leptin and senktide

Hypothalamic Kiss1 neurons control gonadotropin-releasing hormone release through the secretion of kisspeptin. Kiss1 neurons serve as a nodal center that conveys essential regulatory cues for the attainment and maintenance of reproductive function. Despite this critical role, the mechanisms that control kisspeptin synthesis and release remain largely unknown. Using Drop-Seq data from the arcuate nucleus of adult mice and in situ hybridization, we identified Nescient Helix-Loop-Helix 2 (

Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Chromatin; DNA; Estradiol; Female; Fertility; Gene Expression Regulation; Immunoprecipitation; Kisspeptins; Leptin; Luteinizing Hormone; Male; Mice; Mice, Knockout; Neurons; Peptide Fragments; Polymerase Chain Reaction; Sex Factors; Sexual Maturation; Substance P