lennoxamine and aphanorphine

lennoxamine has been researched along with aphanorphine* in 1 studies

Other Studies

1 other study(ies) available for lennoxamine and aphanorphine

Article	Year
Total synthesis of (+/-)-lennoxamine and (+/-)-aphanorphine by intramolecular electrophilic aromatic substitution reactions of 2-amidoacroleins. Organic letters, 2001, Nov-29, Volume: 3, Issue:24 Intramolecular electrophilic aromatic substitution reactions of 2-amidoacroleins constitute the key steps in the total syntheses of lennoxamine and aphanorphine. The aldehyde moiety of one cyclization product was transformed to a double bond, which was then engaged in a radical cyclization to produce the complete ring system of lennoxamine. The aldehyde functionality of the other cyclization product was converted to the corresponding mesylate, which underwent intramolecular displacement by a lactam enolate to furnish the ring system of aphanorphine. [reaction: see text] Topics: Acrolein; Bridged-Ring Compounds; Dioxanes; Heterocyclic Compounds; Pyrroles	2001

Article

Year

Total synthesis of (+/-)-lennoxamine and (+/-)-aphanorphine by intramolecular electrophilic aromatic substitution reactions of 2-amidoacroleins.

Organic letters, 2001, Nov-29, Volume: 3, Issue:24

Intramolecular electrophilic aromatic substitution reactions of 2-amidoacroleins constitute the key steps in the total syntheses of lennoxamine and aphanorphine. The aldehyde moiety of one cyclization product was transformed to a double bond, which was then engaged in a radical cyclization to produce the complete ring system of lennoxamine. The aldehyde functionality of the other cyclization product was converted to the corresponding mesylate, which underwent intramolecular displacement by a lactam enolate to furnish the ring system of aphanorphine. [reaction: see text]

Topics: Acrolein; Bridged-Ring Compounds; Dioxanes; Heterocyclic Compounds; Pyrroles

2001