Compounds > leflunomide

leflunomide and dinoprostone

leflunomide has been researched along with dinoprostone in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Jeske, S; Schlotte, V; Weithmann, KU1
Hamilton, LC; Vojnovic, I; Warner, TD1
Beneytout, JL; Bertin, P; Léger, DY; Liagre, B; Trèves, R; Vergne-Salle, P1
Bode, AM; Dong, Z; Heo, YS; Hwang, MK; Jung, SK; Kang, NJ; Lee, HJ; Lee, KW; Shin, BJ1

Other Studies

6 other study(ies) available for leflunomide and dinoprostone

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Effect of leflunomide on constitutive and inducible pathways of cellular eicosanoid generation.
    Agents and actions, 1994, Volume: 41, Issue:3-4

    Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Bone Marrow; Bone Marrow Cells; Crotonates; Dinoprostone; Humans; Hydroxybutyrates; Hydroxyeicosatetraenoic Acids; Indomethacin; Isoxazoles; Leflunomide; Leukotriene B4; Lipopolysaccharides; Mice; Neutrophils; Nitriles; Prostaglandin-Endoperoxide Synthases; Rabbits; Sheep; Toluidines

1994
A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner.
    British journal of pharmacology, 1999, Volume: 127, Issue:7

    Topics: 6-Ketoprostaglandin F1 alpha; Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Blotting, Western; Cell Survival; Crotonates; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; Humans; Hydroxybutyrates; In Vitro Techniques; Isoenzymes; Isoxazoles; Leflunomide; Macrophages; Male; Membrane Proteins; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitriles; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Substrate Specificity; Toluidines

1999
Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes.
    Cytokine, 2005, Sep-07, Volume: 31, Issue:5

    Topics: Active Transport, Cell Nucleus; Aniline Compounds; Anti-Inflammatory Agents; Apoptosis; Arthritis, Rheumatoid; Cells, Cultured; Crotonates; Cyclooxygenase 2; Cytokines; Dinoprostone; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxybutyrates; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-10; Interleukin-11; Interleukin-8; Isoxazoles; Leflunomide; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Receptors, Tumor Necrosis Factor, Type I; Sialoglycoproteins; Synovial Fluid; Time Factors; Toluidines; Trypsin

2005
Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression.
    Carcinogenesis, 2009, Volume: 30, Issue:2

    Topics: Animals; Anticarcinogenic Agents; Caffeic Acids; Cell Line, Tumor; Chlorogenic Acid; Coffee; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Female; Isoxazoles; Leflunomide; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Phosphorylation; Proto-Oncogene Proteins c-fyn; Pyrimidines; Quinic Acid; Skin; Ultraviolet Rays

2009