leflunomide has been researched along with pyrimidine in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Hartung, HP; Jung, S; Korn, T; Toyka, K | 1 |
| Glover, M; Jawad, AS; Soliotis, F | 1 |
| Arai, Y; Hakeda, Y; Kaneda, T; Kobayashi, Y; Kumegawa, M; Sato, T; Shin, K; Ueyama, S; Yoshida, Y | 1 |
| Stuhlmeier, KM | 1 |
| Chernyak, BV; Chumakov, PM; Evstafieva, AG; Khutornenko, AA; Roudko, VV; Vartapetian, AB | 1 |
| Asara, JM; Brown, KK; Spinelli, JB; Toker, A | 1 |
| Cao, S; Efstratiou, A; Igarashi, I; Kamyingkird, K; Mousa, AA; Nishikawa, Y; Salama, A; Tuvshintulga, B; Xuan, X; Yokoyama, N | 1 |
| Mathur, D; Mulholland, D; Ozturk, S; Parsons, R; Zhou, RW | 1 |
1 review(s) available for leflunomide and pyrimidine
| Article | Year |
|---|---|
Severe skin reaction after leflunomide and etanercept in a patient with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Drug Eruptions; Erythema; Etanercept; Female; Humans; Immunoglobulin G; Isoxazoles; Leflunomide; Pyrimidines; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2002 |
7 other study(ies) available for leflunomide and pyrimidine
| Article | Year |
|---|---|
Suppression of experimental autoimmune neuritis by leflunomide.
Topics: Adoptive Transfer; Animals; Autoantibodies; Calcium; Female; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Myelin Proteins; Neuritis, Autoimmune, Experimental; Pyrimidines; Rats; Rats, Inbred Lew; Sciatic Nerve; T-Lymphocytes | 2001 |
The active metabolite of leflunomide, A771726, inhibits both the generation of and the bone-resorbing activity of osteoclasts by acting directly on cells of the osteoclast lineage.
Topics: Aniline Compounds; Animals; Binding Sites; Bone Resorption; Carrier Proteins; Cell Differentiation; Cell Lineage; Cells, Cultured; Crotonates; Electrophoretic Mobility Shift Assay; Hydroxybutyrates; Isoxazoles; Leflunomide; Membrane Glycoproteins; Mice; NF-kappa B; Nitriles; Osteoclasts; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Rabbits; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Toluidines | 2004 |
Effects of leflunomide on hyaluronan synthases (HAS): NF-kappa B-independent suppression of IL-1-induced HAS1 transcription by leflunomide.
Topics: Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Enzyme Repression; Fibroblasts; Glucuronosyltransferase; Humans; Hyaluronan Synthases; Hyaluronic Acid; Immunosuppressive Agents; Interleukin-1; Isoxazoles; Leflunomide; NF-kappa B; Protein Transport; Pyrimidines; RNA, Messenger; Synovial Membrane; Transcription, Genetic; Uridine | 2005 |
Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway.
Topics: Apoptosis; Cell Line, Tumor; Cell Respiration; Dihydroorotate Dehydrogenase; Electron Transport Complex III; Humans; Isoxazoles; Leflunomide; Membrane Potential, Mitochondrial; Methacrylates; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Oxidoreductases Acting on CH-CH Group Donors; Potassium Cyanide; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Pyrimidines; Quinone Reductases; Reactive Oxygen Species; Signal Transduction; Thiazoles; Tumor Suppressor Protein p53; Up-Regulation | 2010 |
Adaptive Reprogramming of
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cellular Reprogramming; DNA Damage; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Isoxazoles; Leflunomide; Mice; Pyrimidines; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2017 |
Effects of dihydroorotate dehydrogenase (DHODH) inhibitors on the growth of Theileria equi and Babesia caballi in vitro.
Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Atovaquone; Babesia; Babesiosis; Biphenyl Compounds; Computational Biology; Dihydroorotate Dehydrogenase; Diminazene; Enzyme Inhibitors; Horse Diseases; Horses; Inhibitory Concentration 50; Isoxazoles; Leflunomide; Mice; Molecular Weight; Oxidoreductases Acting on CH-CH Group Donors; Phylogeny; Plasmodium berghei; Pyrimidines; Theileria; Theileriasis | 2017 |
Leflunomide triggers synthetic lethality in PTEN-deficient prostate cancer.
Topics: Animals; Cell Line; Cell Line, Tumor; Humans; Immunosuppressive Agents; Leflunomide; Male; Mice; Mice, Nude; Prostatic Neoplasms; PTEN Phosphohydrolase; Pyrimidines; Synthetic Lethal Mutations; Xenograft Model Antitumor Assays | 2020 |