leflunomide and uridine

leflunomide has been researched along with uridine in 30 studies

Research

Studies (30)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	14 (46.67)	18.2507
2000's	13 (43.33)	29.6817
2010's	3 (10.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Caulfield, JP; Cherwinski, HM; Cheung, P; Cohn, RG; Nakano, G; Ransom, JT; Webster, DJ; Xu, YZ; Young, JM	1
Bartlett, RR; Müller, S; Zeitter, D; Zielinski, T	1
Cao, W; Morris, RE; Nair, RV	2
Chong, AS; Finnegan, A; Gong, H; Williams, JW; Xu, X	1
Cao, W; Morris, RE; Shorthouse, R; Silva, HT	1
Groth, CG; Karlsson-Parra, A; Korsgren, O; Liu, J; Rafael, E; Sundberg, B; Wennberg, L; Zhu, S	1
Blinder, L; Chong, AS; Finnegan, A; Gong, H; Shen, J; Williams, JW; Xu, X	1
Blinder, L; Chong, AS; Gong, H; Shen, J; Williams, JW; Xu, X	1
Chong, AS; Finnegan, A; Gong, H; Jäck, HM; Siemasko, K; Williams, JW	1
Carrey, EA; Fairbanks, LD; Hawrylowicz, CM; Kirschbaum, B; Richards, DF; Rückemann, K; Simmonds, HA	1
Amano, Y; Kitagawa, H; Mizushima, Y; Ogata, K	1
Blinder, L; Chong, AS; Clardy, C; Foster, P; Huang, W; Liu, W; Luo, J; Ma, L; Shen, J; Williams, JA; Xiao, F; Xu, W; Xu, X	1
Blinder, L; Chong, AS; Knight, DA; Lurain, NS; Miller, DM; Sedmak, DD; Shen, J; Waldman, WJ; Williams, JW	1
Aggarwal, BB; Manna, SK; Mukhopadhyay, A	1
Fehr, T; Ochsenbein, AF; Pinschewer, DD; Zinkernagel, RM	1
Bickerstaff, A; Gordillo, G; Knight, DA; Orosz, CG; Orosz, K; Waldman, WJ	1
Collins, M; Graves, LM; Huang, M; Mitchell, BS; Wang, Y	1
Mall, JW; Myers, JA; Philipp, AW; Pollmann, C; Saclarides, TJ; Xu, X	1
Jung, S; Korn, T; Magnus, T; Toyka, K	1
Aringer, M; Eselböck, D; Grisar, J; Köller, MD; Pietschmann, P; Smolen, JS; Steiner, CW; Stummvoll, GH; Wagner, L; Zierhut, B; Zwölfer, B	1
Stuhlmeier, KM	1
Chong, AS; Knight, DA; Meister, GT; Shen, J; Waldman, WJ; Williams, JW; Zeng, H	1
Guerne, PA; Magne, D; Mézin, F; Palmer, G	1
Nakayamada, S; Ra, C; Saito, K; Sawamukai, N; Tanaka, Y; Yamaoka, K	1
Adam, C; Baumann, P; Bumeder, I; Mandl-Weber, S; Oduncu, F; Schmidmaier, R; Völkl, A	1
Fukushima, R; Hirashiba, M; Hishikawa, A; Kanamori, S; Kaneto, M; Kitagawa, H; Muranaka, R	1
Jang, HS; Kerkvliet, NI; Koch, DC; Kolluri, SK; Kopparapu, PR; O'Donnell, EF; Phillips, JL; Tanguay, RL	1

Other Studies

30 other study(ies) available for leflunomide and uridine

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:2 Topics: Animals; Cell Cycle; Cell Nucleolus; Cells, Cultured; Dihydroorotate Dehydrogenase; DNA; Enzyme Inhibitors; Female; Humans; Immunosuppressive Agents; Isoxazoles; Ki-67 Antigen; Leflunomide; Lymphocyte Activation; Neoplasm Proteins; Nuclear Proteins; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Proliferating Cell Nuclear Antigen; Pyrimidines; Rats; RNA; T-Lymphocytes; Uridine	1995
Leflunomide, a reversible inhibitor of pyrimidine biosynthesis? Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44 Suppl 2 Topics: Cell Division; Cell Line; Cytidine; Humans; Immunosuppressive Agents; Isoxazoles; Kinetics; Leflunomide; Pyrimidines; Uracil Nucleotides; Uridine	1995
Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine. Immunology letters, 1995, Volume: 48, Issue:2 Topics: Aniline Compounds; Animals; Cell Division; Cell Line; Crotonates; Fibroblast Growth Factor 2; Growth Inhibitors; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mice; Muscle, Smooth; Nitriles; Toluidines; Uridine	1995
Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine. Immunology letters, 1995, Volume: 47, Issue:3 Topics: Aniline Compounds; Animals; Cell Division; Cell Line, Transformed; Crotonates; Graft Rejection; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mice; Muscle, Smooth; Nitriles; Toluidines; Uridine	1995
Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation. Biochemical pharmacology, 1996, Aug-23, Volume: 52, Issue:4 Topics: Animals; Blotting, Western; Dose-Response Relationship, Drug; Immunosuppressive Agents; Isoxazoles; Leflunomide; Leukemia, Experimental; Mice; Protein-Tyrosine Kinases; Tumor Cells, Cultured; Uridine	1996
Mechanism of action of leflunomide: in vivo uridine administration reverses its inhibition of lymphocyte proliferation. Transplantation proceedings, 1996, Volume: 28, Issue:6 Topics: Animals; Dihydroorotate Dehydrogenase; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Inbred Lew; Thymidine; Uridine	1996
Efficacy of immunosuppressive drugs in islet xenotransplantation: leflunomide in combination with cyclosporine and mycophenolate mofetil prevents islet xenograft rejection in the pig-to-rat model. Transplantation, 1997, May-15, Volume: 63, Issue:9 Topics: Animals; Antibodies; Complement System Proteins; Cyclosporine; Drug Interactions; Drug Therapy, Combination; Female; Graft Rejection; Immunoglobulin G; Immunohistochemistry; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Male; Mice; Pregnancy; Rats; Swine; Time Factors; Transplantation, Heterologous; Uridine	1997
In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice. Journal of immunology (Baltimore, Md. : 1950), 1997, Jul-01, Volume: 159, Issue:1 Topics: Aniline Compounds; Animals; Autoimmune Diseases; Crotonates; Dihydroorotate Dehydrogenase; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymph Nodes; Lymphoproliferative Disorders; Mice; Mice, Mutant Strains; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidine Nucleotides; Toluidines; Uridine	1997
Control of lymphoproliferative and autoimmune disease in MRL-lpr/lpr mice by brequinar sodium: mechanisms of action. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:2 Topics: Animals; Autoantibodies; Autoimmune Diseases; Biphenyl Compounds; Cytidine Triphosphate; Female; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphoproliferative Disorders; Mice; Mice, Inbred BALB C; Mice, Inbred MRL lpr; Phosphorylation; Tyrosine; Uridine; Uridine Triphosphate	1997
Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production. Journal of immunology (Baltimore, Md. : 1950), 1998, Feb-15, Volume: 160, Issue:4 Topics: Animals; B-Lymphocytes; Binding, Competitive; DNA-Binding Proteins; Growth Inhibitors; Immunoglobulin G; Immunosuppressive Agents; Interleukin-4; Isoxazoles; Janus Kinase 3; Leflunomide; Lipopolysaccharides; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Protein-Tyrosine Kinases; Signal Transduction; STAT6 Transcription Factor; Trans-Activators; Tyrosine; Uridine	1998
Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans. The Journal of biological chemistry, 1998, Aug-21, Volume: 273, Issue:34 Topics: Adenosine Triphosphate; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Chromatography, High Pressure Liquid; Dihydroorotate Dehydrogenase; Humans; Immunosuppressive Agents; In Vitro Techniques; Isoxazoles; Leflunomide; Lymphocyte Activation; Mice; Mitogens; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Phytohemagglutinins; Pyrimidines; T-Lymphocytes; Uridine; Uridine Triphosphate	1998
Oral administration of leflunomide (HWA486) results in prominent suppression of immunoglobulin E formation in a rat type 1 allergy model. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2 Topics: Administration, Oral; Aniline Compounds; Animals; Antibody Specificity; Crotonates; Disease Models, Animal; Drug Administration Schedule; Female; Hydroxybutyrates; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Nitriles; Ovalbumin; Rats; Rats, Inbred BN; Toluidines; Uridine	1999
In vivo activity of leflunomide: pharmacokinetic analyses and mechanism of immunosuppression. Transplantation, 1999, Jul-15, Volume: 68, Issue:1 Topics: Aniline Compounds; Animals; Cricetinae; Crotonates; Graft Rejection; Heart Transplantation; Humans; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Liver; Lymph Nodes; Mesocricetus; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nitriles; Pyrimidine Nucleotides; Rats; Rats, Inbred Lew; Spleen; Toluidines; Transplantation, Heterologous; Transplantation, Homologous; Uridine	1999
Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide. Intervirology, 1999, Volume: 42, Issue:5-6 Topics: Animals; Antiviral Agents; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; DNA, Viral; Drug Resistance, Microbial; Drug Resistance, Multiple; Endothelium, Vascular; Fibroblasts; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Rats; Uridine	1999
Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. Journal of immunology (Baltimore, Md. : 1950), 2000, Nov-15, Volume: 165, Issue:10 Topics: Apoptosis; Caspase Inhibitors; Caspases; Cells, Cultured; Cytotoxicity, Immunologic; DNA-Binding Proteins; Enzyme Activation; Gene Expression Regulation; Genes, Reporter; Growth Inhibitors; HeLa Cells; Humans; I-kappa B Kinase; I-kappa B Proteins; Immunosuppressive Agents; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leflunomide; Lipid Peroxidation; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Receptors, Tumor Necrosis Factor; Signal Transduction; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; Uridine	2000
Leflunomide-mediated suppression of antiviral antibody and Tcell responses: differential restoration by uridine. Transplantation, 2001, Aug-27, Volume: 72, Issue:4 Topics: Animals; Antibodies, Viral; Antibody Formation; Autoimmune Diseases; CD8-Positive T-Lymphocytes; Diabetes Mellitus; Dose-Response Relationship, Drug; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Transgenic; T-Lymphocytes; T-Lymphocytes, Cytotoxic; Uridine; Vesicular stomatitis Indiana virus	2001
Inhibition of angiogenesis-related endothelial activity by the experimental immunosuppressive agent leflunomide. Transplantation, 2001, Nov-15, Volume: 72, Issue:9 Topics: Angiogenesis Inhibitors; Animals; Cell Division; Cells, Cultured; Culture Media; Cyclosporine; Endothelium, Vascular; Humans; Isoxazoles; Leflunomide; Mice; Microcirculation; Models, Animal; Tacrolimus; Umbilical Veins; Uridine	2001
A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools. Molecular pharmacology, 2002, Volume: 62, Issue:3 Topics: Aniline Compounds; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Cycle Proteins; Cell Differentiation; Cell Division; Crotonates; Cytidine; Cytidine Triphosphate; Dihydroorotase; Drug Interactions; Gene Expression; Glycophorins; Humans; Hydroxybutyrates; Isoxazoles; K562 Cells; Leflunomide; Multienzyme Complexes; Nitriles; Pyrimidines; S Phase; Toluidines; Uridine; Uridine Triphosphate	2002
[Leflunomide reduces the angiogenesis score and tumor growth of subcutaneously implanted colon carcinoma cells in the mouse model]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2002, Volume: 73, Issue:7 Topics: Administration, Oral; Animals; Capillaries; Cell Division; Colonic Neoplasms; HT29 Cells; Humans; Injections, Intraperitoneal; Isoxazoles; Leflunomide; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Random Allocation; Uridine	2002
Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide--mechanisms independent of pyrimidine depletion. Journal of leukocyte biology, 2004, Volume: 76, Issue:5 Topics: Adoptive Transfer; Animals; Animals, Newborn; Antigens, CD; B7-2 Antigen; Cells, Cultured; Chemotaxis, Leukocyte; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Guinea Pigs; Immunosuppressive Agents; Interferon-gamma; Interleukin-10; Interleukin-2; Isoxazoles; Leflunomide; Membrane Glycoproteins; Microglia; Multiple Sclerosis; Myelin Basic Protein; Pyrimidines; Rats; Rats, Inbred Lew; STAT6 Transcription Factor; T-Lymphocytes, Helper-Inducer; Trans-Activators; Uridine	2004
Leflunomide inhibits transendothelial migration of peripheral blood mononuclear cells. Annals of the rheumatic diseases, 2004, Volume: 63, Issue:12 Topics: Antirheumatic Agents; Cell Adhesion; Cell Movement; Cells, Cultured; Chemotaxis, Leukocyte; Endothelium, Vascular; Flow Cytometry; Humans; Hyaluronic Acid; Isoxazoles; Leflunomide; Leukocytes, Mononuclear; Methotrexate; Uridine	2004
Effects of leflunomide on hyaluronan synthases (HAS): NF-kappa B-independent suppression of IL-1-induced HAS1 transcription by leflunomide. Journal of immunology (Baltimore, Md. : 1950), 2005, Jun-01, Volume: 174, Issue:11 Topics: Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Enzyme Repression; Fibroblasts; Glucuronosyltransferase; Humans; Hyaluronan Synthases; Hyaluronic Acid; Immunosuppressive Agents; Interleukin-1; Isoxazoles; Leflunomide; NF-kappa B; Protein Transport; Pyrimidines; RNA, Messenger; Synovial Membrane; Transcription, Genetic; Uridine	2005
Concurrent antiviral and immunosuppressive activities of leflunomide in vivo. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2006, Volume: 6, Issue:1 Topics: Animals; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections; Graft Rejection; Heart; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Lectins, C-Type; Leflunomide; Lung; Rats; Rats, Inbred Lew; Salivary Glands; Spleen; Transplants; Uridine; Viral Proteins	2006
The active metabolite of leflunomide, A77 1726, increases proliferation of human synovial fibroblasts in presence of IL-1beta and TNF-alpha. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2006, Volume: 55, Issue:11 Topics: Aniline Compounds; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Crotonates; Drug Synergism; Enzyme Inhibitors; Fibroblasts; Humans; Hydroxybutyrates; Interleukin-1beta; Isoxazoles; Jurkat Cells; Leflunomide; Nitriles; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Synovial Membrane; Toluidines; Tumor Necrosis Factor-alpha; Uridine	2006
Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells. Journal of immunology (Baltimore, Md. : 1950), 2007, Nov-15, Volume: 179, Issue:10 Topics: Aniline Compounds; Apoptosis; Arthritis, Rheumatoid; Cell Survival; Cells, Cultured; Chronic Disease; Crotonates; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Hydroxybutyrates; Immunosuppressive Agents; Inflammation Mediators; Isoxazoles; Leflunomide; Mast Cells; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Synovial Membrane; Synovitis; Toluidines; Uridine	2007
Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells. Molecular cancer therapeutics, 2009, Volume: 8, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Cell Adhesion Molecules; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Culture Media; Dihydroorotate Dehydrogenase; Down-Regulation; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; G1 Phase; Humans; Isoxazoles; Leflunomide; Multiple Myeloma; Oxidoreductases Acting on CH-CH Group Donors; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Receptors, Cytokine; Ribosomal Protein S6 Kinases, 70-kDa; Stromal Cells; Uridine	2009
Inhibiting the teratogenicity of the immunosuppressant leflunomide in mice by supplementation of exogenous uridine. Toxicological sciences : an official journal of the Society of Toxicology, 2009, Volume: 108, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Dihydroorotate Dehydrogenase; Embryonic Development; Female; Fetal Viability; Fetus; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mice; Mice, Inbred ICR; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Pyrimidine Nucleotides; Teratogens; Uridine	2009
The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells. PloS one, 2012, Volume: 7, Issue:7 Topics: Aniline Compounds; Cell Line, Tumor; Cell Proliferation; Crotonates; Cyclin-Dependent Kinase Inhibitor p21; Dihydroorotate Dehydrogenase; Fluoresceins; Gene Knockdown Techniques; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Melanoma; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Proto-Oncogene Proteins c-myc; Receptors, Aryl Hydrocarbon; Signal Transduction; Succinimides; Toluidines; Uridine	2012