Page last updated: 2024-09-05

lenalidomide and topotecan

lenalidomide has been researched along with topotecan in 3 studies

Compound Research Comparison

Studies (lenalidomide)	Trials (lenalidomide)	Recent Studies (post-2010) (lenalidomide)	Studies (topotecan)	Trials (topotecan)	Recent Studies (post-2010) (topotecan)
3,532	725	2,850	2,392	626	792

Protein Interaction Comparison

Protein	Taxonomy	topotecan (IC50)
Cytochrome P450 3A4	Homo sapiens (human)	1.5211
DNA topoisomerase 1	Homo sapiens (human)	0.8525
DNA topoisomerase 2-alpha	Homo sapiens (human)	0.605
DNA topoisomerase 2-beta	Homo sapiens (human)	0.605
Hypoxia-inducible factor 1-alpha	Homo sapiens (human)	0.06
Multidrug and toxin extrusion protein 2	Homo sapiens (human)	8.6
Multidrug and toxin extrusion protein 1	Homo sapiens (human)	1.3
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	0.17

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Carter, JS; Downs, LS	1

Reviews

1 review(s) available for lenalidomide and topotecan

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for lenalidomide and topotecan

Article	Year
A prospective clinical trial of lenalidomide with topotecan in women with advanced epithelial ovarian carcinoma. International journal of clinical oncology, 2011, Volume: 16, Issue:6 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Lenalidomide; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Neoplasms, Glandular and Epithelial; Neutropenia; Ovarian Neoplasms; Thalidomide; Topotecan	2011

Article

Year

A prospective clinical trial of lenalidomide with topotecan in women with advanced epithelial ovarian carcinoma.

International journal of clinical oncology, 2011, Volume: 16, Issue:6

Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Lenalidomide; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Neoplasms, Glandular and Epithelial; Neutropenia; Ovarian Neoplasms; Thalidomide; Topotecan

2011

Other Studies

1 other study(ies) available for lenalidomide and topotecan

Article	Year
Identification of potent Yes1 kinase inhibitors using a library screening approach. Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15 Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship	2013

Article

Year

Identification of potent Yes1 kinase inhibitors using a library screening approach.

Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013