy in breast carcinoma. The best strategy for your patient].
    MMW Fortschritte der Medizin, 2003, Jun-12, Volume: 145, Issue:24

    Topics: Adult; Age Factors; Aged; Anastrozole; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Immunotherapy; Letrozole; Meta-Analysis as Topic; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Nitriles; Premenopause; Prognosis; Quality of Health Care; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Risk Factors; Selective Estrogen Receptor Modulators; Tamoxifen; Time Factors; Toremifene; Trastuzumab; Triazoles

2003
Role of biologic markers in patient selection and application to disease prevention.
    American journal of clinical oncology, 2003, Volume: 26, Issue:4

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Biomarkers; Bone Density; Breast Neoplasms; Enzyme Inhibitors; ErbB Receptors; Estradiol; Female; Humans; Letrozole; Nitriles; Patient Selection; Postmenopause; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Risk Factors; Tamoxifen; Triazoles

2003
Examining quality of life issues in relation to endocrine therapy for breast cancer.
    American journal of clinical oncology, 2003, Volume: 26, Issue:4

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Decision Making; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Nitriles; Quality of Life; Tamoxifen; Triazoles

2003
Letrozole after tamoxifen for breast cancer--what is the price of success?
    The New England journal of medicine, 2003, Nov-06, Volume: 349, Issue:19

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2003
Beyond tamoxifen--extending endocrine treatment for early-stage breast cancer.
    The New England journal of medicine, 2003, Nov-06, Volume: 349, Issue:19

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2003
Searching for the next tamoxifen.
    U.S. news & world report, 2003, Oct-20, Volume: 135, Issue:13

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Research; Tamoxifen; Triazoles; United States

2003
The intratumoral aromatase model: studies with aromatase inhibitors and antiestrogens.
    The Journal of steroid biochemistry and molecular biology, 2003, Volume: 86, Issue:3-5

    Topics: Androstadienes; Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Cell Line, Tumor; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasms, Hormone-Dependent; Nitriles; Tamoxifen; Treatment Outcome; Triazoles

2003
Use of letrozole as a chemopreventive agent in aromatase overexpressing transgenic mice.
    The Journal of steroid biochemistry and molecular biology, 2003, Volume: 86, Issue:3-5

    Topics: Animals; Anticarcinogenic Agents; Aromatase; Aromatase Inhibitors; Birth Weight; Female; Hyperplasia; Lactation; Letrozole; Male; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Nitriles; Pregnancy; Receptors, Estrogen; RNA, Messenger; Tamoxifen; Triazoles

2003
Critics question price of success in halted clinical trial of aromatase inhibitor letrozole.
    Journal of the National Cancer Institute, 2003, Dec-03, Volume: 95, Issue:23

    Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Controlled Clinical Trials as Topic; Disease-Free Survival; Enzyme Inhibitors; Estrogen Receptor Modulators; Ethics, Research; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Single-Blind Method; Survival Analysis; Tamoxifen; Time Factors; Treatment Outcome; Triazoles; United States

2003
Hormonal therapy: introduction.
    Breast (Edinburgh, Scotland), 2003, Volume: 12 Suppl 2

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Letrozole; Nitriles; Prognosis; Risk Assessment; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles; United Kingdom

2003
Oxytocin receptor is expressed in the penis and mediates an estrogen-dependent smooth muscle contractility.
    Endocrinology, 2004, Volume: 145, Issue:4

    Topics: Animals; Aromatase Inhibitors; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogens; Gonadotropin-Releasing Hormone; Humans; Hypogonadism; In Vitro Techniques; Letrozole; Male; Muscle Contraction; Muscle, Smooth; Nitriles; Osmolar Concentration; Oxytocin; Penis; Rabbits; Receptors, Oxytocin; Tamoxifen; Triazoles; Triptorelin Pamoate

2004
Benefit of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer.
    Clinical breast cancer, 2003, Volume: 4, Issue:5

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Combined Modality Therapy; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles

2003
Letrozole in breast cancer.
    The New England journal of medicine, 2004, Feb-12, Volume: 350, Issue:7

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Postmenopause; Tamoxifen; Triazoles

2004
Letrozole in breast cancer.
    The New England journal of medicine, 2004, Feb-12, Volume: 350, Issue:7

    Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Research Design; Tamoxifen; Time Factors; Triazoles

2004
Letrozole in breast cancer.
    The New England journal of medicine, 2004, Feb-12, Volume: 350, Issue:7

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Triazoles

2004
Letrozole in breast cancer.
    The New England journal of medicine, 2004, Feb-12, Volume: 350, Issue:7

    Topics: Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2004
Drugs may improve long-term outcomes after breast cancer.
    Mayo Clinic health letter (English ed.), 2004, Volume: 22, Issue:3

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2004
New treatment boosts outlook for breast cancer survivors.
    Mayo Clinic women's healthsource, 2004, Volume: 8, Issue:3

    Topics: Antineoplastic Agents; Breast Neoplasms; Female; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Triazoles

2004
Role of endocrine therapy in the neoadjuvant surgical setting.
    Annals of surgical oncology, 2004, Volume: 11, Issue:1 Suppl

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Nitriles; Patient Selection; Tamoxifen; Treatment Outcome; Triazoles

2004
Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in a breast cancer model.
    Journal of the National Cancer Institute, 2004, Mar-17, Volume: 96, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Enzyme Inhibitors; Estrogen Receptor Modulators; Female; Humans; Letrozole; Linear Models; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Hormone-Dependent; Nitriles; Organ Size; Ovariectomy; Tamoxifen; Transplantation, Heterologous; Triazoles; Uterus

2004
Changes in vascular endothelial growth factor (VEGF) after chemoendocrine therapy in breast cancer.
    European journal of gynaecological oncology, 2004, Volume: 25, Issue:1

    Topics: Androstadienes; Angiopoietin-1; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; DNA Primers; Docetaxel; Dose-Response Relationship, Drug; Doxorubicin; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Neovascularization, Pathologic; Nitriles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Tamoxifen; Taxoids; Triazoles; Vascular Endothelial Growth Factor A

2004
Does letrozole have any place in adjuvant setting in breast cancer patients with documented hypercoagulability?
    American journal of clinical oncology, 2004, Volume: 27, Issue:2

    Topics: Aged; Anticoagulants; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Contraindications; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Pulmonary Embolism; Risk; Tamoxifen; Triazoles; Venous Thrombosis; Warfarin

2004
Long-term insurance for breast cancer survivors.
    The Johns Hopkins medical letter health after 50, 2004, Volume: 16, Issue:2

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Insurance, Long-Term Care; Letrozole; Nitriles; Tamoxifen; Triazoles

2004
Comment on "Anastrozole (Arimidex) versus tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: survival analysis and updated safety results" by J.-M. Nabholtz et al.
    European journal of cancer (Oxford, England : 1990), 2004, Volume: 40, Issue:7

    Topics: Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Letrozole; Nitriles; Postmenopause; Survival Analysis; Tamoxifen; Triazoles

2004
Dynamic contrast enhanced magnetic resonance imaging in monitoring bone metastases in breast cancer patients receiving bisphosphonates and endocrine therapy.
    Acta radiologica (Stockholm, Sweden : 1987), 2004, Volume: 45, Issue:1

    Topics: Adult; Aged; Anastrozole; Bone Neoplasms; Breast Neoplasms; Diphosphonates; Female; Goserelin; Humans; Imidazoles; Letrozole; Magnetic Resonance Imaging; Middle Aged; Nitriles; Pamidronate; Pilot Projects; Prospective Studies; Tamoxifen; Triazoles; Zoledronic Acid

2004
Effects of the antiestrogen tamoxifen and the aromatase inhibitor letrozole on serum hormones and bone characteristics in a preclinical tumor model for breast cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Aug-15, Volume: 10, Issue:16

    Topics: Animals; Antineoplastic Agents; Aromatase; Body Composition; Breast Neoplasms; Cell Division; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Letrozole; Mice; Mice, Nude; Mice, Transgenic; Nitriles; Ovariectomy; Tamoxifen; Transplantation, Heterologous; Triazoles

2004
A method for making estimates of the benefit of the late use of letrozole in patients completing 5 years of tamoxifen.
    Clinical breast cancer, 2004, Volume: 5, Issue:4

    Topics: Aged; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Female; Humans; Letrozole; Lymph Nodes; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Prognosis; Receptors, Estrogen; Tamoxifen; Time Factors; Triazoles

2004
Cost utility and budget impact of third-generation aromatase inhibitors for advanced breast cancer: a literature-based model analysis of costs in the Italian National Health Service.
    Clinical therapeutics, 2004, Volume: 26, Issue:9

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Budgets; Cost-Benefit Analysis; Decision Support Techniques; Drug Costs; Female; Humans; Italy; Letrozole; Markov Chains; Megestrol; Models, Economic; National Health Programs; Nitriles; Postmenopause; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2004
Effects of exemestane and tamoxifen in a postmenopausal breast cancer model.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Nov-01, Volume: 10, Issue:21

    Topics: Androstadienes; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Disease Progression; Dose-Response Relationship, Drug; Female; Humans; Letrozole; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Random Allocation; Tamoxifen; Time Factors; Triazoles

2004
Letrozole better than tamoxifen in postmenopausal women.
    The Lancet. Oncology, 2005, Volume: 6, Issue:3

    Topics: Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Nitriles; Postmenopause; Tamoxifen; Triazoles

2005
[Efforts in the individualization of the adjuvant systemic therapy in breast cancer--ASCO, 2004].
    Magyar onkologia, 2004, Volume: 48, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Patient Care Planning; Patient Satisfaction; Patient Selection; Predictive Value of Tests; Quality of Life; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Tamoxifen; Triazoles

2004
Stimulating effects of androgen on proliferation of cultured ovarian germ cells through androgenic and estrogenic actions in embryonic chickens.
    Domestic animal endocrinology, 2005, Volume: 28, Issue:4

    Topics: Animals; Chick Embryo; Coculture Techniques; Female; Flutamide; Hormone Antagonists; Immunohistochemistry; Letrozole; Microscopy, Phase-Contrast; Nitriles; Ovary; Ovum; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-kit; Tamoxifen; Testosterone; Triazoles

2005
Letrozole-, anastrozole-, and tamoxifen-responsive genes in MCF-7aro cells: a microarray approach.
    Molecular cancer research : MCR, 2005, Volume: 3, Issue:4

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cell Division; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Nitriles; Oligonucleotide Array Sequence Analysis; Tamoxifen; Triazoles; Up-Regulation

2005
Further evidence on the safety and success of ovarian stimulation with letrozole and tamoxifen in breast cancer patients undergoing in vitro fertilization to cryopreserve their embryos for fertility preservation.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2005, Jun-01, Volume: 23, Issue:16

    Topics: Aromatase Inhibitors; Breast Neoplasms; Cryopreservation; Embryo, Mammalian; Estrogen Antagonists; Female; Fertility; Fertilization in Vitro; Humans; Letrozole; Nitriles; Oocytes; Ovulation Induction; Tamoxifen; Triazoles

2005
Serum HER-2/neu conversion to positive at the time of disease progression in patients with breast carcinoma on hormone therapy.
    Cancer, 2005, Jul-15, Volume: 104, Issue:2

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Disease Progression; Estrogen Antagonists; Female; Humans; Letrozole; Nitriles; Prognosis; Receptor, ErbB-2; Survival Analysis; Tamoxifen; Triazoles

2005
Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole.
    Cancer research, 2005, Jun-15, Volume: 65, Issue:12

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Drug Administration Schedule; Enzyme Activation; Estrogen Receptor alpha; Female; Humans; Letrozole; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinases; Nitriles; Tamoxifen; Triazoles; Xenograft Model Antitumor Assays

2005
Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model.
    Cancer research, 2005, Jun-15, Volume: 65, Issue:12

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Estradiol; Estrogen Receptor Modulators; Female; Fulvestrant; Humans; Letrozole; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Postmenopause; Tamoxifen; Triazoles; Xenograft Model Antitumor Assays

2005
Model systems: mechanisms involved in the loss of sensitivity to letrozole.
    The Journal of steroid biochemistry and molecular biology, 2005, Volume: 95, Issue:1-5

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Resistance, Neoplasm; Estradiol; Female; Fulvestrant; GRB2 Adaptor Protein; Humans; Letrozole; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Models, Biological; Nitriles; Receptors, Estrogen; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tamoxifen; Triazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2005
Aromatase inhibitors: cellular and molecular effects.
    The Journal of steroid biochemistry and molecular biology, 2005, Volume: 95, Issue:1-5

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cell Proliferation; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Nitriles; Oligonucleotide Array Sequence Analysis; Receptors, Progesterone; Tamoxifen; Triazoles

2005
Letrozole in the extended adjuvant treatment of postmenopausal women with history of early-stage breast cancer who have completed 5 years of adjuvant tamoxifen.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Aug-15, Volume: 11, Issue:16

    Topics: Aged; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bone Density; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Dizziness; Double-Blind Method; Drug Approval; Female; Follow-Up Studies; Headache; Humans; Letrozole; Middle Aged; Multicenter Studies as Topic; Neoplasm Staging; Nitriles; Postmenopause; Randomized Controlled Trials as Topic; Skin Diseases; Tamoxifen; Time Factors; Treatment Outcome; Triazoles; United States; United States Food and Drug Administration

2005
Options for preservation of fertility in women.
    The New England journal of medicine, 2005, Sep-29, Volume: 353, Issue:13

    Topics: Algorithms; Antineoplastic Agents; Breast Neoplasms; Cryopreservation; Drug Therapy, Combination; Embryo, Mammalian; Female; Fertility; Gonadotropins; Humans; Letrozole; Neoplasms; Nitriles; Ovary; Tamoxifen; Transplantation, Heterotopic; Triazoles

2005
Growth inhibition of estrogen receptor-positive and aromatase-positive human breast cancer cells in monolayer and spheroid cultures by letrozole, anastrozole, and tamoxifen.
    The Journal of steroid biochemistry and molecular biology, 2005, Volume: 97, Issue:4

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Estrogen Antagonists; Humans; Inhibitory Concentration 50; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Tamoxifen; Time Factors; Triazoles

2005
Harm or benefit of hormonal treatment in metastatic low-grade endometrial stromal sarcoma: single center experience with 10 cases and review of the literature.
    Gynecologic oncology, 2006, Volume: 101, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Endometrial Stromal Tumors; Estrogen Replacement Therapy; Female; Humans; Letrozole; Medroxyprogesterone Acetate; Middle Aged; Nitriles; Pelvic Neoplasms; Peritoneal Neoplasms; Retrospective Studies; Tamoxifen; Triazoles; Uterine Neoplasms

2006
Aromatase inhibitors--a triumph of translational oncology.
    The New England journal of medicine, 2005, Dec-29, Volume: 353, Issue:26

    Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease Models, Animal; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles

2005
Oral ovulation induction agents combined with low-dose gonadotropin injections and intrauterine insemination: cost- and clinical effectiveness.
    The Journal of reproductive medicine, 2005, Volume: 50, Issue:12

    Topics: Administration, Oral; Adult; Analysis of Variance; Clomiphene; Cost-Benefit Analysis; Female; Fertility Agents, Female; Humans; Infertility; Injections; Insemination, Artificial; Letrozole; Menotropins; Nitriles; Ovulation Induction; Pregnancy; Pregnancy Rate; Retrospective Studies; Tamoxifen; Triazoles

2005
Changing the gold standard in adjuvant therapy for breast cancer:from tamoxifen to aromatase inhibition.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2005, Volume: 59 Suppl 2

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2005
Letrozole in postmenopausal hormone-responsive early-stage breast cancer: a viewpoint by Gerald M. Higa.
    Drugs, 2006, Volume: 66, Issue:3

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Disease-Free Survival; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Osteoporosis, Postmenopausal; Postmenopause; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2006
Resumption of menses with initiation of letrozole after five years of amenorrhea on tamoxifen: caution needed when using tamoxifen followed by aromatase inhibitors.
    Cancer investigation, 2006, Volume: 24, Issue:2

    Topics: Adult; Amenorrhea; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Menstruation; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Premenopause; Tamoxifen; Triazoles

2006
Does survival increase in metastatic breast cancer with recently available anticancer drugs?
    Oncology research, 2006, Volume: 15, Issue:9

    Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Retrospective Studies; Survival Analysis; Tamoxifen; Triazoles

2006
Letrozole or tamoxifen in early breast cancer.
    The New England journal of medicine, 2006, Apr-06, Volume: 354, Issue:14

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Data Interpretation, Statistical; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2006
Letrozole or tamoxifen in early breast cancer.
    The New England journal of medicine, 2006, Apr-06, Volume: 354, Issue:14

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cardiovascular Diseases; Chemotherapy, Adjuvant; Humans; Letrozole; Lymphatic Metastasis; Nitriles; Secondary Prevention; Tamoxifen; Triazoles

2006
Letrozole or tamoxifen in early breast cancer.
    The New England journal of medicine, 2006, Apr-06, Volume: 354, Issue:14

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cardiovascular Diseases; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2006
Adjuvant aromatase inhibitors for early breast cancer after chemotherapy-induced amenorrhoea: caution and suggested guidelines.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Jun-01, Volume: 24, Issue:16

    Topics: Adult; Amenorrhea; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Estrogen Receptor Modulators; Female; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormone; Middle Aged; Neoplasm Staging; Nitriles; Ovariectomy; Practice Guidelines as Topic; Tamoxifen; Triazoles

2006
Pharmacoeconomic analysis of adjuvant therapy with exemestane, anastrozole, letrozole or tamoxifen in postmenopausal women with operable and estrogen receptor-positive breast cancer.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2006, Volume: 8, Issue:5

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Computer Simulation; Cost-Benefit Analysis; Estrogen Antagonists; Estrogens; Fees, Pharmaceutical; Female; Follow-Up Studies; Humans; Letrozole; Markov Chains; Middle Aged; Models, Theoretical; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Receptors, Estrogen; Tamoxifen; Triazoles

2006
Estrogen receptors: role in breast cancer.
    Critical reviews in clinical laboratory sciences, 2006, Volume: 43, Issue:4

    Topics: Anastrozole; Aromatase Inhibitors; Breast Neoplasms; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Gene Expression Regulation, Neoplastic; Gonadotropin-Releasing Hormone; Hormone Replacement Therapy; Humans; Letrozole; Models, Biological; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2006
Management of choroidal metastases from breast carcinomas using aromatase inhibitors.
    Current opinion in ophthalmology, 2006, Volume: 17, Issue:3

    Topics: Aged; Aged, 80 and over; Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Choroid Neoplasms; Combined Modality Therapy; Female; Humans; Letrozole; Mastectomy, Radical; Mastectomy, Segmental; Mastectomy, Simple; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Treatment Outcome; Triazoles

2006
Cost-effectiveness of letrozole in the extended adjuvant treatment of women with early breast cancer.
    Breast cancer research and treatment, 2007, Volume: 101, Issue:1

    Topics: Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Female; Humans; Letrozole; Middle Aged; Nitriles; Quality-Adjusted Life Years; Tamoxifen; Treatment Outcome; Triazoles

2007
Cost-effectiveness of extended adjuvant letrozole therapy after 5 years of adjuvant tamoxifen therapy in postmenopausal women with early-stage breast cancer.
    The American journal of managed care, 2006, Volume: 12, Issue:7

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Cohort Studies; Cost-Benefit Analysis; Decision Support Techniques; Disease Progression; Female; Humans; Letrozole; Markov Chains; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Staging; Nitriles; Postmenopause; Quality-Adjusted Life Years; Tamoxifen; Time Factors; Triazoles; United States

2006
Re: Randomized trial of letrozole following tamoxifen as extended adjuvant therapy in receptor-positive breast cancer: updated findings from NCIC CTG MA.17.
    Journal of the National Cancer Institute, 2006, Aug-16, Volume: 98, Issue:16

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Estrogen Receptor Modulators; Female; Humans; Letrozole; Nitriles; Patient Selection; Progesterone; Randomized Controlled Trials as Topic; Receptors, Estrogen; Tamoxifen; Treatment Outcome; Triazoles

2006
The effect of tamoxifen on the pharmacokinetics of letrozole in female rats.
    Biopharmaceutics & drug disposition, 2006, Volume: 27, Issue:7

    Topics: Animals; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; Drug Interactions; Estrogen Antagonists; Female; Half-Life; Letrozole; Molecular Structure; Nitriles; Rats; Rats, Sprague-Dawley; Tamoxifen; Triazoles

2006
Late risk of relapse and mortality among postmenopausal women with estrogen responsive early breast cancer after 5 years of tamoxifen.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2007, Volume: 18, Issue:1

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; British Columbia; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Prognosis; Risk Factors; Survival Rate; Tamoxifen; Triazoles

2007
Biotransformation of letrozole in rat liver microsomes: effects of gender and tamoxifen.
    Journal of pharmaceutical and biomedical analysis, 2007, Feb-19, Volume: 43, Issue:3

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Biotransformation; Calibration; Chromatography, High Pressure Liquid; Drug Interactions; Female; In Vitro Techniques; Letrozole; Male; Mass Spectrometry; Microsomes, Liver; Nitriles; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sex Characteristics; Spectrophotometry, Ultraviolet; Tamoxifen; Triazoles

2007
Clinically occult cutaneous metastases.
    Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:6

    Topics: Aged; Aged, 80 and over; Anastrozole; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Breast Neoplasms; Capecitabine; Carcinoma; Carcinoma, Basal Cell; Carcinoma, Lobular; Carcinoma, Signet Ring Cell; Deoxycytidine; Estradiol; Facial Neoplasms; Female; Fluorouracil; Fulvestrant; Humans; Incidental Findings; Letrozole; Mastectomy, Radical; Megestrol Acetate; Melanoma; Neoplasms, Second Primary; Neoplastic Cells, Circulating; Nitriles; Selective Estrogen Receptor Modulators; Skin Neoplasms; Tamoxifen; Triazoles; Wound Healing

2006
Aromatase and breast cancer.
    The Journal of steroid biochemistry and molecular biology, 2006, Volume: 102, Issue:1-5

    Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Drug Resistance, Neoplasm; Drug Therapy, Combination; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Letrozole; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Ovariectomy; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Receptors, Estrogen; Signal Transduction; Tamoxifen; Triazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2006
[Correlation of hormone-metabolic status in breast cancer and effectiveness of adjuvant hormone therapy].
    Voprosy onkologii, 2006, Volume: 52, Issue:2

    Topics: Aged; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; C-Peptide; Chemotherapy, Adjuvant; Estradiol; Female; Humans; Insulin; Insulin Resistance; Letrozole; Middle Aged; Nitriles; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Time Factors; Triazoles

2006
Cost-utility of adjuvant hormone therapies with aromatase inhibitors in post-menopausal women with breast cancer: upfront anastrozole, sequential tamoxifen-exemestane and extended tamoxifen-letrozole.
    Breast (Edinburgh, Scotland), 2007, Volume: 16, Issue:3

    Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Belgium; Breast Neoplasms; Canada; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Drug Costs; Female; Humans; Letrozole; Markov Chains; Middle Aged; Nitriles; Postmenopause; Proportional Hazards Models; Quality-Adjusted Life Years; Tamoxifen; Triazoles

2007
Focal adhesion kinase and paxillin: novel regulators of brain sexual differentiation?
    Endocrinology, 2007, Volume: 148, Issue:7

    Topics: Animals; Animals, Newborn; Aromatase; Blotting, Western; Brain; Cells, Cultured; Estradiol; Female; Focal Adhesion Protein-Tyrosine Kinases; Hypothalamus; Immunohistochemistry; Letrozole; Male; Neurites; Nitriles; Paxillin; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Sex Differentiation; Sex Factors; Tamoxifen; Testosterone; Triazoles

2007
Changes in bone mineral density after adjuvant aromatase inhibitors and fracture risk in breast cancer patients.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Apr-10, Volume: 25, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers; Bone Density; Breast Neoplasms; Canada; Chemotherapy, Adjuvant; Collagen Type I; Estrogen Receptor Modulators; Female; Fractures, Bone; Humans; Letrozole; Middle Aged; Nitriles; Peptides; Tamoxifen; Treatment Outcome; Triazoles

2007
Patients' knowledge and experience of adjuvant endocrine therapy for early breast cancer: a European study.
    Breast (Edinburgh, Scotland), 2007, Volume: 16, Issue:5

    Topics: Aged; Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Communication Barriers; Decision Making; Europe; Female; Health Knowledge, Attitudes, Practice; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Selective Estrogen Receptor Modulators; Surveys and Questionnaires; Tamoxifen; Triazoles

2007
Inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, May-01, Volume: 13, Issue:9

    Topics: Androstadienes; Androstenedione; Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor alpha; Estrogen Receptor Modulators; Humans; Letrozole; Mice; Mice, Nude; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Tamoxifen; Triazoles; Wortmannin

2007
Letrozole compared with tamoxifen as initial adjuvant therapy for breast cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, May-20, Volume: 25, Issue:15

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Nitriles; Tamoxifen; Treatment Outcome; Triazoles

2007
Cost-effectiveness of letrozole versus tamoxifen as initial adjuvant therapy in hormone receptor-positive postmenopausal women with early-stage breast cancer.
    Clinical breast cancer, 2007, Volume: 7, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Cost-Benefit Analysis; Drug Costs; Female; Humans; Letrozole; Markov Chains; Middle Aged; Models, Econometric; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles

2007
Cost utility analysis of early adjuvant letrozole or anastrozole versus tamoxifen in postmenopausal women with early invasive breast cancer: the UK perspective.
    The European journal of health economics : HEPAC : health economics in prevention and care, 2008, Volume: 9, Issue:2

    Topics: Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cost-Benefit Analysis; Female; Humans; Letrozole; Markov Chains; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Quality of Life; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles; United Kingdom

2008
Sex-specific effects of androgen and estrogen on proliferation of the embryonic chicken hypothalamic neurons.
    Endocrine, 2007, Volume: 31, Issue:2

    Topics: Androgens; Animals; Aromatase Inhibitors; Cell Proliferation; Cells, Cultured; Chick Embryo; Estrogens; Female; Flutamide; Hormone Antagonists; Hypothalamus; Letrozole; Male; Neurons; Nitriles; Sex Characteristics; Tamoxifen; Triazoles

2007
San Antonio Breast Cancer Symposium.
    The Lancet. Oncology, 2008, Volume: 9, Issue:1

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Docetaxel; Epothilones; Everolimus; Female; Fluorouracil; Humans; Letrozole; Nitriles; Sirolimus; Tamoxifen; Taxoids; Trastuzumab; Triazoles

2008
Joint one-sided and two-sided simultaneous confidence intervals.
    Journal of biopharmaceutical statistics, 2008, Volume: 18, Issue:2

    Topics: Aromatase Inhibitors; Clinical Trials as Topic; Confidence Intervals; Drug Therapy, Combination; Humans; Letrozole; Models, Statistical; Nitriles; Research Design; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2008
Controversies in endocrine treatment: effective utilization of steroidal and nonsteroidal aromatase inhibitors: now and in the future. Forward.
    Anti-cancer drugs, 2008, Volume: 19 Suppl 2

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Tamoxifen; Triazoles

2008
MCF-7aro/ERE, a novel cell line for rapid screening of aromatase inhibitors, ERalpha ligands and ERRalpha ligands.
    Biochemical pharmacology, 2008, Jul-15, Volume: 76, Issue:2

    Topics: Anastrozole; Aromatase Inhibitors; Biological Assay; Cell Line, Tumor; Coumarins; ERRalpha Estrogen-Related Receptor; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Fulvestrant; Genes, Reporter; Genistein; Humans; Letrozole; Ligands; Luciferases; Nitriles; Receptors, Estrogen; Response Elements; Tamoxifen; Thiazoles; Transfection; Triazoles

2008
Regression of chronic lymphocytic leukemia with aromatase inhibitor-letrozole?
    Leukemia research, 2009, Volume: 33, Issue:4

    Topics: Aged; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Leukemia, Lymphocytic, Chronic, B-Cell; Mastectomy, Segmental; Neoplasms, Multiple Primary; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles

2009
Method to test whether late extended letrozole, rather than self- selection, improves the outcome in patients with breast cancer who have completed 5 years of tamoxifen.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Jul-01, Volume: 26, Issue:19

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Letrozole; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Placebos; Postmenopause; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles

2008
Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristics.
    Journal of the National Cancer Institute, 2008, Oct-01, Volume: 100, Issue:19

    Topics: Aged; Analysis of Variance; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Ki-67 Antigen; Letrozole; Lymphatic Metastasis; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Postmenopause; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Receptors, Estrogen; Reproducibility of Results; Risk Assessment; Risk Factors; Tamoxifen; Treatment Outcome; Triazoles

2008
Sonographic evaluation of endothelial function in letrozole and tamoxifen users.
    Maturitas, 2008, Dec-20, Volume: 61, Issue:4

    Topics: Aged; Aromatase Inhibitors; Brachial Artery; Breast Neoplasms; Carotid Artery, External; Case-Control Studies; Endothelium, Vascular; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Triazoles; Tunica Intima; Tunica Media; Ultrasonography; Vasodilation

2008
San Antonio Breast Cancer Symposium.
    The Lancet. Oncology, 2009, Volume: 10, Issue:1

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Diphosphonates; Everolimus; Female; Humans; Imidazoles; Lapatinib; Letrozole; Nitriles; Quinazolines; Sirolimus; Tamoxifen; Trastuzumab; Triazoles; Zoledronic Acid

2009
An ER activity profile including ER, PR, Bcl-2 and IGF-IR may have potential as selection criterion for letrozole or tamoxifen treatment of patients with advanced breast cancer.
    Acta oncologica (Stockholm, Sweden), 2009, Volume: 48, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Disease Progression; Disease-Free Survival; Female; Humans; Immunohistochemistry; Letrozole; Microarray Analysis; Middle Aged; Nitriles; Patient Selection; Pilot Projects; Predictive Value of Tests; Proto-Oncogene Proteins c-bcl-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Treatment Outcome; Triazoles

2009
Effects of binary mixtures of estrogen and antiestrogens on Japanese medaka (Oryzias latipes).
    Aquatic toxicology (Amsterdam, Netherlands), 2009, Jun-04, Volume: 93, Issue:1

    Topics: Animals; Drug Interactions; Endocrine Disruptors; Estradiol; Female; Letrozole; Male; Nitriles; Oryzias; Random Allocation; Reproduction; Statistics, Nonparametric; Tamoxifen; Triazoles; Vitellogenins; Water Pollutants, Chemical

2009
Differential effects of aromatase inhibitors and antiestrogens on estrogen receptor expression in breast cancer cells.
    Anticancer research, 2009, Volume: 29, Issue:6

    Topics: Anastrozole; Aromatase Inhibitors; Blotting, Western; Breast Neoplasms; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Fulvestrant; Humans; Letrozole; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tamoxifen; Triazoles; Tumor Cells, Cultured

2009
Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells.
    Blood, 2009, Sep-10, Volume: 114, Issue:11

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Anemia, Aplastic; Aromatase Inhibitors; Dyskeratosis Congenita; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Female; Flutamide; Gene Expression Regulation, Enzymologic; Hematopoietic Stem Cells; Heterozygote; Humans; Letrozole; Lymphocytes; Male; Mutation; Nitriles; Receptors, Androgen; Tamoxifen; Telomerase; Triazoles

2009
NCCN Guideline update: Breast Cancer Version 1.2004.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2004, Volume: 2, Issue:3

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Combined Modality Therapy; Female; Humans; Letrozole; Lymph Nodes; Lymphatic Metastasis; Mastectomy; Neoplasms, Hormone-Dependent; Nitriles; Receptors, Estrogen; Tamoxifen; Triazoles

2004
Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen and aromatase inhibitors.
    Drug metabolism reviews, 2010, Volume: 42, Issue:1

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Letrozole; Nitriles; Pharmacogenetics; Receptors, Estrogen; Tamoxifen; Triazoles

2010
Molecular characterization of aromatase inhibitor-resistant, tamoxifen-resistant and LTEDaro cell lines.
    The Journal of steroid biochemistry and molecular biology, 2010, Feb-28, Volume: 118, Issue:4-5

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2010
[A case of recurrent breast cancer with extensive liver metastasis successfully treated with endocrine therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:13

    Topics: Androstadienes; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Female; Humans; Letrozole; Liver Neoplasms; Medroxyprogesterone; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Tamoxifen; Toremifene; Triazoles

2009
Introduction to sessions on guidelines and endocrine therapy, the influence of breast screening on number of mastectomies and the challenge between molecular science and traditional dogma in the treatment of breast cancer. Introduction to Session 6.
    Breast cancer research : BCR, 2009, Volume: 11 Suppl 3

    Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Diphosphonates; Female; Humans; Imidazoles; Letrozole; Mass Screening; Mastectomy; Nitriles; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles; Zoledronic Acid

2009
Do BIG1-98 and ZOFAST demand a change in guidelines for endocrine therapy?
    Breast cancer research : BCR, 2009, Volume: 11 Suppl 3

    Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Diphosphonates; Female; Humans; Imidazoles; Letrozole; Nitriles; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles; Zoledronic Acid

2009
Screening of chemicals with anti-estrogenic activity using in vitro and in vivo vitellogenin induction responses in zebrafish (Danio rerio).
    Chemosphere, 2010, Volume: 78, Issue:7

    Topics: Animals; Cells, Cultured; Endocrine Disruptors; Estrogen Antagonists; Female; Hepatocytes; Letrozole; Male; Nitriles; Tamoxifen; Toxicity Tests; Triazoles; Vitellogenins; Water Pollutants, Chemical; Zebrafish

2010
Radiotherapy, antihormonal therapy, and personalised medicine.
    The Lancet. Oncology, 2010, Volume: 11, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Combined Modality Therapy; Female; Humans; Letrozole; Nitriles; Precision Medicine; Radiation Injuries; Tamoxifen; Triazoles

2010
[A case of postoperative liver metastasis of mucinous carcinoma of the breast with complete response to sequential administration of FEC75, tamoxifen citrate, and letrozole].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:3

    Topics: Adenocarcinoma, Mucinous; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubicin; Female; Fluorouracil; Humans; Letrozole; Liver Neoplasms; Mastectomy; Middle Aged; Nitriles; Tamoxifen; Triazoles

2010
EGFR/HER2 inhibitor AEE788 increases ER-mediated transcription in HER2/ER-positive breast cancer cells but functions synergistically with endocrine therapy.
    British journal of cancer, 2010, Apr-13, Volume: 102, Issue:8

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase; Breast Neoplasms; Cell Line, Tumor; Cytoprotection; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Humans; Letrozole; Mice; Mice, Nude; Neoplasms, Hormone-Dependent; Nitriles; Purines; Receptor, ErbB-2; Receptors, Estrogen; Tamoxifen; Transcription, Genetic; Transfection; Triazoles; Xenograft Model Antitumor Assays

2010
Erythrocyte alpha-tocopherol in breast cancer patients treated with letrozol.
    Journal of nutritional science and vitaminology, 2010, Volume: 56, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; alpha-Tocopherol; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cholesterol; Chromatography, High Pressure Liquid; Cohort Studies; Erythrocytes; Female; Follow-Up Studies; Humans; Letrozole; Middle Aged; Nitriles; Tamoxifen; Triazoles

2010
The differences in outcome between ATAC and BIG 1-98 suggest efficacy differences between these two nonsteroidal AIs.
    Cancer investigation, 2010, Volume: 28 Suppl 1

    Topics: Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Female; Humans; Letrozole; Nitriles; Research Design; Tamoxifen; Treatment Outcome; Triazoles

2010
Cognitive changes associated with endocrine therapy for breast cancer.
    Maturitas, 2010, Volume: 67, Issue:3

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Case-Control Studies; Chemotherapy, Adjuvant; Cognition; Cognition Disorders; Female; Humans; Letrozole; Memory; Neoplasms, Hormone-Dependent; Nitriles; Prospective Studies; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles; United States; Women's Health

2010
Development and validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of tamoxifen, anastrozole, and letrozole in human plasma and its application to a clinical study.
    Analytical and bioanalytical chemistry, 2010, Volume: 398, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Breast Neoplasms; Chromatography, Liquid; Female; Humans; Letrozole; Middle Aged; Nitriles; Selective Estrogen Receptor Modulators; Tamoxifen; Tandem Mass Spectrometry; Triazoles

2010
Evaluation of treatment-effect heterogeneity using biomarkers measured on a continuous scale: subpopulation treatment effect pattern plot.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Oct-10, Volume: 28, Issue:29

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Ki-67 Antigen; Letrozole; Models, Statistical; Neoplasms; Nitriles; Outcome Assessment, Health Care; Predictive Value of Tests; Prognosis; Reproducibility of Results; Tamoxifen; Triazoles

2010
Significance of ER-Src axis in hormonal therapy resistance.
    Breast cancer research and treatment, 2011, Volume: 130, Issue:2

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Co-Repressor Proteins; Dasatinib; Drug Resistance, Neoplasm; Drug Synergism; Estrogen Receptor alpha; Female; Gene Knockdown Techniques; Humans; Letrozole; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Pyrimidines; Receptor, ErbB-2; RNA Interference; src-Family Kinases; Tamoxifen; Thiazoles; Transcription Factors; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays

2011
Aromatase inhibitor-induced loss of grip strength is body mass index dependent: hypothesis-generating findings for its pathogenesis.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2011, Volume: 22, Issue:8

    Topics: Aged; Anastrozole; Androstadienes; Aromatase Inhibitors; Arthralgia; Body Mass Index; Breast Neoplasms; Cohort Studies; Female; Hand Strength; Humans; Letrozole; Middle Aged; Musculoskeletal Diseases; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Syndrome; Tamoxifen; Triazoles

2011
Transcriptional responses in the brain, liver and gonad of Japanese ricefish (Oryzias latipes) exposed to two anti-estrogens.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2011, Volume: 153, Issue:4

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Endocrine Disruptors; Estrogen Receptor Modulators; Female; Fish Proteins; Gene Expression Profiling; Gonads; Hypothalamo-Hypophyseal System; Letrozole; Liver; Male; Nitriles; Organ Specificity; Oryzias; RNA, Messenger; Sex Characteristics; Tamoxifen; Toxicity Tests; Transcription, Genetic; Triazoles; Vitellogenins; Water Pollutants, Chemical

2011
A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, Apr-01, Volume: 17, Issue:7

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Resistance, Neoplasm; Estrogen Receptor Modulators; Female; Gene Expression Profiling; Genetic Association Studies; Humans; Kaplan-Meier Estimate; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasms, Hormone-Dependent; Nitriles; Oligonucleotide Array Sequence Analysis; Proportional Hazards Models; Proto-Oncogene Proteins c-myc; RNA Interference; Tamoxifen; Treatment Outcome; Triazoles

2011
[Significance of HER2 testing in breast cancer].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 2011, Volume: 40, Issue:2

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Drug Delivery Systems; Female; Humans; Letrozole; Nitriles; Receptor, ErbB-2; Survival Rate; Tamoxifen; Trastuzumab; Triazoles

2011
The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase (CYP19) and a potential lead compound for novel therapeutic agents.
    Breast cancer research and treatment, 2012, Volume: 133, Issue:1

    Topics: Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Binding Sites; Breast Neoplasms; Catalytic Domain; Computer Simulation; Drug Discovery; Female; Humans; Isoenzymes; Kinetics; Letrozole; Microsomes; Models, Molecular; Nitriles; Tamoxifen; Testosterone; Thermodynamics; Triazoles

2012
Is primary endocrine therapy effective in treating the elderly, unfit patient with breast cancer?
    Annals of the Royal College of Surgeons of England, 2011, Volume: 93, Issue:4

    Topics: Aged; Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease Progression; Female; Humans; Letrozole; Middle Aged; Nitriles; Receptors, Estrogen; Retrospective Studies; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles

2011
Transcriptional responses in Japanese medaka (Oryzias latipes) exposed to binary mixtures of an estrogen and anti-estrogens.
    Aquatic toxicology (Amsterdam, Netherlands), 2011, Volume: 105, Issue:3-4

    Topics: Animals; Biomarkers; Complex Mixtures; Dose-Response Relationship, Drug; Endocrine Disruptors; Endocrine System; Estrogen Receptor Modulators; Estrogens; Ethinyl Estradiol; Female; Gene Expression Profiling; Hypothalamo-Hypophyseal System; Letrozole; Male; Nitriles; Oryzias; Random Allocation; Sex Factors; Tamoxifen; Transcription, Genetic; Triazoles; Water Pollutants, Chemical

2011
Bone mineral density in breast cancer patients treated with adjuvant letrozole, tamoxifen, or sequences of letrozole and tamoxifen in the BIG 1-98 study (SAKK 21/07).
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23, Issue:6

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bone Density; Breast Neoplasms; Female; Hip; Humans; Letrozole; Lumbar Vertebrae; Middle Aged; Multivariate Analysis; Nitriles; Osteoporosis; Postmenopause; Radiography; Randomized Controlled Trials as Topic; Retrospective Studies; Tamoxifen; Triazoles

2012
Choroidal and optic disc metastases from breast cancer and their response to combination pharmacotherapy with tamoxifen, cyclophosphamide hydrate, letrozole, and bevacizumab.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2012, Volume: 28, Issue:1

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Breast Neoplasms; Choroid Neoplasms; Cyclophosphamide; Female; Humans; Letrozole; Middle Aged; Nitriles; Optic Disk; Optic Nerve Neoplasms; Retinal Detachment; Tamoxifen; Treatment Outcome; Triazoles

2012
Hormone treatment without surgery for patients aged 75 years or older with operable breast cancer.
    Annals of surgical oncology, 2012, Volume: 19, Issue:4

    Topics: Aged; Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Disease Progression; Female; Follow-Up Studies; Humans; Letrozole; Nitriles; Receptor, ErbB-2; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles

2012
Dual IGF-1R/InsR inhibitor BMS-754807 synergizes with hormonal agents in treatment of estrogen-dependent breast cancer.
    Cancer research, 2011, Dec-15, Volume: 71, Issue:24

    Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Estradiol; Estrogens; Female; Fulvestrant; Gene Expression Profiling; Humans; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Oligonucleotide Array Sequence Analysis; Pyrazoles; Receptor, IGF Type 1; Receptor, Insulin; Tamoxifen; Triazines; Triazoles; Xenograft Model Antitumor Assays

2011
Antitumor activity of chemoendocrine therapy in premenopausal and postmenopausal models with human breast cancer xenografts.
    Oncology reports, 2012, Volume: 27, Issue:2

    Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase; Breast Neoplasms; Capecitabine; Cell Line, Tumor; Deoxycytidine; Disease Models, Animal; Female; Fluorouracil; Genes, Reporter; Humans; Letrozole; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Postmenopause; Premenopause; Tamoxifen; Thymidine Phosphorylase; Triazoles; Xenograft Model Antitumor Assays

2012
Deep time: the long and the short of adjuvant endocrine therapy for breast cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Mar-01, Volume: 30, Issue:7

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2012
CYP2D6 genotype as a marker for benefit of adjuvant tamoxifen in postmenopausal women: lessons learned.
    Journal of the National Cancer Institute, 2012, Mar-21, Volume: 104, Issue:6

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cytochrome P-450 CYP2D6; Female; Glucuronosyltransferase; Humans; Letrozole; Neoplasm Recurrence, Local; Nitriles; Polymorphism, Single Nucleotide; Postmenopause; Tamoxifen; Triazoles

2012
L-BLP25 vaccine plus letrozole induces a TH1 immune response and has additive antitumor activity in MUC1-expressing mammary tumors in mice.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, May-15, Volume: 18, Issue:10

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Cancer Vaccines; Cyclophosphamide; Estradiol; Estrogen Antagonists; Female; Interferon-gamma; Interleukin-12; Letrozole; Mammary Neoplasms, Animal; Membrane Glycoproteins; Mice; Mucin-1; Neoplasms, Hormone-Dependent; Nitriles; Random Allocation; Tamoxifen; Th1 Cells; Triazoles

2012
Efficacy and mechanism of action of Proellex, an antiprogestin in aromatase overexpressing and Letrozole resistant T47D breast cancer cells.
    The Journal of steroid biochemistry and molecular biology, 2013, Volume: 133

    Topics: Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Base Sequence; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Female; Gene Expression; Genes, erbB-1; Humans; Letrozole; Nitriles; Norpregnadienes; Progestins; Promegestone; Receptors, Progesterone; RNA, Messenger; RNA, Neoplasm; Tamoxifen; Testosterone; Triazoles; Tumor Stem Cell Assay

2013
Comparison of the effects of aromatase inhibitors and tamoxifen on radiation-induced lung toxicity: results of an experimental study.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013, Volume: 21, Issue:3

    Topics: Anastrozole; Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Combined Modality Therapy; Female; Letrozole; Nitriles; Pulmonary Fibrosis; Radiation Injuries, Experimental; Rats; Rats, Wistar; Statistics, Nonparametric; Tamoxifen; Triazoles

2013
Introduction of modern endocrine techniques for the production of monosex population of fishes.
    General and comparative endocrinology, 2013, Jan-15, Volume: 181

    Topics: Animals; Aromatase Inhibitors; Estradiol; Female; Fishes; Letrozole; Male; Methyltestosterone; Nitriles; Sex Differentiation; Tamoxifen; Tilapia; Triazoles

2013
Effectiveness and molecular interactions of the clinically active mTORC1 inhibitor everolimus in combination with tamoxifen or letrozole in vitro and in vivo.
    Breast cancer research : BCR, 2012, Oct-17, Volume: 14, Issue:5

    Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Nucleolus; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Everolimus; Female; Humans; Letrozole; Mechanistic Target of Rapamycin Complex 1; Mice; Multiprotein Complexes; Nitriles; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Receptor, ErbB-3; Receptors, Estrogen; Signal Transduction; Sirolimus; Tamoxifen; TOR Serine-Threonine Kinases; Triazoles; Xenograft Model Antitumor Assays

2012
Letrozole: advancing hormone therapy in breast cancer.
    Women's health (London, England), 2012, Volume: 8, Issue:6

    Topics: Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Neoplasm Staging; Nitriles; Postmenopause; Quality of Life; Tamoxifen; Triazoles

2012
What is the optimal endocrine therapy for postmenopausal women with hormone receptor-positive early breast cancer?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Apr-10, Volume: 31, Issue:11

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Middle Aged; Nitriles; Postmenopause; Practice Guidelines as Topic; Receptors, Estrogen; Tamoxifen; Time Factors; Triazoles

2013
The aromatase inhibitor letrozole reduces adhesion formation after intraperitoneal surgery in a rat uterine horn model.
    European journal of obstetrics, gynecology, and reproductive biology, 2013, Volume: 167, Issue:2

    Topics: Animals; Aromatase Inhibitors; Female; Foreign-Body Reaction; Letrozole; Nitriles; Peritoneal Cavity; Peritoneum; Postoperative Period; Preoperative Period; Random Allocation; Rats; Rats, Wistar; Selective Estrogen Receptor Modulators; Tamoxifen; Tissue Adhesions; Triazoles; Uterus

2013
Should all postmenopausal patients with hormone receptor-positive breast cancer receive initial therapy with aromatase inhibitors?
    Breast (Edinburgh, Scotland), 2013, Volume: 22, Issue:4

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Postmenopause; Receptors, Estrogen; Tamoxifen; Time Factors; Treatment Outcome; Triazoles

2013
Optimal combination of radiotherapy and endocrine drugs in breast cancer treatment.
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2013, Volume: 17, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Apoptosis; Aromatase Inhibitors; bcl-2-Associated X Protein; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Female; Humans; Letrozole; Nitriles; Proto-Oncogene Proteins c-bcl-2; Radiotherapy Dosage; Tamoxifen; Triazoles; Up-Regulation

2013
Tamoxifen therapy for patients with breast cancer.
    Lancet (London, England), 2013, Jun-15, Volume: 381, Issue:9883

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Disease-Free Survival; Female; Humans; Letrozole; Nitriles; Postmenopause; Premenopause; Risk Factors; Tamoxifen; Time Factors; Treatment Outcome; Triazoles

2013
Tamoxifen therapy for patients with breast cancer - Authors' reply.
    Lancet (London, England), 2013, Jun-15, Volume: 381, Issue:9883

    Topics: Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Nitriles; Tamoxifen; Triazoles

2013
Effects of femara and tamoxifen on proliferation of FM3A cells in culture.
    Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Aromatase Inhibitors; Cell Line, Tumor; Cell Proliferation; Estrogen Antagonists; Female; Letrozole; Mammary Neoplasms, Animal; Mice; Mice, Inbred C3H; Mitotic Index; Nitriles; Receptors, Estrogen; Tamoxifen; Triazoles

2013
A UK national survey of breast surgeons on primary endocrine therapy of early operable breast cancer.
    Annals of the Royal College of Surgeons of England, 2013, Volume: 95, Issue:5

    Topics: Aged; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; General Surgery; Health Surveys; Humans; Letrozole; Nitriles; Practice Patterns, Physicians'; Tamoxifen; Triazoles

2013
Letrozole combined with gonadotropin-releasing hormone analog for metastatic male breast cancer.
    Breast cancer research and treatment, 2013, Volume: 141, Issue:1

    Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms, Male; Carcinoma, Ductal, Breast; Carcinoma, Papillary; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Disease-Free Survival; Docetaxel; Epirubicin; Estrogen Receptor Modulators; Estrogens; Fluorouracil; Gonadotropin-Releasing Hormone; Goserelin; Humans; Kaplan-Meier Estimate; Letrozole; Male; Mastectomy, Modified Radical; Methotrexate; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Progesterone; Radiotherapy, Adjuvant; Tamoxifen; Taxoids; Triazoles

2013
Inhibition of ubiquitin conjugating enzyme UBE2C reduces proliferation and sensitizes breast cancer cells to radiation, doxorubicin, tamoxifen and letrozole.
    Cellular oncology (Dordrecht), 2013, Volume: 36, Issue:6

    Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Doxorubicin; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HEK293 Cells; Humans; Letrozole; MCF-7 Cells; Nitriles; Reverse Transcriptase Polymerase Chain Reaction; Tamoxifen; Triazoles; Ubiquitin-Conjugating Enzymes

2013
Expression of estrogen-related gene markers in breast cancer tissue predicts aromatase inhibitor responsiveness.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Biomarkers, Tumor; BRCA1 Protein; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Estrogens; Female; Gene Expression Regulation, Neoplastic; Genetic Markers; Humans; Hydroxyprostaglandin Dehydrogenases; Letrozole; Middle Aged; Nitriles; Receptors, Progesterone; ROC Curve; Tamoxifen; Treatment Outcome; Triazoles

2013
Fertility preservation with ovarian stimulation protocols prior to cancer treatment.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2014, Volume: 30, Issue:3

    Topics: Aromatase Inhibitors; Estrogen Antagonists; Female; Fertility Preservation; Gonadotropins; Humans; Letrozole; Neoplasms; Neoplasms, Hormone-Dependent; Nitriles; Ovulation Induction; Precision Medicine; Tamoxifen; Time-to-Treatment; Triazoles

2014
Symptoms of endocrine treatment and outcome in the BIG 1-98 study.
    Breast cancer research and treatment, 2014, Volume: 143, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Breast Neoplasms; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Humans; Incidence; Letrozole; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Nitriles; Proportional Hazards Models; Retrospective Studies; Risk Factors; Tamoxifen; Time Factors; Treatment Outcome; Triazoles; Tumor Burden

2014
Women commencing anastrozole, letrozole or tamoxifen for early breast cancer: the impact of comorbidity and demographics on initial choice.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Australia; Breast Neoplasms; Cohort Studies; Comorbidity; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Postmenopause; Practice Guidelines as Topic; Premenopause; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles; Tumor Burden

2014
Effect of dietary administration of letrozole and tamoxifen on gonadal development, sex differentiation and biochemical changes in common carp (Cyprinus carpio L.).
    Reproduction, fertility, and development, 2015, Volume: 27, Issue:3

    Topics: Animals; Aromatase Inhibitors; Carps; Estradiol; Estrogen Antagonists; Female; Gonads; Letrozole; Male; Nitriles; Sex Differentiation; Spermatogenesis; Tamoxifen; Triazoles

2015
Tumour grade on core biopsy and evidence of axillary involvement on ultrasound predicts response in elderly co-morbid patients treated with primary hormone therapy for oestrogen receptor positive breast carcinoma.
    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, 2015, Volume: 13, Issue:2

    Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Axilla; Biopsy, Large-Core Needle; Breast Neoplasms; Female; Humans; Letrozole; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Nitriles; Receptors, Estrogen; Retrospective Studies; Tamoxifen; Triazoles

2015
Clinical and laboratory patterns during immune stimulation in hormone responsive metastatic breast cancer.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2014, Volume: 68, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoembryonic Antigen; Cytokines; Disease Progression; Disease-Free Survival; Female; Humans; Immunity, Cellular; Immunotherapy; Interferon-beta; Interleukin-2; Letrozole; Middle Aged; Mucin-1; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nitriles; Proportional Hazards Models; Selective Estrogen Receptor Modulators; T-Lymphocytes; Tamoxifen; Tissue Polypeptide Antigen; Toremifene; Triazoles

2014
Long-term outcome of neoadjuvant endocrine therapy with aromatase inhibitors in elderly women with hormone receptor-positive breast cancer.
    Annals of surgical oncology, 2014, Volume: 21, Issue:5

    Topics: Aged; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Chemotherapy, Adjuvant; Female; Follow-Up Studies; Humans; Letrozole; Neoadjuvant Therapy; Neoplasm Grading; Neoplasm Staging; Nitriles; Postmenopause; Prognosis; Receptor, ErbB-2; Retrospective Studies; Survival Rate; Tamoxifen; Time Factors; Triazoles

2014
Biomarker changes associated with the development of resistance to aromatase inhibitors (AIs) in estrogen receptor-positive breast cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2014, Volume: 25, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Androstadienes; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Insulin Receptor Substrate Proteins; Ki-67 Antigen; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Nitriles; PTEN Phosphohydrolase; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Stathmin; Tamoxifen; Triazoles

2014
Morphological and immunohistochemical analysis in ovaries and fallopian tubes of tamoxifen, letrozole and clomiphene-treated rats.
    Archives of gynecology and obstetrics, 2014, Volume: 290, Issue:3

    Topics: Animals; Cell Nucleus; Chromatin; Clomiphene; Epithelium; Fallopian Tubes; Female; Fertility Agents, Female; Immunohistochemistry; Letrozole; Nitriles; Ovary; Ovulation Induction; Rats; Rats, Wistar; Tamoxifen; Triazoles

2014
VAV3 mediates resistance to breast cancer endocrine therapy.
    Breast cancer research : BCR, 2014, May-28, Volume: 16, Issue:3

    Topics: Androstadienes; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Enzyme Activators; ErbB Receptors; Erlotinib Hydrochloride; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Genetic Association Studies; Genetic Variation; Humans; Indazoles; Letrozole; MCF-7 Cells; Nitriles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-vav; Quinazolines; RNA Interference; RNA, Small Interfering; Tamoxifen; Toremifene; Triazoles

2014
A hard pill to swallow: a qualitative study of women's experiences of adjuvant endocrine therapy for breast cancer.
    BMJ open, 2014, Jun-12, Volume: 4, Issue:6

    Topics: Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Attitude to Health; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Medication Adherence; Middle Aged; Nitriles; Qualitative Research; Quality of Life; Tamoxifen; Triazoles

2014
Is there a role for hormonal therapy in neuroendocrine carcinoma of the breast? A Paradigmatic case report.
    Clinical breast cancer, 2014, Volume: 14, Issue:5

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Neuroendocrine; Cytodiagnosis; Diagnostic Errors; Female; Humans; Letrozole; Lymphatic Metastasis; Mastectomy; Middle Aged; Nitriles; Tamoxifen; Triazoles

2014
Clinical response to primary letrozole therapy in elderly patients with early breast cancer: possible role for p53 as a biomarker.
    International journal of surgery (London, England), 2014, Volume: 12, Issue:8

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Disease-Free Survival; ErbB Receptors; Female; Humans; Letrozole; Nitriles; Pilot Projects; Proto-Oncogene Proteins c-bcl-2; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Tamoxifen; Triazoles; Tumor Suppressor Protein p53

2014
Arthralgia induced by endocrine treatment for breast cancer: A prospective study of serum levels of insulin like growth factor-I, its binding protein and oestrogens.
    European journal of cancer (Oxford, England : 1990), 2014, Volume: 50, Issue:17

    Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Chemotherapy, Adjuvant; Estrogens; Female; Humans; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Letrozole; Middle Aged; Musculoskeletal Pain; Nitriles; Prospective Studies; Tamoxifen; Triazoles

2014
Longitudinal trends in utilization of endocrine therapies for breast cancer: an international comparison.
    Journal of clinical pharmacy and therapeutics, 2015, Volume: 40, Issue:1

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Australia; Breast Neoplasms; Developed Countries; Drug Utilization Review; England; Female; France; Humans; Internationality; Letrozole; Longitudinal Studies; Netherlands; Nitriles; Scandinavian and Nordic Countries; Tamoxifen; Triazoles

2015
Primary Hormonal Therapy for Elderly Breast Cancer Patients: Single Institution Experience.
    Gynecologic and obstetric investigation, 2015, Volume: 80, Issue:1

    Topics: Aged; Aged, 80 and over; Anastrozole; Androstadienes; Antineoplastic Agents, Hormonal; Breast Neoplasms; Estradiol; Female; Fulvestrant; Humans; Letrozole; Nitriles; Receptors, Estrogen; Retrospective Studies; Spain; Tamoxifen; Treatment Outcome; Triazoles

2015
Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance.
    Carcinogenesis, 2015, Volume: 36, Issue:1

    Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Biomarkers, Tumor; BRCA1 Protein; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Flow Cytometry; Gene Expression Profiling; Gene Regulatory Networks; Humans; Immune System Phenomena; Immunoenzyme Techniques; Letrozole; Mammary Neoplasms, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nitriles; Oligonucleotide Array Sequence Analysis; Precancerous Conditions; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tamoxifen; Triazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2015
[Effect of sex inversion in embryos of domestic chicken (Gallu gallus domesticus) by influence of letrozole and tamoxifen].
    Tsitologiia, 2014, Volume: 56, Issue:2

    Topics: Animals; Aromatase Inhibitors; Chick Embryo; Chickens; Chromosome Mapping; Estrogen Antagonists; Estrogen Receptor alpha; Female; Gene Expression; Genetic Loci; Gonadal Dysgenesis; Humans; Letrozole; Male; Nitriles; Ovary; Prophase; Protein Interaction Mapping; Sex Chromosomes; Sex Differentiation; Tamoxifen; Testis; Triazoles

2014
New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane.
    International journal of oncology, 2015, Volume: 46, Issue:4

    Topics: Androstadienes; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Culture Techniques; Cell Proliferation; Drug Resistance, Neoplasm; Estradiol; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; Humans; Letrozole; MCF-7 Cells; Models, Biological; Nitriles; Tamoxifen; Triazoles

2015
Management of Premenopausal Women with Neoadjuvant Endocrine Therapy: A Single-Institution Experience.
    Annals of surgical oncology, 2015, Volume: 22, Issue:12

    Topics: Adult; Anastrozole; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Chemotherapy, Adjuvant; Female; Gonadotropin-Releasing Hormone; Humans; Letrozole; Middle Aged; Neoadjuvant Therapy; Nitriles; Premenopause; Receptors, Estrogen; Response Evaluation Criteria in Solid Tumors; Tamoxifen; Triazoles

2015
Adjuvant treatments of breast cancer increase the risk of depressive disorders: A population-based study.
    Journal of affective disorders, 2015, Aug-15, Volume: 182

    Topics: Adult; Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Depressive Disorder; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Letrozole; Middle Aged; Nitriles; Population Surveillance; Proportional Hazards Models; Retrospective Studies; Risk; Taiwan; Tamoxifen; Trastuzumab; Triazoles

2015
Adjuvant regimens with trastuzumab administered for small HER2-positive breast cancer in routine clinical practice.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2015, Volume: 17, Issue:11

    Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Chemoradiotherapy; Chemotherapy, Adjuvant; Cross-Sectional Studies; Cyclophosphamide; Docetaxel; Doxorubicin; Female; Humans; Letrozole; Middle Aged; Nitriles; Paclitaxel; Receptor, ErbB-2; Tamoxifen; Taxoids; Trastuzumab; Triazoles

2015
Healthcare professionals' preferences for surgery or primary endocrine therapy to treat older women with operable breast cancer.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2015, Volume: 41, Issue:9

    Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents, Hormonal; Attitude of Health Personnel; Breast Neoplasms; Female; Geriatrics; Humans; Letrozole; Mastectomy; Nitriles; Oncology Nursing; Patient Preference; Receptors, Estrogen; Surgeons; Surveys and Questionnaires; Tamoxifen; Triazoles; United Kingdom

2015
Evaluation of response to hormone therapy in patients with measurable adult granulosa cell tumors of the ovary.
    Acta obstetricia et gynecologica Scandinavica, 2015, Volume: 94, Issue:11

    Topics: Adult; Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Chemotherapy, Adjuvant; Disease Progression; Disease-Free Survival; Female; Goserelin; Granulosa Cell Tumor; Humans; Letrozole; Megestrol Acetate; Middle Aged; Nitriles; Ovarian Neoplasms; Ovariectomy; Radiotherapy, Adjuvant; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Salpingectomy; Tamoxifen; Triazoles

2015
Picking the optimal endocrine adjuvant treatment for pre-menopausal women.
    Breast (Edinburgh, Scotland), 2015, Volume: 24 Suppl 2

    Topics: Age Factors; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Goserelin; Humans; Letrozole; Nitriles; Ovary; Premenopause; Tamoxifen; Triazoles

2015
Neoadjuvant endocrine therapy: Patient selection, treatment duration and surrogate endpoints.
    Breast (Edinburgh, Scotland), 2015, Volume: 24 Suppl 2

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Ki-67 Antigen; Letrozole; Neoadjuvant Therapy; Neoplasm Staging; Nitriles; Patient Selection; Prognosis; Tamoxifen; Time Factors; Triazoles

2015
Everolimus in Metastatic Breast Cancer: Clinical Experience as a Late Treatment Line.
    Oncology, 2015, Volume: 89, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Case-Control Studies; Estradiol; Everolimus; Female; Follow-Up Studies; Fulvestrant; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Nitriles; Prognosis; Retrospective Studies; Survival Rate; Tamoxifen; Triazoles

2015
The Effects of Adjuvant Endocrine Treatment on Serum Leptin, Serum Adiponectin and Body Composition in Patients with Breast Cancer: The Izmir Oncology Group (IZOG) Study.
    Chemotherapy, 2016, Volume: 61, Issue:2

    Topics: Adiponectin; Adult; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Body Composition; Body Mass Index; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Follow-Up Studies; Humans; Leptin; Letrozole; Middle Aged; Nitriles; Tamoxifen; Triazoles

2016
Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.
    Nature communications, 2016, Feb-09, Volume: 7

    Topics: AC133 Antigen; Anastrozole; Androstadienes; Animals; Antigens, CD; Antineoplastic Agents, Hormonal; Bone Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Cell Line, Tumor; Cell Self Renewal; Drug Resistance, Neoplasm; Estradiol; Female; Flow Cytometry; Fulvestrant; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; In Vitro Techniques; Interleukin-6; Letrozole; Leuprolide; MCF-7 Cells; Mice, Inbred NOD; Mice, SCID; Neoplasm Metastasis; Neoplasm Transplantation; Neoplastic Stem Cells; Nitriles; Oxidative Phosphorylation; Peptides; Real-Time Polymerase Chain Reaction; Receptor, Notch3; Receptors, Estrogen; Receptors, Notch; Signal Transduction; Tamoxifen; Triazoles

2016
MicroRNA-206, let-7a and microRNA-21 pathways involved in the anti-angiogenesis effects of the interval exercise training and hormone therapy in breast cancer.
    Life sciences, 2016, Apr-15, Volume: 151

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Combined Modality Therapy; Exercise Therapy; Female; Letrozole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; MicroRNAs; Muscle, Skeletal; Neovascularization, Pathologic; Nitriles; Signal Transduction; Tamoxifen; Triazoles

2016
Clinical Features of Male Breast Cancer: Experiences from Seven Institutions Over 20 Years.
    Cancer research and treatment, 2016, Volume: 48, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms, Male; Chemotherapy, Adjuvant; Female; Hormone Replacement Therapy; Humans; Letrozole; Male; Mastectomy; Middle Aged; Neoplasms, Second Primary; Nitriles; Prognosis; Receptor, ErbB-2; Republic of Korea; Tamoxifen; Trastuzumab; Treatment Outcome; Triazoles

2016
Evaluating Markers for Guiding Treatment.
    Journal of the National Cancer Institute, 2016, Volume: 108, Issue:9

    Topics: Age Factors; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Body Mass Index; Breast Neoplasms; Clinical Decision-Making; Decision Support Techniques; Disease-Free Survival; Female; Humans; Ki-67 Antigen; Letrozole; Logistic Models; Lymphatic Metastasis; Nitriles; Predictive Value of Tests; Randomized Controlled Trials as Topic; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles; Tumor Burden

2016
Aromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study.
    Breast (Edinburgh, Scotland), 2016, Volume: 28

    Topics: Anastrozole; Androstadienes; Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Chemotherapy, Adjuvant; Female; Letrozole; Nitriles; Pulmonary Fibrosis; Radiation Injuries, Experimental; Radiotherapy; Rats; Rats, Wistar; Tamoxifen; Triazoles

2016
Circulating oxysterol metabolites as potential new surrogate markers in patients with hormone receptor-positive breast cancer: Results of the OXYTAM study.
    The Journal of steroid biochemistry and molecular biology, 2017, Volume: 169

    Topics: Adult; Aged; Androstadienes; Aromatase; Aromatase Inhibitors; Biomarkers; Body Mass Index; Breast Neoplasms; Cholestanes; Cholesterol; Feasibility Studies; Female; Gas Chromatography-Mass Spectrometry; Hormones; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Oxidative Stress; Oxysterols; Pilot Projects; Prognosis; Prospective Studies; Reproducibility of Results; Signal Transduction; Tamoxifen; Triazoles

2017
The Effect of Undaria pinnatifida Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer.
    Integrative cancer therapies, 2018, Volume: 17, Issue:1

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Female; Herb-Drug Interactions; Humans; Letrozole; Middle Aged; Nitriles; Phytotherapy; Polysaccharides; Tamoxifen; Triazoles; Undaria

2018
Hormonal Maintenance Therapy for Women With Low-Grade Serous Cancer of the Ovary or Peritoneum.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017, Apr-01, Volume: 35, Issue:10

    Topics: Adult; Aged; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Cytoreduction Surgical Procedures; Disease Progression; Disease-Free Survival; Female; Follow-Up Studies; Humans; Letrozole; Leuprolide; Maintenance Chemotherapy; Medroxyprogesterone Acetate; Middle Aged; Neoplasm Grading; Neoplasm Staging; Neoplasms, Cystic, Mucinous, and Serous; Nitriles; Ovarian Neoplasms; Peritoneal Neoplasms; Platinum Compounds; Survival Rate; Tamoxifen; Triazoles; Watchful Waiting; Young Adult

2017
Estimating efficacy in trials with selective crossover.
    Statistics in medicine, 2017, 07-10, Volume: 36, Issue:15

    Topics: Antineoplastic Agents; Binomial Distribution; Biostatistics; Breast Neoplasms; Clinical Trials as Topic; Computer Simulation; Cross-Over Studies; Disease-Free Survival; Female; Humans; Letrozole; Likelihood Functions; Models, Statistical; Nitriles; Proportional Hazards Models; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Triazoles

2017
Melasma treatment: A novel approach using a topical agent that contains an anti-estrogen and a vascular endothelial growth factor inhibitor.
    Medical hypotheses, 2017, Volume: 101

    Topics: Administration, Topical; Anastrozole; Androstadienes; Aromatase Inhibitors; Estrogens; Female; Genetic Predisposition to Disease; Humans; Hyperpigmentation; Letrozole; Male; Melanosis; Neovascularization, Pathologic; Nitriles; Pregnancy; Raloxifene Hydrochloride; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Triazoles; Ultraviolet Rays; Vascular Endothelial Growth Factor A

2017
The prognostic significance of Cdc6 and Cdt1 in breast cancer.
    Scientific reports, 2017, 04-20, Volume: 7, Issue:1

    Topics: Animals; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; DNA Replication; Female; Gene Expression Regulation, Neoplastic; Humans; Letrozole; MCF-7 Cells; Mice; Nitriles; Nuclear Proteins; Prognosis; RAW 264.7 Cells; Receptors, Estrogen; Survival Analysis; Tamoxifen; Triazoles; Up-Regulation

2017
Evaluation of Active Hexose Correlated Compound (AHCC) in Combination With Anticancer Hormones in Orthotopic Breast Cancer Models.
    Integrative cancer therapies, 2017, Volume: 16, Issue:3

    Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Estradiol; Estrogen Antagonists; Female; Humans; Letrozole; MCF-7 Cells; Mice; Nitriles; Polysaccharides; Tamoxifen; Triazoles

2017
Fulvestrant plus LHRH analogues in male with synchronous breast and prostate cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2017, 08-01, Volume: 28, Issue:8

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms, Male; Estradiol; Fulvestrant; Gonadotropin-Releasing Hormone; Humans; Letrozole; Male; Neoplasms, Multiple Primary; Nitriles; Prostatic Neoplasms; Tamoxifen; Triazoles

2017
Avoidance of Negative Results in Adjuvant Endocrine Therapy Trials for Estrogen Receptor-Positive Breast Cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017, 08-10, Volume: 35, Issue:23

    Topics: Anastrozole; Breast Neoplasms; Humans; Letrozole; Negative Results; Postmenopause; Receptors, Estrogen; Tamoxifen

2017
Different patterns in the risk of newly developed fatty liver and lipid changes with tamoxifen versus aromatase inhibitors in postmenopausal women with early breast cancer: A propensity score-matched cohort study.
    European journal of cancer (Oxford, England : 1990), 2017, Volume: 82

    Topics: Adult; Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers; Breast Neoplasms; Chemotherapy, Adjuvant; Fatty Liver; Female; Humans; Incidence; Letrozole; Lipids; Middle Aged; Nitriles; Propensity Score; Retrospective Studies; Tamoxifen; Triazoles

2017
The role of hormonal therapy in patients with relapsed high-grade ovarian carcinoma: a retrospective series of tamoxifen and letrozole.
    BMC cancer, 2017, Jun-30, Volume: 17, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Carcinoma; Female; Humans; Letrozole; Middle Aged; Neoplasm Grading; Neoplasm Staging; Nitriles; Ovarian Neoplasms; Receptors, Estrogen; Recurrence; Retreatment; Retrospective Studies; Tamoxifen; Treatment Outcome; Triazoles; Young Adult

2017
Primary cytoreductive surgery and adjuvant hormonal monotherapy in women with advanced low-grade serous ovarian carcinoma: Reducing overtreatment without compromising survival?
    Gynecologic oncology, 2017, Volume: 147, Issue:1

    Topics: Adult; Aged; Anastrozole; Antineoplastic Agents; Chemotherapy, Adjuvant; Combined Modality Therapy; Cystadenocarcinoma, Serous; Cytoreduction Surgical Procedures; Female; Humans; Letrozole; Medical Overuse; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Ovarian Neoplasms; Retrospective Studies; Survival Analysis; Tamoxifen; Triazoles

2017
The Impact of Perioperative Hormonal Therapy for Breast Cancer on Transverse Rectus Abdominis Myocutaneous Flap Abdominal Complications.
    Annals of plastic surgery, 2018, Volume: 80, Issue:6S Suppl 6

    Topics: Adult; Aged; Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Incisional Hernia; Letrozole; Mammaplasty; Middle Aged; Myocutaneous Flap; Odds Ratio; Rectus Abdominis; Retrospective Studies; Risk Factors; Surgical Wound Infection; Tamoxifen; Treatment Outcome

2018
Adjuvant aromatase inhibition: more options for patients.
    The Lancet. Oncology, 2018, Volume: 19, Issue:4

    Topics: Anastrozole; Androstadienes; Aromatase; Breast Neoplasms; Humans; Letrozole; Tamoxifen

2018
Metastatic cutaneous apocrine carcinoma: a multidisciplinary approach incorporating endocrine therapy.
    European journal of dermatology : EJD, 2018, Jun-01, Volume: 28, Issue:3

    Topics: Antineoplastic Agents, Hormonal; Apocrine Glands; Carcinoma; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Middle Aged; Pleural Neoplasms; Radiotherapy, Adjuvant; Sweat Gland Neoplasms; Tamoxifen

2018
Acute Generalized Exanthematous Pustulosis Induced by Docetaxel and Recurrent With Letrozole: A Case Report.
    Clinical breast cancer, 2018, Volume: 18, Issue:5

    Topics: Acute Generalized Exanthematous Pustulosis; Adrenal Cortex Hormones; Antineoplastic Agents; Breast Neoplasms; Combined Modality Therapy; Docetaxel; Female; Humans; Letrozole; Middle Aged; Tamoxifen; Treatment Outcome

2018
Economic Evaluation of Letrozole for Early Breast Cancer in a Health Resource-Limited Setting.
    BioMed research international, 2018, Volume: 2018

    Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; China; Cost-Benefit Analysis; Female; Health Resources; Humans; Letrozole; Neoplasm Recurrence, Local; Postmenopause; Quality-Adjusted Life Years; Tamoxifen

2018
Clinical outcomes comparison of 10 years versus 5 years of adjuvant endocrine therapy in patients with early breast cancer.
    BMC cancer, 2018, Oct-12, Volume: 18, Issue:1

    Topics: Age of Onset; Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Letrozole; Postmenopause; Prospective Studies; Tamoxifen; Treatment Outcome

2018
Endocrine treatment of high grade serous ovarian carcinoma; quantification of efficacy and identification of response predictors.
    Gynecologic oncology, 2019, Volume: 152, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; CA-125 Antigen; Cystadenocarcinoma, Serous; Female; Humans; Letrozole; Megestrol Acetate; Membrane Proteins; Middle Aged; Neoplasm Grading; Ovarian Neoplasms; Predictive Value of Tests; Receptors, Estrogen; Retrospective Studies; Tamoxifen

2019
Competing risks of extended adjuvant aromatase inhibitors.
    The Lancet. Oncology, 2019, Volume: 20, Issue:1

    Topics: Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Double-Blind Method; Humans; Letrozole; Postmenopause; Tamoxifen

2019
Pattern of endocrine treatment for epithelial ovarian cancer in the Southeast medical region of Sweden: a population-based study.
    Acta oncologica (Stockholm, Sweden), 2019, Volume: 58, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Carcinoma, Ovarian Epithelial; Cohort Studies; Estrogen Antagonists; Fallopian Tube Neoplasms; Female; Humans; Letrozole; Middle Aged; Ovarian Neoplasms; Peritoneal Neoplasms; Sweden; Tamoxifen; Treatment Outcome

2019
Exemestane may be less detrimental than letrozole to bone health in women homozygous for the UGT2B17*2 gene deletion.
    Breast cancer research and treatment, 2019, Volume: 175, Issue:2

    Topics: Androstadienes; Aromatase Inhibitors; Bone and Bones; Bone Density; Bone Remodeling; Breast Neoplasms; Female; Gene Deletion; Genetic Association Studies; Genotype; Glucuronosyltransferase; Humans; Letrozole; Middle Aged; Minor Histocompatibility Antigens; Pharmacogenetics; Postmenopause; Tamoxifen

2019
Disparate Effect of Aromatization on the Central Regulation of GH Secretion by Estrogens in Men and Postmenopausal Women.
    The Journal of clinical endocrinology and metabolism, 2019, 07-01, Volume: 104, Issue:7

    Topics: Aromatase Inhibitors; Cross-Over Studies; Estradiol; Estrogen Antagonists; Female; Human Growth Hormone; Humans; Letrozole; Male; Middle Aged; Pituitary Gland; Postmenopause; Tamoxifen

2019
Comparison of Time-Dependent Contralateral Breast Cancer Incidence Requires Comparable Lengths of Follow-Up.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019, 06-10, Volume: 37, Issue:17

    Topics: Breast Neoplasms; Female; Follow-Up Studies; Humans; Incidence; Letrozole; Neoplasms, Second Primary; Postmenopause; Tamoxifen

2019
Reply to K.-D. Yu et al.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019, 06-10, Volume: 37, Issue:17

    Topics: Breast Neoplasms; Female; Follow-Up Studies; Humans; Letrozole; Postmenopause; Tamoxifen

2019
A new immunotherapy schedule in addition to first-line hormone therapy for metastatic breast cancer patients in a state of clinical benefit during hormone therapy.
    Journal of molecular medicine (Berlin, Germany), 2020, Volume: 98, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Case-Control Studies; Female; Humans; Immunotherapy; Letrozole; Male; Middle Aged; Receptor, ErbB-2; Retrospective Studies; Selective Estrogen Receptor Modulators; Survival Analysis; Tamoxifen; Toremifene

2020
Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer.
    Breast cancer research : BCR, 2020, 05-19, Volume: 22, Issue:1

    Topics: Animals; Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Female; Humans; Letrozole; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Receptors, Estrogen; Tamoxifen; Xenograft Model Antitumor Assays

2020
Overestimation of Late Distant Recurrences in High-Risk Patients With ER-Positive Breast Cancer: Validity and Accuracy of the CTS5 Risk Score in the TEAM and IDEAL Trials.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2020, 10-01, Volume: 38, Issue:28

    Topics: Aged; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Cohort Studies; Female; Humans; Letrozole; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Proportional Hazards Models; Randomized Controlled Trials as Topic; Receptors, Estrogen; Reproducibility of Results; Risk Assessment; Tamoxifen

2020
Plasma thymidine kinase 1 activity and outcome of ER+ HER2- metastatic breast cancer patients treated with palbociclib and endocrine therapy.
    Breast cancer research : BCR, 2020, 09-14, Volume: 22, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Estrogen Receptor alpha; Female; Fulvestrant; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Piperazines; Prognosis; Prospective Studies; Pyridines; Receptor, ErbB-2; Survival Rate; Tamoxifen; Thymidine Kinase

2020
Clinical behavior of recurrent hormone receptor-positive breast cancer by adjuvant endocrine therapy within the Breast International Group 1-98 clinical trial.
    Cancer, 2021, 03-01, Volume: 127, Issue:5

    Topics: Adult; Aged; Breast Neoplasms; Estrogen Receptor alpha; Female; Humans; Letrozole; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local; Proportional Hazards Models; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen

2021
Effects of letrozole or tamoxifen coadministered with a standard stimulation protocol on fertility preservation among breast cancer patients.
    Journal of assisted reproduction and genetics, 2021, Volume: 38, Issue:3

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Fertility Preservation; Humans; Infertility, Female; Letrozole; Oocytes; Ovulation Induction; Retrospective Studies; Tamoxifen; Young Adult

2021
Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment.
    European journal of medicinal chemistry, 2022, Feb-05, Volume: 229

    Topics: Anastrozole; Antineoplastic Agents; Apoptosis; Biological Products; Breast Neoplasms; Cell Proliferation; Down-Regulation; Estrogen Receptor alpha; Humans; Letrozole; MCF-7 Cells; Molecular Docking Simulation; Protein Binding; Proteolysis; Raloxifene Hydrochloride; Reactive Oxygen Species; Sesterterpenes; Signal Transduction; Structure-Activity Relationship; Tamoxifen

2022
Health-related quality of life among elderly breast cancer patients treated with adjuvant endocrine therapy: a U.S Medicare population-based study.
    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2022, Volume: 31, Issue:5

    Topics: Aged; Anastrozole; Breast Neoplasms; Chemotherapy, Adjuvant; Cross-Sectional Studies; Female; Humans; Letrozole; Male; Medicare; Quality of Life; Retrospective Studies; Tamoxifen; United States

2022
Efficacy, Safety, and Prognosis of Sequential Therapy with Tamoxifen and Letrozole versus Letrozole Monotherapy for Breast Carcinoma.
    Computational and mathematical methods in medicine, 2022, Volume: 2022

    Topics: Breast Neoplasms; Cholesterol, HDL; Female; Humans; Letrozole; Postmenopause; Prognosis; Retrospective Studies; Tamoxifen

2022
    Current computer-aided drug design, 2022, Volume: 18, Issue:3

    Topics: Anastrozole; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Carica; Catechin; Chlorogenic Acid; Cyclophosphamide; Estrogen Receptor Modulators; Estrogens; Female; Humans; Letrozole; Ligands; Molecular Docking Simulation; Paclitaxel; Quercetin; Tamoxifen; Trastuzumab

2022
Evaluation of the Sensitivity of Breast Cancer Cell Lines to Cardiac Glycosides Unveils ATP1B3 as a Possible Biomarker for the Personalized Treatment of ERα Expressing Breast Cancers.
    International journal of molecular sciences, 2022, Sep-21, Volume: 23, Issue:19

    Topics: Adenosine Triphosphatases; Anastrozole; Aromatase Inhibitors; Biomarkers; Breast Neoplasms; Cardiac Glycosides; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Estradiol; Estrogen Receptor alpha; Female; Fulvestrant; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Letrozole; MCF-7 Cells; Ouabain; Precision Medicine; Sodium-Potassium-Exchanging ATPase; Tamoxifen

2022
Esr1 but Not CYP19A1 Overexpression in Mammary Epithelial Cells during Reproductive Senescence Induces Pregnancy-Like Proliferative Mammary Disease Responsive to Anti-Hormonals.
    The American journal of pathology, 2023, Volume: 193, Issue:1

    Topics: Animals; Aromatase; Epithelial Cells; Estrogen Receptor alpha; Estrogens; Female; Gene Expression; Letrozole; Mammary Glands, Animal; Mice; Pregnancy; Tamoxifen

2023
Adherence to Adjuvant Endocrine Therapy and Survival Among Older Women with Early-Stage Hormone Receptor-Positive Breast Cancer.
    Clinical drug investigation, 2023, Volume: 43, Issue:3

    Topics: Aged; Anastrozole; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Letrozole; Medicare; Nitriles; Tamoxifen; United States

2023
Unchartered waters: Significance of fall in Ki67 index after short-term preoperative endocrine therapy in early breast cancers.
    Breast disease, 2023, Volume: 42, Issue:1

    Topics: Breast Neoplasms; Estrogens; Female; Humans; Ki-67 Antigen; Letrozole; Tamoxifen

2023
Breast cancer cell growth arrest and chemopreventive effects of Passiflora edulis Sims (Passifloraceae) ethanolic leaves extract on a rat model of mammary carcinoma.
    Journal of ethnopharmacology, 2023, Jul-15, Volume: 311

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma; Ethanol; Letrozole; Passiflora; Passifloraceae; Plant Extracts; Rats; Rats, Wistar; Tamoxifen

2023
Projected Savings for Generic Oncology Drugs Purchased via Mark Cuban Cost Plus Drug Company Versus in Medicare.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2023, 10-10, Volume: 41, Issue:29

    Topics: Aged; Anastrozole; Cost Savings; Drug Costs; Drugs, Generic; Humans; Imatinib Mesylate; Letrozole; Medicare Part D; Prescription Drugs; Tamoxifen; United States

2023
Are we there yet? Optimal duration of endocrine therapy in women with postmenopausal early-stage hormone receptor-positive breast cancer.
    Journal of the National Cancer Institute, 2023, Nov-08, Volume: 115, Issue:11

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Female; Humans; Letrozole; Postmenopause; Tamoxifen

2023