leptin and morin

Between 5 and 10 percent of fractures do not heal, a condition known as nonunion. In clinical practice, stable fracture fixation associated with autologous iliac crest bone graft placement is the gold standard for treatment. However, some recalcitrant nonunions do not resolve satisfactorily with this technique. For these cases, biological alternatives are sought based on the molecular mechanisms of bone healing, whose most recent findings are reviewed in this article. The pro-osteogenic efficacy of morin (a pale yellow crystalline flavonoid pigment found in old fustic and osage orange trees) has recently been reported, and the combined use of bone morphogenetic protein-9 (BMP9) and leptin might improve fracture healing. Inhibition with methyl-piperidino-pyrazole of estrogen receptor alpha signaling delays bone regeneration. Smoking causes a chondrogenic disorder, aberrant activity of the skeleton's stem and progenitor cells, and an intense initial inflammatory response. Smoking cessation 4 weeks before surgery is therefore highly recommended. The delay in fracture consolidation in diabetic animals is related to BMP6 deficiency (35 kDa). The combination of bioceramics and expanded autologous human mesenchymal stem cells from bone marrow is a new and encouraging alternative for treating recalcitrant nonunions.

Topics: Animals; Bone Substitutes; Flavonoids; Fracture Healing; Growth Differentiation Factor 2; Humans; Leptin; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Osteocytes; Osteogenesis

The present study deals with the synthesis, characterization of zinc-morin complex and evaluation of its antidiabetic efficacy in High Fat Diet (HFD)-fedStreptozotocin (STZ) induced diabetic rats. Oral administration of zinc-morin complex to diabetic rats (5mg/kg body weight/day) for a period of 30 days resulted in the decreased levels of blood glucose and HbA1c. Oral administrations of the zinc-morin complex for 30 days significantly improved hyperglycemia, glucose intolerance, and insulin resistance. The elevated levels of lipid peroxides declined and the antioxidant competence was found to be improved in diabetic rats treated with the complex. The status of the lipid and lipoprotein profile in the serum was normalized upon treatment. Levels of TNFα decreased upon treatment with the complex. The altered levels of adipokines such as adiponectin and leptin were normalized upon treatment with the complex. In conclusion, the present study indicates that the zinc-morin complex possesses antidiabetic, antidyslipidemic and antioxidant potentials in HFD-fedSTZ induced diabetic rats.

Topics: Adiponectin; Animals; Blood Glucose; Coordination Complexes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Flavonoids; Glucose Tolerance Test; Glycated Hemoglobin; Insulin; Leptin; Magnetic Resonance Spectroscopy; Male; Random Allocation; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Tumor Necrosis Factor-alpha; Zinc