leflunomide and sirolimus

leflunomide has been researched along with sirolimus in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's14 (40.00)18.2507
2000's9 (25.71)29.6817
2010's11 (31.43)24.3611
2020's1 (2.86)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Kahan, BD1
Berry, GJ; Billingham, ME; Gregory, CR; Huang, X; Morris, RE; Rowan, R; Shorthouse, R1
Chong, AS; Finnegan, A; Foster, P; Gebel, H; Jiang, XL; Petraitis, EE; Sankary, HN; Williams, JW1
Groth, CG; Karlsson-Parra, A; Korsgren, O; Liu, J; Rafael, E; Sundberg, B; Tibell, A; Wallgren, AC; Wennberg, L; Zhu, S1
Adams, B; Berry, GJ; Brazelton, T; Morris, RE; Reichenspurner, H; Reitz, BA; Shorthouse, R; Soni, V1
Halloran, PF1
Brazelton, TR; Morris, RE1
Lin, Y; Vandeputte, M; Waer, M1
Lin, Y; Waer, M1
Hausen, B; Morris, RE1
Waer, M1
Gregory, CR1
Bonham, CA; Gerber, DA; Thomson, AW1
Gummert, JF; Ikonen, T; Morris, RE1
Craigmill, AL; Gregory, CR; Kyles, AE1
Dambrin, C; Klupp, J; Morris, RE1
Ambach, A; Konstandin, M; Meuer, SC; Samstag, Y; Saunus, J; Wesselborg, S1
Drosos, AA1
Kushwaha, SS; Mayer, DF1
Casadio, F; Corti, B; Croci, S; D'Errico Grigioni, A; Grigioni, WF; Landuzzi, L; Lollini, PL1
Behnisch, B; Bergow, C; Boeger, R; Connolly, AJ; Deuse, T; Erben, RG; Ikeno, F; Pelletier, MP; Reichenspurner, H; Robbins, RC; Schrepfer, S1
Hou, J; Li, J; Tang, DN; Wei, JM; Xu, Y; Yu, ZY1
Liacini, A; Muruve, DA; Seamone, ME; Tibbles, LA1
Basu, G; John, GT; Mani, SE; Manipadam, MT; Mohapatra, A1
Mishra, OP; Mittal, R; Prasad, R; Singh, UK1
Chen, X; Li, G; Li, X; Shen, B; Sun, S; Sun, Y; Zhao, J; Zou, X1
Lei, T; Liu, G; Peng, J; Sun, C; Wang, R; Wu, T; Xu, K; Zhang, L; Zhao, Y1
Chan, TM1
Boucher, A; Collette, S; Dandavino, R; Lamarche, C; Senécal, L; Tran, D; Vallée, M1
Cook, L; Foulke, L; J Conti, D; Keys, B; Lopez-Soler, RI; Stellrecht, K; Yang, D1
Basile, G; Delbue, S; Dolci, M; Favi, E; Ferrante, P; Ferraresso, M; Signorini, L; Ticozzi, R; Villani, S1

Reviews

15 review(s) available for leflunomide and sirolimus

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
New immunosuppressive drugs--pharmacologic approaches to alter immunoregulation.
    Therapeutic immunology, 1994, Volume: 1, Issue:1

    Topics: Animals; Antimetabolites; Azathioprine; Biphenyl Compounds; Cell Differentiation; Cyclosporine; Guanidines; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytes; Lymphokines; Oligonucleotides, Antisense; Polyenes; Receptors, Cytokine; Ribonucleosides; Signal Transduction; Sirolimus; Tacrolimus

1994
Molecular mechanisms of new immunosuppressants.
    Clinical transplantation, 1996, Volume: 10, Issue:1 Pt 2

    Topics: Amino Acid Isomerases; B-Lymphocytes; Biphenyl Compounds; Calcineurin; Calmodulin-Binding Proteins; Carrier Proteins; Cyclosporine; Enzyme Inhibitors; Humans; Immunosuppressive Agents; IMP Dehydrogenase; Isoxazoles; Leflunomide; Mycophenolic Acid; Oxidoreductases; Peptidylprolyl Isomerase; Phosphoprotein Phosphatases; Polyenes; Purines; Pyrimidines; Receptors, Cytokine; Ribonucleosides; Signal Transduction; Sirolimus; T-Lymphocytes; Tacrolimus

1996
Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide.
    Current opinion in immunology, 1996, Volume: 8, Issue:5

    Topics: Animals; Autoimmune Diseases; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycophenolic Acid; Polyenes; Pyrimidine Nucleotides; Sirolimus; Tacrolimus; Xenobiotics

1996
Review of immunosuppression for lung transplantation. Novel drugs, new uses for conventional immunosuppressants, and alternative strategies.
    Clinics in chest medicine, 1997, Volume: 18, Issue:2

    Topics: Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lung Transplantation; Lymphatic Irradiation; Methotrexate; Mycophenolic Acid; Photopheresis; Polyenes; Recurrence; Sirolimus; Tacrolimus

1997
New immunosuppressive agents for organ transplantation.
    Acta clinica Belgica, 1997, Volume: 52, Issue:4

    Topics: Graft Rejection; Guanidines; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycophenolic Acid; Nitriles; Organ Transplantation; Polyenes; Sirolimus; Tacrolimus

1997
Immunosuppressive approaches to the prevention of graft vascular disease.
    Transplantation proceedings, 1998, Volume: 30, Issue:3

    Topics: Coronary Disease; Cyclosporine; Heart Transplantation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycophenolic Acid; Polyenes; Postoperative Complications; Sirolimus; Tacrolimus

1998
Immunosuppressive agents: recent developments in molecular action and clinical application.
    Transplantation proceedings, 1998, Volume: 30, Issue:4

    Topics: Cyclosporine; Guanidines; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Models, Biological; Mycophenolic Acid; Polyenes; Ribonucleosides; Sirolimus; T-Lymphocytes; Tacrolimus; Transplantation Immunology

1998
Newer immunosuppressive drugs: a review.
    Journal of the American Society of Nephrology : JASN, 1999, Volume: 10, Issue:6

    Topics: Animals; Clinical Trials as Topic; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycophenolic Acid; Sirolimus; Tacrolimus

1999
Pharmacodynamics of immunosuppressive drugs.
    Current opinion in immunology, 2000, Volume: 12, Issue:5

    Topics: Animals; Cyclosporine; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycophenolic Acid; Sirolimus; Tacrolimus

2000
Newer immunosuppressive drugs: their potential role in rheumatoid arthritis therapy.
    Drugs, 2002, Volume: 62, Issue:6

    Topics: Animals; Arthritis, Rheumatoid; Cyclosporine; Cytokines; Gene Expression Regulation; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mitogen-Activated Protein Kinases; Mycophenolic Acid; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Sirolimus; Tacrolimus

2002
Transplant immunosuppressant agents and their role in autoimmune rheumatic diseases.
    Current opinion in rheumatology, 2003, Volume: 15, Issue:3

    Topics: Autoimmune Diseases; Azathioprine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mycophenolic Acid; Rheumatic Diseases; Severity of Illness Index; Sirolimus; Tacrolimus; Transplants; Treatment Outcome

2003
Immunosuppressive therapy in children.
    Journal of the Indian Medical Association, 2011, Volume: 109, Issue:2

    Topics: Antilymphocyte Serum; Autoimmune Diseases; Azathioprine; Child; Cyclophosphamide; Cyclosporine; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mercaptopurine; Methotrexate; Mycophenolic Acid; Nitriles; Sirolimus; Tacrolimus

2011
Treatment of severe lupus nephritis: the new horizon.
    Nature reviews. Nephrology, 2015, Volume: 11, Issue:1

    Topics: Antimalarials; Azathioprine; Biological Products; Cyclophosphamide; Cyclosporine; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lupus Nephritis; Mycophenolic Acid; Ribonucleosides; Severity of Illness Index; Sirolimus; Tacrolimus

2015
JC polyomavirus nephropathy, a rare cause of transplant dysfunction: Case report and review of literature.
    Transplant infectious disease : an official journal of the Transplantation Society, 2017, Volume: 19, Issue:2

    Topics: Biopsy; BK Virus; Creatinine; Graft Rejection; Humans; Immunoglobulins, Intravenous; Immunosuppression Therapy; Immunosuppressive Agents; Incidence; Isoxazoles; JC Virus; Kidney Failure, Chronic; Kidney Function Tests; Kidney Transplantation; Leflunomide; Male; Middle Aged; Mycophenolic Acid; Nephritis; Polymerase Chain Reaction; Polyomavirus Infections; Sirolimus; Tacrolimus; Transplantation, Homologous; Viremia

2017

Other Studies

20 other study(ies) available for leflunomide and sirolimus

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Studies in experimental models of chronic rejection: use of rapamycin (sirolimus) and isoxazole derivatives (leflunomide and its analogue) for the suppression of graft vascular disease and obliterative bronchiolitis.
    Transplantation proceedings, 1995, Volume: 27, Issue:3

    Topics: Animals; Bronchiolitis Obliterans; Cyclosporine; Graft Occlusion, Vascular; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Polyenes; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sirolimus; Tunica Intima

1995
Leflunomide, a novel immunomodulatory agent: in vitro analyses of the mechanism of immunosuppression.
    Transplantation proceedings, 1993, Volume: 25, Issue:1 Pt 1

    Topics: Cells, Cultured; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Polyenes; Sirolimus; T-Lymphocytes; Thymidine; Tritium

1993
Immunosuppression with leflunomide and cyclosporine prevents pig-to-rat islet xenograft rejection.
    Transplantation proceedings, 1995, Volume: 27, Issue:6

    Topics: Animals; Antibodies, Heterophile; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Immunosuppression Therapy; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Male; Polyenes; Rats; Rats, Inbred Lew; Sirolimus; Swine; Tacrolimus; Transplantation, Heterologous

1995
Obliterative airway disease after heterotopic tracheal xenotransplantation in a concordant rodent model: pathogenesis and treatment.
    Transplantation proceedings, 1996, Volume: 28, Issue:2

    Topics: Airway Obstruction; Animals; Bronchiolitis Obliterans; Cricetinae; Cyclosporine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mesocricetus; Polyenes; Rats; Rats, Inbred Lew; Sirolimus; Trachea; Transplantation, Heterologous

1996
A short-term combination therapy with cyclosporine and rapamycin or leflunomide induces long-term heart allograft survival in a strongly immunogenic strain combination in rats.
    Transplant international : official journal of the European Society for Organ Transplantation, 1996, Volume: 9 Suppl 1

    Topics: Animals; Cyclosporine; Drug Therapy, Combination; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Male; Polyenes; Rats; Rats, Inbred Strains; Sirolimus

1996
Progressive change in tolerance mechanisms after withdrawing combination immunosuppression with cyclosporine and rapamycine or leflunomide.
    Transplantation proceedings, 1996, Volume: 28, Issue:6

    Topics: Animals; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immune Tolerance; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Polyenes; Rats; Rats, Inbred Strains; Sirolimus; T-Lymphocytes; Time Factors; Transplantation, Homologous

1996
Comparison of the in vitro antiproliferative effects of five immunosuppressive drugs on lymphocytes in whole blood from cats.
    American journal of veterinary research, 2000, Volume: 61, Issue:8

    Topics: Animals; Cats; Cell Division; Coloring Agents; Concanavalin A; Cyclosporine; Dose-Response Relationship, Drug; Immunosuppressive Agents; Inhibitory Concentration 50; Isoxazoles; Leflunomide; Lymphocyte Activation; Mycophenolic Acid; Pokeweed Mitogens; Scintillation Counting; Sirolimus; Tacrolimus; Trypan Blue

2000
The serine phosphatases PP1 and PP2A associate with and activate the actin-binding protein cofilin in human T lymphocytes.
    European journal of immunology, 2000, Volume: 30, Issue:12

    Topics: Actin Depolymerizing Factors; Cyclosporine; Dexamethasone; Humans; Isoxazoles; Leflunomide; Microfilament Proteins; Mycophenolic Acid; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Sirolimus; T-Lymphocytes; Tacrolimus

2000
Toward the definition of immunosuppressive regimens with antitumor activity.
    Transplantation proceedings, 2005, Volume: 37, Issue:5

    Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Cyclosporine; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Jurkat Cells; Leflunomide; Liver Neoplasms; Mycophenolic Acid; Rhabdomyosarcoma; Sirolimus

2005
Introducing the first polymer-free leflunomide eluting stent.
    Atherosclerosis, 2008, Volume: 200, Issue:1

    Topics: Animals; Cells, Cultured; Drug-Eluting Stents; Endothelial Cells; Enzyme Inhibitors; Humans; Isoxazoles; Leflunomide; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; Sirolimus; Tomography, Optical Coherence; Tunica Intima; Tunica Media

2008
The effect of Malononitrilamides (FK778) on phenotypic properties of human peripheral dendritic cells.
    Transplantation proceedings, 2009, Volume: 41, Issue:5

    Topics: Adjuvants, Immunologic; Alkynes; Antigens, CD; Cell Differentiation; Cell Survival; Cells, Cultured; Dendritic Cells; Flow Cytometry; Humans; Isoxazoles; Leflunomide; Nitriles; Phenotype; Reference Values; Sirolimus

2009
Immunosuppressants: JC virus encephalopathy. Rare but fatal.
    Prescrire international, 2009, Volume: 18, Issue:102

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antirheumatic Agents; Humans; Immunosuppressive Agents; Isoxazoles; JC Virus; Leflunomide; Leukoencephalopathy, Progressive Multifocal; Mycophenolic Acid; Natalizumab; Rituximab; Sirolimus; Tacrolimus

2009
Anti-BK virus mechanisms of sirolimus and leflunomide alone and in combination: toward a new therapy for BK virus infection.
    Transplantation, 2010, Dec-27, Volume: 90, Issue:12

    Topics: Antigens, Viral; Antigens, Viral, Tumor; Antiviral Agents; BK Virus; Cell Line; Drug Therapy, Combination; Epithelial Cells; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Kidney Tubules; Leflunomide; Polymerase Chain Reaction; Polyomavirus Infections; Signal Transduction; Sirolimus; Transplantation Immunology

2010
Leflunomide with low-dose everolimus for treatment of Kaposi's sarcoma in a renal allograft recipient.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Volume: 26, Issue:10

    Topics: Antineoplastic Agents; Everolimus; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Diseases; Kidney Transplantation; Leflunomide; Male; Middle Aged; Proto-Oncogene Proteins c-akt; Sarcoma, Kaposi; Sirolimus; Transplantation, Homologous; Treatment Outcome

2011
Combined use of rapamycin and leflunomide in prevention of acute cardiac allografts rejection in rats.
    Transplant immunology, 2012, Volume: 27, Issue:1

    Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Isoxazoles; Kidney; Leflunomide; Liver; Lymphocyte Count; Male; Random Allocation; Rats; Rats, Inbred Lew; Sirolimus

2012
Immunosuppressive drugs on inducing Ag-specific CD4(+)CD25(+)Foxp3(+) Treg cells during immune response in vivo.
    Transplant immunology, 2012, Volume: 27, Issue:1

    Topics: Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; Cell Count; Cyclophosphamide; Cyclosporine; Fingolimod Hydrochloride; Forkhead Transcription Factors; Immune Tolerance; Immunity; Immunosuppressive Agents; Interleukin-2 Receptor alpha Subunit; Isoxazoles; Leflunomide; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, Transgenic; Mycophenolic Acid; Ovalbumin; Propylene Glycols; Sirolimus; Sphingosine; Spleen; T-Lymphocytes, Regulatory

2012
Treatment of Polyomavirus-Associated Nephropathy With the Association of Sirolimus and Leflunomide.
    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2015, Volume: 13, Issue:6

    Topics: Antiviral Agents; Humans; Isoxazoles; Kidney Diseases; Kidney Transplantation; Leflunomide; Polyomavirus Infections; Retrospective Studies; Sirolimus

2015
In Vitro Study Evaluating the Effect of Different Immunosuppressive Agents on Human Polyomavirus BK Replication.
    Transplantation proceedings, 2022, Volume: 54, Issue:7

    Topics: Antiviral Agents; BK Virus; Everolimus; Humans; Immunosuppressive Agents; Kidney Transplantation; Leflunomide; Mycophenolic Acid; Polyomavirus Infections; Sirolimus; Tacrolimus; Tumor Virus Infections; Viral Proteins

2022