Page last updated: 2024-09-05

latrepirdine and memantine

latrepirdine has been researched along with memantine in 8 studies

Compound Research Comparison

Studies
(latrepirdine)
Trials
(latrepirdine)
Recent Studies (post-2010)
(latrepirdine)
Studies
(memantine)
Trials
(memantine)
Recent Studies (post-2010) (memantine)
1267592,6843411,425

Protein Interaction Comparison

ProteinTaxonomylatrepirdine (IC50)memantine (IC50)
Neuronal acetylcholine receptor subunit alpha-3Rattus norvegicus (Norway rat)6
Neuronal acetylcholine receptor subunit beta-4Rattus norvegicus (Norway rat)6
AcetylcholinesteraseHomo sapiens (human)0.0049
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)1.4167
Neuronal acetylcholine receptor subunit alpha-6Rattus norvegicus (Norway rat)6
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)1.4167
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)1.5
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)1.5
Glutamate receptor ionotropic, NMDA 1Homo sapiens (human)4.3212
Glutamate receptor ionotropic, NMDA 2AHomo sapiens (human)3.662
Glutamate receptor ionotropic, NMDA 2BHomo sapiens (human)5.31
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)1.5
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)1.5
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)1.5

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (50.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Bachurin, SO; Dranyi, OA; Grigorev, VV1
Bachurin, SO; Kireeva, EG; Shevtsova, EF1
van Marum, RJ1
Kovács, T1
Alfaro, IE; Altar, CA; Bernales, S; Cremers, T; Drieu La Rochelle, C; Gibbons, JA; Giorgetti, M; Hutter-Paier, B; Protter, AA; Wronski, R1
Shoji, M1
Gravitz, L1

Reviews

3 review(s) available for latrepirdine and memantine

ArticleYear
Current and future therapy in Alzheimer's disease.
    Fundamental & clinical pharmacology, 2008, Volume: 22, Issue:3

    Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Docosahexaenoic Acids; Estrogen Replacement Therapy; Excitatory Amino Acid Antagonists; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunotherapy; Indoles; Memantine; Receptors, N-Methyl-D-Aspartate

2008
[Therapy of Alzheimer disease].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2009, Volume: 11, Issue:1

    Topics: Alzheimer Disease; Alzheimer Vaccines; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Cognition; Dopamine Agents; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Memantine; Neurofibrillary Tangles; Neuroprotective Agents; Nootropic Agents; Receptors, N-Methyl-D-Aspartate; Severity of Illness Index; tau Proteins

2009
[Drug therapy for Alzheimer's disease].
    Brain and nerve = Shinkei kenkyu no shinpo, 2010, Volume: 62, Issue:7

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Clioquinol; Drug Design; Excitatory Amino Acid Antagonists; Flurbiprofen; Indoles; Memantine; Meta-Analysis as Topic; Randomized Controlled Trials as Topic

2010

Other Studies

5 other study(ies) available for latrepirdine and memantine

ArticleYear
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons.
    Bulletin of experimental biology and medicine, 2003, Volume: 136, Issue:5

    Topics: Animals; Benzothiadiazines; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indoles; Kainic Acid; Memantine; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate

2003
[Mitochondria as the target for neuroprotectors].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 2005, Issue:9

    Topics: Animals; Antiparkinson Agents; Brain; Cell Death; Cells, Cultured; Dopamine Agents; Ginkgo biloba; Indoles; Intracellular Membranes; Ion Channels; Lipid Peroxidation; Memantine; Mitochondria; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neurodegenerative Diseases; Neuroprotective Agents; Neurotoxins; Nootropic Agents; Permeability; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Tacrine

2005
Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:3

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Behavior, Animal; Brain Chemistry; Cholinesterase Inhibitors; Cognition; Donepezil; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Indans; Indoles; Male; Memantine; Microdialysis; Piperidines; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Histamine H1; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology

2010
Drugs: a tangled web of targets.
    Nature, 2011, Jul-13, Volume: 475, Issue:7355

    Topics: Alanine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Azepines; Clinical Trials as Topic; Disease Progression; Genetic Therapy; Glycogen Synthase Kinase 3; Humans; Indoles; Memantine; Methylene Blue; Molecular Targeted Therapy; Nerve Growth Factor; Neurofibrillary Tangles; Phosphorylation; tau Proteins

2011