laurencin has been researched along with 2-hexadecynoic-acid* in 1 studies
1 other study(ies) available for laurencin and 2-hexadecynoic-acid
Article | Year |
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An approach to lauroxanes by iterative use of Co(2)(CO)(6)-acetylenic complexes. a formal synthesis of (+)-laurencin.
A new approach to lauroxanes by a powerful and highly convergent methodology based on iterative use of Co(2)(CO)(6)-acetylenic complexes is described. The strategy employs an intermolecular Nicholas reaction to form unsaturated branched linear ethers, a ring closing metathesis to obtain the cobalt complex cyclic ethers, and an isomerization promoted by montmorillonite K-10. A short synthesis of cyclic ethers of seven-, eight-, and nine-membered rings is described. Additionally, the methodology is exemplified by the formal synthesis of (+)-laurencin, a red algae metabolite. Topics: Alkynes; Cobalt; Cyclization; Fatty Acids, Unsaturated; Molecular Structure; Organometallic Compounds; Oxocins; Stereoisomerism | 2010 |