lead has been researched along with succimer in 178 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (8.99) | 18.7374 |
| 1990's | 59 (33.15) | 18.2507 |
| 2000's | 61 (34.27) | 29.6817 |
| 2010's | 32 (17.98) | 24.3611 |
| 2020's | 10 (5.62) | 2.80 |
| Authors | Studies |
|---|---|
| Dragovic, D; Friedheim, E; Graziano, JH; Kaul, B; Popovac, D | 1 |
| Friedheim, E; Graziano, JH; Leong, JK | 1 |
| Graziano, JH; Lolacono, NJ; Mitchell, ME; Moulton, T; Slavkovich, V; Zarate, C | 1 |
| Bauchner, H; Glotzer, DE | 1 |
| Bergamaschi, E; Cohen, A; Gonick, HC; Khalil-Manesh, F; Mutti, A | 1 |
| Flegal, AR; Smith, DR | 1 |
| Chisolm, JJ | 3 |
| Wegmann, K | 1 |
| Atkins, LM; Basinger, MA; Gale, GR; Jones, MM; Milligan, LB; Singh, PK; Smith, AB; Stone, A; Walker, EM | 1 |
| Mann, KV; Travers, JD | 1 |
| Banner, W | 1 |
| Flora, SJ; Tandon, SK | 2 |
| Aposhian, HV; Bruce, DC; Maiorino, RM | 1 |
| Atkins, LM; Gale, GR; Jones, MM; Singh, PK; Smith, AB; Xu, Z | 1 |
| Aposhian, HV; Fernando, Q; Rivera, M; Zheng, W | 1 |
| Graziano, JH; Kapoor, SC; LoIacono, NJ; Wielopolski, L | 1 |
| Aposhian, HV; Fernando, Q; Rivera, M | 1 |
| Dhawan, M; Flora, SJ; Singh, S; Tandon, SK | 1 |
| Cory-Slechta, DA | 1 |
| Graziano, JH; LoIacono, N; Silverberg, SJ; Siris, ES; Turgeon, L | 1 |
| Bankowska, J; Hine, C | 1 |
| Flora, SJ; Singh, S; Tandon, SK | 1 |
| Behar, R; Bentur, Y; Brook, JG; Taitelman, U | 1 |
| Kolton, L; Yaari, Y | 1 |
| Chen, LX; Ding, GS; Liang, YY; Shi, JM | 1 |
| Fang, X; Fernando, Q | 1 |
| Ahlquist, JT; Allen, EM; Banner, W; Nuttall, KL; Pappas, JB | 1 |
| Flora, GJ; Mathur, R; Prakash, AO; Seth, PK | 1 |
| Bhattacharya, R; Flora, SJ; Vijayaraghavan, R | 1 |
| Buchet, JP; de Jong, VJ; Lauwerys, RR; Louwerse, ES; Van Dijk, MA | 1 |
| Ahn, KD; Lee, BK; Schwartz, BS; Stewart, W | 1 |
| Blanusa, M; Jones, MM; Kostial, K; Piasek, M; Singh, PK | 1 |
| Chen, ZJ; Liang, YY; Tao, ZQ; Xu, XH; Yan, XM; Zhang, JS | 1 |
| Crick, J; Flegal, AR; Markowitz, ME; Rosen, JF; Smith, DR | 1 |
| Aposhian, HV; Dart, RC; Hassen, LV; Hurlbut, KM; Maiorino, RM; Mayersohn, M | 1 |
| Gonick, HC; Khalil-Manesh, F; Prins, B; Purdy, R; Ren, Q; Weber, MA; Weiler, EW | 1 |
| Atkins, LM; Basinger, MA; Gale, GR; Jones, MM; Smith, AB; Stone, A | 1 |
| Munné, P; Nogué, S; Sanz-Gallén, P; To-Figueras, J | 1 |
| Aposhian, HV; Aposhian, MM; Li, Y; Maiorino, RM; Polt, RL; Xu, ZF | 1 |
| Graef, JW; Liebelt, EL; Shannon, M | 1 |
| Mortensen, ME; Walson, PD | 1 |
| Casteel, SW; Chastain, CB; Faggella, AM; Nunn, JW; Ramsey, DT; Schaeffer, DJ | 1 |
| Cherian, MG; Goyer, RA; Jones, MM; Reigart, JR | 1 |
| Bernal, J; Ruvalcaba, S | 1 |
| Rhoads, GG; Rogan, WJ | 1 |
| Cline, HT; Jones, KW; Witte, S | 1 |
| Ercal, N; Grannemann, NH; Hammond, TC; Matthews, RH; Spitz, DR; Treeratphan, P | 1 |
| Gansow, OA; Garmestani, K; Jones, SB; Kozak, RW; Tiffany, LJ | 1 |
| Hashkanazi, R; Lifshitz, M; Phillip, M | 1 |
| Blanusa, M; Jones, MM; Kostial, K; Piasek, M; Restek-Samarozija, N; Singh, PK | 1 |
| Ahn, KD; Kelsey, K; Lee, BK; Schwartz, BS; Sithisarankul, P; Stewart, W; Strickland, PT | 1 |
| Evans, HL; Gong, Z | 1 |
| Bernal, J; Cribbs, LL; Lee, JH; Perez-Reyes, E | 1 |
| Grandjean, P; Guldager, B; Holmstrup, P; Jørgensen, PJ; Larsen, IB | 1 |
| Ding, Y; Gonick, HC; Vaziri, ND | 1 |
| Behari, JR; Misra, M | 1 |
| Burda, A; Gossman, W; Leikin, JB; Sigg, T; Umanos, J | 1 |
| Bayer, L; Smith, D; Strupp, BJ | 1 |
| Erçal, N; Gürer, H; Neal, R; Ozgünes, H; Spitz, DR | 1 |
| Mathur, N; Prasad, S; Singh, S; Tandon, SK | 1 |
| Amin, Z; Gordon, RA; Paloucek, FP; Roberts, G; Williams, RH | 1 |
| Blanusa, M; Corović, N; Jurasović, J; Pizent, A; Restek-Samarzija, N; Samarzija, M; Turk, R | 1 |
| Blanchard, J; Fernando, Q; Lott, JR; Pigman, EA | 1 |
| Chen, S; Dietert, RR; Golemboski, KA; Sanders, FS | 1 |
| Börjesson, J; Gerhardsson, L; Mattsson, S; Schütz, A; Skerfving, S | 1 |
| Links, JM; Schwartz, BS; Stewart, WF; Todd, AC | 1 |
| O'Connor, ME; Rich, D | 1 |
| McCabe, MJ; Pokorski, PL; Pounds, JG | 1 |
| Lever, SZ; Parsons, TL | 1 |
| Cremin, JD; Laughlin, NK; Luck, ML; Smith, DR | 2 |
| Calacsan, C; Cremin, J; Laughlin, NK; Luck, M; Smith, DR; Woolard, D | 1 |
| Arora, U; Flora, GJ; Seth, PK | 1 |
| Laughlin, NK; Luck, ML; Smith, DR; Woolard, D | 1 |
| McKinney, PE | 1 |
| Denver, MC; Galey, FD; Kass, PH; Tell, LA; Trupkiewicz, JG | 1 |
| Ahn, KD; Kim, YB; Lee, BK; Lee, GS; Lee, SS; Schwartz, BS | 1 |
| Kelsey, K; Lee, BK; Lee, GS; Schwartz, BS; Simon, D; Stewart, WF; Todd, AC | 1 |
| Ahn, KD; Lee, BK; Lee, GS; Moshier, EL; Schwartz, BS; Todd, AC | 1 |
| Ahn, KD; Bolla, KI; Hwang, KY; Kim, YB; Lee, BK; Lee, GS; Lee, SS; Parsons, PJ; Schwartz, BS; Simon, D; Stewart, WF; Todd, AC | 1 |
| Coresh, J; Schwartz, BS; Stewart, WF; Tassler, PL; Todd, AC | 1 |
| Chisolm, JJ; Dietrich, KN; Dockery, DW; Jones, RL; Radcliffe, J; Ragan, NB; Rhoads, GG; Rogan, WJ; Salganik, M; Ware, JH | 1 |
| Mushak, P; Rosen, JF | 1 |
| Junk, JE; Kent, M; Knight, TE | 1 |
| Lasky, RE; Laughlin, NK; Luck, ML | 1 |
| Farrar, HC; McLeane, LR; Wallace, M; Watson, J; White, K | 1 |
| Chambers-Emerson, J; Dethlefsen, M; McNutt, TK; Shah, R | 1 |
| Cordellini, S; Malvezzi, CK; Moreira, EG; Vassilieff, I; Vassilieff, VS | 1 |
| Binns, H; Shannon, M; Woolf, A | 1 |
| Buchanan, S; Kim, D; McGeehin, M; Noonan, G | 1 |
| Henretig, F | 1 |
| Shannon, M | 1 |
| Kelsey, K; Lee, BK; Lee, GS; Lee, SS; Schwartz, BS; Simon, D; Stewart, WF; Todd, AC | 1 |
| Bennett, PN; Gordon, JN; Taylor, A | 1 |
| Flora, SJ; Pande, M | 1 |
| Prasad, S; Siddiqui, MK; Singh, S; Srivastava, S; Tandon, SK | 1 |
| Dietrich, KN; Liu, X; Radcliffe, J; Ragan, NB; Rhoads, GG; Rogan, WJ | 1 |
| Muller, D; Nascimento, PC; Nogueira, CW; Rocha, JB; Soares, FA | 1 |
| Garza-Ocañas, L; Piñeyro-López, A; Torres-Alanís, O | 1 |
| Rademacher, DJ; Steinpreis, RE; Weber, DN | 1 |
| Calle, P; Cook, R; Hoogesteijn, AL; Kollias, G; Raphael, BL | 1 |
| Ko, KW; Meldrum, JB | 1 |
| Akanno, J; Akhtar, AJ; Funnyé, AS | 1 |
| Blanusa, M; Juresa, D; Kostial, K; Piasek, M; Sarić, M; Varnai, VM | 1 |
| Kuypers, M; Smith, D; Stangle, DE; Strawderman, MS; Strupp, BJ | 1 |
| Adubato, S; Bornschein, RL; Davoli, CT; Denckla, MB; Dietrich, KN; Dockery, DW; Fay, ME; Jones, RL; Radcliffe, J; Rhoads, GG; Rogan, WJ; Salganik, M; Schwarz, D; Ware, JH | 1 |
| Liu, NQ; Lu, ZB; Wang, XF; Zhang, J; Zhao, BL | 1 |
| Flora, SJ; Saxena, G | 1 |
| Flora, SJ; Kannan, GM; Mehta, A; Pande, M | 1 |
| Chen, A; Dietrich, KN; Radcliffe, J; Rogan, WJ; Ware, JH | 1 |
| Brent, RL; Florin, TA; Weitzman, M | 1 |
| Nogueira, CW; Rocha, JB; Santos, FW | 1 |
| Buchet, JP; Decerf, L; Haufroid, V; Hoet, P; Lavalleye, B; Lison, D | 1 |
| Chen, A; Radcliffe, J; Rogan, WJ; Schwarz, D | 1 |
| Deepak, KK; Madan, K; Makharia, G; Poojary, G; Sharma, PK | 1 |
| An, L; Jin, Y; Li, G; Liao, Y; Lu, C; Yang, J; Yu, F; Zhang, J; Zhi, X | 1 |
| Cai, B; Chen, A; Dietrich, KN; Radcliffe, J; Rogan, WJ | 1 |
| Flora, SJ; Mehta, A; Saxena, G | 1 |
| Auyang, ED; Bhattacharya, A; Bornschein, R; Dietrich, KN; Shukla, R | 1 |
| Flora, G; Flora, SJ; Mishra, M; Saxena, G | 1 |
| Flora, SJ; Gautam, P; Gill, KD; Kaur, P; Saxena, G | 1 |
| Jin, Y; Li, G; Li, Y; Liao, Y; Lu, C; Ren, Y; Yang, J; Yu, F; Zhao, Y | 1 |
| Addleman, RS; Choi, D; Fryxell, GE; Hongsirikarn, K; Sangvanich, T; Timchalk, C; Toloczko, MB; Warner, CL; Warner, MG; Yantasee, W | 1 |
| Krishnakumar, N; Palaniappan, PL; Sabhanayakam, S; Vadivelu, M | 1 |
| Chomchai, C; Hussain, J; McCullough, L; Petranovic, M; Woolf, AD | 1 |
| Hjelmhaug, J; Lobner, D; Rush, T | 1 |
| Krishnakumar, N; Palaniappan, PL; Vadivelu, M; Vijayasundaram, V | 1 |
| Lv, GY; Wang, HM; Xia, DZ; Yang, Q; Yu, XF | 1 |
| Shen, XM; Wu, SH; Xu, J; Yan, CH; Yu, GY; Yu, XG; Zou, XY; Zuo, Y | 1 |
| Bradberry, S; Sheehan, T; Vale, A | 1 |
| Aslani, MR; Mohri, M; Najarnezhad, V | 1 |
| Bradberry, S; Vale, A | 1 |
| Caldwell, KL; Cao, Y; Chen, A; Dietrich, KN; Jones, RL; Radcliffe, J; Rogan, WJ | 1 |
| Buters, JT; Eyer, F; Felgenhauer, N; Willi, RF; Zilker, T | 1 |
| Crinnion, WJ; Tran, JQ | 1 |
| Charlier, C; Denooz, R; Ho, G; Keutgens, A; Kotolenko, S; Schoofs, R | 1 |
| Cyrus, RM; Edwards, CQ; Pugh, MR; Stevens, MH; Stevens, SM; Woller, SC | 1 |
| Hou, B; Hu, X; Peng, L; Peng, S; Wang, L; Wang, Y; Wu, J; Xu, Y; Zhang, X; Zhao, M; Zheng, M | 1 |
| Crinnion, WJ | 1 |
| Jin, Y; Liao, Y; Liu, M; Liu, S; Xu, J; Yang, J; Yu, F | 1 |
| Chen, W; Liu, X; Tian, F; Wang, G; Zhai, Q; Zhang, H; Zhao, J | 1 |
| Dubey, M; Flora, SJ; Kushwaha, P; Pachauri, V; Yadav, A | 1 |
| Spriggs, D; Tsutsui, RS; Van Schalkwyk, J | 1 |
| Gottipolu, RR; Kadeyala, PK; Sannadi, S | 1 |
| Smith, D; Strupp, BJ | 1 |
| McKay, CA | 1 |
| Mongolu, S; Sharp, P | 1 |
| Bao, YT; Chen, Y; Feng, WW; Ji, PC; Li, Q; Ma, RH; Wu, J; Wu, XY; Yang, LQ; Zhou, ZX; Zou, Y | 1 |
| Cordellini, S; Gaspar, AF | 1 |
| Ahmed, O; Datta-Mitra, A | 1 |
| Daughtry, LK; Jones, AC; Rajanna, B; Rajanna, S; Velaga, MK; Yallapragada, PR | 1 |
| Yassa, HA | 1 |
| Chen, Y; Feng, W; Li, Q; Mao, G; Wang, W; Wu, X; Yang, L; Zhao, T; Zhou, Z; Zou, Y | 1 |
| Alcaraz-Contreras, Y; Gallegos-Corona, MA; Martínez-Alcaraz, ER; Martínez-Alfaro, M; Mendoza-Lozano, RP; Ramírez-Morales, MA; Vázquez-Guevara, MA | 1 |
| Bradberry, SM; de Vries, I; Hunault, CC; Meulenbelt, J; Olie, JD; Vale, JA; van Eijkeren, JC | 1 |
| Bradberry, SM; Clewell, HJ; de Vries, I; Hunault, CC; Meulenbelt, J; Olie, JD; Vale, JA; van Eijkeren, JC | 1 |
| Bischoff, K; de Matos, R; Walter, KM | 1 |
| Bai, Z; Feng, N; Guo, X; Liu, Z; Long, J; Mao, F; Mo, W; Sun, Y; Wang, S; Wei, X; Xiang, Y; Xiaoyang, W; Yang, C; Zhang, S; Zheng, L | 1 |
| Xie, Y; Zhou, G | 1 |
| El Zahran, T; Hindman, D; King, A; Morgan, BW; Ralston, A | 1 |
| Abu-Dari, KI; Ata, SA; Mubarak, MS; Tutunji, MF | 1 |
| Davuljigari, CB; Kumar, KP; Reddy, GR; Saritha, S | 1 |
| Ji, X; Li, S; Liu, J; Sun, S; Xu, J; Yan, C; Zhang, Y; Zhou, L | 1 |
| Feng, W; Guiju, S; Honglei, P; Huali, T; Jianghong, L; Ligang, Y; Shaokang, W | 1 |
| Miller, CA; Zhang, YV | 1 |
| Abdelrahman, SA; El-Kersh, MAL; Habashy, NH; Mogahed, FAK; Shaban, NZ; Talaat, IM | 1 |
| Abd El-Kader, SE; El-Kersh, MAL; Habashy, NH; Mogahed, FAK; Shaban, NZ | 1 |
| Balali-Mood, M; Banagozar Mohammadi, A; Moshiri, M; Vahabzadeh, M | 1 |
| Chiroma, SM; Fannami, IM; Garba, SH | 1 |
| Badrane, N; Chaoui, H; Elhamri, H; Fekhaoui, M; Jouhadi, Z; Kalouch, S; Moutawakil, BE; Rouzi, L; Salam, S | 1 |
| Smith, DR; Strupp, BJ | 1 |
| Kennedy, JM; Mycyk, MB; Routsolias, JC | 1 |
| Cohen, ET; Koziatek, C; Mahonski, S; Mohan, S; Smith, S; Su, MK | 1 |
10 review(s) available for lead and succimer
| Article | Year |
|---|---|
Chelation therapy to treat lead toxicity in children.
Topics: Chelation Therapy; Child; Humans; Lead; Lead Poisoning; Succimer | 1992 |
Succimer, an oral lead chelator.
Topics: Administration, Oral; Chelation Therapy; Drug Interactions; Drug Monitoring; Drug Stability; Humans; Lead; Lead Poisoning; Succimer | 1991 |
Evaluation of the potential role of chelation therapy in treatment of low to moderate lead exposures.
Topics: Animals; Chelating Agents; Chelation Therapy; Drug Evaluation; Edetic Acid; Humans; Lead; Lead Poisoning; Succimer | 1990 |
Chelation therapy for childhood lead poisoning. The changing scene in the 1990s.
Topics: Chelation Therapy; Child; Dimercaprol; Edetic Acid; Humans; Lead; Lead Poisoning; Penicillamine; Succimer | 1993 |
Aggressive approach in the treatment of acute lead encephalopathy with an extraordinarily high concentration of lead.
Topics: Brain Diseases; Child, Preschool; Dimercaprol; Edetic Acid; Environmental Exposure; Female; Humans; Iron Chelating Agents; Lead; Lead Poisoning; Paint; Polyethylene Glycols; Succimer; Therapeutic Irrigation | 1998 |
Lead poisoning treatment--a continuing need (commentary).
Topics: Chelating Agents; Chelation Therapy; Child; Child Development; Child, Preschool; Cognition Disorders; Environmental Exposure; Humans; Lead; Lead Poisoning; Randomized Controlled Trials as Topic; Succimer; Treatment Outcome | 2001 |
Arsenic and lead induced free radical generation and their reversibility following chelation.
Topics: Acetylcysteine; Adjuvants, Pharmaceutic; Animals; Antioxidants; Arsenic; Arsenic Poisoning; Ascorbic Acid; Calcium; Chelating Agents; Free Radicals; Humans; Lead; Lead Poisoning; Melatonin; Metals; Micronutrients; Molecular Structure; Succimer; Taurine; Thioctic Acid; Unithiol; Vitamin E | 2007 |
A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning.
Topics: Administration, Oral; Animals; Antidotes; Chelating Agents; Clinical Trials as Topic; Edetic Acid; Humans; Lead; Lead Poisoning; Succimer | 2009 |
The scientific basis for chelation: animal studies and lead chelation.
Topics: Animals; Behavior, Animal; Body Burden; Brain; Chelating Agents; Chelation Therapy; Disease Models, Animal; Humans; Lead; Lead Poisoning; Risk Assessment; Risk Factors; Succimer; Time Factors; Treatment Outcome | 2013 |
Animal Models of Childhood Exposure to Lead or Manganese: Evidence for Impaired Attention, Impulse Control, and Affect Regulation and Assessment of Potential Therapies.
Topics: Adolescent; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Chelating Agents; Child; Humans; Lead; Manganese; Methylphenidate; Models, Animal; Succimer | 2023 |
18 trial(s) available for lead and succimer
| Article | Year |
|---|---|
Controlled study of meso-2,3-dimercaptosuccinic acid for the management of childhood lead intoxication.
Topics: Administration, Oral; Ambulatory Care; Aminolevulinic Acid; Calcium; Chelating Agents; Child; Child, Preschool; Dimercaprol; Edetic Acid; Erythrocytes; Follow-Up Studies; Humans; Infant; Injections, Intravenous; Lead; Lead Poisoning; Porphobilinogen Synthase; Safety; Succimer; Zinc | 1992 |
Provocative chelation with DMSA and EDTA: evidence for differential access to lead storage sites.
Topics: Adult; Chelation Therapy; Dose-Response Relationship, Drug; Edetic Acid; Environmental Monitoring; Humans; Korea; Lead; Male; Middle Aged; Occupational Exposure; Succimer; Time Factors | 1995 |
The effects of succimer on the absorption of lead in adults determined by using the stable isotope 204Pb.
Topics: Adult; Bone and Bones; Double-Blind Method; Feces; Humans; Intestinal Absorption; Isotopes; Lead; Male; Middle Aged; Succimer | 1994 |
Placebo response in environmental disease. Chelation therapy of patients with symptoms attributed to amalgam fillings.
Topics: Adult; Aged; Chelating Agents; Denmark; Dental Amalgam; Double-Blind Method; Environmental Illness; Female; Humans; Lead; Male; Mercury; Middle Aged; Placebo Effect; Succimer | 1997 |
The Treatment of Lead-exposed Children (TLC) trial: design and recruitment for a study of the effect of oral chelation on growth and development in toddlers.
Topics: Chelating Agents; Chelation Therapy; Child Development; Child, Preschool; Double-Blind Method; Housing; Humans; Infant; Lead; Lead Poisoning; Succimer; United States | 1998 |
Children with moderately elevated lead levels: is chelation with DMSA helpful?
Topics: Chelating Agents; Child, Preschool; Follow-Up Studies; Humans; Lead; Lead Poisoning; Succimer | 1999 |
Safety and efficacy of meso-2,3-dimercaptosuccinic acid (DMSA) in children with elevated blood lead concentrations.
Topics: Administration, Oral; Alkaline Phosphatase; Anemia, Sickle Cell; Antidotes; Chelating Agents; Child; Child, Preschool; Copper; Creatinine; Demography; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant; Lead; Lead Poisoning; Male; Metabolic Clearance Rate; Succimer; Treatment Outcome; Zinc | 2000 |
Safety and efficacy of succimer in toddlers with blood lead levels of 20-44 microg/dL. Treatment of Lead-Exposed Children (TLC) Trial Group.
Topics: Chelating Agents; Child, Preschool; Drug Eruptions; Humans; Infant; Lead; Lead Poisoning, Nervous System, Childhood; Safety; Scalp; Succimer; Wounds and Injuries | 2000 |
The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead.
Topics: Chelating Agents; Chelation Therapy; Child Behavior; Child Development; Child, Preschool; Cognition; Double-Blind Method; Female; Humans; Infant; Intelligence; Lead; Lead Poisoning; Male; Neuropsychological Tests; Poverty Areas; Succimer; Urban Population | 2001 |
A comparison of two dosing regimens of succimer in children with chronic lead poisoning.
Topics: Chelating Agents; Child; Child, Preschool; Chronic Disease; Drug Administration Schedule; Female; Humans; Infant; Lead; Lead Poisoning, Nervous System, Childhood; Male; Succimer | 1999 |
Do children with falling blood lead levels have improved cognition?
Topics: Chelating Agents; Child Development; Child, Preschool; Cognition Disorders; Double-Blind Method; Female; Humans; Infant; Lead; Lead Poisoning; Male; Neuropsychological Tests; Placebos; Succimer; Treatment Outcome | 2002 |
Effects of calcium disodium EDTA and meso-2,3-dimercaptosuccinic acid on tissue concentrations of lead for use in treatment of calves with experimentally induced lead toxicosis.
Topics: Animals; Bone and Bones; Brain Chemistry; Cattle; Chelating Agents; Drug Therapy, Combination; Edetic Acid; Kidney; Lead; Lead Poisoning; Liver; Male; Muscle, Skeletal; Succimer; Testis | 2003 |
Effect of chelation therapy on the neuropsychological and behavioral development of lead-exposed children after school entry.
Topics: Chelating Agents; Chelation Therapy; Child; Child Behavior; Child Development; Child, Preschool; Double-Blind Method; Environmental Exposure; Humans; Infant; Intelligence; Lead; Lead Poisoning; Neuropsychological Tests; Succimer | 2004 |
IQ and blood lead from 2 to 7 years of age: are the effects in older children the residual of high blood lead concentrations in 2-year-olds?
Topics: Age Factors; Chelating Agents; Child; Child Development; Child, Preschool; Cognition Disorders; Confounding Factors, Epidemiologic; Cross-Sectional Studies; Female; Humans; Intelligence; Lead; Lead Poisoning; Male; Placebos; Succimer | 2005 |
Clinical evaluation of a lead mobilization test using the chelating agent dimercaptosuccinic acid.
Topics: Adult; Chelating Agents; Copper; Environmental Pollutants; Female; Humans; Lead; Lead Poisoning; Male; Middle Aged; Occupational Diseases; Succimer; Zinc | 2006 |
Effect of succimer chelation therapy on postural balance and gait outcomes in children with early exposure to environmental lead.
Topics: Cerebellum; Chelating Agents; Child, Preschool; Cohort Studies; Edetic Acid; Environmental Exposure; Female; Gait; Humans; Infant; Lead; Lead Poisoning, Nervous System, Childhood; Male; Mechanoreceptors; Neural Pathways; Postural Balance; Psychomotor Performance; Socioeconomic Factors; Succimer; Vestibule, Labyrinth | 2007 |
Does background postnatal methyl mercury exposure in toddlers affect cognition and behavior?
Topics: Age Factors; Antidotes; Child Behavior Disorders; Child Development; Child, Preschool; Cognition; Cognition Disorders; Female; Humans; Infant; Intelligence; Lead; Lead Poisoning, Nervous System, Childhood; Longitudinal Studies; Male; Mercury Poisoning, Nervous System; Methylmercury Compounds; Neuropsychological Tests; Statistics as Topic; Succimer | 2010 |
Therapeutic efficiency of succimer used with calcium and ascorbic acid in the treatment of mild lead-poisoning.
Topics: Aging; Animals; Ascorbic Acid; Bone and Bones; Calcium Carbonate; Chelating Agents; Child; Child, Preschool; Colorimetry; Environmental Exposure; Female; Free Radical Scavengers; Humans; Lead; Lead Poisoning; Male; Mice; Porphobilinogen Synthase; Succimer | 2011 |
150 other study(ies) available for lead and succimer
| Article | Year |
|---|---|
Treatment of lead poisoning by 2,3-dimercaptosuccinic acid.
Topics: Administration, Oral; Adult; Chemical Phenomena; Chemistry; Drug Administration Schedule; Drug Evaluation; Edetic Acid; Humans; Injections, Intravenous; Lead; Lead Poisoning; Metallurgy; Middle Aged; Succimer; Sulfhydryl Compounds | 1978 |
2,3-Dimercaptosuccinic acid: a new agent for the treatment of lead poisoning.
Topics: Animals; Dimercaprol; Lead; Lead Poisoning; Male; Mice; Rats; Succimer; Sulfhydryl Compounds | 1978 |
Management of childhood lead poisoning: a survey.
Topics: Chelating Agents; Child; Clinical Protocols; Drug Utilization; Edetic Acid; Humans; Lead; Lead Poisoning; Penicillamine; Succimer; United States | 1992 |
Experimental model of lead nephropathy. II. Effect of removal from lead exposure and chelation treatment with dimercaptosuccinic acid (DMSA).
Topics: Acetylglucosaminidase; Albuminuria; Animals; Blood Urea Nitrogen; Creatinine; Erythrocyte Membrane; Glomerular Filtration Rate; Glutathione Transferase; Hematocrit; Kidney; Kidney Diseases; Lead; Lead Poisoning; Male; Rats; Rats, Inbred Strains; Silicon; Sodium-Potassium-Exchanging ATPase; Succimer | 1992 |
Stable isotopic tracers of lead mobilized by DMSA chelation in low lead-exposed rats.
Topics: Animals; Female; Isotopes; Lead; Rats; Rats, Inbred Strains; Succimer; Tissue Distribution | 1992 |
BAL, EDTA, DMSA and DMPS in the treatment of lead poisoning in children.
Topics: Administration, Oral; Beverages; Chelation Therapy; Child; Child, Preschool; Dimercaprol; Edetic Acid; Female; Housing; Humans; Infant; Lead; Lead Poisoning; Male; Penicillamine; Succimer; Unithiol | 1992 |
Mobilization of lead in mice by administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid.
Topics: Animals; Brain; Esters; Kidney; Lead; Lethal Dose 50; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Succimer | 1992 |
Succimer: controversial issues involving the release of a new product.
Topics: Chelation Therapy; Humans; Lead; Succimer; United States; United States Food and Drug Administration | 1991 |
Beneficial effects of zinc supplementation during chelation treatment of lead intoxication in rats.
Topics: Acetates; Acetic Acid; Administration, Oral; Aminolevulinic Acid; Animals; Chelation Therapy; Drug Therapy, Combination; Edetic Acid; Lead; Lead Poisoning; Male; Penicillamine; Porphobilinogen Synthase; Protoporphyrins; Rats; Succimer | 1990 |
Determination and metabolism of dithiol chelating agents. VI. Isolation and identification of the mixed disulfides of meso-2,3-dimercaptosuccinic acid with L-cysteine in human urine.
Topics: Adult; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Copper; Cysteine; Cystinuria; Disulfides; Humans; Lead; Male; Species Specificity; Succimer; Sulfhydryl Compounds; Zinc | 1989 |
Mobilization of lead by esters of meso-2,3-dimercaptosuccinic acid.
Topics: Animals; Esters; Lead; Lead Radioisotopes; Liver; Male; Mice; Mice, Inbred Strains; Structure-Activity Relationship; Succimer; Sulfhydryl Compounds; Tissue Distribution | 1989 |
Determination and metabolism of dithiol chelating agents. VIII. Metal complexes of meso-dimercaptosuccinic acid.
Topics: Animals; Bile; Binding Sites; Cadmium; Chelating Agents; Esterification; Lead; Male; Mercury; Potentiometry; Rats; Rats, Inbred Strains; Succimer; Sulfhydryl Compounds | 1989 |
Therapeutic efficacy of dimercaptosuccinic acid and thiamine/ascorbic acid on lead intoxication in rats.
Topics: Aminolevulinic Acid; Animals; Ascorbic Acid; Lead; Lead Poisoning; Male; Porphobilinogen Synthase; Protoporphyrins; Rats; Succimer; Sulfhydryl Compounds; Thiamine | 1989 |
Influence of 2,3-dimercaptosuccinic acid on gastrointestinal lead absorption and whole-body lead retention.
Topics: Administration, Oral; Animals; Body Burden; Injections, Intraperitoneal; Intestinal Absorption; Lead; Rats; Rats, Inbred Strains; Succimer; Sulfhydryl Compounds | 1989 |
Lead chelates of meso- and racemic-dimercaptosuccinic acid.
Topics: Chelating Agents; Hydrogen-Ion Concentration; Lead; Molecular Structure; Potentiometry; Solubility; Solutions; Spectrophotometry, Infrared; Stereoisomerism; Succimer; Sulfhydryl Compounds | 1989 |
Chelation of lead during co-exposure to ethanol.
Topics: Acrylates; Animals; Chelating Agents; Edetic Acid; Ethanol; Lead; Lead Poisoning; Male; Penicillamine; Rats; Succimer; Sulfhydryl Compounds | 1989 |
Mobilization of lead over the course of DMSA chelation therapy and long-term efficacy.
Topics: Analysis of Variance; Animals; Chelating Agents; Lead; Lead Poisoning; Rats; Succimer; Sulfhydryl Compounds; Time Factors; Tissue Distribution | 1988 |
2,3-Dimercaptosuccinic acid as an antidote for lead intoxication.
Topics: Administration, Oral; Adult; Aminolevulinic Acid; Analysis of Variance; Drug Evaluation; Humans; Lead; Lead Poisoning; Male; Middle Aged; Occupational Diseases; Porphobilinogen Synthase; Random Allocation; Spectrophotometry, Atomic; Succimer; Sulfhydryl Compounds | 1985 |
Retention of lead in the rat.
Topics: Animals; Chelating Agents; Diet; Edetic Acid; Lead; Male; Rats; Rats, Inbred Strains; Succimer | 1985 |
Chelation in metal intoxication XXI: Chelation in lead intoxication during vitamin B complex deficiency.
Topics: Aminolevulinic Acid; Animals; Body Burden; Chelating Agents; Edetic Acid; Lead; Lead Poisoning; Male; Rats; Succimer; Vitamin B Deficiency | 1986 |
Meso-2,3-dimercaptosuccinic acid in the diagnosis and treatment of lead poisoning.
Topics: Adult; Bread; Edetic Acid; Food Contamination; Humans; Lead; Lead Poisoning; Male; Succimer; Sulfhydryl Compounds | 1987 |
Sites of action of lead on spontaneous transmitter release from motor nerve terminals.
Topics: Animals; Calcium; Cell Membrane Permeability; Edetic Acid; In Vitro Techniques; Lead; Membrane Potentials; Motor Endplate; Neuromuscular Junction; Neurotransmitter Agents; Rana ridibunda; Succimer | 1982 |
[Dimercaptosuccinic acid per os promoted the excretions of Pb, Cu, Sb, Sr, Tl and Pm (author's transl)].
Topics: Animals; Antimony; Copper; Dogs; Lead; Lethal Dose 50; Metals; Mice; Promethium; Rabbits; Rats; Strontium; Succimer; Sulfhydryl Compounds; Thallium | 1980 |
Stereoisomeric selectivity of 2,3-dimercaptosuccinic acids in chelation therapy for lead poisoning.
Topics: Chelating Agents; Hydrogen-Ion Concentration; Lead; Lead Poisoning; Ligands; Potentiometry; Sodium; Spectrophotometry, Infrared; Stereoisomerism; Succimer | 1995 |
Oral dimercaptosuccinic acid and ongoing exposure to lead: effects on heme synthesis and lead distribution in a rat model.
Topics: Administration, Oral; Animals; Heme; Lead; Male; Rats; Rats, Sprague-Dawley; Succimer | 1995 |
Therapeutic efficacy of combined meso 2,3-dimercaptosuccinic acid and calcium disodium edetate treatment during acute lead intoxication in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Aminolevulinic Acid; Animals; Aspartate Aminotransferases; Drug Therapy, Combination; Edetic Acid; Glutathione; Hemoglobins; Kidney; Lead; Lead Poisoning; Liver; Male; Porphobilinogen Synthase; Proteinuria; Rats; Succimer | 1995 |
Combined therapeutic potential of meso-2,3-dimercaptosuccinic acid and calcium disodium edetate on the mobilization and distribution of lead in experimental lead intoxication in rats.
Topics: Alkaline Phosphatase; Animals; Brain Chemistry; Copper; Drug Therapy, Combination; Edetic Acid; Femur; Kidney; Lead; Lead Poisoning; Liver; Male; Rats; Rats, Wistar; Succimer; Transaminases; Zinc | 1995 |
Urinary excretion of lead and mercury after oral administration of meso-2,3-dimercaptosuccinic acid in patients with motor neurone disease.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Case-Control Studies; Chelation Therapy; Female; Humans; Lead; Male; Mercury; Middle Aged; Muscular Atrophy, Spinal; Succimer | 1995 |
Reduction of lead retention by mono-3-methylbutan-1-yl meso-2,3-dimercaptosuccinate in suckling rats.
Topics: Animals; Animals, Suckling; Bone and Bones; Brain; Chelating Agents; Kidney; Lead; Liver; Rats; Rats, Wistar; Spectrophotometry, Atomic; Succimer | 1995 |
[Effect of dimercaptosuccinic acid per os on distribution and excretion of 210Pb and 203Hg in mice].
Topics: Animals; Lead; Lead Poisoning; Male; Mercury; Mercury Poisoning; Mice; Succimer; Tissue Distribution | 1994 |
Pharmacokinetics of meso-2,3-dimercaptosuccinic acid in patients with lead poisoning and in healthy adults.
Topics: Adult; Age Factors; Case-Control Studies; Child; Child, Preschool; Female; Humans; Lead; Lead Poisoning; Male; Middle Aged; Succimer | 1994 |
Effect of chelation treatment with dimercaptosuccinic acid (DMSA) on lead-related blood pressure changes.
Topics: Animals; Blood Pressure; Chelation Therapy; Cyclic GMP; Endothelins; Lead; Male; Rats; Rats, Sprague-Dawley; Succimer | 1994 |
Effect of chelate treatments on kidney, bone and brain lead levels of lead-intoxicated mice.
Topics: Animals; Bone and Bones; Brain; Brain Chemistry; Chelating Agents; Edetic Acid; Injections, Intraperitoneal; Kidney; Lead; Lead Poisoning; Mice; Pentetic Acid; Spectrophotometry, Atomic; Succimer | 1994 |
[2,3-dimercaptosuccinic acid: a new chelating agent, safe and efficacious, for lead poisoning].
Topics: Chelation Therapy; Humans; Lead; Lead Poisoning; Male; Middle Aged; Occupational Diseases; Succimer | 1993 |
Determination and metabolism of dithiol chelating agents. XV. The meso-2,3-dimercaptosuccinic acid-cysteine (1:2) mixed disulfide, a major urinary metabolite of DMSA in the human, increases the urinary excretion of lead in the rat.
Topics: Animals; Biotransformation; Chelating Agents; Cysteine; Kidney; Lead; Male; Rats; Rats, Sprague-Dawley; Succimer; Tissue Distribution | 1993 |
Efficacy of oral meso-2,3-dimercaptosuccinic acid therapy for low-level childhood plumbism.
Topics: Adolescent; Child; Child, Preschool; Cohort Studies; Female; Humans; Infant; Lead; Lead Poisoning; Male; Retrospective Studies; Succimer; Treatment Outcome | 1994 |
Use of orally administered succimer (meso-2,3-dimercaptosuccinic acid) for treatment of lead poisoning in dogs.
Topics: Administration, Oral; Administration, Rectal; Animals; Chelating Agents; Dog Diseases; Dogs; Female; Lead; Lead Poisoning; Male; Prospective Studies; Succimer | 1996 |
Role of chelating agents for prevention, intervention, and treatment of exposures to toxic metals.
Topics: Chelating Agents; Chelation Therapy; Edetic Acid; Humans; Lead; Mercury; Penicillamine; Succimer | 1995 |
Pharmacological prevention of acute lead poisoning in Paramecium.
Topics: Animals; Antidotes; Ascorbic Acid; Cations, Divalent; Cell Membrane; Chelating Agents; Cilia; Edetic Acid; Lead; Paramecium; Succimer; Sulfonamides; Swimming; Time Factors | 1996 |
Treatment of lead-exposed children.
Topics: Body Surface Area; Chelating Agents; Child; Child, Preschool; Humans; Lead; Lead Poisoning; Succimer | 1996 |
Low lead levels stunt neuronal growth in a reversible manner.
Topics: Animals; Calcium Channels; Electrophysiology; Lead; Neurons; Polyvinyls; Rana pipiens; Succimer; Superior Colliculi; Synaptic Transmission | 1996 |
In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetylcysteine.
Topics: Acetylcysteine; Animals; Brain; Cysteine; Glutathione; Lead; Liver; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Oxidative Stress; Succimer | 1996 |
Evaluation of dithiol chelating agents as potential adjuvants for anti-IL-2 receptor lead or bismuth alpha radioimmunotherapy.
Topics: Adjuvants, Immunologic; Animals; Bismuth; Cell Division; Cell Survival; Chelating Agents; Female; Flow Cytometry; Indicators and Reagents; Lead; Lead Radioisotopes; Mice; Mice, Nude; Radioimmunotherapy; Radioisotopes; Rats; Receptors, Interleukin-2; Succimer; Sulfhydryl Compounds; Tumor Cells, Cultured; Unithiol | 1996 |
The effect of 2,3 dimercaptosuccinic acid in the treatment of lead poisoning in adults.
Topics: Administration, Oral; Adult; Aged; Humans; Lead; Lead Poisoning; Middle Aged; Succimer | 1997 |
Comparative in vivo lead mobilization of meso- and rac-2,3-dimercaptosuccinic acids in albino Wistar rats.
Topics: Animals; Body Weight; Brain Chemistry; Female; Femur; Kidney; Lead; Liver; Rats; Rats, Wistar; Stereoisomerism; Succimer | 1997 |
delta-Aminolevulinic acid dehydratase genotype modifies four hour urinary lead excretion after oral administration of dimercaptosuccinic acid.
Topics: Administration, Oral; Adult; Biomarkers; Chelating Agents; Chromatography, High Pressure Liquid; Genotype; Humans; Lead; Male; Middle Aged; Occupational Exposure; Polymerase Chain Reaction; Porphobilinogen Synthase; Predictive Value of Tests; Random Allocation; Succimer | 1997 |
Effect of chelation with meso-dimercaptosuccinic acid (DMSA) before and after the appearance of lead-induced neurotoxicity in the rat.
Topics: Animals; Behavior, Animal; Body Weight; Brain Chemistry; Central Nervous System Diseases; Chelating Agents; Drinking; Glial Fibrillary Acidic Protein; Lead; Male; Rats; Rats, Inbred F344; Succimer | 1997 |
Full reversal of Pb++ block of L-type Ca++ channels requires treatment with heavy metal antidotes.
Topics: Animals; Antidotes; Calcium Channel Blockers; Dose-Response Relationship, Drug; Edetic Acid; Humans; Lead; Rabbits; Succimer; Xenopus laevis | 1997 |
Lead-induced hypertension. II. Response to sequential infusions of L-arginine, superoxide dismutase, and nitroprusside.
Topics: Animals; Arginine; Blood Pressure; Hypertension; Lead; Male; Malondialdehyde; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Succimer; Superoxide Dismutase | 1998 |
Effect of liposome-encapsulated meso-2,3-dimercaptosuccinic acid on mice exposed to lead through drinking water.
Topics: Animals; Chelating Agents; Drug Carriers; Lead; Liposomes; Male; Mice; Succimer; Water Supply | 1997 |
A report of pediatric SUCCIMER overdose.
Topics: Antidotes; Cathartics; Charcoal; Chelating Agents; Child, Preschool; Female; Humans; Lead; Lead Poisoning; Sorbitol; Succimer | 1998 |
Efficacy of succimer chelation for reducing brain Pb levels in a rodent model.
Topics: Administration, Oral; Animals; Animals, Newborn; Brain; Brain Chemistry; Chelating Agents; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Lead; Lead Poisoning; Male; Random Allocation; Rats; Succimer | 1998 |
Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats.
Topics: Acetylcysteine; Animals; Antioxidants; Blood Cell Count; Erythrocytes; Glutathione; Lead; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Inbred F344; Succimer | 1998 |
Mobilization of lead by calcium versenate and dimercaptosuccinate in the rat.
Topics: Animals; Body Burden; Bone and Bones; Brain; Calcium; Chelating Agents; Edetic Acid; Iron; Lead; Male; Rats; Succimer; Zinc | 1998 |
Meso-2,3-dimercaptosuccinic acid in the treatment of occupationally exposed lead workers.
Topics: Adult; Chelating Agents; Humans; Lead; Lead Poisoning; Male; Middle Aged; Occupational Exposure; Succimer | 1998 |
Use of the Caco-2 cell model to assess the relative lead-chelating ability of diasterioisomers of 2,3-dimercaptosuccinic acid.
Topics: Caco-2 Cells; Cell Membrane; Cell Survival; Chelating Agents; Humans; Lead; Spectrometry, X-Ray Emission; Stereoisomerism; Succimer | 1999 |
Persistent effect of in utero meso-2,3-dimercaptosuccinic acid (DMSA) on immune function and lead-induced immunotoxicity.
Topics: Animals; Antidotes; Cells, Cultured; Chelating Agents; Cytokines; Embryonic and Fetal Development; Female; Hypersensitivity, Delayed; Immune System; Lactation; Lead; Macrophages; Male; Milk; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred F344; Spleen; Succimer | 1999 |
Chelated lead in relation to lead in bone and ALAD genotype.
Topics: Age Factors; Body Burden; Bone and Bones; Chelating Agents; Dose-Response Relationship, Drug; Fingers; Genotype; Humans; Lead; Mass Spectrometry; Metallurgy; Occupational Exposure; Porphobilinogen Synthase; Regression Analysis; Retirement; Spectrometry, X-Ray Emission; Spectrophotometry, Atomic; Succimer; Time Factors | 1999 |
Predictors of dimercaptosuccinic acid chelatable lead and tibial lead in former organolead manufacturing workers.
Topics: Adult; Aged; Aging; Chelating Agents; Chemical Industry; Cross-Sectional Studies; Environmental Monitoring; Humans; Lead; Linear Models; Middle Aged; Occupational Exposure; Risk Factors; Succimer; Tibia | 1999 |
Lead inhibits meso-2,3-dimercaptosuccinic acid induced calcium transients in cultured rhesus monkey kidney cells.
Topics: Animals; Calcium; Cells, Cultured; Chelating Agents; Kidney; Lead; Macaca mulatta; Succimer | 1999 |
The presence of lead decreases the availability of meso-2, 3-dimercaptosuccinic acid for analysis in the monobromobimane assay.
Topics: Bridged Bicyclo Compounds; Chelating Agents; Chromatography, High Pressure Liquid; Dithiothreitol; Edetic Acid; Lead; Organometallic Compounds; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Succimer; Sulfhydryl Compounds; Sulfhydryl Reagents | 1999 |
Efficacy of succimer chelation for reducing brain lead in a primate model of human lead exposure.
Topics: Animals; Brain; Chelating Agents; Chelation Therapy; Disease Models, Animal; Environmental Exposure; Humans; Lead; Lead Poisoning, Nervous System; Macaca mulatta; Male; Succimer | 1999 |
Succimer and the urinary excretion of essential elements in a primate model of childhood lead exposure.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Lead; Lead Poisoning; Macaca mulatta; Male; Succimer; Trace Elements | 2000 |
Influence of combined therapeutic potential of meso 2,3-dimercaptosuccinic acid and calcium disodium edetate on lead-induced testicular alterations in rats.
Topics: Animals; Chelating Agents; Edetic Acid; Lead; Male; Rats; Succimer; Testicular Neoplasms; Testis | 1999 |
Succimer and the reduction of tissue lead in juvenile monkeys.
Topics: Animals; Body Burden; Chelating Agents; Female; Lead; Macaca mulatta; Succimer | 2000 |
Acute elevation of blood lead levels within hours of ingestion of large quantities of lead shot.
Topics: Antidotes; Bisacodyl; Child, Preschool; Dietary Fiber; Female; Foreign Bodies; Humans; Lead; Lead Poisoning; Radiography; Stomach; Succimer; Therapeutic Irrigation; Treatment Outcome | 2000 |
Comparison of two heavy metal chelators for treatment of lead toxicosis in cockatiels.
Topics: Animals; Bird Diseases; Body Weight; Chelating Agents; Edetic Acid; Female; Kidney; Lead; Lead Poisoning; Liver; Male; Psittaciformes; Random Allocation; Spectrophotometry, Atomic; Spleen; Succimer; Survival Analysis; Thyroid Gland | 2000 |
A comparison of different lead biomarkers in their associations with lead-related symptoms.
Topics: Adult; Aminolevulinic Acid; Biomarkers; Case-Control Studies; Chelating Agents; Humans; Korea; Lead; Lead Poisoning; Linear Models; Logistic Models; Male; Occupational Diseases; Odds Ratio; Predictive Value of Tests; Protoporphyrins; Succimer; Surveys and Questionnaires | 2000 |
Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with polymorphisms in the vitamin D receptor and [delta]-aminolevulinic acid dehydratase genes.
Topics: Adolescent; Adult; Chelating Agents; Cross-Sectional Studies; Female; Humans; Lead; Male; Middle Aged; Occupational Exposure; Polymorphism, Genetic; Porphobilinogen Synthase; Receptors, Calcitriol; Succimer; Tibia; Tissue Distribution | 2000 |
Predictors of DMSA chelatable lead, tibial lead, and blood lead in 802 Korean lead workers.
Topics: Adult; Chelating Agents; Cross-Sectional Studies; Female; Humans; Korea; Lead; Longitudinal Studies; Male; Metallurgy; Middle Aged; Occupational Exposure; Regression Analysis; Risk Assessment; Succimer; Tibia | 2001 |
Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with neurobehavioral test scores in South Korean lead workers.
Topics: Adult; Case-Control Studies; Chelating Agents; Cross-Sectional Studies; Female; Humans; Korea; Lead; Lead Poisoning, Nervous System, Adult; Longitudinal Studies; Male; Middle Aged; Occupational Diseases; Occupational Exposure; Peripheral Nervous System Diseases; Psychomotor Performance; Radiography; Spectrometry, X-Ray Emission; Succimer; Tibia | 2001 |
Associations of tibia lead, DMSA-chelatable lead, and blood lead with measures of peripheral nervous system function in former organolead manufacturing workers.
Topics: Adult; Aged; Chemical Industry; Cohort Studies; Hand Strength; Humans; Lead; Male; Middle Aged; Motor Activity; Peripheral Nervous System; Radiography; Sensory Thresholds; Succimer; Tibia; Touch; Workforce | 2001 |
Primary prevention of childhood lead poisoning--the only solution.
Topics: Chelating Agents; Chelation Therapy; Child Development; Child, Preschool; Cognition; Cost Savings; Humans; Lead; Lead Poisoning; Primary Prevention; Succimer | 2001 |
Succimer for treatment of lead toxicosis in two cats.
Topics: Animals; Anorexia; Cat Diseases; Cats; Chelating Agents; Female; Kidney; Lead; Lead Poisoning; Liver; Seizures; Succimer; Tissue Distribution; Vomiting | 2001 |
Oral succimer decreases the gastrointestinal absorption of lead in juvenile monkeys.
Topics: Administration, Oral; Animals; Chelating Agents; Child; Disease Models, Animal; Female; Humans; Intestinal Absorption; Isotopes; Lead; Lead Poisoning; Macaca mulatta; Succimer | 2001 |
The effects of elevated blood lead levels and succimer chelation therapy on physical growth in developing rhesus monkeys.
Topics: Administration, Oral; Animals; Body Height; Body Weight; Chelating Agents; Cross-Over Studies; Environmental Exposure; Female; Lead; Lead Poisoning; Macaca mulatta; Random Allocation; Succimer; Treatment Outcome | 2001 |
Bite the bullet: lead poisoning after ingestion of 206 lead bullets.
Topics: Antidotes; Chelating Agents; Colon; Edetic Acid; Foreign Bodies; Gastrointestinal Hemorrhage; Humans; Lead; Lead Poisoning; Male; Middle Aged; Schizophrenia; Succimer; Suicide, Attempted; Therapeutic Irrigation; Treatment Outcome | 2001 |
Effect of L-arginine, dimercaptosuccinic acid (DMSA) and the association of L-arginine and DMSA on tissue lead mobilization and blood pressure level in plumbism.
Topics: Animals; Aorta; Arginine; Blood Pressure; Chelating Agents; Drug Therapy, Combination; Femur; Hypertension; Kidney; Lead; Lead Poisoning; Liver; Male; Rats; Rats, Wistar; Succimer | 2001 |
Chelation therapy in children exposed to lead.
Topics: Chelating Agents; Chelation Therapy; Child; Humans; Lead; Lead Poisoning; Penicillamine; Succimer; Unithiol | 2001 |
Treatment of children with elevated blood lead levels.
Topics: Chelating Agents; Chelation Therapy; Child; Humans; Lead; Lead Poisoning; Succimer | 2002 |
Lead poisoning prevention, not chelation (commentary).
Topics: Chelating Agents; Chelation Therapy; Child; Child Development; Child, Preschool; Cognition Disorders; Double-Blind Method; Humans; Lead; Lead Poisoning; Neuropsychological Tests; Randomized Controlled Trials as Topic; Succimer | 2001 |
Associations of lead biomarkers and delta-aminolevulinic acid dehydratase and vitamin D receptor genotypes with hematopoietic outcomes in Korean lead workers.
Topics: Adolescent; Adult; Biomarkers; Case-Control Studies; Chelating Agents; Cross-Sectional Studies; Female; Hematologic Tests; Hematopoiesis; Humans; Korea; Lead; Linear Models; Male; Middle Aged; Occupational Exposure; Polymorphism, Genetic; Porphobilinogen Synthase; Receptors, Calcitriol; Succimer; Tibia; Tissue Distribution | 2001 |
Lead poisoning: case studies.
Topics: Acute Disease; Adult; Chelating Agents; Edetic Acid; Humans; Lead; Lead Poisoning; Male; Middle Aged; Occupational Diseases; Succimer | 2002 |
Lead induced oxidative damage and its response to combined administration of alpha-lipoic acid and succimers in rats.
Topics: Animals; Antioxidants; Brain; Chelating Agents; Drug Therapy, Combination; Glutathione; Hematopoiesis; Kidney; Lead; Male; Oxidative Stress; Rats; Rats, Wistar; Succimer; Superoxide Dismutase; Thioctic Acid | 2002 |
Reversal of lead-induced oxidative stress by chelating agent, antioxidant, or their combination in the rat.
Topics: Acetylcysteine; Aminolevulinic Acid; Animals; Antioxidants; Brain; Catalase; Chelating Agents; Free Radical Scavengers; Glutathione; Kidney; Lead; Lead Poisoning; Male; Malondialdehyde; Oxidative Stress; Rats; Succimer | 2002 |
2,3-Dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase mercury- and cadmium-induced inhibition of delta-aminolevulinate dehydratase.
Topics: Animals; Cadmium; Chelating Agents; Drug Synergism; Enzyme Inhibitors; Lead; Male; Mercury; Mice; Polarography; Porphobilinogen Synthase; Succimer; Unithiol; Zinc | 2003 |
Effect of meso-2,3-dimercaptosuccinic acid on urinary lead excretion in exposed men.
Topics: Administration, Oral; Adult; Chelating Agents; Humans; Lead; Lead Poisoning; Male; Occupational Diseases; Succimer; Treatment Outcome | 2002 |
Effects of dietary lead and/or dimercaptosuccinic acid exposure on regional serotonin and serotonin metabolite content in rainbow trout (Oncorhynchus mykiss).
Topics: Animals; Antidotes; Brain Stem; Cerebellum; Chelating Agents; Diet; Hazardous Substances; Hydroxyindoleacetic Acid; Lead; Medulla Oblongata; Oncorhynchus mykiss; Serotonin; Succimer; Superior Colliculi | 2003 |
Oral treatment of avian lead intoxication with meso-2,3-dimercaptosuccinic acid.
Topics: Administration, Oral; Animals; Animals, Zoo; Bird Diseases; Birds; Chelating Agents; Lead; Lead Poisoning; Longitudinal Studies; Regression Analysis; Retrospective Studies; Succimer | 2003 |
Gunshot-induced plumbism in an adult male.
Topics: Abdominal Pain; Adult; Anemia, Hemolytic; Chelating Agents; Humans; Lead; Lead Poisoning; Male; Succimer; Time Factors; Wounds, Gunshot | 2003 |
Ascorbic acid supplementation does not improve efficacy of meso-dimercaptosuccinic acid treatment in lead-exposed suckling rats.
Topics: Administration, Oral; Animals; Animals, Suckling; Antidotes; Ascorbic Acid; Chelating Agents; Drug Synergism; Drug Therapy, Combination; Female; Lead; Lead Poisoning; Male; Rats; Rats, Wistar; Succimer | 2003 |
Reductions in blood lead overestimate reductions in brain lead following repeated succimer regimens in a rodent model of childhood lead exposure.
Topics: Animals; Biomarkers; Brain; Chelating Agents; Disease Models, Animal; Endpoint Determination; Female; Forecasting; Lead; Lead Poisoning; Male; Models, Theoretical; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Succimer; Tissue Distribution; Treatment Outcome | 2004 |
The effects of meso-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus.
Topics: Animals; Anthocyanins; Apoptosis; bcl-2-Associated X Protein; Chelating Agents; Free Radical Scavengers; Free Radicals; Glutathione; Glutathione Reductase; Hippocampus; Lead; Lead Poisoning; Lipid Peroxidation; Male; Neurons; Oxidation-Reduction; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Succimer; Time Factors | 2004 |
Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats.
Topics: Animals; Brain; Chelating Agents; Drug Therapy, Combination; Edetic Acid; Glutathione; Hemoglobins; Kidney; Lead; Lead Poisoning; Male; Metals; Oxidative Stress; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Wistar; Succimer; Unithiol | 2004 |
Lead induced oxidative stress and its recovery following co-administration of melatonin or N-acetylcysteine during chelation with succimer in male rats.
Topics: Acetylcysteine; Animals; Antioxidants; Brain; Brain Chemistry; Chelating Agents; Kidney; Lead; Lead Poisoning; Liver; Male; Melatonin; Oxidative Stress; Rats; Succimer | 2004 |
The need for vigilance: the persistence of lead poisoning in children.
Topics: Cheek; Chelation Therapy; Child, Preschool; Dimercaprol; Drug Therapy, Combination; Edema; Edetic Acid; Environmental Exposure; Foreign Bodies; Humans; Lead; Lead Poisoning; Male; Pica; Play and Playthings; Protoporphyrins; Seizures; Self-Injurious Behavior; Succimer; Wounds, Gunshot | 2005 |
2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase lead-induced inhibition of delta-aminolevulinate dehydratase in vitro and ex vivo.
Topics: Animals; Brain; Chelating Agents; Dimercaprol; Drug Synergism; Enzyme Inhibitors; Humans; In Vitro Techniques; Kidney; Lead; Liver; Male; Mice; Nerve Tissue Proteins; Porphobilinogen Synthase; Succimer; Unithiol | 2006 |
Maternal IQ, child IQ, behavior, and achievement in urban 5-7 year olds.
Topics: Achievement; Chelating Agents; Child; Child Behavior Disorders; Child, Preschool; Female; Humans; Intellectual Disability; Intelligence; Intelligence Tests; Lead; Lead Poisoning; Male; Mothers; Neuropsychological Tests; Random Allocation; Social Environment; Succimer; Urban Population | 2006 |
Autonomic dysfunction due to lead poisoning.
Topics: Adult; Anemia; Autonomic Nervous System Diseases; Chelating Agents; Erectile Dysfunction; Humans; Intestinal Pseudo-Obstruction; Lead; Lead Poisoning, Nervous System, Adult; Male; Medicine, Ayurvedic; Plants, Medicinal; Succimer | 2007 |
Therapeutic potentials of combined use of DMSA with calcium and ascorbic acid in the treatment of mild to moderately lead intoxicated mice.
Topics: Animals; Ascorbic Acid; Calcium; Drug Therapy, Combination; Female; Lead; Lead Poisoning; Mice; Porphobilinogen Synthase; Severity of Illness Index; Succimer; Vitamins | 2008 |
Lead exposure, IQ, and behavior in urban 5- to 7-year-olds: does lead affect behavior only by lowering IQ?
Topics: Age Distribution; Causality; Chelating Agents; Child; Child Behavior Disorders; Child, Preschool; Cognition Disorders; Comorbidity; Environmental Exposure; Environmental Monitoring; Epidemiological Monitoring; Female; Follow-Up Studies; Humans; Intelligence; Lead; Lead Poisoning, Nervous System, Childhood; Male; Odds Ratio; Regression Analysis; Succimer; United States; Urban Population | 2007 |
Reversal of lead-induced neuronal apoptosis by chelation treatment in rats: role of reactive oxygen species and intracellular Ca(2+).
Topics: Animals; Apoptosis; Behavior, Animal; Brain; Calcium; Chelating Agents; Edetic Acid; Lead; Male; Mitochondria; Neurons; Neurotransmitter Agents; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer | 2007 |
Response of lead-induced oxidative stress and alterations in biogenic amines in different rat brain regions to combined administration of DMSA and MiADMSA.
Topics: Amines; Animals; Brain; Copper; Erythrocytes; Heme; Lead; Male; Oxidative Stress; Rats; Rats, Wistar; Succimer; Zinc | 2007 |
Effects of in utero meso-2,3-dimercaptosuccinic acid with calcium and ascorbic acid on lead-induced fetal development.
Topics: Animals; Ascorbic Acid; Body Burden; Body Weight; Calcium Carbonate; Chelating Agents; Female; Fetal Development; Growth; Hemoglobins; Lead; Male; Mice; Nervous System; Pregnancy; Succimer | 2008 |
Direct detection of Pb in urine and Cd, Pb, Cu, and Ag in natural waters using electrochemical sensors immobilized with DMSA functionalized magnetic nanoparticles.
Topics: Animals; Cadmium; Chelating Agents; Copper; Electrochemistry; Environmental Monitoring; Environmental Pollutants; Ferric Compounds; Lead; Magnetics; Metal Nanoparticles; Metals, Heavy; Rats; Rats, Sprague-Dawley; Silver; Succimer; Water Pollutants, Chemical | 2008 |
Morphological changes due to Lead exposure and the influence of DMSA on the gill tissues of the freshwater fish, Catla catla.
Topics: Animals; Antidotes; Cyprinidae; Environmental Exposure; Fresh Water; Gills; Lead; Microscopy, Electron, Scanning; Succimer; Time Factors | 2008 |
Infantile lead poisoning from an Asian tongue powder: a case report & subsequent public health inquiry.
Topics: Chelating Agents; Drug Contamination; Edetic Acid; Fluorescence; Humans; Infant; Lead; Lead Poisoning; Male; Medicine, East Asian Traditional; Plant Preparations; Spectrometry, X-Ray Emission; Succimer; Thailand; Tongue | 2008 |
Effects of chelators on mercury, iron, and lead neurotoxicity in cortical culture.
Topics: Animals; Brain Chemistry; Cell Death; Cells, Cultured; Cerebral Cortex; Chelating Agents; Drug Synergism; Edetic Acid; Female; Iron; Lead; Mercuric Chloride; Methylmercury Compounds; Mice; Penicillamine; Pregnancy; Succimer; Thimerosal; Unithiol | 2009 |
The study of the changes in the biochemical and mineral contents of bones of Catla catla due to lead intoxication.
Topics: Animals; Bone and Bones; Bone Density; Cyprinidae; Lead; Lead Poisoning; Succimer; Water Pollutants, Chemical | 2010 |
[Antagonism of total flavonoids from Chrysanthemum morifolium against lead induced oxidative injury in mice].
Topics: Administration, Oral; Animals; Brain; Chrysanthemum; Copper; Drug Antagonism; Flavonoids; Kidney; Lead; Liver; Male; Mice; Mice, Inbred ICR; Oxidative Stress; Random Allocation; Succimer; Zinc | 2008 |
[Effects of chelation therapy with succimer in young rabbits of moderate lead poisoning].
Topics: Animals; Chelation Therapy; Lead; Lead Poisoning; Male; Rabbits; Succimer | 2009 |
Use of oral dimercaptosuccinic acid (succimer) in adult patients with inorganic lead poisoning.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antidotes; Chelating Agents; Chelation Therapy; Drug Evaluation; Female; Humans; Lead; Lead Poisoning; Male; Middle Aged; Succimer; Young Adult | 2009 |
Individual and combined effect of meso-2,3-dimercaptosuccinic acid and allicin on blood and tissue lead content in mice.
Topics: Animals; Bone and Bones; Chelating Agents; Disulfides; Drug Synergism; Drug Therapy, Combination; Female; Garlic; Lead; Lead Poisoning; Mice; Phytotherapy; Succimer; Sulfinic Acids | 2010 |
[Lead intoxication in a group of workers in Germany].
Topics: Antidotes; Chelating Agents; Germany; Humans; Kinetics; Lead; Lead Poisoning; Occupational Diseases; Occupational Exposure; Pain; Porphobilinogen Synthase; Succimer | 2009 |
Case report: heavy metal burden presenting as Bartter syndrome.
Topics: Bartter Syndrome; Beryllium; Cadmium; Chelating Agents; Failure to Thrive; Female; Glass; Humans; Infant; Lead; Male; Mercury; Metals, Heavy; Occupational Exposure; Pregnancy; Prenatal Exposure Delayed Effects; Succimer | 2010 |
Blood, urine, and hair kinetic analysis following an acute lead intoxication.
Topics: Chelating Agents; Chelation Therapy; Female; Hair; Humans; Kinetics; Lead; Lead Poisoning; Middle Aged; Succimer; Unithiol | 2011 |
Treatment of chronic lead toxicity with succimer: a case series of 2 adults with retained lead shotgun fragments.
Topics: Adult; Chelating Agents; Female; Foreign Bodies; Humans; Lead; Lead Poisoning; Male; Succimer; Wounds, Gunshot | 2011 |
Lead detoxification activities of a class of novel DMSA--amino acid conjugates.
Topics: Amino Acid Sequence; Amino Acids; Animals; Antidotes; Lead; Lead Poisoning; Male; Mice; Succimer | 2011 |
EDTA redistribution of lead and cadmium into the soft tissues in a human with a high lead burden - should DMSA always be used to follow EDTA in such cases?
Topics: Cadmium; Chelation Therapy; Dose-Response Relationship, Drug; Drug Therapy, Combination; Edetic Acid; Humans; Lead; Lead Poisoning; Male; Middle Aged; Occupational Exposure; Succimer; Tissue Distribution; Treatment Outcome | 2011 |
Lactobacillus plantarum CCFM8661 alleviates lead toxicity in mice.
Topics: Animals; Biomarkers; Chelating Agents; Chelation Therapy; Hot Temperature; Lactobacillus plantarum; Lead; Lead Poisoning; Male; Mice; Mice, Inbred Strains; Microbial Viability; Organometallic Compounds; Oxidative Stress; Porphobilinogen Synthase; Probiotics; Random Allocation; Reactive Oxygen Species; Succimer; Tissue Distribution | 2012 |
Monensin potentiates lead chelation efficacy of MiADMSA in rat brain post chronic lead exposure.
Topics: Animals; Antioxidants; Biomarkers; Brain; Chelating Agents; DNA Damage; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Kidney; Lead; Male; Monensin; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2012 |
Lead poisoning from Ayurvedic medicines.
Topics: Adult; Chelating Agents; Humans; Lead; Lead Poisoning; Male; Medicine, Ayurvedic; Succimer | 2013 |
Reversal effect of monoisoamyl dimercaptosuccinic acid (MiADMSA) for arsenic and lead induced perturbations in apoptosis and antioxidant enzymes in developing rat brain.
Topics: Age Factors; Animals; Animals, Newborn; Antioxidants; Apoptosis; Arsenates; Brain; Catalase; Embryo, Mammalian; Female; Lead; Male; Malondialdehyde; Oxidative Stress; Pregnancy; Rats; Rats, Wistar; Succimer; Superoxide Dismutase | 2013 |
Role of chelation in the treatment of lead poisoning: discussion of the Treatment of Lead-Exposed Children Trial (TLC).
Topics: Age Factors; Biomarkers; Chelating Agents; Chelation Therapy; Child; Child, Preschool; Cognition; Environmental Exposure; Female; Humans; Infant; Infant Behavior; Lead; Lead Poisoning, Nervous System, Childhood; Male; Randomized Controlled Trials as Topic; Succimer; Time Factors; Treatment Outcome | 2013 |
Acute abdominal pain and constipation due to lead poisoning.
Topics: Abdominal Pain; Acute Pain; Adult; Chelating Agents; Constipation; Diagnosis, Differential; Humans; Hypogonadism; Lead; Lead Poisoning; Male; Medicine, Ayurvedic; Plant Preparations; Succimer; Treatment Outcome | 2013 |
Protective effect of mulberry extract against Pb-induced learning and memory deficits in mice.
Topics: Animals; Chelating Agents; Lead; Learning; Memory Disorders; Mice; Morus; Plant Extracts; Random Allocation; Succimer | 2014 |
Combination therapy for the cardiovascular effects of perinatal lead exposure in young and adult rats.
Topics: Age Factors; Animals; Antihypertensive Agents; Arginine; Blood Pressure; Body Weight; Cardiovascular System; Chelating Agents; Combined Modality Therapy; Enalapril; Female; Hypertension; Lactation; Lead; Lead Poisoning; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Wistar; Succimer; Time Factors; Treatment Outcome | 2014 |
Ayurvedic medicine use and lead poisoning in a child: a continued concern in the United States.
Topics: Chelating Agents; Humans; Infant; Lead; Lead Poisoning; Male; Medicine, Ayurvedic; Succimer; United States | 2015 |
Attenuation of lead-induced oxidative stress in rat brain, liver, kidney and blood of male Wistar rats by Moringa oleifera seed powder.
Topics: Animals; Antioxidants; Brain; Chelating Agents; Kidney; Lead; Liver; Male; Moringa oleifera; Oxidative Stress; Plant Extracts; Powders; Rats; Rats, Wistar; Seeds; Succimer; Tissue Distribution | 2014 |
Autism: a form of lead and mercury toxicity.
Topics: Autistic Disorder; Case-Control Studies; Chelating Agents; Child; Child, Preschool; Environmental Pollutants; Female; Humans; Lead; Male; Mercury; Risk Factors; Succimer; Surveys and Questionnaires; Treatment Outcome | 2014 |
Protective Effect of Porcine Cerebral Hydrolysate Peptides on Learning and Memory Deficits and Oxidative Stress in Lead-Exposed Mice.
Topics: Animals; Behavior, Animal; Brain; Hydrolysis; Iron; Lead; Learning; Maze Learning; Memory Disorders; Mice; Movement; Nitric Oxide Synthase; Organ Size; Oxidative Stress; Peptides; Protein Hydrolysates; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Subtilisins; Succimer; Swine; Ultrasonics; Zinc | 2015 |
Silymarin and dimercaptosuccinic acid ameliorate lead-induced nephrotoxicity and genotoxicity in rats.
Topics: Animals; Antidotes; Kidney Diseases; Lead; Male; Random Allocation; Rats; Rats, Wistar; Silymarin; Succimer | 2016 |
Modelling dimercaptosuccinic acid (DMSA) plasma kinetics in humans.
Topics: Adult; Chelating Agents; Chelation Therapy; Humans; Lead; Lead Poisoning; Male; Models, Biological; Succimer; Young Adult | 2016 |
Modeling the effect of succimer (DMSA; dimercaptosuccinic acid) chelation therapy in patients poisoned by lead.
Topics: Adolescent; Adult; Antidotes; Chelating Agents; Chelation Therapy; Humans; Lead; Lead Poisoning; Male; Medicine, Traditional; Models, Biological; Occupational Exposure; Reproducibility of Results; Succimer | 2017 |
Severe Lead Toxicosis in a Lionhead Rabbit.
Topics: Animals; Antidotes; Chelating Agents; Gastroparesis; Lead; Lead Poisoning; Male; Rabbits; Succimer | 2017 |
Lead adsorption, anticoagulation and in vivo toxicity studies on the new magnetic nanomaterial Fe
Topics: Adsorption; Animals; Ferrosoferric Oxide; Hemoperfusion; Lead; Lead Poisoning; Materials Testing; Nanoparticles; Rabbits; Silicon Dioxide; Succimer; Swine; Toxicity Tests | 2017 |
Effects of meso-2,3-dimercaptosuccinic acid, potassium iodide and chlorophyll on lead accumulation in male mice.
Topics: Animals; Chelating Agents; Chlorophyll; Food Additives; Kidney; Lead; Lead Poisoning; Liver; Male; Mice; Potassium Iodide; Succimer; Testis | 2017 |
Elevated lead level from a tobacco source requiring chelation in a 12-year-old child.
Topics: Adult; Chelating Agents; Child; Environmental Exposure; Female; Humans; Lead; Lead Poisoning; Male; Nicotiana; Succimer; Thailand; Tobacco, Smokeless; Treatment Outcome; United States | 2018 |
Reversing the adverse biochemical effects in lead-intoxicated rats by N,N`- bis[(1,2-didehydro-1-hydroxy-2-thioxopyrid-4-yl)-carbonyl]- L-lysine.
Topics: Animals; Chelating Agents; Chelation Therapy; Edetic Acid; Lead; Lead Poisoning; Male; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Wistar; Succimer | 2018 |
Effects of combined arsenic and lead exposure on the brain monoaminergic system and behavioral functions in rats: Reversal effect of MiADMSA.
Topics: Animals; Arsenic; Behavior, Animal; Biogenic Monoamines; Brain; Exploratory Behavior; Female; Lead; Male; Motor Activity; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Succimer | 2019 |
Impacts of lead exposure and chelation therapy on bone metabolism during different developmental stages of rats.
Topics: Animals; Bone and Bones; Bone Development; Chelating Agents; Chelation Therapy; Lead; Lead Poisoning; Male; Rats; Succimer | 2019 |
Effects of combined administration of calcium, iron, zinc, chrysanthemum flavonoids, and DMSA on the treatment of lead intoxication in mice.
Topics: Animals; Calcium; Chrysanthemum; Disease Models, Animal; Drug Therapy, Combination; Female; Flavonoids; Glutathione; Glutathione Peroxidase; Hippocampus; Iron; Lead; Lead Poisoning; Liver; Malondialdehyde; Mice; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Plant Extracts; Porphobilinogen Synthase; Succimer; Superoxide Dismutase; Treatment Outcome; Zinc | 2020 |
Clinical Chemistry of Abdominal X-Rays.
Topics: Edetic Acid; Humans; Infant; Lead; Lead Poisoning; Male; Paint; Radiography, Abdominal; Succimer | 2020 |
The synergistic hepatoprotective potential of Beta vulgaris juice and 2,3- dimercaptosuccinic acid in lead-intoxicated rats via improving the hepatic oxidative and inflammatory stress.
Topics: Administration, Oral; Animals; Antioxidants; Beta vulgaris; Chelating Agents; Disease Models, Animal; Drug Synergism; Egypt; Fruit and Vegetable Juices; Inflammation; Lead; Lead Poisoning; Liver; Male; Oxidative Stress; Rats; Succimer | 2020 |
Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats.
Topics: Animals; Antioxidants; Beta vulgaris; Brain; DNA Fragmentation; Drug Synergism; Inflammation; Lead; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Plant Extracts; Rats; Succimer | 2021 |
Efficacy and expenses of succimer vs. d-penicillamine plus garlic in the treatment of lead poisoning: a retrospective cross-sectional study.
Topics: Adult; Antidotes; Cost-Benefit Analysis; Cross-Sectional Studies; Drug Therapy, Combination; Garlic; Humans; Iran; Lead; Lead Poisoning; Male; Penicillamine; Phytochemicals; Retrospective Studies; Succimer; Treatment Outcome | 2021 |
Adansonia digitata L. fruit shell extract alleviates lead-induced neurotoxicity in mice via modulation of oxidative stress and a possible chelating activity.
Topics: Adansonia; Animals; Antioxidants; Biomarkers; Chelating Agents; Eosine Yellowish-(YS); Fruit; Lead; Male; Mice; Oxidative Stress; Plant Extracts; Succimer; Superoxide Dismutase | 2022 |
Lead poisoning with encephalic and neuropathic involvement in a child: case report.
Topics: Brain; Child; Child, Preschool; Family; Female; Humans; Lead; Lead Poisoning; Peripheral Nervous System Diseases; Succimer | 2022 |
Succimer Mitigates the Perioperative Risk for an Increase in Blood Lead Levels During Bulletectomy: A Case Report.
Topics: Adult; Chelating Agents; Humans; Lead; Lead Poisoning; Male; Succimer; Wounds, Gunshot | 2023 |
Induction of Labor at Term for Severe Antenatal Lead Poisoning.
Topics: Adult; Chelating Agents; Female; Humans; Infant; Infant, Newborn; Labor, Induced; Lead; Lead Poisoning; Pregnancy; Succimer; Young Adult | 2023 |