leptin and trimethylamine

leptin has been researched along with trimethylamine* in 2 studies

Other Studies

2 other study(ies) available for leptin and trimethylamine

Article	Year
Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms. eLife, 2022, 01-24, Volume: 11 Obesity has repeatedly been linked to reorganization of the gut microbiome, yet to this point obesity therapeutics have been targeted exclusively toward the human host. Here, we show that gut microbe-targeted inhibition of the trimethylamine N-oxide (TMAO) pathway protects mice against the metabolic disturbances associated with diet-induced obesity (DIO) or leptin deficiency ( Topics: Animals; Choline; Circadian Rhythm; Diet, High-Fat; Enzyme Inhibitors; Gastrointestinal Microbiome; Leptin; Lyases; Male; Methylamines; Mice; Mice, Inbred C57BL; Obesity	2022
Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes. Environmental research, 2022, Volume: 215, Issue:Pt 1 Triclosan is a broad-spectrum antimicrobial, and was thought to affect intrauterine development, but the mechanism remains unclear.. To explore the association between prenatal triclosan exposure and birth outcomes.. Based on 726 mother-child pairs from the Sheyang Mini Birth Cohort Study (SMBCS), we used the available (published) data of triclosan in maternal urines, the hormones including thyroid-related hormones, gonadal hormones in cord blood, and adipokines, trimethylamine-N-oxide (TMAO) and its precursors in cord blood to explore possible health effects of triclosan on birth outcomes through assessing different hormones and parameters, using Bayesian mediation analysis.. Maternal triclosan exposure was associated with ponderal index (β = 0.317) and head circumference (β = -0.172) in generalized linear models. In Bayesian mediation analysis of PI model, estradiol (β = 0.806) and trimethylamine (TMA, β = 0.164) showed positive mediation effects, while total thyroxine (TT4, β = -0.302), leptin (β = -2.023) and TMAO (β = -0.110) showed negative mediation effects. As for model of head circumference, positive mediation effects were observed in free thyroxine (FT4, β = 0.493), TMA (β = 0.178), and TMAO (β = 0.683), negative mediation effects were observed in TT4 (β = -0.231), testosterone (β = -0.331), estradiol (β = -1.153), leptin (β = -2.361), choline (β = -0.169), betaine (β = -0.104), acetyl-L-carnitine (β = -0.773).. The results indicated triclosan can affect intrauterine growth by interfering thyroid-related hormones, gonadal hormones, adipokines, TMAO and its precursors. Topics: Acetylcarnitine; Bayes Theorem; Betaine; Choline; Cohort Studies; Estradiol; Female; Humans; Leptin; Maternal Exposure; Methylamines; Oxides; Pregnancy; Testosterone; Thyroid Hormones; Thyroxine; Triclosan	2022

Article

Year

Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms.

eLife, 2022, 01-24, Volume: 11

Obesity has repeatedly been linked to reorganization of the gut microbiome, yet to this point obesity therapeutics have been targeted exclusively toward the human host. Here, we show that gut microbe-targeted inhibition of the trimethylamine N-oxide (TMAO) pathway protects mice against the metabolic disturbances associated with diet-induced obesity (DIO) or leptin deficiency (

Topics: Animals; Choline; Circadian Rhythm; Diet, High-Fat; Enzyme Inhibitors; Gastrointestinal Microbiome; Leptin; Lyases; Male; Methylamines; Mice; Mice, Inbred C57BL; Obesity

2022

Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes.

Environmental research, 2022, Volume: 215, Issue:Pt 1

Triclosan is a broad-spectrum antimicrobial, and was thought to affect intrauterine development, but the mechanism remains unclear.. To explore the association between prenatal triclosan exposure and birth outcomes.. Based on 726 mother-child pairs from the Sheyang Mini Birth Cohort Study (SMBCS), we used the available (published) data of triclosan in maternal urines, the hormones including thyroid-related hormones, gonadal hormones in cord blood, and adipokines, trimethylamine-N-oxide (TMAO) and its precursors in cord blood to explore possible health effects of triclosan on birth outcomes through assessing different hormones and parameters, using Bayesian mediation analysis.. Maternal triclosan exposure was associated with ponderal index (β = 0.317) and head circumference (β = -0.172) in generalized linear models. In Bayesian mediation analysis of PI model, estradiol (β = 0.806) and trimethylamine (TMA, β = 0.164) showed positive mediation effects, while total thyroxine (TT4, β = -0.302), leptin (β = -2.023) and TMAO (β = -0.110) showed negative mediation effects. As for model of head circumference, positive mediation effects were observed in free thyroxine (FT4, β = 0.493), TMA (β = 0.178), and TMAO (β = 0.683), negative mediation effects were observed in TT4 (β = -0.231), testosterone (β = -0.331), estradiol (β = -1.153), leptin (β = -2.361), choline (β = -0.169), betaine (β = -0.104), acetyl-L-carnitine (β = -0.773).. The results indicated triclosan can affect intrauterine growth by interfering thyroid-related hormones, gonadal hormones, adipokines, TMAO and its precursors.

Topics: Acetylcarnitine; Bayes Theorem; Betaine; Choline; Cohort Studies; Estradiol; Female; Humans; Leptin; Maternal Exposure; Methylamines; Oxides; Pregnancy; Testosterone; Thyroid Hormones; Thyroxine; Triclosan

2022