leflunomide has been researched along with sirolimus in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (40.00) | 18.2507 |
| 2000's | 9 (25.71) | 29.6817 |
| 2010's | 11 (31.43) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Kahan, BD | 1 |
| Berry, GJ; Billingham, ME; Gregory, CR; Huang, X; Morris, RE; Rowan, R; Shorthouse, R | 1 |
| Chong, AS; Finnegan, A; Foster, P; Gebel, H; Jiang, XL; Petraitis, EE; Sankary, HN; Williams, JW | 1 |
| Groth, CG; Karlsson-Parra, A; Korsgren, O; Liu, J; Rafael, E; Sundberg, B; Tibell, A; Wallgren, AC; Wennberg, L; Zhu, S | 1 |
| Adams, B; Berry, GJ; Brazelton, T; Morris, RE; Reichenspurner, H; Reitz, BA; Shorthouse, R; Soni, V | 1 |
| Halloran, PF | 1 |
| Brazelton, TR; Morris, RE | 1 |
| Lin, Y; Vandeputte, M; Waer, M | 1 |
| Lin, Y; Waer, M | 1 |
| Hausen, B; Morris, RE | 1 |
| Waer, M | 1 |
| Gregory, CR | 1 |
| Bonham, CA; Gerber, DA; Thomson, AW | 1 |
| Gummert, JF; Ikonen, T; Morris, RE | 1 |
| Craigmill, AL; Gregory, CR; Kyles, AE | 1 |
| Dambrin, C; Klupp, J; Morris, RE | 1 |
| Ambach, A; Konstandin, M; Meuer, SC; Samstag, Y; Saunus, J; Wesselborg, S | 1 |
| Drosos, AA | 1 |
| Kushwaha, SS; Mayer, DF | 1 |
| Casadio, F; Corti, B; Croci, S; D'Errico Grigioni, A; Grigioni, WF; Landuzzi, L; Lollini, PL | 1 |
| Behnisch, B; Bergow, C; Boeger, R; Connolly, AJ; Deuse, T; Erben, RG; Ikeno, F; Pelletier, MP; Reichenspurner, H; Robbins, RC; Schrepfer, S | 1 |
| Hou, J; Li, J; Tang, DN; Wei, JM; Xu, Y; Yu, ZY | 1 |
| Liacini, A; Muruve, DA; Seamone, ME; Tibbles, LA | 1 |
| Basu, G; John, GT; Mani, SE; Manipadam, MT; Mohapatra, A | 1 |
| Mishra, OP; Mittal, R; Prasad, R; Singh, UK | 1 |
| Chen, X; Li, G; Li, X; Shen, B; Sun, S; Sun, Y; Zhao, J; Zou, X | 1 |
| Lei, T; Liu, G; Peng, J; Sun, C; Wang, R; Wu, T; Xu, K; Zhang, L; Zhao, Y | 1 |
| Chan, TM | 1 |
| Boucher, A; Collette, S; Dandavino, R; Lamarche, C; Senécal, L; Tran, D; Vallée, M | 1 |
| Cook, L; Foulke, L; J Conti, D; Keys, B; Lopez-Soler, RI; Stellrecht, K; Yang, D | 1 |
| Basile, G; Delbue, S; Dolci, M; Favi, E; Ferrante, P; Ferraresso, M; Signorini, L; Ticozzi, R; Villani, S | 1 |
15 review(s) available for leflunomide and sirolimus
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
New immunosuppressive drugs--pharmacologic approaches to alter immunoregulation.
Topics: Animals; Antimetabolites; Azathioprine; Biphenyl Compounds; Cell Differentiation; Cyclosporine; Guanidines; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocytes; Lymphokines; Oligonucleotides, Antisense; Polyenes; Receptors, Cytokine; Ribonucleosides; Signal Transduction; Sirolimus; Tacrolimus | 1994 |
Molecular mechanisms of new immunosuppressants.
Topics: Amino Acid Isomerases; B-Lymphocytes; Biphenyl Compounds; Calcineurin; Calmodulin-Binding Proteins; Carrier Proteins; Cyclosporine; Enzyme Inhibitors; Humans; Immunosuppressive Agents; IMP Dehydrogenase; Isoxazoles; Leflunomide; Mycophenolic Acid; Oxidoreductases; Peptidylprolyl Isomerase; Phosphoprotein Phosphatases; Polyenes; Purines; Pyrimidines; Receptors, Cytokine; Ribonucleosides; Signal Transduction; Sirolimus; T-Lymphocytes; Tacrolimus | 1996 |
Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide.
Topics: Animals; Autoimmune Diseases; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycophenolic Acid; Polyenes; Pyrimidine Nucleotides; Sirolimus; Tacrolimus; Xenobiotics | 1996 |
Review of immunosuppression for lung transplantation. Novel drugs, new uses for conventional immunosuppressants, and alternative strategies.
Topics: Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lung Transplantation; Lymphatic Irradiation; Methotrexate; Mycophenolic Acid; Photopheresis; Polyenes; Recurrence; Sirolimus; Tacrolimus | 1997 |
New immunosuppressive agents for organ transplantation.
Topics: Graft Rejection; Guanidines; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycophenolic Acid; Nitriles; Organ Transplantation; Polyenes; Sirolimus; Tacrolimus | 1997 |
Immunosuppressive approaches to the prevention of graft vascular disease.
Topics: Coronary Disease; Cyclosporine; Heart Transplantation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycophenolic Acid; Polyenes; Postoperative Complications; Sirolimus; Tacrolimus | 1998 |
Immunosuppressive agents: recent developments in molecular action and clinical application.
Topics: Cyclosporine; Guanidines; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Models, Biological; Mycophenolic Acid; Polyenes; Ribonucleosides; Sirolimus; T-Lymphocytes; Tacrolimus; Transplantation Immunology | 1998 |
Newer immunosuppressive drugs: a review.
Topics: Animals; Clinical Trials as Topic; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycophenolic Acid; Sirolimus; Tacrolimus | 1999 |
Pharmacodynamics of immunosuppressive drugs.
Topics: Animals; Cyclosporine; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mycophenolic Acid; Sirolimus; Tacrolimus | 2000 |
Newer immunosuppressive drugs: their potential role in rheumatoid arthritis therapy.
Topics: Animals; Arthritis, Rheumatoid; Cyclosporine; Cytokines; Gene Expression Regulation; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mitogen-Activated Protein Kinases; Mycophenolic Acid; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Sirolimus; Tacrolimus | 2002 |
Transplant immunosuppressant agents and their role in autoimmune rheumatic diseases.
Topics: Autoimmune Diseases; Azathioprine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Mycophenolic Acid; Rheumatic Diseases; Severity of Illness Index; Sirolimus; Tacrolimus; Transplants; Treatment Outcome | 2003 |
Immunosuppressive therapy in children.
Topics: Antilymphocyte Serum; Autoimmune Diseases; Azathioprine; Child; Cyclophosphamide; Cyclosporine; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mercaptopurine; Methotrexate; Mycophenolic Acid; Nitriles; Sirolimus; Tacrolimus | 2011 |
Treatment of severe lupus nephritis: the new horizon.
Topics: Antimalarials; Azathioprine; Biological Products; Cyclophosphamide; Cyclosporine; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lupus Nephritis; Mycophenolic Acid; Ribonucleosides; Severity of Illness Index; Sirolimus; Tacrolimus | 2015 |
JC polyomavirus nephropathy, a rare cause of transplant dysfunction: Case report and review of literature.
Topics: Biopsy; BK Virus; Creatinine; Graft Rejection; Humans; Immunoglobulins, Intravenous; Immunosuppression Therapy; Immunosuppressive Agents; Incidence; Isoxazoles; JC Virus; Kidney Failure, Chronic; Kidney Function Tests; Kidney Transplantation; Leflunomide; Male; Middle Aged; Mycophenolic Acid; Nephritis; Polymerase Chain Reaction; Polyomavirus Infections; Sirolimus; Tacrolimus; Transplantation, Homologous; Viremia | 2017 |
20 other study(ies) available for leflunomide and sirolimus
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Studies in experimental models of chronic rejection: use of rapamycin (sirolimus) and isoxazole derivatives (leflunomide and its analogue) for the suppression of graft vascular disease and obliterative bronchiolitis.
Topics: Animals; Bronchiolitis Obliterans; Cyclosporine; Graft Occlusion, Vascular; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Polyenes; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sirolimus; Tunica Intima | 1995 |
Leflunomide, a novel immunomodulatory agent: in vitro analyses of the mechanism of immunosuppression.
Topics: Cells, Cultured; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Polyenes; Sirolimus; T-Lymphocytes; Thymidine; Tritium | 1993 |
Immunosuppression with leflunomide and cyclosporine prevents pig-to-rat islet xenograft rejection.
Topics: Animals; Antibodies, Heterophile; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Immunosuppression Therapy; Immunosuppressive Agents; Islets of Langerhans Transplantation; Isoxazoles; Leflunomide; Male; Polyenes; Rats; Rats, Inbred Lew; Sirolimus; Swine; Tacrolimus; Transplantation, Heterologous | 1995 |
Obliterative airway disease after heterotopic tracheal xenotransplantation in a concordant rodent model: pathogenesis and treatment.
Topics: Airway Obstruction; Animals; Bronchiolitis Obliterans; Cricetinae; Cyclosporine; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mesocricetus; Polyenes; Rats; Rats, Inbred Lew; Sirolimus; Trachea; Transplantation, Heterologous | 1996 |
A short-term combination therapy with cyclosporine and rapamycin or leflunomide induces long-term heart allograft survival in a strongly immunogenic strain combination in rats.
Topics: Animals; Cyclosporine; Drug Therapy, Combination; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Male; Polyenes; Rats; Rats, Inbred Strains; Sirolimus | 1996 |
Progressive change in tolerance mechanisms after withdrawing combination immunosuppression with cyclosporine and rapamycine or leflunomide.
Topics: Animals; Cyclosporine; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immune Tolerance; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Leflunomide; Polyenes; Rats; Rats, Inbred Strains; Sirolimus; T-Lymphocytes; Time Factors; Transplantation, Homologous | 1996 |
Comparison of the in vitro antiproliferative effects of five immunosuppressive drugs on lymphocytes in whole blood from cats.
Topics: Animals; Cats; Cell Division; Coloring Agents; Concanavalin A; Cyclosporine; Dose-Response Relationship, Drug; Immunosuppressive Agents; Inhibitory Concentration 50; Isoxazoles; Leflunomide; Lymphocyte Activation; Mycophenolic Acid; Pokeweed Mitogens; Scintillation Counting; Sirolimus; Tacrolimus; Trypan Blue | 2000 |
The serine phosphatases PP1 and PP2A associate with and activate the actin-binding protein cofilin in human T lymphocytes.
Topics: Actin Depolymerizing Factors; Cyclosporine; Dexamethasone; Humans; Isoxazoles; Leflunomide; Microfilament Proteins; Mycophenolic Acid; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Sirolimus; T-Lymphocytes; Tacrolimus | 2000 |
Toward the definition of immunosuppressive regimens with antitumor activity.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Cyclosporine; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Isoxazoles; Jurkat Cells; Leflunomide; Liver Neoplasms; Mycophenolic Acid; Rhabdomyosarcoma; Sirolimus | 2005 |
Introducing the first polymer-free leflunomide eluting stent.
Topics: Animals; Cells, Cultured; Drug-Eluting Stents; Endothelial Cells; Enzyme Inhibitors; Humans; Isoxazoles; Leflunomide; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; Sirolimus; Tomography, Optical Coherence; Tunica Intima; Tunica Media | 2008 |
The effect of Malononitrilamides (FK778) on phenotypic properties of human peripheral dendritic cells.
Topics: Adjuvants, Immunologic; Alkynes; Antigens, CD; Cell Differentiation; Cell Survival; Cells, Cultured; Dendritic Cells; Flow Cytometry; Humans; Isoxazoles; Leflunomide; Nitriles; Phenotype; Reference Values; Sirolimus | 2009 |
Immunosuppressants: JC virus encephalopathy. Rare but fatal.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antirheumatic Agents; Humans; Immunosuppressive Agents; Isoxazoles; JC Virus; Leflunomide; Leukoencephalopathy, Progressive Multifocal; Mycophenolic Acid; Natalizumab; Rituximab; Sirolimus; Tacrolimus | 2009 |
Anti-BK virus mechanisms of sirolimus and leflunomide alone and in combination: toward a new therapy for BK virus infection.
Topics: Antigens, Viral; Antigens, Viral, Tumor; Antiviral Agents; BK Virus; Cell Line; Drug Therapy, Combination; Epithelial Cells; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Transplantation; Kidney Tubules; Leflunomide; Polymerase Chain Reaction; Polyomavirus Infections; Signal Transduction; Sirolimus; Transplantation Immunology | 2010 |
Leflunomide with low-dose everolimus for treatment of Kaposi's sarcoma in a renal allograft recipient.
Topics: Antineoplastic Agents; Everolimus; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Diseases; Kidney Transplantation; Leflunomide; Male; Middle Aged; Proto-Oncogene Proteins c-akt; Sarcoma, Kaposi; Sirolimus; Transplantation, Homologous; Treatment Outcome | 2011 |
Combined use of rapamycin and leflunomide in prevention of acute cardiac allografts rejection in rats.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Drug Therapy, Combination; Graft Rejection; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Isoxazoles; Kidney; Leflunomide; Liver; Lymphocyte Count; Male; Random Allocation; Rats; Rats, Inbred Lew; Sirolimus | 2012 |
Immunosuppressive drugs on inducing Ag-specific CD4(+)CD25(+)Foxp3(+) Treg cells during immune response in vivo.
Topics: Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; Cell Count; Cyclophosphamide; Cyclosporine; Fingolimod Hydrochloride; Forkhead Transcription Factors; Immune Tolerance; Immunity; Immunosuppressive Agents; Interleukin-2 Receptor alpha Subunit; Isoxazoles; Leflunomide; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, Transgenic; Mycophenolic Acid; Ovalbumin; Propylene Glycols; Sirolimus; Sphingosine; Spleen; T-Lymphocytes, Regulatory | 2012 |
Treatment of Polyomavirus-Associated Nephropathy With the Association of Sirolimus and Leflunomide.
Topics: Antiviral Agents; Humans; Isoxazoles; Kidney Diseases; Kidney Transplantation; Leflunomide; Polyomavirus Infections; Retrospective Studies; Sirolimus | 2015 |
In Vitro Study Evaluating the Effect of Different Immunosuppressive Agents on Human Polyomavirus BK Replication.
Topics: Antiviral Agents; BK Virus; Everolimus; Humans; Immunosuppressive Agents; Kidney Transplantation; Leflunomide; Mycophenolic Acid; Polyomavirus Infections; Sirolimus; Tacrolimus; Tumor Virus Infections; Viral Proteins | 2022 |