Compounds > lestaurtinib
Page last updated: 2024-09-03

lestaurtinib and staurosporine

lestaurtinib has been researched along with staurosporine in 28 studies

Compound Research Comparison

Studies
(lestaurtinib)		Trials
(lestaurtinib)		Recent Studies (post-2010)
(lestaurtinib)		Studies
(staurosporine)		Trials
(staurosporine)		Recent Studies (post-2010) (staurosporine)
12412634160286
12412636,27258976

Protein Interaction Comparison

ProteinTaxonomylestaurtinib (IC50)staurosporine (IC50)
Chain A, Glycogen Synthase Kinase-3 BetaHomo sapiens (human)0.015
Chain B, Glycogen Synthase Kinase-3 BetaHomo sapiens (human)0.015
Chain A, Glycogen Synthase Kinase-3 BetaHomo sapiens (human)0.015
Chain A, Tyrosine-protein kinase ZAP-70Homo sapiens (human)0.0558
Chain A, Tyrosine-protein kinase SYKHomo sapiens (human)0.012
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1Homo sapiens (human)0.01
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1Homo sapiens (human)0.01
Chain X, Proto-oncogene tyrosine-protein kinase FynHomo sapiens (human)0.0048
Chain A, Serine/threonine-protein kinase TAO2Rattus norvegicus (Norway rat)3
epidermal growth factor receptor isoform a precursorHomo sapiens (human)0.4467
Serine/threonine-protein kinase Sgk1Homo sapiens (human)0.01
Cell division cycle 7-related protein kinaseHomo sapiens (human)0.0549
Serine/threonine-protein kinase PLK4Homo sapiens (human)0.0083
Serine/threonine-protein kinase 25Homo sapiens (human)0.0029
Citron Rho-interacting kinaseHomo sapiens (human)0.749
Dual specificity mitogen-activated protein kinase kinase 7Homo sapiens (human)0.9255
Telomerase reverse transcriptaseHomo sapiens (human)6.9517
Serine/threonine-protein kinase Chk1Homo sapiens (human)0.1772
Inhibitor of nuclear factor kappa-B kinase subunit betaHomo sapiens (human)0.5561
Aurora kinase AHomo sapiens (human)0.0087
Cyclin-G-associated kinaseHomo sapiens (human)0.011
Serine/threonine-protein kinase DCLK1Homo sapiens (human)0.267
Inhibitor of nuclear factor kappa-B kinase subunit alphaHomo sapiens (human)0.1265
Muscle, skeletal receptor tyrosine-protein kinaseHomo sapiens (human)0.1161
Mitogen-activated protein kinase 13Homo sapiens (human)0.4137
3-phosphoinositide-dependent protein kinase 1Homo sapiens (human)0.0072
Death-associated protein kinase 3Homo sapiens (human)0.0026
Mitogen-activated protein kinase kinase kinase 7Homo sapiens (human)0.0565
Receptor-interacting serine/threonine-protein kinase 2Homo sapiens (human)0.356
Dual specificity tyrosine-phosphorylation-regulated kinase 3Homo sapiens (human)0.0231
NUAK family SNF1-like kinase 1Homo sapiens (human)0.003
Cyclin-T1Homo sapiens (human)0.0118
Cyclin-T2Homo sapiens (human)0.0038
Tyrosine-protein kinase JAK2Homo sapiens (human)0.0016
Rho-associated protein kinase 2Homo sapiens (human)0.0045
Serine/threonine-protein kinase ULK1Homo sapiens (human)0.0096
Serine/threonine-protein kinase/endoribonuclease IRE1Homo sapiens (human)0.1246
Ribosomal protein S6 kinase alpha-5Homo sapiens (human)0.0011
Ribosomal protein S6 kinase alpha-4Homo sapiens (human)0.0071
Serine/threonine-protein kinase 16Homo sapiens (human)0.2385
Cyclin-KHomo sapiens (human)0.0948
Serine/threonine-protein kinase PAK 3Homo sapiens (human)0.0003
Serine/threonine-protein kinase 17BHomo sapiens (human)0.0258
Serine/threonine-protein kinase 10Homo sapiens (human)0.008
Serine/threonine-protein kinase D3Homo sapiens (human)0.1446
Cyclin-dependent kinase 14Homo sapiens (human)0.1145
G2/mitotic-specific cyclin-B2Homo sapiens (human)0.0107
Mitogen-activated protein kinase kinase kinase 6Homo sapiens (human)0.2829
Mitogen-activated protein kinase kinase kinase kinase 4Homo sapiens (human)0.0005
Serine/threonine-protein kinase LATS1Homo sapiens (human)0.013
Serine/threonine-protein kinase PAK 4Homo sapiens (human)0.0132
Serine/threonine-protein kinase Chk2Homo sapiens (human)0.0212
G1/S-specific cyclin-E2Homo sapiens (human)0.011
cAMP-dependent protein kinase catalytic subunit alphaBos taurus (cattle)0.0812
Tyrosine-protein kinase ABL1Homo sapiens (human)0.1233
Proto-oncogene tyrosine-protein kinase SrcGallus gallus (chicken)0.0063
Epidermal growth factor receptorHomo sapiens (human)0.083
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)0.1281
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)0.0713
High affinity nerve growth factor receptorHomo sapiens (human)0.2403
Protein kinase C gamma typeHomo sapiens (human)0.1167
Platelet-derived growth factor receptor betaMus musculus (house mouse)0.002
Protein kinase C alpha typeRattus norvegicus (Norway rat)0.2327
Protein kinase C beta typeHomo sapiens (human)0.0684
Prostaglandin G/H synthase 1Ovis aries (sheep)0.056
Insulin receptorHomo sapiens (human)0.0706
Tyrosine-protein kinase LckHomo sapiens (human)0.1784
Tyrosine-protein kinase FynHomo sapiens (human)0.0929
Retinoblastoma-associated protein Homo sapiens (human)0.066
Cyclin-dependent kinase 1Homo sapiens (human)0.0075
Tyrosine-protein kinase Fes/FpsHomo sapiens (human)0.0039
Macrophage colony-stimulating factor 1 receptorHomo sapiens (human)0.1269
Tyrosine-protein kinase YesHomo sapiens (human)0.0029
Tyrosine-protein kinase LynHomo sapiens (human)0.0012
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)0.0021
Insulin-like growth factor 1 receptorHomo sapiens (human)0.5534
Hepatocyte growth factor receptorHomo sapiens (human)0.1917
Tyrosine-protein kinase HCKHomo sapiens (human)0.0025
Proto-oncogene tyrosine-protein kinase ROSHomo sapiens (human)0.0004
Protein kinase C delta typeRattus norvegicus (Norway rat)0.274
Protein kinase C epsilon typeRattus norvegicus (Norway rat)0.274
Protein kinase C zeta typeRattus norvegicus (Norway rat)0.274
Platelet-derived growth factor receptor betaHomo sapiens (human)0.3707
Tyrosine-protein kinase FgrHomo sapiens (human)0.0009
Cytochrome P450 2D6Homo sapiens (human)0.0002
Mast/stem cell growth factor receptor KitHomo sapiens (human)0.0412
Breakpoint cluster region proteinHomo sapiens (human)0.0945
Calcium/calmodulin-dependent protein kinase type II subunit alphaRattus norvegicus (Norway rat)0.059
Serine/threonine-protein kinase pim-1Homo sapiens (human)0.0216
Fibroblast growth factor receptor 1Homo sapiens (human)0.0699
Cyclin-dependent kinase 1 Mus musculus (house mouse)0.008
Cyclin-dependent kinase 4Homo sapiens (human)0.0429
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.3642
Acyl-CoA desaturase 1Mus musculus (house mouse)3.4
Insulin receptor-related proteinHomo sapiens (human)0.0113
G2/mitotic-specific cyclin-B1Homo sapiens (human)0.0088
Dipeptidyl peptidase 4Rattus norvegicus (Norway rat)0.003
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)4
Serine/threonine-protein kinase B-rafHomo sapiens (human)0.0107
Insulin receptorMus musculus (house mouse)0.2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoformHomo sapiens (human)0.0004
Platelet-derived growth factor receptor alphaHomo sapiens (human)0.0007
Tyrosine-protein kinase FerHomo sapiens (human)0.0008
Protein kinase C alpha typeHomo sapiens (human)0.0655
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)0.0115
Vascular endothelial growth factor receptor 1 Homo sapiens (human)0.0149
Cytochrome P450 11B2, mitochondrialHomo sapiens (human)0.011
Interferon-induced, double-stranded RNA-activated protein kinaseHomo sapiens (human)0.1
Amine oxidase [flavin-containing] BRattus norvegicus (Norway rat)0.0025
Casein kinase II subunit alpha'Homo sapiens (human)2.0215
Cyclin-A2Homo sapiens (human)0.009
Cannabinoid receptor 1Rattus norvegicus (Norway rat)0.01
Serine/threonine-protein kinase MAKHomo sapiens (human)0.0257
Ephrin type-A receptor 1Homo sapiens (human)0.0947
Fibroblast growth factor receptor 2Homo sapiens (human)0.0504
Receptor tyrosine-protein kinase erbB-3Homo sapiens (human)0.0106
Fibroblast growth factor receptor 4Homo sapiens (human)0.17
Fibroblast growth factor receptor 3Homo sapiens (human)0.0554
cAMP-dependent protein kinase catalytic subunit gammaHomo sapiens (human)0.0137
Cyclin-OHomo sapiens (human)0.0015
cAMP-dependent protein kinase catalytic subunit betaHomo sapiens (human)0.0148
Ribosomal protein S6 kinase beta-1Homo sapiens (human)0.0007
Tyrosine-protein kinase JAK1Homo sapiens (human)0.004
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)0.028
G1/S-specific cyclin-D1Homo sapiens (human)0.0355
Protein kinase C eta typeHomo sapiens (human)0.1165
Cyclin-CHomo sapiens (human)0.0105
G1/S-specific cyclin-E1Homo sapiens (human)0.0108
Cyclin-dependent kinase 2Homo sapiens (human)0.0073
Beta-adrenergic receptor kinase 1Homo sapiens (human)1.1595
Platelet-derived growth factor receptor alpha Mus musculus (house mouse)0.002
Mitogen-activated protein kinase 3 Homo sapiens (human)4.6724
MAP/microtubule affinity-regulating kinase 3Homo sapiens (human)0.0004
cAMP-dependent protein kinase catalytic subunit alpha Rattus norvegicus (Norway rat)0.055
Mitogen-activated protein kinase 1Homo sapiens (human)2.6853
Ephrin type-A receptor 2Homo sapiens (human)0.1257
Ephrin type-A receptor 3Homo sapiens (human)0.0347
Ephrin type-A receptor 8Homo sapiens (human)0.1061
Ephrin type-B receptor 2Homo sapiens (human)0.1191
Leukocyte tyrosine kinase receptorHomo sapiens (human)0.0173
Non-receptor tyrosine-protein kinase TYK2Homo sapiens (human)0.0137
G1/S-specific cyclin-D3Homo sapiens (human)0.055
Tyrosine-protein kinase receptor UFOHomo sapiens (human)0.0131
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)0.1848
RAC-beta serine/threonine-protein kinaseHomo sapiens (human)0.4119
G protein-coupled receptor kinase 4Homo sapiens (human)0.0914
Kinesin-1 heavy chainHomo sapiens (human)0.0015
G protein-coupled receptor kinase 5Homo sapiens (human)0.0489
Hexokinase-4Homo sapiens (human)0.0006
Beta-adrenergic receptor kinase 2Homo sapiens (human)0.856
Vascular endothelial growth factor receptor 3Homo sapiens (human)0.0146
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.1791
Dual specificity mitogen-activated protein kinase kinase 2Homo sapiens (human)0.026
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.0014
Bone morphogenetic protein receptor type-1AHomo sapiens (human)4.288
Activin receptor type-1BHomo sapiens (human)9.118
TGF-beta receptor type-1Homo sapiens (human)2.2823
Serine/threonine-protein kinase receptor R3Homo sapiens (human)0.85
Tyrosine-protein kinase CSKHomo sapiens (human)0.2071
Protein kinase C iota typeHomo sapiens (human)0.1739
Megakaryocyte-associated tyrosine-protein kinaseHomo sapiens (human)0.442
Tyrosine-protein kinase TecHomo sapiens (human)0.0338
Tyrosine-protein kinase TXKHomo sapiens (human)0.0203
Tyrosine-protein kinase ABL2Homo sapiens (human)0.0505
Tyrosine-protein kinase FRKHomo sapiens (human)0.0108
G protein-coupled receptor kinase 6Homo sapiens (human)0.0473
Tyrosine-protein kinase ZAP-70Homo sapiens (human)0.0175
Tyrosine-protein kinase SYKHomo sapiens (human)0.0057
Mitogen-activated protein kinase 8Homo sapiens (human)1.1067
Mitogen-activated protein kinase 9Homo sapiens (human)2.0555
Dual specificity mitogen-activated protein kinase kinase 4Homo sapiens (human)0.863
Phosphorylase b kinase regulatory subunit alpha, liver isoformHomo sapiens (human)0.0005
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoformHomo sapiens (human)0.0005
Dual specificity mitogen-activated protein kinase kinase 3Homo sapiens (human)0.0099
Casein kinase I isoform alphaHomo sapiens (human)3.412
Casein kinase I isoform deltaHomo sapiens (human)1.4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)9
MAP kinase-activated protein kinase 2Homo sapiens (human)0.735
Cyclin-dependent kinase 8Homo sapiens (human)0.0105
Casein kinase I isoform epsilonHomo sapiens (human)1.4
Dual specificity protein kinase CLK1Homo sapiens (human)0.0108
Dual specificity protein kinase CLK2Homo sapiens (human)0.6508
Dual specificity protein kinase CLK3Homo sapiens (human)0.92
Glycogen synthase kinase-3 alphaHomo sapiens (human)0.0103
Glycogen synthase kinase-3 betaHomo sapiens (human)0.0435
D(1A) dopamine receptorSus scrofa (pig)0.001
Cyclin-dependent kinase 7Homo sapiens (human)0.2793
Cyclin-dependent kinase 9Homo sapiens (human)0.0474
Tyrosine-protein kinase BlkHomo sapiens (human)0.0011
Interleukin-1 receptor-associated kinase 1Homo sapiens (human)0.0377
Ribosomal protein S6 kinase alpha-3Homo sapiens (human)0.0002
Cytoplasmic tyrosine-protein kinase BMXHomo sapiens (human)0.0046
cAMP-dependent protein kinase catalytic subunit PRKXHomo sapiens (human)0.0014
Cyclin-HHomo sapiens (human)0.2793
CDK-activating kinase assembly factor MAT1Homo sapiens (human)0.1216
Serine/threonine-protein kinase Nek2Homo sapiens (human)1.7683
Serine/threonine-protein kinase Nek4Homo sapiens (human)0.0851
Tyrosine-protein kinase JAK3Homo sapiens (human)0.0084
Dual specificity mitogen-activated protein kinase kinase 6Homo sapiens (human)0.0036
Serine/threonine-protein kinase PLK1Homo sapiens (human)0.4397
Death-associated protein kinase 1Homo sapiens (human)0.0101
LIM domain kinase 1Homo sapiens (human)0.0026
LIM domain kinase 2Homo sapiens (human)0.0956
Mitogen-activated protein kinase 12Homo sapiens (human)0.4512
Mitogen-activated protein kinase 10Homo sapiens (human)0.0731
5'-AMP-activated protein kinase subunit gamma-1Homo sapiens (human)1.1354
Ephrin type-B receptor 3Homo sapiens (human)1.2855
Ephrin type-A receptor 5Homo sapiens (human)0.0159
Ephrin type-B receptor 4Homo sapiens (human)0.1869
Ephrin type-B receptor 1Homo sapiens (human)0.0694
Ephrin type-A receptor 4Homo sapiens (human)0.0105
Serine/threonine-protein kinase SIK1Homo sapiens (human)0.0009
Calcium-dependent protein kinase 1Plasmodium falciparum K10.24
Protein kinase C gamma typeRattus norvegicus (Norway rat)0.2168
Casein kinase II subunit betaHomo sapiens (human)3.4
Casein kinase II subunit alphaHomo sapiens (human)3.4723
Protein kinase C beta typeRattus norvegicus (Norway rat)0.2029
SRSF protein kinase 2Homo sapiens (human)0.206
Casein kinase I isoform gamma-2Homo sapiens (human)1.9467
Cyclin-A1Homo sapiens (human)0.0013
Mitogen-activated protein kinase kinase kinase 9Homo sapiens (human)0.0044
MO15-related protein kinase Pfmrk Plasmodium falciparum (malaria parasite P. falciparum)4
Cyclin-dependent kinase 3Homo sapiens (human)0.0118
Cyclin-dependent kinase 6Homo sapiens (human)0.0395
Cyclin-dependent-like kinase 5 Homo sapiens (human)0.0141
Cyclin-dependent kinase 16Homo sapiens (human)0.0206
Cyclin-dependent kinase 17Homo sapiens (human)0.0135
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)0.048
Protein kinase C epsilon typeHomo sapiens (human)0.0767
Dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)0.2314
Angiopoietin-1 receptorHomo sapiens (human)0.0823
Mitogen-activated protein kinase kinase kinase 10Homo sapiens (human)0.1952
Protein kinase C theta typeHomo sapiens (human)0.1168
Activin receptor type-1Homo sapiens (human)1.1354
Macrophage-stimulating protein receptorHomo sapiens (human)0.2195
Focal adhesion kinase 1Homo sapiens (human)0.078
Protein kinase C zeta typeHomo sapiens (human)0.1722
Protein kinase C delta typeHomo sapiens (human)0.1283
Tyrosine-protein kinase BTKHomo sapiens (human)0.0288
Aldehyde oxidaseHomo sapiens (human)0.0023
Tyrosine-protein kinase receptor TYRO3Homo sapiens (human)0.0177
Cyclin-dependent kinase 18Homo sapiens (human)0.0587
Activated CDC42 kinase 1Homo sapiens (human)0.0299
Epithelial discoidin domain-containing receptor 1Homo sapiens (human)0.9655
Tyrosine-protein kinase ITK/TSKHomo sapiens (human)0.0068
Myotonin-protein kinaseHomo sapiens (human)0.1735
Mitogen-activated protein kinase kinase kinase 12Homo sapiens (human)0.0992
Tyrosine-protein kinase MerHomo sapiens (human)0.0331
Serine/threonine-protein kinase 4Homo sapiens (human)0.0013
Serine/threonine-protein kinase PAK 1Homo sapiens (human)0.0004
Dual specificity mitogen-activated protein kinase kinase 5Homo sapiens (human)0.0252
Mitogen-activated protein kinase 7Homo sapiens (human)4.0032
Serine/threonine-protein kinase PAK 2Homo sapiens (human)0.0021
Serine/threonine-protein kinase 3Homo sapiens (human)0.0034
Mitogen-activated protein kinase kinase kinase 1Homo sapiens (human)0.438
cGMP-dependent protein kinase 2Homo sapiens (human)0.0161
Rho-associated protein kinase 1Homo sapiens (human)0.0038
Non-receptor tyrosine-protein kinase TNK1Homo sapiens (human)0.0012
Calcium/calmodulin-dependent protein kinase type II subunit betaHomo sapiens (human)0.0018
Calcium/calmodulin-dependent protein kinase type II subunit gammaHomo sapiens (human)0.0026
Calcium/calmodulin-dependent protein kinase type II subunit deltaHomo sapiens (human)0.0024
Dual specificity tyrosine-phosphorylation-regulated kinase 1AHomo sapiens (human)0.0095
Bone morphogenetic protein receptor type-2Homo sapiens (human)1.94
Protein-tyrosine kinase 6Homo sapiens (human)0.484
cGMP-dependent protein kinase 1 Homo sapiens (human)0.0027
Cyclin-dependent kinase 13Homo sapiens (human)0.057
Calcium/calmodulin-dependent protein kinase type 1Homo sapiens (human)0.0032
Inhibitor of nuclear factor kappa-B kinase subunit epsilonHomo sapiens (human)0.0003
Protein-tyrosine kinase 2-betaHomo sapiens (human)0.0095
Maternal embryonic leucine zipper kinaseHomo sapiens (human)0.0006
Lysine--tRNA ligaseHomo sapiens (human)0.0049
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)0.0141
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrialHomo sapiens (human)0.0005
Serine/threonine-protein kinase D1Homo sapiens (human)0.1448
Serine/threonine-protein kinase 38Homo sapiens (human)0.0037
Receptor tyrosine-protein kinase erbB-4Homo sapiens (human)0.183
Ribosomal protein S6 kinase alpha-2Homo sapiens (human)0.0002
Ephrin type-A receptor 7Homo sapiens (human)0.0477
Ribosomal protein S6 kinase alpha-1Homo sapiens (human)0.0004
Dual specificity testis-specific protein kinase 1Homo sapiens (human)0.1995
Myosin light chain kinase, smooth muscleHomo sapiens (human)0.0448
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Homo sapiens (human)0.037
Mitogen-activated protein kinase 11Homo sapiens (human)1
Serine/threonine-protein kinase STK11Homo sapiens (human)0.0598
Rhodopsin kinase GRK1Homo sapiens (human)0.068
Coiled-coil domain-containing protein 6Homo sapiens (human)0.0022
NT-3 growth factor receptorHomo sapiens (human)0.0002
Serine/threonine-protein kinase N1Homo sapiens (human)0.0025
Serine/threonine-protein kinase N2Homo sapiens (human)0.0055
Mitogen-activated protein kinase 14Homo sapiens (human)0.5052
Calcium/calmodulin-dependent protein kinase type IVHomo sapiens (human)0.1475
Mitogen-activated protein kinase kinase kinase 11Homo sapiens (human)0.016
BDNF/NT-3 growth factors receptorHomo sapiens (human)0.0004
MAP kinase-activated protein kinase 3Homo sapiens (human)2.775
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoformHomo sapiens (human)0.0017
Discoidin domain-containing receptor 2Homo sapiens (human)0.0008
Thioredoxin reductase 1, cytoplasmicHomo sapiens (human)0.0432
Rho-associated protein kinase 2Bos taurus (cattle)0.0417
Myosin light chain kinase 3Homo sapiens (human)0.1585
Serine/threonine-protein kinase SBK1Homo sapiens (human)0.1464
Mitogen-activated protein kinase kinase kinase 19Homo sapiens (human)0.0087
Leucine-rich repeat serine/threonine-protein kinase 2Homo sapiens (human)0.0077
Mitogen-activated protein kinase kinase kinase 21Homo sapiens (human)1.1175
Serine/threonine-protein kinase MRCK alphaHomo sapiens (human)0.0032
Sigma non-opioid intracellular receptor 1Cavia porcellus (domestic guinea pig)0.0067
Testis-specific serine/threonine-protein kinase 1Mus musculus (house mouse)0.0003
Dual specificity tyrosine-phosphorylation-regulated kinase 1ARattus norvegicus (Norway rat)0.012
Protein kinase C eta typeRattus norvegicus (Norway rat)0.274
Serine/threonine-protein kinase MRCK gammaHomo sapiens (human)0.0005
Calcium/calmodulin-dependent protein kinase type 1BHomo sapiens (human)0.0044
Serine/threonine-protein kinase Nek5Homo sapiens (human)0.0864
Serine/threonine-protein kinase N3Homo sapiens (human)0.0105
Serine/threonine-protein kinase ULK3Homo sapiens (human)0.0027
Kinase suppressor of Ras 2Homo sapiens (human)5.4
Dual serine/threonine and tyrosine protein kinaseHomo sapiens (human)0.0552
Serine/threonine-protein kinase/endoribonuclease IRE2Homo sapiens (human)0.0416
Serine/threonine-protein kinase MARK2Homo sapiens (human)0.0001
Serine/threonine-protein kinase TAO1Homo sapiens (human)0.0008
Serine/threonine-protein kinase Nek8Homo sapiens (human)0.0263
Serine/threonine-protein kinase tousled-like 2Homo sapiens (human)0.0035
Serine/threonine-protein kinase 32CHomo sapiens (human)0.232
Serine/threonine-protein kinase pim-3Homo sapiens (human)0.0001
Myosin light chain kinase family member 4Homo sapiens (human)0.0537
Homeodomain-interacting protein kinase 1Homo sapiens (human)2.639
Calcium/calmodulin-dependent protein kinase type 1DHomo sapiens (human)0.0003
Mitogen-activated protein kinase kinase kinase kinase 3Homo sapiens (human)0.0001
Kinase suppressor of Ras 1Homo sapiens (human)6.265
Cyclin-dependent kinase-like 3Homo sapiens (human)1.1
MAP kinase-activated protein kinase 5Homo sapiens (human)0.212
Serine/threonine-protein kinase BRSK2Homo sapiens (human)0.0028
Serine/threonine-protein kinase NIM1Homo sapiens (human)0.1102
Serine/threonine-protein kinase ULK2Homo sapiens (human)0.0032
Misshapen-like kinase 1Homo sapiens (human)0.0004
Serine/threonine-protein kinase DCLK2Homo sapiens (human)0.089
Calcium/calmodulin-dependent protein kinase kinase 1Homo sapiens (human)0.0359
Casein kinase I isoform alpha-likeHomo sapiens (human)1.84
Cyclin-YHomo sapiens (human)0.0518
Homeodomain-interacting protein kinase 4Homo sapiens (human)0.226
Myosin-IIIaHomo sapiens (human)0.0425
Serine/threonine-protein kinase Nek11Homo sapiens (human)0.521
Protein odd-skipped-related 1Homo sapiens (human)0.0402
Mitogen-activated protein kinase 15Homo sapiens (human)0.0081
Serine/threonine-protein kinase Nek9Homo sapiens (human)0.101
Serine/threonine-protein kinase BRSK1Homo sapiens (human)0.0007
Serine/threonine-protein kinase haspinHomo sapiens (human)0.0422
Rhodopsin kinase GRK7Homo sapiens (human)0.0053
G2/mitotic-specific cyclin-B3Homo sapiens (human)0.0107
Myosin-IIIbHomo sapiens (human)0.0058
Dual specificity tyrosine-phosphorylation-regulated kinase 2Homo sapiens (human)0.18
Phosphorylase b kinase regulatory subunit betaHomo sapiens (human)0.0005
Serine/threonine-protein kinase Sgk3Homo sapiens (human)0.073
Aurora kinase BHomo sapiens (human)0.007
Lymphokine-activated killer T-cell-originated protein kinaseHomo sapiens (human)0.0691
MAP/microtubule affinity-regulating kinase 4Homo sapiens (human)0.0001
Calcium/calmodulin-dependent protein kinase type 1GHomo sapiens (human)0.0047
Testis-specific serine/threonine-protein kinase 2Homo sapiens (human)0.0038
Testis-specific serine/threonine-protein kinase 3Homo sapiens (human)0.0051
Serine/threonine-protein kinase Nek1Homo sapiens (human)0.0122
PAS domain-containing serine/threonine-protein kinaseHomo sapiens (human)0.0107
Calcium/calmodulin-dependent protein kinase kinase 2Homo sapiens (human)0.0246
SRSF protein kinase 1Homo sapiens (human)0.0337
Mitogen-activated protein kinase kinase kinase 14Homo sapiens (human)2.3
Mitogen-activated protein kinase kinase kinase 5Homo sapiens (human)0.215
Mitogen-activated protein kinase kinase kinase 3Homo sapiens (human)0.0092
MAP kinase-interacting serine/threonine-protein kinase 1Homo sapiens (human)0.0531
Testis-specific serine/threonine-protein kinase 6Homo sapiens (human)0.1525
Serine/threonine-protein kinase 33Homo sapiens (human)0.0374
Serine/threonine-protein kinase D2Homo sapiens (human)0.0014
NUAK family SNF1-like kinase 2Homo sapiens (human)0.0018
Serine/threonine-protein kinase SIK2Homo sapiens (human)0.3669
Myosin light chain kinase 2, skeletal/cardiac muscleHomo sapiens (human)0.0147
STE20-like serine/threonine-protein kinase Homo sapiens (human)0.0142
Serine/threonine-protein kinase TAO3Homo sapiens (human)0.0017
Homeodomain-interacting protein kinase 2Homo sapiens (human)0.3655
Tyrosine-protein kinase SrmsHomo sapiens (human)6.5
Homeodomain-interacting protein kinase 3Homo sapiens (human)0.456
Serine/threonine-protein kinase PLK3Homo sapiens (human)0.203
Inactive tyrosine-protein kinase PEAK1Homo sapiens (human)0.0025
Dual specificity protein kinase CLK4Homo sapiens (human)0.0723
MAP kinase-interacting serine/threonine-protein kinase 2Homo sapiens (human)0.0221
Serine/threonine-protein kinase Sgk2Homo sapiens (human)0.0159
Casein kinase I isoform gamma-1Homo sapiens (human)5.3367
NADPH oxidase 4Homo sapiens (human)0.0708
Serine/threonine-protein kinase PAK 6Homo sapiens (human)0.0327
SNF-related serine/threonine-protein kinaseHomo sapiens (human)0.0059
Serine/threonine-protein kinase LATS2Homo sapiens (human)0.0062
Interleukin-1 receptor-associated kinase 4Homo sapiens (human)0.0122
Serine/threonine-protein kinase 32BHomo sapiens (human)0.0375
Cyclin-dependent kinase 12Homo sapiens (human)0.053
Serine/threonine-protein kinase PLK2Homo sapiens (human)0.546
Serine/threonine-protein kinase MARK1Homo sapiens (human)0.0003
Serine/threonine-protein kinase pim-2Homo sapiens (human)0.0813
Serine/threonine-protein kinase PAK 5Homo sapiens (human)0.0039
Serine/threonine-protein kinase 26Homo sapiens (human)0.0124
Serine/threonine-protein kinase NLKHomo sapiens (human)0.0666
Ribosomal protein S6 kinase beta-2Homo sapiens (human)0.0015
Protein DBF4 homolog AHomo sapiens (human)0.0549
Serine/threonine-protein kinase 17AHomo sapiens (human)0.0386
STE20/SPS1-related proline-alanine-rich protein kinaseHomo sapiens (human)0.0158
Ephrin type-A receptor 6Homo sapiens (human)0.0161
Serine/threonine-protein kinase TBK1Homo sapiens (human)0.003
Death-associated protein kinase 2Homo sapiens (human)0.0064
Ribosomal protein S6 kinase alpha-6Homo sapiens (human)0.0001
TRAF2 and NCK-interacting protein kinaseHomo sapiens (human)0.0103
Serine/threonine-protein kinase tousled-like 1Homo sapiens (human)0.0295
Serine/threonine-protein kinase TAO2Homo sapiens (human)0.0076
ALK tyrosine kinase receptorHomo sapiens (human)0.0044
SRSF protein kinase 3Homo sapiens (human)1.77
Serine/threonine-protein kinase ICKHomo sapiens (human)0.0443
Aurora kinase CHomo sapiens (human)0.0022
Calcium/calmodulin-dependent protein kinase type II subunit alphaHomo sapiens (human)0.0024
Protein kinase C theta typeRattus norvegicus (Norway rat)0.274
RAC-gamma serine/threonine-protein kinaseHomo sapiens (human)0.3701
Serine/threonine-protein kinase 38-likeHomo sapiens (human)0.0012
Serine/threonine-protein kinase SIK3Homo sapiens (human)0.1541
Mitogen-activated protein kinase kinase kinase 2Homo sapiens (human)0.0335
Serine/threonine-protein kinase WNK2Homo sapiens (human)1.455
Dual specificity tyrosine-phosphorylation-regulated kinase 1BHomo sapiens (human)0.0017
5'-AMP-activated protein kinase subunit beta-1Homo sapiens (human)1.1354
Mitogen-activated protein kinase kinase kinase kinase 5Homo sapiens (human)0.0002
Serine/threonine-protein kinase MRCK betaHomo sapiens (human)0.0027
Serine/threonine-protein kinase 24Homo sapiens (human)0.0065
Casein kinase I isoform gamma-3Homo sapiens (human)2.675
Chain A, Ribosomal protein S6 kinase alpha-1Homo sapiens (human)0.0003
Chain X, Tyrosine-protein kinase LynHomo sapiens (human)0.0013

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's13 (46.43)29.6817
2010's12 (42.86)24.3611
2020's3 (10.71)2.80

Authors

AuthorsStudies
Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Dewhurst, S; Gelbard, HA; Goodfellow, VS; Loweth, CJ; Marker, DF; Nguyen, T; Polesskaya, O; Pollack, S; Ravula, SB; Sheppard, D; Todd, DE; Wiemann, T; Xu, Y1
Abdel-Aziz, AK; Abouzid, KAM; Dokla, EME; McPhillie, MJ; Milik, SN; Minucci, S1
Zhang, GS1
Kiyoi, H2
Berdel, WE; Müller-Tidow, C; Serve, H; Tickenbrock, L1
Brown, P; Cohen, P; Deangelo, D; Estey, E; Galinsky, I; Giles, F; Kantarjian, H; Karp, JE; Levis, M; Pham, R; Roesel, J; Small, D; Smith, BD; Stine, A; Stone, R; Wang, Y1
Austin, SJ; Burnett, AK; Gilkes, AF; Knapper, S; Mills, KI; Walsh, V1
Ehninger, G; Illmer, T1
Gary Gilliland, D; Tam, WF1
Tallman, M1
Gore, SD1
Karp, J1
Armstrong, RC; Belli, B; Bhagwat, SS; Brigham, D; Chao, Q; Cramer, MD; Gardner, MF; Gunawardane, RN; James, J; Karaman, MW; Levis, M; Pallares, G; Patel, HK; Pratz, KW; Sprankle, KG; Zarrinkar, PP1
Burnett, A; Lo-Coco, F; Löwenberg, B; Sanz, M1
Levis, M; Murphy, KM; Pratz, KW; Rajkhowa, T; Sato, T; Stine, A1
Ashman, LK; Griffith, R; Mashkani, B1
Burnett, A; Galkin, S; Knapper, S; Levis, M; Sato, T; Small, D; Smith, BD; White, P; Yang, X1
Chabner, BA; Fathi, AT1
Freeman, C; Giles, F; Swords, R1
Bharate, SB; Sawant, SD; Singh, PP; Vishwakarma, RA1
Bai, Y; Bennett, K; Colinge, J; Eschrich, S; Fang, B; Grebien, F; Haura, EB; Kim, JY; Koomen, J; Li, J; Okamoto, I; Qian, X; Rawal, B; Rix, U; Schell, M; Song, L; Stukalov, A; Superti-Furga, G; Winter, G; Yoshida, T; Zhang, G1
Courts, C; Gallala, H; Janzen, V; Kraus, D; Nowak, M; Perner, S; Probstmeier, R; Veit, N; Winter, J1
Li, JS; Wang, XW; Wang, YW; Zhang, HY1
Asami, Y; Crump, A; Ōmura, S1
Antar, AI; Bazarbachi, A; Jabbour, E; Mohty, M; Otrock, ZK1
Albors Ferreiro, M; Alonso Vence, N; Antelo Rodríguez, B; Bao Pérez, L; Bello López, JL; Cerchione, C; Cid López, M; Díaz Arias, JÁ; Ferreiro Ferro, R; González Pérez, MS; Martinelli, G; Mosquera Orgueira, A; Mosquera Torre, A; Peleteiro Raíndo, A; Pérez Encinas, MM1

Reviews

11 review(s) available for lestaurtinib and staurosporine

ArticleYear
[Possibility of targeting FLT3 kinase for the treatment of leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2005, Volume: 46, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Benzoquinones; Carbazoles; Drug Design; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Lactams, Macrocyclic; Leukemia; Mutation; Piperazines; Pyrroles; Quinazolines; Quinones; Rifabutin; Staurosporine; Sunitinib

2005
Emerging Flt3 kinase inhibitors in the treatment of leukaemia.
    Expert opinion on emerging drugs, 2006, Volume: 11, Issue:1

    Topics: Animals; Antineoplastic Agents; Carbazoles; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug Therapy, Combination; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Leukemia, Myeloid, Acute; Mutation; Protein Kinase Inhibitors; Pyrroles; Signal Transduction; Staurosporine

2006
[Novel molecularly target therapies for leukemia].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Jan-28, Volume: 65 Suppl 1

    Topics: Antineoplastic Agents; Carbazoles; Farnesyltranstransferase; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Leukemia; Piperazines; Quinazolines; Staurosporine

2007
FLT3 kinase inhibitors in the management of acute myeloid leukemia.
    Clinical lymphoma & myeloma, 2007, Volume: 8 Suppl 1

    Topics: Benzenesulfonates; Carbazoles; Clinical Trials as Topic; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Leukemia, Myeloid, Acute; Niacinamide; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyridines; Pyrroles; Quinazolines; Sorafenib; Staurosporine; Sunitinib

2007
Can FLT3 inhibitors overcome resistance in AML?
    Best practice & research. Clinical haematology, 2008, Volume: 21, Issue:1

    Topics: Antineoplastic Agents; Carbazoles; Clinical Trials as Topic; Drug Design; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Leukemia, Myeloid, Acute; Mutation; Piperazines; Quinazolines; Staurosporine

2008
FLT3 inhibition as a targeted therapy for acute myeloid leukemia.
    Current opinion in oncology, 2009, Volume: 21, Issue:6

    Topics: Acute Disease; Animals; Carbazoles; Drug Evaluation, Preclinical; fms-Like Tyrosine Kinase 3; Furans; Humans; Leukemia, Myeloid; Molecular Structure; Mutation; Staurosporine

2009
Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia.
    Leukemia, 2012, Volume: 26, Issue:10

    Topics: Benzenesulfonates; Benzothiazoles; Carbazoles; CCAAT-Enhancer-Binding Protein-alpha; fms-Like Tyrosine Kinase 3; Furans; Humans; Leukemia, Myeloid, Acute; Mutation; Niacinamide; Phenylurea Compounds; Prognosis; Pyridines; Sorafenib; Staurosporine

2012
Kinase inhibitors of marine origin.
    Chemical reviews, 2013, Aug-14, Volume: 113, Issue:8

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Aquatic Organisms; Aza Compounds; Carbazoles; Chemistry, Pharmaceutical; Depsipeptides; Furans; Humans; Indoles; Naphthyridines; Peptides, Cyclic; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Pyrimidines; Staurosporine; Terpenes

2013
Staurosporine: new lease of life for parent compound of today's novel and highly successful anti-cancer drugs.
    The Journal of antibiotics, 2018, Volume: 71, Issue:8

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Bacterial Infections; Carbazoles; Drug Discovery; Furans; Humans; Imatinib Mesylate; Neoplasms; Protein Kinase Inhibitors; Staurosporine

2018
FLT3 inhibitors in acute myeloid leukemia: ten frequently asked questions.
    Leukemia, 2020, Volume: 34, Issue:3

    Topics: Aniline Compounds; Antineoplastic Agents; Benzimidazoles; Benzothiazoles; Carbazoles; DNA Methylation; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Furans; Humans; Leukemia, Myeloid, Acute; Mutation; Neoplasm Recurrence, Local; Phenylurea Compounds; Piperidines; Prognosis; Pyrazines; Randomized Controlled Trials as Topic; Sorafenib; Staurosporine; Treatment Outcome

2020
FLT3 inhibitors in the treatment of acute myeloid leukemia: current status and future perspectives.
    Minerva medica, 2020, Volume: 111, Issue:5

    Topics: Aniline Compounds; Antineoplastic Agents; Benzimidazoles; Benzothiazoles; Carbazoles; Drug Resistance, Multiple; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; Forecasting; Furans; Hematopoietic Stem Cell Transplantation; Humans; Imidazoles; Leukemia, Myeloid, Acute; Maintenance Chemotherapy; Mutation; Phenylurea Compounds; Piperidines; Point Mutation; Protein Kinase Inhibitors; Pyrazines; Pyridazines; Recurrence; Sorafenib; Staurosporine

2020

Other Studies

17 other study(ies) available for lestaurtinib and staurosporine

ArticleYear
Comprehensive analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2011, Oct-30, Volume: 29, Issue:11

    Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity

2011
Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.
    Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20

    Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Blood-Brain Barrier; Brain; Carbazoles; Cells, Cultured; Cognition Disorders; Drug Discovery; HIV Infections; Humans; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinase Kinase 11; Models, Chemical; Molecular Structure; Monocytes; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Pyrroles; tat Gene Products, Human Immunodeficiency Virus; Tumor Necrosis Factor-alpha

2013
Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemia.
    Bioorganic & medicinal chemistry, 2022, 02-15, Volume: 56

    Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Cell Line; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; fms-Like Tyrosine Kinase 3; Humans; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Receptor, trkA; Structure-Activity Relationship

2022
[New targets for molecular therapy of acute leukemia: a "single-hit" or "multiple-hit" strategy against signaling pathway].
    Zhonghua yi xue za zhi, 2005, Feb-23, Volume: 85, Issue:7

    Topics: Acute Disease; Antineoplastic Agents; Carbazoles; Furans; Humans; Indoles; Leukemia; Leukemia, Myeloid, Acute; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Quinolones; ras Proteins; Staurosporine

2005
Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors.
    Blood, 2006, Nov-15, Volume: 108, Issue:10

    Topics: Antineoplastic Agents; Carbazoles; Case-Control Studies; Cell Line; Cell Survival; Cells, Cultured; Drug Screening Assays, Antitumor; Enzyme Inhibitors; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Inhibitory Concentration 50; Leukemia; Pharmacokinetics; Plasma; Staurosporine

2006
The effects of lestaurtinib (CEP701) and PKC412 on primary AML blasts: the induction of cytotoxicity varies with dependence on FLT3 signaling in both FLT3-mutated and wild-type cases.
    Blood, 2006, Nov-15, Volume: 108, Issue:10

    Topics: Acute Disease; Adolescent; Adult; Aged; Apoptosis; Blast Crisis; Carbazoles; Drug Screening Assays, Antitumor; Female; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Leukemia, Myeloid; Male; Middle Aged; Mutation; Protein Kinase C; Protein-Tyrosine Kinases; Signal Transduction; Staurosporine; Tumor Cells, Cultured

2006
Existing and emerging therapeutic options for the treatment of acute myeloid leukemia.
    Clinical advances in hematology & oncology : H&O, 2008, Volume: 6, Issue:11

    Topics: Adenine; Adenine Nucleotides; Aminoglycosides; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arabinonucleosides; Carbazoles; Clofarabine; Cytarabine; Dasatinib; Daunorubicin; fms-Like Tyrosine Kinase 3; Furans; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Naphthalimides; Organophosphonates; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Sesquiterpenes; Staurosporine; Stem Cell Transplantation; Thiazoles; Tretinoin

2008
New agents for the treatment of AML recent study findings.
    Clinical advances in hematology & oncology : H&O, 2008, Volume: 6, Issue:11

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Azacitidine; Carbazoles; Clofarabine; Decitabine; Enzyme Inhibitors; Furans; Humans; Hydrazines; Immunotherapy; Lenalidomide; Leukemia, Myeloid, Acute; Quinolones; Staurosporine; Sulfonamides; Thalidomide

2008
Future research directions for the treatment of AML.
    Clinical advances in hematology & oncology : H&O, 2008, Volume: 6, Issue:11

    Topics: Antineoplastic Agents; Azacitidine; Biomedical Research; Carbazoles; Carboplatin; Cytarabine; Daunorubicin; Decitabine; Enzyme Inhibitors; Etoposide; Flavonoids; Furans; Humans; Leukemia, Myeloid, Acute; Mitoxantrone; Piperidines; Quinolones; Staurosporine; Topotecan; Tretinoin

2008
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).
    Blood, 2009, Oct-01, Volume: 114, Issue:14

    Topics: Animals; Benzenesulfonates; Benzothiazoles; Bone Marrow; Carbazoles; Cell Line, Tumor; Cell Proliferation; Female; fms-Like Tyrosine Kinase 3; Furans; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Nude; Mice, SCID; Niacinamide; Phenylurea Compounds; Phosphorylation; Piperazines; Prognosis; Protein Interaction Mapping; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Quinazolines; Sorafenib; Staurosporine; Xenograft Model Antitumor Assays

2009
FLT3-mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML.
    Blood, 2010, Feb-18, Volume: 115, Issue:7

    Topics: Alleles; Antineoplastic Agents; Benzenesulfonates; Benzothiazoles; Carbazoles; Cell Death; Cell Line, Tumor; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; Furans; Humans; Indazoles; Indoles; Leukemia, Myeloid, Acute; Mutation; Niacinamide; Phenylurea Compounds; Phosphorylation; Piperazines; Pyridines; Pyrroles; Sorafenib; Staurosporine; Sunitinib

2010
Colony stimulating factor-1 receptor as a target for small molecule inhibitors.
    Bioorganic & medicinal chemistry, 2010, Mar-01, Volume: 18, Issue:5

    Topics: Benzamides; Binding Sites; Carbazoles; Computer Simulation; Dasatinib; Drug Design; Furans; Humans; Hydrogen Bonding; Imatinib Mesylate; Indoles; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Staurosporine; Sunitinib; Thiazoles

2010
FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo.
    Blood, 2011, Mar-24, Volume: 117, Issue:12

    Topics: Antineoplastic Agents; Benzenesulfonates; Carbazoles; Cells, Cultured; Drug Antagonism; fms-Like Tyrosine Kinase 3; Furans; Humans; Indazoles; Inhibitory Concentration 50; Leukemia, Myeloid, Acute; Membrane Proteins; Multicenter Studies as Topic; Niacinamide; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Sorafenib; Staurosporine; Treatment Outcome

2011
FLT3 inhibition as therapy in acute myeloid leukemia: a record of trials and tribulations.
    The oncologist, 2011, Volume: 16, Issue:8

    Topics: Antineoplastic Agents; Benzothiazoles; Carbazoles; Clinical Trials as Topic; Cytokines; fms-Like Tyrosine Kinase 3; Furans; Humans; Indoles; Leukemia, Myeloid, Acute; Phenylurea Compounds; Pyrroles; Staurosporine; Sunitinib; Tandem Repeat Sequences

2011
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.
    Molecular systems biology, 2013, Nov-05, Volume: 9

    Topics: Antineoplastic Agents; Carbazoles; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Furans; Gene Expression Regulation, Neoplastic; Humans; Mutation; Neoplasm Proteins; Phosphorylation; Protein Interaction Maps; Protein Kinase Inhibitors; Quinazolines; Staurosporine

2013
Staurosporine analogs promote distinct patterns of process outgrowth and polyploidy in small cell lung carcinoma cells.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:4

    Topics: Carbazoles; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Furans; Humans; Indole Alkaloids; Polyploidy; Signal Transduction; Small Cell Lung Carcinoma; Staurosporine

2015
Integrated Exploitation of the Structural Diversity Space of Chemotherapy Drugs to Selectively Inhibit HER2 T798M Mutant in Lung Cancer.
    Chemistry & biodiversity, 2017, Volume: 14, Issue:3

    Topics: Binding Sites; Carbazoles; Catalytic Domain; Furans; Humans; Kinetics; Ligands; Lung Neoplasms; Molecular Docking Simulation; Mutation; Protein Binding; Protein Kinase Inhibitors; Receptor, ErbB-2; Staurosporine; Thermodynamics

2017