Compounds > latrepirdine
Page last updated: 2024-09-05

latrepirdine and cyclosporine

latrepirdine has been researched along with cyclosporine in 3 studies

Compound Research Comparison

Studies
(latrepirdine)		Trials
(latrepirdine)		Recent Studies (post-2010)
(latrepirdine)		Studies
(cyclosporine)		Trials
(cyclosporine)		Recent Studies (post-2010) (cyclosporine)
1267593772170
12675930,5473,8026,558

Protein Interaction Comparison

ProteinTaxonomylatrepirdine (IC50)cyclosporine (IC50)
ATP-binding cassette sub-family C member 3Homo sapiens (human)0.6315
Bile salt export pumpRattus norvegicus (Norway rat)0.6
Bile salt export pumpHomo sapiens (human)3.5
Interleukin-2Mus musculus (house mouse)0.005
ATP-dependent translocase ABCB1Mus musculus (house mouse)0.7
ATP-dependent translocase ABCB1Homo sapiens (human)1.6792
Cytochrome P450 3A4Homo sapiens (human)3.734
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 25.82
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)9.34
Cytochrome P450 3A5Homo sapiens (human)2.06
ATP-dependent translocase ABCB1Mus musculus (house mouse)4.8
Substance-K receptorHomo sapiens (human)4.139
Peptidyl-prolyl cis-trans isomerase BHomo sapiens (human)0.0088
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)9.34
Cytochrome P450 3A7Homo sapiens (human)2.06
Cytochrome P450 2C19Homo sapiens (human)7
Multidrug resistance-associated protein 1 Homo sapiens (human)3.5082
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)9.34
Peptidyl-prolyl cis-trans isomerase A Homo sapiens (human)0.0252
Peptidyl-prolyl cis-trans isomerase FKBP4Homo sapiens (human)0.016
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformHomo sapiens (human)0.183
Peptidyl-prolyl cis-trans isomerase DHomo sapiens (human)0.0036
Sodium/bile acid cotransporterHomo sapiens (human)1
Reverse transcriptase/RNaseH Human immunodeficiency virus 10.455
Cytochrome P450 3A43 Homo sapiens (human)2.06
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Mus musculus (house mouse)0.57
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)1.3
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)4.3
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.95

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Bachurin, SO; Kireeva, EG; Oxenkrug, GF; Sablin, SO; Shevtsova, EP1
Aliev, G; Bachurin, SO; Kireeva, EG; Reddy, VP; Shevtsova, EF; Vinogradova, DV1

Other Studies

3 other study(ies) available for latrepirdine and cyclosporine

ArticleYear
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Mitochondria as a target for neurotoxins and neuroprotective agents.
    Annals of the New York Academy of Sciences, 2003, Volume: 993

    Topics: 1-Methyl-4-phenylpyridinium; Amyloid beta-Peptides; Animals; Calcium; Cholinesterase Inhibitors; Cyclosporine; Enzyme Inhibitors; Indoles; Lipid Peroxidation; Mitochondria, Liver; Neuroprotective Agents; Nootropic Agents; Peptide Fragments; Permeability; Rats; Rats, Wistar; Serotonin; Tacrine

2003
Dimebon attenuates the Aβ-induced mitochondrial permeabilization.
    Current Alzheimer research, 2014, Volume: 11, Issue:5

    Topics: Amyloid beta-Peptides; Animals; Brain; Calcium; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Liver; Male; Mitochondria; Mitochondrial ADP, ATP Translocases; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Permeability; Protein Conformation; Rats; Rats, Wistar; Time Factors

2014