leptin and 3-3--dioctadecylindocarbocyanine

leptin has been researched along with 3-3--dioctadecylindocarbocyanine* in 1 studies

Other Studies

1 other study(ies) available for leptin and 3-3--dioctadecylindocarbocyanine

Article	Year
Trophic action of leptin on hypothalamic neurons that regulate feeding. Science (New York, N.Y.), 2004, Apr-02, Volume: 304, Issue:5667 In adult mammals, the adipocyte-derived hormone leptin acts on the brain to reduce food intake by regulating the activity of neurons in the arcuate nucleus of the hypothalamus (ARH). Here, we report that neural projection pathways from the ARH are permanently disrupted in leptin-deficient (Lepob/Lepob) mice and leptin treatment in adulthood does not reverse these neuroanatomical defects. However, treatment of Lepob/Lepob neonates with exogenous leptin rescues the development of ARH projections, and leptin promotes neurite outgrowth from ARH neurons in vitro. These results suggest that leptin plays a neurotrophic role during the development of the hypothalamus and that this activity is restricted to a neonatal critical period that precedes leptin's acute regulation of food intake in adults. Topics: Agouti-Related Protein; alpha-MSH; Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; Axons; Carbocyanines; Culture Techniques; Dorsomedial Hypothalamic Nucleus; Eating; Feeding Behavior; Hypothalamic Area, Lateral; Hypothalamus; Intercellular Signaling Peptides and Proteins; Leptin; Mice; Mice, Inbred C57BL; Mice, Obese; Nerve Fibers; Neurites; Neurons; Paraventricular Hypothalamic Nucleus; Proteins; Recombinant Proteins; Signal Transduction	2004

Article

Year

Trophic action of leptin on hypothalamic neurons that regulate feeding.

Science (New York, N.Y.), 2004, Apr-02, Volume: 304, Issue:5667

In adult mammals, the adipocyte-derived hormone leptin acts on the brain to reduce food intake by regulating the activity of neurons in the arcuate nucleus of the hypothalamus (ARH). Here, we report that neural projection pathways from the ARH are permanently disrupted in leptin-deficient (Lepob/Lepob) mice and leptin treatment in adulthood does not reverse these neuroanatomical defects. However, treatment of Lepob/Lepob neonates with exogenous leptin rescues the development of ARH projections, and leptin promotes neurite outgrowth from ARH neurons in vitro. These results suggest that leptin plays a neurotrophic role during the development of the hypothalamus and that this activity is restricted to a neonatal critical period that precedes leptin's acute regulation of food intake in adults.

Topics: Agouti-Related Protein; alpha-MSH; Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; Axons; Carbocyanines; Culture Techniques; Dorsomedial Hypothalamic Nucleus; Eating; Feeding Behavior; Hypothalamic Area, Lateral; Hypothalamus; Intercellular Signaling Peptides and Proteins; Leptin; Mice; Mice, Inbred C57BL; Mice, Obese; Nerve Fibers; Neurites; Neurons; Paraventricular Hypothalamic Nucleus; Proteins; Recombinant Proteins; Signal Transduction

2004