Page last updated: 2024-08-25

lead and succimer

lead has been researched along with succimer in 178 studies

Research

Studies (178)

TimeframeStudies, this research(%)All Research%
pre-199016 (8.99)18.7374
1990's59 (33.15)18.2507
2000's61 (34.27)29.6817
2010's32 (17.98)24.3611
2020's10 (5.62)2.80

Authors

AuthorsStudies
Dragovic, D; Friedheim, E; Graziano, JH; Kaul, B; Popovac, D1
Friedheim, E; Graziano, JH; Leong, JK1
Graziano, JH; Lolacono, NJ; Mitchell, ME; Moulton, T; Slavkovich, V; Zarate, C1
Bauchner, H; Glotzer, DE1
Bergamaschi, E; Cohen, A; Gonick, HC; Khalil-Manesh, F; Mutti, A1
Flegal, AR; Smith, DR1
Chisolm, JJ3
Wegmann, K1
Atkins, LM; Basinger, MA; Gale, GR; Jones, MM; Milligan, LB; Singh, PK; Smith, AB; Stone, A; Walker, EM1
Mann, KV; Travers, JD1
Banner, W1
Flora, SJ; Tandon, SK2
Aposhian, HV; Bruce, DC; Maiorino, RM1
Atkins, LM; Gale, GR; Jones, MM; Singh, PK; Smith, AB; Xu, Z1
Aposhian, HV; Fernando, Q; Rivera, M; Zheng, W1
Graziano, JH; Kapoor, SC; LoIacono, NJ; Wielopolski, L1
Aposhian, HV; Fernando, Q; Rivera, M1
Dhawan, M; Flora, SJ; Singh, S; Tandon, SK1
Cory-Slechta, DA1
Graziano, JH; LoIacono, N; Silverberg, SJ; Siris, ES; Turgeon, L1
Bankowska, J; Hine, C1
Flora, SJ; Singh, S; Tandon, SK1
Behar, R; Bentur, Y; Brook, JG; Taitelman, U1
Kolton, L; Yaari, Y1
Chen, LX; Ding, GS; Liang, YY; Shi, JM1
Fang, X; Fernando, Q1
Ahlquist, JT; Allen, EM; Banner, W; Nuttall, KL; Pappas, JB1
Flora, GJ; Mathur, R; Prakash, AO; Seth, PK1
Bhattacharya, R; Flora, SJ; Vijayaraghavan, R1
Buchet, JP; de Jong, VJ; Lauwerys, RR; Louwerse, ES; Van Dijk, MA1
Ahn, KD; Lee, BK; Schwartz, BS; Stewart, W1
Blanusa, M; Jones, MM; Kostial, K; Piasek, M; Singh, PK1
Chen, ZJ; Liang, YY; Tao, ZQ; Xu, XH; Yan, XM; Zhang, JS1
Crick, J; Flegal, AR; Markowitz, ME; Rosen, JF; Smith, DR1
Aposhian, HV; Dart, RC; Hassen, LV; Hurlbut, KM; Maiorino, RM; Mayersohn, M1
Gonick, HC; Khalil-Manesh, F; Prins, B; Purdy, R; Ren, Q; Weber, MA; Weiler, EW1
Atkins, LM; Basinger, MA; Gale, GR; Jones, MM; Smith, AB; Stone, A1
Munné, P; Nogué, S; Sanz-Gallén, P; To-Figueras, J1
Aposhian, HV; Aposhian, MM; Li, Y; Maiorino, RM; Polt, RL; Xu, ZF1
Graef, JW; Liebelt, EL; Shannon, M1
Mortensen, ME; Walson, PD1
Casteel, SW; Chastain, CB; Faggella, AM; Nunn, JW; Ramsey, DT; Schaeffer, DJ1
Cherian, MG; Goyer, RA; Jones, MM; Reigart, JR1
Bernal, J; Ruvalcaba, S1
Rhoads, GG; Rogan, WJ1
Cline, HT; Jones, KW; Witte, S1
Ercal, N; Grannemann, NH; Hammond, TC; Matthews, RH; Spitz, DR; Treeratphan, P1
Gansow, OA; Garmestani, K; Jones, SB; Kozak, RW; Tiffany, LJ1
Hashkanazi, R; Lifshitz, M; Phillip, M1
Blanusa, M; Jones, MM; Kostial, K; Piasek, M; Restek-Samarozija, N; Singh, PK1
Ahn, KD; Kelsey, K; Lee, BK; Schwartz, BS; Sithisarankul, P; Stewart, W; Strickland, PT1
Evans, HL; Gong, Z1
Bernal, J; Cribbs, LL; Lee, JH; Perez-Reyes, E1
Grandjean, P; Guldager, B; Holmstrup, P; Jørgensen, PJ; Larsen, IB1
Ding, Y; Gonick, HC; Vaziri, ND1
Behari, JR; Misra, M1
Burda, A; Gossman, W; Leikin, JB; Sigg, T; Umanos, J1
Bayer, L; Smith, D; Strupp, BJ1
Erçal, N; Gürer, H; Neal, R; Ozgünes, H; Spitz, DR1
Mathur, N; Prasad, S; Singh, S; Tandon, SK1
Amin, Z; Gordon, RA; Paloucek, FP; Roberts, G; Williams, RH1
Blanusa, M; Corović, N; Jurasović, J; Pizent, A; Restek-Samarzija, N; Samarzija, M; Turk, R1
Blanchard, J; Fernando, Q; Lott, JR; Pigman, EA1
Chen, S; Dietert, RR; Golemboski, KA; Sanders, FS1
Börjesson, J; Gerhardsson, L; Mattsson, S; Schütz, A; Skerfving, S1
Links, JM; Schwartz, BS; Stewart, WF; Todd, AC1
O'Connor, ME; Rich, D1
McCabe, MJ; Pokorski, PL; Pounds, JG1
Lever, SZ; Parsons, TL1
Cremin, JD; Laughlin, NK; Luck, ML; Smith, DR2
Calacsan, C; Cremin, J; Laughlin, NK; Luck, M; Smith, DR; Woolard, D1
Arora, U; Flora, GJ; Seth, PK1
Laughlin, NK; Luck, ML; Smith, DR; Woolard, D1
McKinney, PE1
Denver, MC; Galey, FD; Kass, PH; Tell, LA; Trupkiewicz, JG1
Ahn, KD; Kim, YB; Lee, BK; Lee, GS; Lee, SS; Schwartz, BS1
Kelsey, K; Lee, BK; Lee, GS; Schwartz, BS; Simon, D; Stewart, WF; Todd, AC1
Ahn, KD; Lee, BK; Lee, GS; Moshier, EL; Schwartz, BS; Todd, AC1
Ahn, KD; Bolla, KI; Hwang, KY; Kim, YB; Lee, BK; Lee, GS; Lee, SS; Parsons, PJ; Schwartz, BS; Simon, D; Stewart, WF; Todd, AC1
Coresh, J; Schwartz, BS; Stewart, WF; Tassler, PL; Todd, AC1
Chisolm, JJ; Dietrich, KN; Dockery, DW; Jones, RL; Radcliffe, J; Ragan, NB; Rhoads, GG; Rogan, WJ; Salganik, M; Ware, JH1
Mushak, P; Rosen, JF1
Junk, JE; Kent, M; Knight, TE1
Lasky, RE; Laughlin, NK; Luck, ML1
Farrar, HC; McLeane, LR; Wallace, M; Watson, J; White, K1
Chambers-Emerson, J; Dethlefsen, M; McNutt, TK; Shah, R1
Cordellini, S; Malvezzi, CK; Moreira, EG; Vassilieff, I; Vassilieff, VS1
Binns, H; Shannon, M; Woolf, A1
Buchanan, S; Kim, D; McGeehin, M; Noonan, G1
Henretig, F1
Shannon, M1
Kelsey, K; Lee, BK; Lee, GS; Lee, SS; Schwartz, BS; Simon, D; Stewart, WF; Todd, AC1
Bennett, PN; Gordon, JN; Taylor, A1
Flora, SJ; Pande, M1
Prasad, S; Siddiqui, MK; Singh, S; Srivastava, S; Tandon, SK1
Dietrich, KN; Liu, X; Radcliffe, J; Ragan, NB; Rhoads, GG; Rogan, WJ1
Muller, D; Nascimento, PC; Nogueira, CW; Rocha, JB; Soares, FA1
Garza-Ocañas, L; Piñeyro-López, A; Torres-Alanís, O1
Rademacher, DJ; Steinpreis, RE; Weber, DN1
Calle, P; Cook, R; Hoogesteijn, AL; Kollias, G; Raphael, BL1
Ko, KW; Meldrum, JB1
Akanno, J; Akhtar, AJ; Funnyé, AS1
Blanusa, M; Juresa, D; Kostial, K; Piasek, M; Sarić, M; Varnai, VM1
Kuypers, M; Smith, D; Stangle, DE; Strawderman, MS; Strupp, BJ1
Adubato, S; Bornschein, RL; Davoli, CT; Denckla, MB; Dietrich, KN; Dockery, DW; Fay, ME; Jones, RL; Radcliffe, J; Rhoads, GG; Rogan, WJ; Salganik, M; Schwarz, D; Ware, JH1
Liu, NQ; Lu, ZB; Wang, XF; Zhang, J; Zhao, BL1
Flora, SJ; Saxena, G1
Flora, SJ; Kannan, GM; Mehta, A; Pande, M1
Chen, A; Dietrich, KN; Radcliffe, J; Rogan, WJ; Ware, JH1
Brent, RL; Florin, TA; Weitzman, M1
Nogueira, CW; Rocha, JB; Santos, FW1
Buchet, JP; Decerf, L; Haufroid, V; Hoet, P; Lavalleye, B; Lison, D1
Chen, A; Radcliffe, J; Rogan, WJ; Schwarz, D1
Deepak, KK; Madan, K; Makharia, G; Poojary, G; Sharma, PK1
An, L; Jin, Y; Li, G; Liao, Y; Lu, C; Yang, J; Yu, F; Zhang, J; Zhi, X1
Cai, B; Chen, A; Dietrich, KN; Radcliffe, J; Rogan, WJ1
Flora, SJ; Mehta, A; Saxena, G1
Auyang, ED; Bhattacharya, A; Bornschein, R; Dietrich, KN; Shukla, R1
Flora, G; Flora, SJ; Mishra, M; Saxena, G1
Flora, SJ; Gautam, P; Gill, KD; Kaur, P; Saxena, G1
Jin, Y; Li, G; Li, Y; Liao, Y; Lu, C; Ren, Y; Yang, J; Yu, F; Zhao, Y1
Addleman, RS; Choi, D; Fryxell, GE; Hongsirikarn, K; Sangvanich, T; Timchalk, C; Toloczko, MB; Warner, CL; Warner, MG; Yantasee, W1
Krishnakumar, N; Palaniappan, PL; Sabhanayakam, S; Vadivelu, M1
Chomchai, C; Hussain, J; McCullough, L; Petranovic, M; Woolf, AD1
Hjelmhaug, J; Lobner, D; Rush, T1
Krishnakumar, N; Palaniappan, PL; Vadivelu, M; Vijayasundaram, V1
Lv, GY; Wang, HM; Xia, DZ; Yang, Q; Yu, XF1
Shen, XM; Wu, SH; Xu, J; Yan, CH; Yu, GY; Yu, XG; Zou, XY; Zuo, Y1
Bradberry, S; Sheehan, T; Vale, A1
Aslani, MR; Mohri, M; Najarnezhad, V1
Bradberry, S; Vale, A1
Caldwell, KL; Cao, Y; Chen, A; Dietrich, KN; Jones, RL; Radcliffe, J; Rogan, WJ1
Buters, JT; Eyer, F; Felgenhauer, N; Willi, RF; Zilker, T1
Crinnion, WJ; Tran, JQ1
Charlier, C; Denooz, R; Ho, G; Keutgens, A; Kotolenko, S; Schoofs, R1
Cyrus, RM; Edwards, CQ; Pugh, MR; Stevens, MH; Stevens, SM; Woller, SC1
Hou, B; Hu, X; Peng, L; Peng, S; Wang, L; Wang, Y; Wu, J; Xu, Y; Zhang, X; Zhao, M; Zheng, M1
Crinnion, WJ1
Jin, Y; Liao, Y; Liu, M; Liu, S; Xu, J; Yang, J; Yu, F1
Chen, W; Liu, X; Tian, F; Wang, G; Zhai, Q; Zhang, H; Zhao, J1
Dubey, M; Flora, SJ; Kushwaha, P; Pachauri, V; Yadav, A1
Spriggs, D; Tsutsui, RS; Van Schalkwyk, J1
Gottipolu, RR; Kadeyala, PK; Sannadi, S1
Smith, D; Strupp, BJ1
McKay, CA1
Mongolu, S; Sharp, P1
Bao, YT; Chen, Y; Feng, WW; Ji, PC; Li, Q; Ma, RH; Wu, J; Wu, XY; Yang, LQ; Zhou, ZX; Zou, Y1
Cordellini, S; Gaspar, AF1
Ahmed, O; Datta-Mitra, A1
Daughtry, LK; Jones, AC; Rajanna, B; Rajanna, S; Velaga, MK; Yallapragada, PR1
Yassa, HA1
Chen, Y; Feng, W; Li, Q; Mao, G; Wang, W; Wu, X; Yang, L; Zhao, T; Zhou, Z; Zou, Y1
Alcaraz-Contreras, Y; Gallegos-Corona, MA; Martínez-Alcaraz, ER; Martínez-Alfaro, M; Mendoza-Lozano, RP; Ramírez-Morales, MA; Vázquez-Guevara, MA1
Bradberry, SM; de Vries, I; Hunault, CC; Meulenbelt, J; Olie, JD; Vale, JA; van Eijkeren, JC1
Bradberry, SM; Clewell, HJ; de Vries, I; Hunault, CC; Meulenbelt, J; Olie, JD; Vale, JA; van Eijkeren, JC1
Bischoff, K; de Matos, R; Walter, KM1
Bai, Z; Feng, N; Guo, X; Liu, Z; Long, J; Mao, F; Mo, W; Sun, Y; Wang, S; Wei, X; Xiang, Y; Xiaoyang, W; Yang, C; Zhang, S; Zheng, L1
Xie, Y; Zhou, G1
El Zahran, T; Hindman, D; King, A; Morgan, BW; Ralston, A1
Abu-Dari, KI; Ata, SA; Mubarak, MS; Tutunji, MF1
Davuljigari, CB; Kumar, KP; Reddy, GR; Saritha, S1
Ji, X; Li, S; Liu, J; Sun, S; Xu, J; Yan, C; Zhang, Y; Zhou, L1
Feng, W; Guiju, S; Honglei, P; Huali, T; Jianghong, L; Ligang, Y; Shaokang, W1
Miller, CA; Zhang, YV1
Abdelrahman, SA; El-Kersh, MAL; Habashy, NH; Mogahed, FAK; Shaban, NZ; Talaat, IM1
Abd El-Kader, SE; El-Kersh, MAL; Habashy, NH; Mogahed, FAK; Shaban, NZ1
Balali-Mood, M; Banagozar Mohammadi, A; Moshiri, M; Vahabzadeh, M1
Chiroma, SM; Fannami, IM; Garba, SH1
Badrane, N; Chaoui, H; Elhamri, H; Fekhaoui, M; Jouhadi, Z; Kalouch, S; Moutawakil, BE; Rouzi, L; Salam, S1
Smith, DR; Strupp, BJ1
Kennedy, JM; Mycyk, MB; Routsolias, JC1
Cohen, ET; Koziatek, C; Mahonski, S; Mohan, S; Smith, S; Su, MK1

Reviews

10 review(s) available for lead and succimer

ArticleYear
Chelation therapy to treat lead toxicity in children.
    Minnesota medicine, 1992, Volume: 75, Issue:11

    Topics: Chelation Therapy; Child; Humans; Lead; Lead Poisoning; Succimer

1992
Succimer, an oral lead chelator.
    Clinical pharmacy, 1991, Volume: 10, Issue:12

    Topics: Administration, Oral; Chelation Therapy; Drug Interactions; Drug Monitoring; Drug Stability; Humans; Lead; Lead Poisoning; Succimer

1991
Evaluation of the potential role of chelation therapy in treatment of low to moderate lead exposures.
    Environmental health perspectives, 1990, Volume: 89

    Topics: Animals; Chelating Agents; Chelation Therapy; Drug Evaluation; Edetic Acid; Humans; Lead; Lead Poisoning; Succimer

1990
Chelation therapy for childhood lead poisoning. The changing scene in the 1990s.
    Clinical pediatrics, 1993, Volume: 32, Issue:5

    Topics: Chelation Therapy; Child; Dimercaprol; Edetic Acid; Humans; Lead; Lead Poisoning; Penicillamine; Succimer

1993
Aggressive approach in the treatment of acute lead encephalopathy with an extraordinarily high concentration of lead.
    Archives of pediatrics & adolescent medicine, 1998, Volume: 152, Issue:11

    Topics: Brain Diseases; Child, Preschool; Dimercaprol; Edetic Acid; Environmental Exposure; Female; Humans; Iron Chelating Agents; Lead; Lead Poisoning; Paint; Polyethylene Glycols; Succimer; Therapeutic Irrigation

1998
Lead poisoning treatment--a continuing need (commentary).
    Journal of toxicology. Clinical toxicology, 2001, Volume: 39, Issue:7

    Topics: Chelating Agents; Chelation Therapy; Child; Child Development; Child, Preschool; Cognition Disorders; Environmental Exposure; Humans; Lead; Lead Poisoning; Randomized Controlled Trials as Topic; Succimer; Treatment Outcome

2001
Arsenic and lead induced free radical generation and their reversibility following chelation.
    Cellular and molecular biology (Noisy-le-Grand, France), 2007, Apr-15, Volume: 53, Issue:1

    Topics: Acetylcysteine; Adjuvants, Pharmaceutic; Animals; Antioxidants; Arsenic; Arsenic Poisoning; Ascorbic Acid; Calcium; Chelating Agents; Free Radicals; Humans; Lead; Lead Poisoning; Melatonin; Metals; Micronutrients; Molecular Structure; Succimer; Taurine; Thioctic Acid; Unithiol; Vitamin E

2007
A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning.
    Clinical toxicology (Philadelphia, Pa.), 2009, Volume: 47, Issue:9

    Topics: Administration, Oral; Animals; Antidotes; Chelating Agents; Clinical Trials as Topic; Edetic Acid; Humans; Lead; Lead Poisoning; Succimer

2009
The scientific basis for chelation: animal studies and lead chelation.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2013, Volume: 9, Issue:4

    Topics: Animals; Behavior, Animal; Body Burden; Brain; Chelating Agents; Chelation Therapy; Disease Models, Animal; Humans; Lead; Lead Poisoning; Risk Assessment; Risk Factors; Succimer; Time Factors; Treatment Outcome

2013
Animal Models of Childhood Exposure to Lead or Manganese: Evidence for Impaired Attention, Impulse Control, and Affect Regulation and Assessment of Potential Therapies.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2023, Volume: 20, Issue:1

    Topics: Adolescent; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Chelating Agents; Child; Humans; Lead; Manganese; Methylphenidate; Models, Animal; Succimer

2023

Trials

18 trial(s) available for lead and succimer

ArticleYear
Controlled study of meso-2,3-dimercaptosuccinic acid for the management of childhood lead intoxication.
    The Journal of pediatrics, 1992, Volume: 120, Issue:1

    Topics: Administration, Oral; Ambulatory Care; Aminolevulinic Acid; Calcium; Chelating Agents; Child; Child, Preschool; Dimercaprol; Edetic Acid; Erythrocytes; Follow-Up Studies; Humans; Infant; Injections, Intravenous; Lead; Lead Poisoning; Porphobilinogen Synthase; Safety; Succimer; Zinc

1992
Provocative chelation with DMSA and EDTA: evidence for differential access to lead storage sites.
    Occupational and environmental medicine, 1995, Volume: 52, Issue:1

    Topics: Adult; Chelation Therapy; Dose-Response Relationship, Drug; Edetic Acid; Environmental Monitoring; Humans; Korea; Lead; Male; Middle Aged; Occupational Exposure; Succimer; Time Factors

1995
The effects of succimer on the absorption of lead in adults determined by using the stable isotope 204Pb.
    Environmental research, 1994, Volume: 67, Issue:1

    Topics: Adult; Bone and Bones; Double-Blind Method; Feces; Humans; Intestinal Absorption; Isotopes; Lead; Male; Middle Aged; Succimer

1994
Placebo response in environmental disease. Chelation therapy of patients with symptoms attributed to amalgam fillings.
    Journal of occupational and environmental medicine, 1997, Volume: 39, Issue:8

    Topics: Adult; Aged; Chelating Agents; Denmark; Dental Amalgam; Double-Blind Method; Environmental Illness; Female; Humans; Lead; Male; Mercury; Middle Aged; Placebo Effect; Succimer

1997
The Treatment of Lead-exposed Children (TLC) trial: design and recruitment for a study of the effect of oral chelation on growth and development in toddlers.
    Paediatric and perinatal epidemiology, 1998, Volume: 12, Issue:3

    Topics: Chelating Agents; Chelation Therapy; Child Development; Child, Preschool; Double-Blind Method; Housing; Humans; Infant; Lead; Lead Poisoning; Succimer; United States

1998
Children with moderately elevated lead levels: is chelation with DMSA helpful?
    Clinical pediatrics, 1999, Volume: 38, Issue:6

    Topics: Chelating Agents; Child, Preschool; Follow-Up Studies; Humans; Lead; Lead Poisoning; Succimer

1999
Safety and efficacy of meso-2,3-dimercaptosuccinic acid (DMSA) in children with elevated blood lead concentrations.
    Journal of toxicology. Clinical toxicology, 2000, Volume: 38, Issue:4

    Topics: Administration, Oral; Alkaline Phosphatase; Anemia, Sickle Cell; Antidotes; Chelating Agents; Child; Child, Preschool; Copper; Creatinine; Demography; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Infant; Lead; Lead Poisoning; Male; Metabolic Clearance Rate; Succimer; Treatment Outcome; Zinc

2000
Safety and efficacy of succimer in toddlers with blood lead levels of 20-44 microg/dL. Treatment of Lead-Exposed Children (TLC) Trial Group.
    Pediatric research, 2000, Volume: 48, Issue:5

    Topics: Chelating Agents; Child, Preschool; Drug Eruptions; Humans; Infant; Lead; Lead Poisoning, Nervous System, Childhood; Safety; Scalp; Succimer; Wounds and Injuries

2000
The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead.
    The New England journal of medicine, 2001, May-10, Volume: 344, Issue:19

    Topics: Chelating Agents; Chelation Therapy; Child Behavior; Child Development; Child, Preschool; Cognition; Double-Blind Method; Female; Humans; Infant; Intelligence; Lead; Lead Poisoning; Male; Neuropsychological Tests; Poverty Areas; Succimer; Urban Population

2001
A comparison of two dosing regimens of succimer in children with chronic lead poisoning.
    Journal of clinical pharmacology, 1999, Volume: 39, Issue:2

    Topics: Chelating Agents; Child; Child, Preschool; Chronic Disease; Drug Administration Schedule; Female; Humans; Infant; Lead; Lead Poisoning, Nervous System, Childhood; Male; Succimer

1999
Do children with falling blood lead levels have improved cognition?
    Pediatrics, 2002, Volume: 110, Issue:4

    Topics: Chelating Agents; Child Development; Child, Preschool; Cognition Disorders; Double-Blind Method; Female; Humans; Infant; Lead; Lead Poisoning; Male; Neuropsychological Tests; Placebos; Succimer; Treatment Outcome

2002
Effects of calcium disodium EDTA and meso-2,3-dimercaptosuccinic acid on tissue concentrations of lead for use in treatment of calves with experimentally induced lead toxicosis.
    American journal of veterinary research, 2003, Volume: 64, Issue:6

    Topics: Animals; Bone and Bones; Brain Chemistry; Cattle; Chelating Agents; Drug Therapy, Combination; Edetic Acid; Kidney; Lead; Lead Poisoning; Liver; Male; Muscle, Skeletal; Succimer; Testis

2003
Effect of chelation therapy on the neuropsychological and behavioral development of lead-exposed children after school entry.
    Pediatrics, 2004, Volume: 114, Issue:1

    Topics: Chelating Agents; Chelation Therapy; Child; Child Behavior; Child Development; Child, Preschool; Double-Blind Method; Environmental Exposure; Humans; Infant; Intelligence; Lead; Lead Poisoning; Neuropsychological Tests; Succimer

2004
IQ and blood lead from 2 to 7 years of age: are the effects in older children the residual of high blood lead concentrations in 2-year-olds?
    Environmental health perspectives, 2005, Volume: 113, Issue:5

    Topics: Age Factors; Chelating Agents; Child; Child Development; Child, Preschool; Cognition Disorders; Confounding Factors, Epidemiologic; Cross-Sectional Studies; Female; Humans; Intelligence; Lead; Lead Poisoning; Male; Placebos; Succimer

2005
Clinical evaluation of a lead mobilization test using the chelating agent dimercaptosuccinic acid.
    Clinical chemistry, 2006, Volume: 52, Issue:1

    Topics: Adult; Chelating Agents; Copper; Environmental Pollutants; Female; Humans; Lead; Lead Poisoning; Male; Middle Aged; Occupational Diseases; Succimer; Zinc

2006
Effect of succimer chelation therapy on postural balance and gait outcomes in children with early exposure to environmental lead.
    Neurotoxicology, 2007, Volume: 28, Issue:3

    Topics: Cerebellum; Chelating Agents; Child, Preschool; Cohort Studies; Edetic Acid; Environmental Exposure; Female; Gait; Humans; Infant; Lead; Lead Poisoning, Nervous System, Childhood; Male; Mechanoreceptors; Neural Pathways; Postural Balance; Psychomotor Performance; Socioeconomic Factors; Succimer; Vestibule, Labyrinth

2007
Does background postnatal methyl mercury exposure in toddlers affect cognition and behavior?
    Neurotoxicology, 2010, Volume: 31, Issue:1

    Topics: Age Factors; Antidotes; Child Behavior Disorders; Child Development; Child, Preschool; Cognition; Cognition Disorders; Female; Humans; Infant; Intelligence; Lead; Lead Poisoning, Nervous System, Childhood; Longitudinal Studies; Male; Mercury Poisoning, Nervous System; Methylmercury Compounds; Neuropsychological Tests; Statistics as Topic; Succimer

2010
Therapeutic efficiency of succimer used with calcium and ascorbic acid in the treatment of mild lead-poisoning.
    Environmental toxicology and pharmacology, 2011, Volume: 31, Issue:1

    Topics: Aging; Animals; Ascorbic Acid; Bone and Bones; Calcium Carbonate; Chelating Agents; Child; Child, Preschool; Colorimetry; Environmental Exposure; Female; Free Radical Scavengers; Humans; Lead; Lead Poisoning; Male; Mice; Porphobilinogen Synthase; Succimer

2011

Other Studies

150 other study(ies) available for lead and succimer

ArticleYear
Treatment of lead poisoning by 2,3-dimercaptosuccinic acid.
    Lancet (London, England), 1978, Dec-09, Volume: 2, Issue:8102

    Topics: Administration, Oral; Adult; Chemical Phenomena; Chemistry; Drug Administration Schedule; Drug Evaluation; Edetic Acid; Humans; Injections, Intravenous; Lead; Lead Poisoning; Metallurgy; Middle Aged; Succimer; Sulfhydryl Compounds

1978
2,3-Dimercaptosuccinic acid: a new agent for the treatment of lead poisoning.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 206, Issue:3

    Topics: Animals; Dimercaprol; Lead; Lead Poisoning; Male; Mice; Rats; Succimer; Sulfhydryl Compounds

1978
Management of childhood lead poisoning: a survey.
    Pediatrics, 1992, Volume: 89, Issue:4 Pt 1

    Topics: Chelating Agents; Child; Clinical Protocols; Drug Utilization; Edetic Acid; Humans; Lead; Lead Poisoning; Penicillamine; Succimer; United States

1992
Experimental model of lead nephropathy. II. Effect of removal from lead exposure and chelation treatment with dimercaptosuccinic acid (DMSA).
    Environmental research, 1992, Volume: 58, Issue:1

    Topics: Acetylglucosaminidase; Albuminuria; Animals; Blood Urea Nitrogen; Creatinine; Erythrocyte Membrane; Glomerular Filtration Rate; Glutathione Transferase; Hematocrit; Kidney; Kidney Diseases; Lead; Lead Poisoning; Male; Rats; Rats, Inbred Strains; Silicon; Sodium-Potassium-Exchanging ATPase; Succimer

1992
Stable isotopic tracers of lead mobilized by DMSA chelation in low lead-exposed rats.
    Toxicology and applied pharmacology, 1992, Volume: 116, Issue:1

    Topics: Animals; Female; Isotopes; Lead; Rats; Rats, Inbred Strains; Succimer; Tissue Distribution

1992
BAL, EDTA, DMSA and DMPS in the treatment of lead poisoning in children.
    Journal of toxicology. Clinical toxicology, 1992, Volume: 30, Issue:4

    Topics: Administration, Oral; Beverages; Chelation Therapy; Child; Child, Preschool; Dimercaprol; Edetic Acid; Female; Housing; Humans; Infant; Lead; Lead Poisoning; Male; Penicillamine; Succimer; Unithiol

1992
Mobilization of lead in mice by administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid.
    Toxicology, 1992, Nov-22, Volume: 76, Issue:1

    Topics: Animals; Brain; Esters; Kidney; Lead; Lethal Dose 50; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Succimer

1992
Succimer: controversial issues involving the release of a new product.
    Clinical pharmacy, 1991, Volume: 10, Issue:12

    Topics: Chelation Therapy; Humans; Lead; Succimer; United States; United States Food and Drug Administration

1991
Beneficial effects of zinc supplementation during chelation treatment of lead intoxication in rats.
    Toxicology, 1990, Volume: 64, Issue:2

    Topics: Acetates; Acetic Acid; Administration, Oral; Aminolevulinic Acid; Animals; Chelation Therapy; Drug Therapy, Combination; Edetic Acid; Lead; Lead Poisoning; Male; Penicillamine; Porphobilinogen Synthase; Protoporphyrins; Rats; Succimer

1990
Determination and metabolism of dithiol chelating agents. VI. Isolation and identification of the mixed disulfides of meso-2,3-dimercaptosuccinic acid with L-cysteine in human urine.
    Toxicology and applied pharmacology, 1989, Volume: 97, Issue:2

    Topics: Adult; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Copper; Cysteine; Cystinuria; Disulfides; Humans; Lead; Male; Species Specificity; Succimer; Sulfhydryl Compounds; Zinc

1989
Mobilization of lead by esters of meso-2,3-dimercaptosuccinic acid.
    Journal of toxicology and environmental health, 1989, Volume: 27, Issue:4

    Topics: Animals; Esters; Lead; Lead Radioisotopes; Liver; Male; Mice; Mice, Inbred Strains; Structure-Activity Relationship; Succimer; Sulfhydryl Compounds; Tissue Distribution

1989
Determination and metabolism of dithiol chelating agents. VIII. Metal complexes of meso-dimercaptosuccinic acid.
    Toxicology and applied pharmacology, 1989, Volume: 100, Issue:1

    Topics: Animals; Bile; Binding Sites; Cadmium; Chelating Agents; Esterification; Lead; Male; Mercury; Potentiometry; Rats; Rats, Inbred Strains; Succimer; Sulfhydryl Compounds

1989
Therapeutic efficacy of dimercaptosuccinic acid and thiamine/ascorbic acid on lead intoxication in rats.
    Bulletin of environmental contamination and toxicology, 1989, Volume: 43, Issue:5

    Topics: Aminolevulinic Acid; Animals; Ascorbic Acid; Lead; Lead Poisoning; Male; Porphobilinogen Synthase; Protoporphyrins; Rats; Succimer; Sulfhydryl Compounds; Thiamine

1989
Influence of 2,3-dimercaptosuccinic acid on gastrointestinal lead absorption and whole-body lead retention.
    Toxicology and applied pharmacology, 1989, Mar-01, Volume: 97, Issue:3

    Topics: Administration, Oral; Animals; Body Burden; Injections, Intraperitoneal; Intestinal Absorption; Lead; Rats; Rats, Inbred Strains; Succimer; Sulfhydryl Compounds

1989
Lead chelates of meso- and racemic-dimercaptosuccinic acid.
    Journal of inorganic biochemistry, 1989, Volume: 37, Issue:4

    Topics: Chelating Agents; Hydrogen-Ion Concentration; Lead; Molecular Structure; Potentiometry; Solubility; Solutions; Spectrophotometry, Infrared; Stereoisomerism; Succimer; Sulfhydryl Compounds

1989
Chelation of lead during co-exposure to ethanol.
    Biochemistry international, 1989, Volume: 19, Issue:5

    Topics: Acrylates; Animals; Chelating Agents; Edetic Acid; Ethanol; Lead; Lead Poisoning; Male; Penicillamine; Rats; Succimer; Sulfhydryl Compounds

1989
Mobilization of lead over the course of DMSA chelation therapy and long-term efficacy.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1

    Topics: Analysis of Variance; Animals; Chelating Agents; Lead; Lead Poisoning; Rats; Succimer; Sulfhydryl Compounds; Time Factors; Tissue Distribution

1988
2,3-Dimercaptosuccinic acid as an antidote for lead intoxication.
    Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:4

    Topics: Administration, Oral; Adult; Aminolevulinic Acid; Analysis of Variance; Drug Evaluation; Humans; Lead; Lead Poisoning; Male; Middle Aged; Occupational Diseases; Porphobilinogen Synthase; Random Allocation; Spectrophotometry, Atomic; Succimer; Sulfhydryl Compounds

1985
Retention of lead in the rat.
    Archives of environmental contamination and toxicology, 1985, Volume: 14, Issue:5

    Topics: Animals; Chelating Agents; Diet; Edetic Acid; Lead; Male; Rats; Rats, Inbred Strains; Succimer

1985
Chelation in metal intoxication XXI: Chelation in lead intoxication during vitamin B complex deficiency.
    Bulletin of environmental contamination and toxicology, 1986, Volume: 37, Issue:3

    Topics: Aminolevulinic Acid; Animals; Body Burden; Chelating Agents; Edetic Acid; Lead; Lead Poisoning; Male; Rats; Succimer; Vitamin B Deficiency

1986
Meso-2,3-dimercaptosuccinic acid in the diagnosis and treatment of lead poisoning.
    Journal of toxicology. Clinical toxicology, 1987, Volume: 25, Issue:1-2

    Topics: Adult; Bread; Edetic Acid; Food Contamination; Humans; Lead; Lead Poisoning; Male; Succimer; Sulfhydryl Compounds

1987
Sites of action of lead on spontaneous transmitter release from motor nerve terminals.
    Israel journal of medical sciences, 1982, Volume: 18, Issue:1

    Topics: Animals; Calcium; Cell Membrane Permeability; Edetic Acid; In Vitro Techniques; Lead; Membrane Potentials; Motor Endplate; Neuromuscular Junction; Neurotransmitter Agents; Rana ridibunda; Succimer

1982
[Dimercaptosuccinic acid per os promoted the excretions of Pb, Cu, Sb, Sr, Tl and Pm (author's transl)].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1980, Volume: 15, Issue:6

    Topics: Animals; Antimony; Copper; Dogs; Lead; Lethal Dose 50; Metals; Mice; Promethium; Rabbits; Rats; Strontium; Succimer; Sulfhydryl Compounds; Thallium

1980
Stereoisomeric selectivity of 2,3-dimercaptosuccinic acids in chelation therapy for lead poisoning.
    Chemical research in toxicology, 1995, Volume: 8, Issue:4

    Topics: Chelating Agents; Hydrogen-Ion Concentration; Lead; Lead Poisoning; Ligands; Potentiometry; Sodium; Spectrophotometry, Infrared; Stereoisomerism; Succimer

1995
Oral dimercaptosuccinic acid and ongoing exposure to lead: effects on heme synthesis and lead distribution in a rat model.
    Toxicology and applied pharmacology, 1995, Volume: 133, Issue:1

    Topics: Administration, Oral; Animals; Heme; Lead; Male; Rats; Rats, Sprague-Dawley; Succimer

1995
Therapeutic efficacy of combined meso 2,3-dimercaptosuccinic acid and calcium disodium edetate treatment during acute lead intoxication in rats.
    Human & experimental toxicology, 1995, Volume: 14, Issue:5

    Topics: Alanine Transaminase; Alkaline Phosphatase; Aminolevulinic Acid; Animals; Aspartate Aminotransferases; Drug Therapy, Combination; Edetic Acid; Glutathione; Hemoglobins; Kidney; Lead; Lead Poisoning; Liver; Male; Porphobilinogen Synthase; Proteinuria; Rats; Succimer

1995
Combined therapeutic potential of meso-2,3-dimercaptosuccinic acid and calcium disodium edetate on the mobilization and distribution of lead in experimental lead intoxication in rats.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1995, Volume: 25, Issue:2

    Topics: Alkaline Phosphatase; Animals; Brain Chemistry; Copper; Drug Therapy, Combination; Edetic Acid; Femur; Kidney; Lead; Lead Poisoning; Liver; Male; Rats; Rats, Wistar; Succimer; Transaminases; Zinc

1995
Urinary excretion of lead and mercury after oral administration of meso-2,3-dimercaptosuccinic acid in patients with motor neurone disease.
    International archives of occupational and environmental health, 1995, Volume: 67, Issue:2

    Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Case-Control Studies; Chelation Therapy; Female; Humans; Lead; Male; Mercury; Middle Aged; Muscular Atrophy, Spinal; Succimer

1995
Reduction of lead retention by mono-3-methylbutan-1-yl meso-2,3-dimercaptosuccinate in suckling rats.
    The Analyst, 1995, Volume: 120, Issue:3

    Topics: Animals; Animals, Suckling; Bone and Bones; Brain; Chelating Agents; Kidney; Lead; Liver; Rats; Rats, Wistar; Spectrophotometry, Atomic; Succimer

1995
[Effect of dimercaptosuccinic acid per os on distribution and excretion of 210Pb and 203Hg in mice].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1994, Volume: 15, Issue:4

    Topics: Animals; Lead; Lead Poisoning; Male; Mercury; Mercury Poisoning; Mice; Succimer; Tissue Distribution

1994
Pharmacokinetics of meso-2,3-dimercaptosuccinic acid in patients with lead poisoning and in healthy adults.
    The Journal of pediatrics, 1994, Volume: 125, Issue:2

    Topics: Adult; Age Factors; Case-Control Studies; Child; Child, Preschool; Female; Humans; Lead; Lead Poisoning; Male; Middle Aged; Succimer

1994
Effect of chelation treatment with dimercaptosuccinic acid (DMSA) on lead-related blood pressure changes.
    Environmental research, 1994, Volume: 65, Issue:1

    Topics: Animals; Blood Pressure; Chelation Therapy; Cyclic GMP; Endothelins; Lead; Male; Rats; Rats, Sprague-Dawley; Succimer

1994
Effect of chelate treatments on kidney, bone and brain lead levels of lead-intoxicated mice.
    Toxicology, 1994, Apr-18, Volume: 89, Issue:2

    Topics: Animals; Bone and Bones; Brain; Brain Chemistry; Chelating Agents; Edetic Acid; Injections, Intraperitoneal; Kidney; Lead; Lead Poisoning; Mice; Pentetic Acid; Spectrophotometry, Atomic; Succimer

1994
[2,3-dimercaptosuccinic acid: a new chelating agent, safe and efficacious, for lead poisoning].
    Medicina clinica, 1993, Oct-16, Volume: 101, Issue:12

    Topics: Chelation Therapy; Humans; Lead; Lead Poisoning; Male; Middle Aged; Occupational Diseases; Succimer

1993
Determination and metabolism of dithiol chelating agents. XV. The meso-2,3-dimercaptosuccinic acid-cysteine (1:2) mixed disulfide, a major urinary metabolite of DMSA in the human, increases the urinary excretion of lead in the rat.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3

    Topics: Animals; Biotransformation; Chelating Agents; Cysteine; Kidney; Lead; Male; Rats; Rats, Sprague-Dawley; Succimer; Tissue Distribution

1993
Efficacy of oral meso-2,3-dimercaptosuccinic acid therapy for low-level childhood plumbism.
    The Journal of pediatrics, 1994, Volume: 124, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Cohort Studies; Female; Humans; Infant; Lead; Lead Poisoning; Male; Retrospective Studies; Succimer; Treatment Outcome

1994
Use of orally administered succimer (meso-2,3-dimercaptosuccinic acid) for treatment of lead poisoning in dogs.
    Journal of the American Veterinary Medical Association, 1996, Feb-01, Volume: 208, Issue:3

    Topics: Administration, Oral; Administration, Rectal; Animals; Chelating Agents; Dog Diseases; Dogs; Female; Lead; Lead Poisoning; Male; Prospective Studies; Succimer

1996
Role of chelating agents for prevention, intervention, and treatment of exposures to toxic metals.
    Environmental health perspectives, 1995, Volume: 103, Issue:11

    Topics: Chelating Agents; Chelation Therapy; Edetic Acid; Humans; Lead; Mercury; Penicillamine; Succimer

1995
Pharmacological prevention of acute lead poisoning in Paramecium.
    Toxicology, 1996, Apr-30, Volume: 108, Issue:3

    Topics: Animals; Antidotes; Ascorbic Acid; Cations, Divalent; Cell Membrane; Chelating Agents; Cilia; Edetic Acid; Lead; Paramecium; Succimer; Sulfonamides; Swimming; Time Factors

1996
Treatment of lead-exposed children.
    Pediatrics, 1996, Volume: 98, Issue:1

    Topics: Body Surface Area; Chelating Agents; Child; Child, Preschool; Humans; Lead; Lead Poisoning; Succimer

1996
Low lead levels stunt neuronal growth in a reversible manner.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Sep-03, Volume: 93, Issue:18

    Topics: Animals; Calcium Channels; Electrophysiology; Lead; Neurons; Polyvinyls; Rana pipiens; Succimer; Superior Colliculi; Synaptic Transmission

1996
In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetylcysteine.
    Free radical biology & medicine, 1996, Volume: 21, Issue:2

    Topics: Acetylcysteine; Animals; Brain; Cysteine; Glutathione; Lead; Liver; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Oxidative Stress; Succimer

1996
Evaluation of dithiol chelating agents as potential adjuvants for anti-IL-2 receptor lead or bismuth alpha radioimmunotherapy.
    Nuclear medicine and biology, 1996, Volume: 23, Issue:2

    Topics: Adjuvants, Immunologic; Animals; Bismuth; Cell Division; Cell Survival; Chelating Agents; Female; Flow Cytometry; Indicators and Reagents; Lead; Lead Radioisotopes; Mice; Mice, Nude; Radioimmunotherapy; Radioisotopes; Rats; Receptors, Interleukin-2; Succimer; Sulfhydryl Compounds; Tumor Cells, Cultured; Unithiol

1996
The effect of 2,3 dimercaptosuccinic acid in the treatment of lead poisoning in adults.
    Annals of medicine, 1997, Volume: 29, Issue:1

    Topics: Administration, Oral; Adult; Aged; Humans; Lead; Lead Poisoning; Middle Aged; Succimer

1997
Comparative in vivo lead mobilization of meso- and rac-2,3-dimercaptosuccinic acids in albino Wistar rats.
    Pharmacology & toxicology, 1997, Volume: 80, Issue:4

    Topics: Animals; Body Weight; Brain Chemistry; Female; Femur; Kidney; Lead; Liver; Rats; Rats, Wistar; Stereoisomerism; Succimer

1997
delta-Aminolevulinic acid dehydratase genotype modifies four hour urinary lead excretion after oral administration of dimercaptosuccinic acid.
    Occupational and environmental medicine, 1997, Volume: 54, Issue:4

    Topics: Administration, Oral; Adult; Biomarkers; Chelating Agents; Chromatography, High Pressure Liquid; Genotype; Humans; Lead; Male; Middle Aged; Occupational Exposure; Polymerase Chain Reaction; Porphobilinogen Synthase; Predictive Value of Tests; Random Allocation; Succimer

1997
Effect of chelation with meso-dimercaptosuccinic acid (DMSA) before and after the appearance of lead-induced neurotoxicity in the rat.
    Toxicology and applied pharmacology, 1997, Volume: 144, Issue:2

    Topics: Animals; Behavior, Animal; Body Weight; Brain Chemistry; Central Nervous System Diseases; Chelating Agents; Drinking; Glial Fibrillary Acidic Protein; Lead; Male; Rats; Rats, Inbred F344; Succimer

1997
Full reversal of Pb++ block of L-type Ca++ channels requires treatment with heavy metal antidotes.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:1

    Topics: Animals; Antidotes; Calcium Channel Blockers; Dose-Response Relationship, Drug; Edetic Acid; Humans; Lead; Rabbits; Succimer; Xenopus laevis

1997
Lead-induced hypertension. II. Response to sequential infusions of L-arginine, superoxide dismutase, and nitroprusside.
    Environmental research, 1998, Volume: 76, Issue:2

    Topics: Animals; Arginine; Blood Pressure; Hypertension; Lead; Male; Malondialdehyde; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Succimer; Superoxide Dismutase

1998
Effect of liposome-encapsulated meso-2,3-dimercaptosuccinic acid on mice exposed to lead through drinking water.
    Bollettino chimico farmaceutico, 1997, Volume: 136, Issue:10

    Topics: Animals; Chelating Agents; Drug Carriers; Lead; Liposomes; Male; Mice; Succimer; Water Supply

1997
A report of pediatric SUCCIMER overdose.
    Veterinary and human toxicology, 1998, Volume: 40, Issue:2

    Topics: Antidotes; Cathartics; Charcoal; Chelating Agents; Child, Preschool; Female; Humans; Lead; Lead Poisoning; Sorbitol; Succimer

1998
Efficacy of succimer chelation for reducing brain Pb levels in a rodent model.
    Environmental research, 1998, Volume: 78, Issue:2

    Topics: Administration, Oral; Animals; Animals, Newborn; Brain; Brain Chemistry; Chelating Agents; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Lead; Lead Poisoning; Male; Random Allocation; Rats; Succimer

1998
Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats.
    Toxicology, 1998, Jul-17, Volume: 128, Issue:3

    Topics: Acetylcysteine; Animals; Antioxidants; Blood Cell Count; Erythrocytes; Glutathione; Lead; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Inbred F344; Succimer

1998
Mobilization of lead by calcium versenate and dimercaptosuccinate in the rat.
    Clinical and experimental pharmacology & physiology, 1998, Volume: 25, Issue:9

    Topics: Animals; Body Burden; Bone and Bones; Brain; Calcium; Chelating Agents; Edetic Acid; Iron; Lead; Male; Rats; Succimer; Zinc

1998
Meso-2,3-dimercaptosuccinic acid in the treatment of occupationally exposed lead workers.
    Arhiv za higijenu rada i toksikologiju, 1998, Volume: 49, Issue:2

    Topics: Adult; Chelating Agents; Humans; Lead; Lead Poisoning; Male; Middle Aged; Occupational Exposure; Succimer

1998
Use of the Caco-2 cell model to assess the relative lead-chelating ability of diasterioisomers of 2,3-dimercaptosuccinic acid.
    Environmental health perspectives, 1999, Volume: 107, Issue:2

    Topics: Caco-2 Cells; Cell Membrane; Cell Survival; Chelating Agents; Humans; Lead; Spectrometry, X-Ray Emission; Stereoisomerism; Succimer

1999
Persistent effect of in utero meso-2,3-dimercaptosuccinic acid (DMSA) on immune function and lead-induced immunotoxicity.
    Toxicology, 1999, Jan-01, Volume: 132, Issue:1

    Topics: Animals; Antidotes; Cells, Cultured; Chelating Agents; Cytokines; Embryonic and Fetal Development; Female; Hypersensitivity, Delayed; Immune System; Lactation; Lead; Macrophages; Male; Milk; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred F344; Spleen; Succimer

1999
Chelated lead in relation to lead in bone and ALAD genotype.
    Environmental research, 1999, Volume: 80, Issue:4

    Topics: Age Factors; Body Burden; Bone and Bones; Chelating Agents; Dose-Response Relationship, Drug; Fingers; Genotype; Humans; Lead; Mass Spectrometry; Metallurgy; Occupational Exposure; Porphobilinogen Synthase; Regression Analysis; Retirement; Spectrometry, X-Ray Emission; Spectrophotometry, Atomic; Succimer; Time Factors

1999
Predictors of dimercaptosuccinic acid chelatable lead and tibial lead in former organolead manufacturing workers.
    Occupational and environmental medicine, 1999, Volume: 56, Issue:1

    Topics: Adult; Aged; Aging; Chelating Agents; Chemical Industry; Cross-Sectional Studies; Environmental Monitoring; Humans; Lead; Linear Models; Middle Aged; Occupational Exposure; Risk Factors; Succimer; Tibia

1999
Lead inhibits meso-2,3-dimercaptosuccinic acid induced calcium transients in cultured rhesus monkey kidney cells.
    Toxicology, 1999, May-03, Volume: 134, Issue:1

    Topics: Animals; Calcium; Cells, Cultured; Chelating Agents; Kidney; Lead; Macaca mulatta; Succimer

1999
The presence of lead decreases the availability of meso-2, 3-dimercaptosuccinic acid for analysis in the monobromobimane assay.
    Chemical research in toxicology, 1999, Volume: 12, Issue:11

    Topics: Bridged Bicyclo Compounds; Chelating Agents; Chromatography, High Pressure Liquid; Dithiothreitol; Edetic Acid; Lead; Organometallic Compounds; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Succimer; Sulfhydryl Compounds; Sulfhydryl Reagents

1999
Efficacy of succimer chelation for reducing brain lead in a primate model of human lead exposure.
    Toxicology and applied pharmacology, 1999, Dec-15, Volume: 161, Issue:3

    Topics: Animals; Brain; Chelating Agents; Chelation Therapy; Disease Models, Animal; Environmental Exposure; Humans; Lead; Lead Poisoning, Nervous System; Macaca mulatta; Male; Succimer

1999
Succimer and the urinary excretion of essential elements in a primate model of childhood lead exposure.
    Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 54, Issue:2

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Lead; Lead Poisoning; Macaca mulatta; Male; Succimer; Trace Elements

2000
Influence of combined therapeutic potential of meso 2,3-dimercaptosuccinic acid and calcium disodium edetate on lead-induced testicular alterations in rats.
    Biomedical and environmental sciences : BES, 1999, Volume: 12, Issue:4

    Topics: Animals; Chelating Agents; Edetic Acid; Lead; Male; Rats; Succimer; Testicular Neoplasms; Testis

1999
Succimer and the reduction of tissue lead in juvenile monkeys.
    Toxicology and applied pharmacology, 2000, Aug-01, Volume: 166, Issue:3

    Topics: Animals; Body Burden; Chelating Agents; Female; Lead; Macaca mulatta; Succimer

2000
Acute elevation of blood lead levels within hours of ingestion of large quantities of lead shot.
    Journal of toxicology. Clinical toxicology, 2000, Volume: 38, Issue:4

    Topics: Antidotes; Bisacodyl; Child, Preschool; Dietary Fiber; Female; Foreign Bodies; Humans; Lead; Lead Poisoning; Radiography; Stomach; Succimer; Therapeutic Irrigation; Treatment Outcome

2000
Comparison of two heavy metal chelators for treatment of lead toxicosis in cockatiels.
    American journal of veterinary research, 2000, Volume: 61, Issue:8

    Topics: Animals; Bird Diseases; Body Weight; Chelating Agents; Edetic Acid; Female; Kidney; Lead; Lead Poisoning; Liver; Male; Psittaciformes; Random Allocation; Spectrophotometry, Atomic; Spleen; Succimer; Survival Analysis; Thyroid Gland

2000
A comparison of different lead biomarkers in their associations with lead-related symptoms.
    International archives of occupational and environmental health, 2000, Volume: 73, Issue:5

    Topics: Adult; Aminolevulinic Acid; Biomarkers; Case-Control Studies; Chelating Agents; Humans; Korea; Lead; Lead Poisoning; Linear Models; Logistic Models; Male; Occupational Diseases; Odds Ratio; Predictive Value of Tests; Protoporphyrins; Succimer; Surveys and Questionnaires

2000
Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with polymorphisms in the vitamin D receptor and [delta]-aminolevulinic acid dehydratase genes.
    Environmental health perspectives, 2000, Volume: 108, Issue:10

    Topics: Adolescent; Adult; Chelating Agents; Cross-Sectional Studies; Female; Humans; Lead; Male; Middle Aged; Occupational Exposure; Polymorphism, Genetic; Porphobilinogen Synthase; Receptors, Calcitriol; Succimer; Tibia; Tissue Distribution

2000
Predictors of DMSA chelatable lead, tibial lead, and blood lead in 802 Korean lead workers.
    Occupational and environmental medicine, 2001, Volume: 58, Issue:2

    Topics: Adult; Chelating Agents; Cross-Sectional Studies; Female; Humans; Korea; Lead; Longitudinal Studies; Male; Metallurgy; Middle Aged; Occupational Exposure; Regression Analysis; Risk Assessment; Succimer; Tibia

2001
Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with neurobehavioral test scores in South Korean lead workers.
    American journal of epidemiology, 2001, Mar-01, Volume: 153, Issue:5

    Topics: Adult; Case-Control Studies; Chelating Agents; Cross-Sectional Studies; Female; Humans; Korea; Lead; Lead Poisoning, Nervous System, Adult; Longitudinal Studies; Male; Middle Aged; Occupational Diseases; Occupational Exposure; Peripheral Nervous System Diseases; Psychomotor Performance; Radiography; Spectrometry, X-Ray Emission; Succimer; Tibia

2001
Associations of tibia lead, DMSA-chelatable lead, and blood lead with measures of peripheral nervous system function in former organolead manufacturing workers.
    American journal of industrial medicine, 2001, Volume: 39, Issue:3

    Topics: Adult; Aged; Chemical Industry; Cohort Studies; Hand Strength; Humans; Lead; Male; Middle Aged; Motor Activity; Peripheral Nervous System; Radiography; Sensory Thresholds; Succimer; Tibia; Touch; Workforce

2001
Primary prevention of childhood lead poisoning--the only solution.
    The New England journal of medicine, 2001, May-10, Volume: 344, Issue:19

    Topics: Chelating Agents; Chelation Therapy; Child Development; Child, Preschool; Cognition; Cost Savings; Humans; Lead; Lead Poisoning; Primary Prevention; Succimer

2001
Succimer for treatment of lead toxicosis in two cats.
    Journal of the American Veterinary Medical Association, 2001, Jun-15, Volume: 218, Issue:12

    Topics: Animals; Anorexia; Cat Diseases; Cats; Chelating Agents; Female; Kidney; Lead; Lead Poisoning; Liver; Seizures; Succimer; Tissue Distribution; Vomiting

2001
Oral succimer decreases the gastrointestinal absorption of lead in juvenile monkeys.
    Environmental health perspectives, 2001, Volume: 109, Issue:6

    Topics: Administration, Oral; Animals; Chelating Agents; Child; Disease Models, Animal; Female; Humans; Intestinal Absorption; Isotopes; Lead; Lead Poisoning; Macaca mulatta; Succimer

2001
The effects of elevated blood lead levels and succimer chelation therapy on physical growth in developing rhesus monkeys.
    Environmental research, 2001, Volume: 87, Issue:1

    Topics: Administration, Oral; Animals; Body Height; Body Weight; Chelating Agents; Cross-Over Studies; Environmental Exposure; Female; Lead; Lead Poisoning; Macaca mulatta; Random Allocation; Succimer; Treatment Outcome

2001
Bite the bullet: lead poisoning after ingestion of 206 lead bullets.
    Veterinary and human toxicology, 2001, Volume: 43, Issue:5

    Topics: Antidotes; Chelating Agents; Colon; Edetic Acid; Foreign Bodies; Gastrointestinal Hemorrhage; Humans; Lead; Lead Poisoning; Male; Middle Aged; Schizophrenia; Succimer; Suicide, Attempted; Therapeutic Irrigation; Treatment Outcome

2001
Effect of L-arginine, dimercaptosuccinic acid (DMSA) and the association of L-arginine and DMSA on tissue lead mobilization and blood pressure level in plumbism.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2001, Volume: 34, Issue:10

    Topics: Animals; Aorta; Arginine; Blood Pressure; Chelating Agents; Drug Therapy, Combination; Femur; Hypertension; Kidney; Lead; Lead Poisoning; Liver; Male; Rats; Rats, Wistar; Succimer

2001
Chelation therapy in children exposed to lead.
    The New England journal of medicine, 2001, Oct-18, Volume: 345, Issue:16

    Topics: Chelating Agents; Chelation Therapy; Child; Humans; Lead; Lead Poisoning; Penicillamine; Succimer; Unithiol

2001
Treatment of children with elevated blood lead levels.
    American journal of preventive medicine, 2002, Volume: 22, Issue:1

    Topics: Chelating Agents; Chelation Therapy; Child; Humans; Lead; Lead Poisoning; Succimer

2002
Lead poisoning prevention, not chelation (commentary).
    Journal of toxicology. Clinical toxicology, 2001, Volume: 39, Issue:7

    Topics: Chelating Agents; Chelation Therapy; Child; Child Development; Child, Preschool; Cognition Disorders; Double-Blind Method; Humans; Lead; Lead Poisoning; Neuropsychological Tests; Randomized Controlled Trials as Topic; Succimer

2001
Associations of lead biomarkers and delta-aminolevulinic acid dehydratase and vitamin D receptor genotypes with hematopoietic outcomes in Korean lead workers.
    Scandinavian journal of work, environment & health, 2001, Volume: 27, Issue:6

    Topics: Adolescent; Adult; Biomarkers; Case-Control Studies; Chelating Agents; Cross-Sectional Studies; Female; Hematologic Tests; Hematopoiesis; Humans; Korea; Lead; Linear Models; Male; Middle Aged; Occupational Exposure; Polymorphism, Genetic; Porphobilinogen Synthase; Receptors, Calcitriol; Succimer; Tibia; Tissue Distribution

2001
Lead poisoning: case studies.
    British journal of clinical pharmacology, 2002, Volume: 53, Issue:5

    Topics: Acute Disease; Adult; Chelating Agents; Edetic Acid; Humans; Lead; Lead Poisoning; Male; Middle Aged; Occupational Diseases; Succimer

2002
Lead induced oxidative damage and its response to combined administration of alpha-lipoic acid and succimers in rats.
    Toxicology, 2002, Aug-15, Volume: 177, Issue:2-3

    Topics: Animals; Antioxidants; Brain; Chelating Agents; Drug Therapy, Combination; Glutathione; Hematopoiesis; Kidney; Lead; Male; Oxidative Stress; Rats; Rats, Wistar; Succimer; Superoxide Dismutase; Thioctic Acid

2002
Reversal of lead-induced oxidative stress by chelating agent, antioxidant, or their combination in the rat.
    Environmental research, 2002, Volume: 90, Issue:1

    Topics: Acetylcysteine; Aminolevulinic Acid; Animals; Antioxidants; Brain; Catalase; Chelating Agents; Free Radical Scavengers; Glutathione; Kidney; Lead; Lead Poisoning; Male; Malondialdehyde; Oxidative Stress; Rats; Succimer

2002
2,3-Dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase mercury- and cadmium-induced inhibition of delta-aminolevulinate dehydratase.
    Toxicology, 2003, Mar-03, Volume: 184, Issue:2-3

    Topics: Animals; Cadmium; Chelating Agents; Drug Synergism; Enzyme Inhibitors; Lead; Male; Mercury; Mice; Polarography; Porphobilinogen Synthase; Succimer; Unithiol; Zinc

2003
Effect of meso-2,3-dimercaptosuccinic acid on urinary lead excretion in exposed men.
    Human & experimental toxicology, 2002, Volume: 21, Issue:11

    Topics: Administration, Oral; Adult; Chelating Agents; Humans; Lead; Lead Poisoning; Male; Occupational Diseases; Succimer; Treatment Outcome

2002
Effects of dietary lead and/or dimercaptosuccinic acid exposure on regional serotonin and serotonin metabolite content in rainbow trout (Oncorhynchus mykiss).
    Neuroscience letters, 2003, Mar-20, Volume: 339, Issue:2

    Topics: Animals; Antidotes; Brain Stem; Cerebellum; Chelating Agents; Diet; Hazardous Substances; Hydroxyindoleacetic Acid; Lead; Medulla Oblongata; Oncorhynchus mykiss; Serotonin; Succimer; Superior Colliculi

2003
Oral treatment of avian lead intoxication with meso-2,3-dimercaptosuccinic acid.
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2003, Volume: 34, Issue:1

    Topics: Administration, Oral; Animals; Animals, Zoo; Bird Diseases; Birds; Chelating Agents; Lead; Lead Poisoning; Longitudinal Studies; Regression Analysis; Retrospective Studies; Succimer

2003
Gunshot-induced plumbism in an adult male.
    Journal of the National Medical Association, 2003, Volume: 95, Issue:10

    Topics: Abdominal Pain; Adult; Anemia, Hemolytic; Chelating Agents; Humans; Lead; Lead Poisoning; Male; Succimer; Time Factors; Wounds, Gunshot

2003
Ascorbic acid supplementation does not improve efficacy of meso-dimercaptosuccinic acid treatment in lead-exposed suckling rats.
    Pharmacology & toxicology, 2003, Volume: 93, Issue:4

    Topics: Administration, Oral; Animals; Animals, Suckling; Antidotes; Ascorbic Acid; Chelating Agents; Drug Synergism; Drug Therapy, Combination; Female; Lead; Lead Poisoning; Male; Rats; Rats, Wistar; Succimer

2003
Reductions in blood lead overestimate reductions in brain lead following repeated succimer regimens in a rodent model of childhood lead exposure.
    Environmental health perspectives, 2004, Volume: 112, Issue:3

    Topics: Animals; Biomarkers; Brain; Chelating Agents; Disease Models, Animal; Endpoint Determination; Female; Forecasting; Lead; Lead Poisoning; Male; Models, Theoretical; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Succimer; Tissue Distribution; Treatment Outcome

2004
The effects of meso-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus.
    Free radical biology & medicine, 2004, Oct-01, Volume: 37, Issue:7

    Topics: Animals; Anthocyanins; Apoptosis; bcl-2-Associated X Protein; Chelating Agents; Free Radical Scavengers; Free Radicals; Glutathione; Glutathione Reductase; Hippocampus; Lead; Lead Poisoning; Lipid Peroxidation; Male; Neurons; Oxidation-Reduction; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Succimer; Time Factors

2004
Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats.
    Journal of biochemical and molecular toxicology, 2004, Volume: 18, Issue:4

    Topics: Animals; Brain; Chelating Agents; Drug Therapy, Combination; Edetic Acid; Glutathione; Hemoglobins; Kidney; Lead; Lead Poisoning; Male; Metals; Oxidative Stress; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Wistar; Succimer; Unithiol

2004
Lead induced oxidative stress and its recovery following co-administration of melatonin or N-acetylcysteine during chelation with succimer in male rats.
    Cellular and molecular biology (Noisy-le-Grand, France), 2004, Volume: 50 Online Pub

    Topics: Acetylcysteine; Animals; Antioxidants; Brain; Brain Chemistry; Chelating Agents; Kidney; Lead; Lead Poisoning; Liver; Male; Melatonin; Oxidative Stress; Rats; Succimer

2004
The need for vigilance: the persistence of lead poisoning in children.
    Pediatrics, 2005, Volume: 115, Issue:6

    Topics: Cheek; Chelation Therapy; Child, Preschool; Dimercaprol; Drug Therapy, Combination; Edema; Edetic Acid; Environmental Exposure; Foreign Bodies; Humans; Lead; Lead Poisoning; Male; Pica; Play and Playthings; Protoporphyrins; Seizures; Self-Injurious Behavior; Succimer; Wounds, Gunshot

2005
2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase lead-induced inhibition of delta-aminolevulinate dehydratase in vitro and ex vivo.
    Toxicology in vitro : an international journal published in association with BIBRA, 2006, Volume: 20, Issue:3

    Topics: Animals; Brain; Chelating Agents; Dimercaprol; Drug Synergism; Enzyme Inhibitors; Humans; In Vitro Techniques; Kidney; Lead; Liver; Male; Mice; Nerve Tissue Proteins; Porphobilinogen Synthase; Succimer; Unithiol

2006
Maternal IQ, child IQ, behavior, and achievement in urban 5-7 year olds.
    Pediatric research, 2006, Volume: 59, Issue:3

    Topics: Achievement; Chelating Agents; Child; Child Behavior Disorders; Child, Preschool; Female; Humans; Intellectual Disability; Intelligence; Intelligence Tests; Lead; Lead Poisoning; Male; Mothers; Neuropsychological Tests; Random Allocation; Social Environment; Succimer; Urban Population

2006
Autonomic dysfunction due to lead poisoning.
    Autonomic neuroscience : basic & clinical, 2007, Mar-30, Volume: 132, Issue:1-2

    Topics: Adult; Anemia; Autonomic Nervous System Diseases; Chelating Agents; Erectile Dysfunction; Humans; Intestinal Pseudo-Obstruction; Lead; Lead Poisoning, Nervous System, Adult; Male; Medicine, Ayurvedic; Plants, Medicinal; Succimer

2007
Therapeutic potentials of combined use of DMSA with calcium and ascorbic acid in the treatment of mild to moderately lead intoxicated mice.
    Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2008, Volume: 21, Issue:1

    Topics: Animals; Ascorbic Acid; Calcium; Drug Therapy, Combination; Female; Lead; Lead Poisoning; Mice; Porphobilinogen Synthase; Severity of Illness Index; Succimer; Vitamins

2008
Lead exposure, IQ, and behavior in urban 5- to 7-year-olds: does lead affect behavior only by lowering IQ?
    Pediatrics, 2007, Volume: 119, Issue:3

    Topics: Age Distribution; Causality; Chelating Agents; Child; Child Behavior Disorders; Child, Preschool; Cognition Disorders; Comorbidity; Environmental Exposure; Environmental Monitoring; Epidemiological Monitoring; Female; Follow-Up Studies; Humans; Intelligence; Lead; Lead Poisoning, Nervous System, Childhood; Male; Odds Ratio; Regression Analysis; Succimer; United States; Urban Population

2007
Reversal of lead-induced neuronal apoptosis by chelation treatment in rats: role of reactive oxygen species and intracellular Ca(2+).
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:1

    Topics: Animals; Apoptosis; Behavior, Animal; Brain; Calcium; Chelating Agents; Edetic Acid; Lead; Male; Mitochondria; Neurons; Neurotransmitter Agents; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer

2007
Response of lead-induced oxidative stress and alterations in biogenic amines in different rat brain regions to combined administration of DMSA and MiADMSA.
    Chemico-biological interactions, 2007, Dec-15, Volume: 170, Issue:3

    Topics: Amines; Animals; Brain; Copper; Erythrocytes; Heme; Lead; Male; Oxidative Stress; Rats; Rats, Wistar; Succimer; Zinc

2007
Effects of in utero meso-2,3-dimercaptosuccinic acid with calcium and ascorbic acid on lead-induced fetal development.
    Archives of toxicology, 2008, Volume: 82, Issue:7

    Topics: Animals; Ascorbic Acid; Body Burden; Body Weight; Calcium Carbonate; Chelating Agents; Female; Fetal Development; Growth; Hemoglobins; Lead; Male; Mice; Nervous System; Pregnancy; Succimer

2008
Direct detection of Pb in urine and Cd, Pb, Cu, and Ag in natural waters using electrochemical sensors immobilized with DMSA functionalized magnetic nanoparticles.
    The Analyst, 2008, Volume: 133, Issue:3

    Topics: Animals; Cadmium; Chelating Agents; Copper; Electrochemistry; Environmental Monitoring; Environmental Pollutants; Ferric Compounds; Lead; Magnetics; Metal Nanoparticles; Metals, Heavy; Rats; Rats, Sprague-Dawley; Silver; Succimer; Water Pollutants, Chemical

2008
Morphological changes due to Lead exposure and the influence of DMSA on the gill tissues of the freshwater fish, Catla catla.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:7

    Topics: Animals; Antidotes; Cyprinidae; Environmental Exposure; Fresh Water; Gills; Lead; Microscopy, Electron, Scanning; Succimer; Time Factors

2008
Infantile lead poisoning from an Asian tongue powder: a case report & subsequent public health inquiry.
    Clinical toxicology (Philadelphia, Pa.), 2008, Volume: 46, Issue:9

    Topics: Chelating Agents; Drug Contamination; Edetic Acid; Fluorescence; Humans; Infant; Lead; Lead Poisoning; Male; Medicine, East Asian Traditional; Plant Preparations; Spectrometry, X-Ray Emission; Succimer; Thailand; Tongue

2008
Effects of chelators on mercury, iron, and lead neurotoxicity in cortical culture.
    Neurotoxicology, 2009, Volume: 30, Issue:1

    Topics: Animals; Brain Chemistry; Cell Death; Cells, Cultured; Cerebral Cortex; Chelating Agents; Drug Synergism; Edetic Acid; Female; Iron; Lead; Mercuric Chloride; Methylmercury Compounds; Mice; Penicillamine; Pregnancy; Succimer; Thimerosal; Unithiol

2009
The study of the changes in the biochemical and mineral contents of bones of Catla catla due to lead intoxication.
    Environmental toxicology, 2010, Volume: 25, Issue:1

    Topics: Animals; Bone and Bones; Bone Density; Cyprinidae; Lead; Lead Poisoning; Succimer; Water Pollutants, Chemical

2010
[Antagonism of total flavonoids from Chrysanthemum morifolium against lead induced oxidative injury in mice].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008, Volume: 33, Issue:23

    Topics: Administration, Oral; Animals; Brain; Chrysanthemum; Copper; Drug Antagonism; Flavonoids; Kidney; Lead; Liver; Male; Mice; Mice, Inbred ICR; Oxidative Stress; Random Allocation; Succimer; Zinc

2008
[Effects of chelation therapy with succimer in young rabbits of moderate lead poisoning].
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2009, Volume: 43, Issue:1

    Topics: Animals; Chelation Therapy; Lead; Lead Poisoning; Male; Rabbits; Succimer

2009
Use of oral dimercaptosuccinic acid (succimer) in adult patients with inorganic lead poisoning.
    QJM : monthly journal of the Association of Physicians, 2009, Volume: 102, Issue:10

    Topics: Administration, Oral; Adolescent; Adult; Aged; Antidotes; Chelating Agents; Chelation Therapy; Drug Evaluation; Female; Humans; Lead; Lead Poisoning; Male; Middle Aged; Succimer; Young Adult

2009
Individual and combined effect of meso-2,3-dimercaptosuccinic acid and allicin on blood and tissue lead content in mice.
    Planta medica, 2010, Volume: 76, Issue:3

    Topics: Animals; Bone and Bones; Chelating Agents; Disulfides; Drug Synergism; Drug Therapy, Combination; Female; Garlic; Lead; Lead Poisoning; Mice; Phytotherapy; Succimer; Sulfinic Acids

2010
[Lead intoxication in a group of workers in Germany].
    Deutsche medizinische Wochenschrift (1946), 2009, Volume: 134, Issue:50

    Topics: Antidotes; Chelating Agents; Germany; Humans; Kinetics; Lead; Lead Poisoning; Occupational Diseases; Occupational Exposure; Pain; Porphobilinogen Synthase; Succimer

2009
Case report: heavy metal burden presenting as Bartter syndrome.
    Alternative medicine review : a journal of clinical therapeutic, 2010, Volume: 15, Issue:4

    Topics: Bartter Syndrome; Beryllium; Cadmium; Chelating Agents; Failure to Thrive; Female; Glass; Humans; Infant; Lead; Male; Mercury; Metals, Heavy; Occupational Exposure; Pregnancy; Prenatal Exposure Delayed Effects; Succimer

2010
Blood, urine, and hair kinetic analysis following an acute lead intoxication.
    Journal of analytical toxicology, 2011, Volume: 35, Issue:1

    Topics: Chelating Agents; Chelation Therapy; Female; Hair; Humans; Kinetics; Lead; Lead Poisoning; Middle Aged; Succimer; Unithiol

2011
Treatment of chronic lead toxicity with succimer: a case series of 2 adults with retained lead shotgun fragments.
    The American journal of forensic medicine and pathology, 2011, Volume: 32, Issue:3

    Topics: Adult; Chelating Agents; Female; Foreign Bodies; Humans; Lead; Lead Poisoning; Male; Succimer; Wounds, Gunshot

2011
Lead detoxification activities of a class of novel DMSA--amino acid conjugates.
    Chemical research in toxicology, 2011, Jun-20, Volume: 24, Issue:6

    Topics: Amino Acid Sequence; Amino Acids; Animals; Antidotes; Lead; Lead Poisoning; Male; Mice; Succimer

2011
EDTA redistribution of lead and cadmium into the soft tissues in a human with a high lead burden - should DMSA always be used to follow EDTA in such cases?
    Alternative medicine review : a journal of clinical therapeutic, 2011, Volume: 16, Issue:2

    Topics: Cadmium; Chelation Therapy; Dose-Response Relationship, Drug; Drug Therapy, Combination; Edetic Acid; Humans; Lead; Lead Poisoning; Male; Middle Aged; Occupational Exposure; Succimer; Tissue Distribution; Treatment Outcome

2011
Lactobacillus plantarum CCFM8661 alleviates lead toxicity in mice.
    Biological trace element research, 2012, Volume: 150, Issue:1-3

    Topics: Animals; Biomarkers; Chelating Agents; Chelation Therapy; Hot Temperature; Lactobacillus plantarum; Lead; Lead Poisoning; Male; Mice; Mice, Inbred Strains; Microbial Viability; Organometallic Compounds; Oxidative Stress; Porphobilinogen Synthase; Probiotics; Random Allocation; Reactive Oxygen Species; Succimer; Tissue Distribution

2012
Monensin potentiates lead chelation efficacy of MiADMSA in rat brain post chronic lead exposure.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:12

    Topics: Animals; Antioxidants; Biomarkers; Brain; Chelating Agents; DNA Damage; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Kidney; Lead; Male; Monensin; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2012
Lead poisoning from Ayurvedic medicines.
    The New Zealand medical journal, 2013, May-10, Volume: 126, Issue:1374

    Topics: Adult; Chelating Agents; Humans; Lead; Lead Poisoning; Male; Medicine, Ayurvedic; Succimer

2013
Reversal effect of monoisoamyl dimercaptosuccinic acid (MiADMSA) for arsenic and lead induced perturbations in apoptosis and antioxidant enzymes in developing rat brain.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2013, Volume: 31, Issue:7

    Topics: Age Factors; Animals; Animals, Newborn; Antioxidants; Apoptosis; Arsenates; Brain; Catalase; Embryo, Mammalian; Female; Lead; Male; Malondialdehyde; Oxidative Stress; Pregnancy; Rats; Rats, Wistar; Succimer; Superoxide Dismutase

2013
Role of chelation in the treatment of lead poisoning: discussion of the Treatment of Lead-Exposed Children Trial (TLC).
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2013, Volume: 9, Issue:4

    Topics: Age Factors; Biomarkers; Chelating Agents; Chelation Therapy; Child; Child, Preschool; Cognition; Environmental Exposure; Female; Humans; Infant; Infant Behavior; Lead; Lead Poisoning, Nervous System, Childhood; Male; Randomized Controlled Trials as Topic; Succimer; Time Factors; Treatment Outcome

2013
Acute abdominal pain and constipation due to lead poisoning.
    Acute medicine, 2013, Volume: 12, Issue:4

    Topics: Abdominal Pain; Acute Pain; Adult; Chelating Agents; Constipation; Diagnosis, Differential; Humans; Hypogonadism; Lead; Lead Poisoning; Male; Medicine, Ayurvedic; Plant Preparations; Succimer; Treatment Outcome

2013
Protective effect of mulberry extract against Pb-induced learning and memory deficits in mice.
    Biomedical and environmental sciences : BES, 2014, Volume: 27, Issue:1

    Topics: Animals; Chelating Agents; Lead; Learning; Memory Disorders; Mice; Morus; Plant Extracts; Random Allocation; Succimer

2014
Combination therapy for the cardiovascular effects of perinatal lead exposure in young and adult rats.
    Arquivos brasileiros de cardiologia, 2014, Volume: 103, Issue:3

    Topics: Age Factors; Animals; Antihypertensive Agents; Arginine; Blood Pressure; Body Weight; Cardiovascular System; Chelating Agents; Combined Modality Therapy; Enalapril; Female; Hypertension; Lactation; Lead; Lead Poisoning; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Wistar; Succimer; Time Factors; Treatment Outcome

2014
Ayurvedic medicine use and lead poisoning in a child: a continued concern in the United States.
    Clinical pediatrics, 2015, Volume: 54, Issue:7

    Topics: Chelating Agents; Humans; Infant; Lead; Lead Poisoning; Male; Medicine, Ayurvedic; Succimer; United States

2015
Attenuation of lead-induced oxidative stress in rat brain, liver, kidney and blood of male Wistar rats by Moringa oleifera seed powder.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2014, Volume: 33, Issue:4

    Topics: Animals; Antioxidants; Brain; Chelating Agents; Kidney; Lead; Liver; Male; Moringa oleifera; Oxidative Stress; Plant Extracts; Powders; Rats; Rats, Wistar; Seeds; Succimer; Tissue Distribution

2014
Autism: a form of lead and mercury toxicity.
    Environmental toxicology and pharmacology, 2014, Volume: 38, Issue:3

    Topics: Autistic Disorder; Case-Control Studies; Chelating Agents; Child; Child, Preschool; Environmental Pollutants; Female; Humans; Lead; Male; Mercury; Risk Factors; Succimer; Surveys and Questionnaires; Treatment Outcome

2014
Protective Effect of Porcine Cerebral Hydrolysate Peptides on Learning and Memory Deficits and Oxidative Stress in Lead-Exposed Mice.
    Biological trace element research, 2015, Volume: 168, Issue:2

    Topics: Animals; Behavior, Animal; Brain; Hydrolysis; Iron; Lead; Learning; Maze Learning; Memory Disorders; Mice; Movement; Nitric Oxide Synthase; Organ Size; Oxidative Stress; Peptides; Protein Hydrolysates; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Subtilisins; Succimer; Swine; Ultrasonics; Zinc

2015
Silymarin and dimercaptosuccinic acid ameliorate lead-induced nephrotoxicity and genotoxicity in rats.
    Human & experimental toxicology, 2016, Volume: 35, Issue:4

    Topics: Animals; Antidotes; Kidney Diseases; Lead; Male; Random Allocation; Rats; Rats, Wistar; Silymarin; Succimer

2016
Modelling dimercaptosuccinic acid (DMSA) plasma kinetics in humans.
    Clinical toxicology (Philadelphia, Pa.), 2016, Volume: 54, Issue:9

    Topics: Adult; Chelating Agents; Chelation Therapy; Humans; Lead; Lead Poisoning; Male; Models, Biological; Succimer; Young Adult

2016
Modeling the effect of succimer (DMSA; dimercaptosuccinic acid) chelation therapy in patients poisoned by lead.
    Clinical toxicology (Philadelphia, Pa.), 2017, Volume: 55, Issue:2

    Topics: Adolescent; Adult; Antidotes; Chelating Agents; Chelation Therapy; Humans; Lead; Lead Poisoning; Male; Medicine, Traditional; Models, Biological; Occupational Exposure; Reproducibility of Results; Succimer

2017
Severe Lead Toxicosis in a Lionhead Rabbit.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2017, Volume: 13, Issue:1

    Topics: Animals; Antidotes; Chelating Agents; Gastroparesis; Lead; Lead Poisoning; Male; Rabbits; Succimer

2017
Lead adsorption, anticoagulation and in vivo toxicity studies on the new magnetic nanomaterial Fe
    Nanomedicine : nanotechnology, biology, and medicine, 2017, Volume: 13, Issue:4

    Topics: Adsorption; Animals; Ferrosoferric Oxide; Hemoperfusion; Lead; Lead Poisoning; Materials Testing; Nanoparticles; Rabbits; Silicon Dioxide; Succimer; Swine; Toxicity Tests

2017
Effects of meso-2,3-dimercaptosuccinic acid, potassium iodide and chlorophyll on lead accumulation in male mice.
    International journal of occupational medicine and environmental health, 2017, Feb-21, Volume: 30, Issue:1

    Topics: Animals; Chelating Agents; Chlorophyll; Food Additives; Kidney; Lead; Lead Poisoning; Liver; Male; Mice; Potassium Iodide; Succimer; Testis

2017
Elevated lead level from a tobacco source requiring chelation in a 12-year-old child.
    Clinical toxicology (Philadelphia, Pa.), 2018, Volume: 56, Issue:11

    Topics: Adult; Chelating Agents; Child; Environmental Exposure; Female; Humans; Lead; Lead Poisoning; Male; Nicotiana; Succimer; Thailand; Tobacco, Smokeless; Treatment Outcome; United States

2018
Reversing the adverse biochemical effects in lead-intoxicated rats by N,N`- bis[(1,2-didehydro-1-hydroxy-2-thioxopyrid-4-yl)-carbonyl]- L-lysine.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2018, Volume: 50

    Topics: Animals; Chelating Agents; Chelation Therapy; Edetic Acid; Lead; Lead Poisoning; Male; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Wistar; Succimer

2018
Effects of combined arsenic and lead exposure on the brain monoaminergic system and behavioral functions in rats: Reversal effect of MiADMSA.
    Toxicology and industrial health, 2019, Volume: 35, Issue:2

    Topics: Animals; Arsenic; Behavior, Animal; Biogenic Monoamines; Brain; Exploratory Behavior; Female; Lead; Male; Motor Activity; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Succimer

2019
Impacts of lead exposure and chelation therapy on bone metabolism during different developmental stages of rats.
    Ecotoxicology and environmental safety, 2019, Nov-15, Volume: 183

    Topics: Animals; Bone and Bones; Bone Development; Chelating Agents; Chelation Therapy; Lead; Lead Poisoning; Male; Rats; Succimer

2019
Effects of combined administration of calcium, iron, zinc, chrysanthemum flavonoids, and DMSA on the treatment of lead intoxication in mice.
    Journal of biochemical and molecular toxicology, 2020, Volume: 34, Issue:2

    Topics: Animals; Calcium; Chrysanthemum; Disease Models, Animal; Drug Therapy, Combination; Female; Flavonoids; Glutathione; Glutathione Peroxidase; Hippocampus; Iron; Lead; Lead Poisoning; Liver; Malondialdehyde; Mice; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Plant Extracts; Porphobilinogen Synthase; Succimer; Superoxide Dismutase; Treatment Outcome; Zinc

2020
Clinical Chemistry of Abdominal X-Rays.
    Clinical chemistry, 2020, 06-01, Volume: 66, Issue:6

    Topics: Edetic Acid; Humans; Infant; Lead; Lead Poisoning; Male; Paint; Radiography, Abdominal; Succimer

2020
The synergistic hepatoprotective potential of Beta vulgaris juice and 2,3- dimercaptosuccinic acid in lead-intoxicated rats via improving the hepatic oxidative and inflammatory stress.
    BMC complementary medicine and therapies, 2020, Sep-01, Volume: 20, Issue:1

    Topics: Administration, Oral; Animals; Antioxidants; Beta vulgaris; Chelating Agents; Disease Models, Animal; Drug Synergism; Egypt; Fruit and Vegetable Juices; Inflammation; Lead; Lead Poisoning; Liver; Male; Oxidative Stress; Rats; Succimer

2020
Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats.
    Scientific reports, 2021, 01-08, Volume: 11, Issue:1

    Topics: Animals; Antioxidants; Beta vulgaris; Brain; DNA Fragmentation; Drug Synergism; Inflammation; Lead; Male; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Plant Extracts; Rats; Succimer

2021
Efficacy and expenses of succimer vs. d-penicillamine plus garlic in the treatment of lead poisoning: a retrospective cross-sectional study.
    Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2021, Volume: 29, Issue:2

    Topics: Adult; Antidotes; Cost-Benefit Analysis; Cross-Sectional Studies; Drug Therapy, Combination; Garlic; Humans; Iran; Lead; Lead Poisoning; Male; Penicillamine; Phytochemicals; Retrospective Studies; Succimer; Treatment Outcome

2021
Adansonia digitata L. fruit shell extract alleviates lead-induced neurotoxicity in mice via modulation of oxidative stress and a possible chelating activity.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2022, Volume: 74

    Topics: Adansonia; Animals; Antioxidants; Biomarkers; Chelating Agents; Eosine Yellowish-(YS); Fruit; Lead; Male; Mice; Oxidative Stress; Plant Extracts; Succimer; Superoxide Dismutase

2022
Lead poisoning with encephalic and neuropathic involvement in a child: case report.
    The Pan African medical journal, 2022, Volume: 42

    Topics: Brain; Child; Child, Preschool; Family; Female; Humans; Lead; Lead Poisoning; Peripheral Nervous System Diseases; Succimer

2022
Succimer Mitigates the Perioperative Risk for an Increase in Blood Lead Levels During Bulletectomy: A Case Report.
    JBJS case connector, 2023, Apr-01, Volume: 13, Issue:2

    Topics: Adult; Chelating Agents; Humans; Lead; Lead Poisoning; Male; Succimer; Wounds, Gunshot

2023
Induction of Labor at Term for Severe Antenatal Lead Poisoning.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2023, Volume: 19, Issue:4

    Topics: Adult; Chelating Agents; Female; Humans; Infant; Infant, Newborn; Labor, Induced; Lead; Lead Poisoning; Pregnancy; Succimer; Young Adult

2023