Page last updated: 2024-08-24

lathosterol and simvastatin

lathosterol has been researched along with simvastatin in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.17)18.7374
1990's6 (25.00)18.2507
2000's13 (54.17)29.6817
2010's4 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Boulton-Jones, JM; Grierson, D; Murray, L; Packard, CJ; Shepherd, J; Stewart, JP; Warwick, GL1
Gevers Leuven, JA; Glatz, JF; Katan, MB; Kempen, HJ; van der Voort, HA1
Ball, M; Chisholm, A; Sutherland, W1
De Cuyper, I; van Doormaal, JJ; Wijnandts, PN; Wolthers, BG1
Colette, C; Crastes De Paulet, A; Descomps, B; Farnier, M; Feillet, C; Monnier, LH; Percheron, C1
Croft, KD; Kelly, JM; Naoumova, RP; Riches, FM; Thompson, GR; Watts, GF1
Kim, KD; Naoumova, RP; Pfohl, M; Thompson, GR1
Gylling, H; Miettinen, TA; Strandberg, TE1
Demacker, PN; Kroon, AA; Stalenhoef, AF; van't Hof, MA1
Amati, B; Crosignani, A; Del Puppo, M; Galli Kienle, M; Petroni, ML; Podda, M; Zuin, M1
Aldaghlas, TA; Berthold, HK; Holleran, AL; Kelleher, JK; Lindenthal, B; Sudhop, T; Von Bergmann, K1
Gylling, H; Miettinen, TA2
Brown, BG; Giovanni, A; Lichtenstein, AH; Matthan, NR; Schaefer, EJ1
Gylling, H; Lindbohm, N; Miettinen, TA; Miettinen, TE; Rajaratnam, RA; Relas, H1
De Paepe, B; Laakso, J; Laaksonen, R; Lehtimäki, T; Lütjohann, D; Mattila, KM; Päivä, H; Smet, J; Thelen, KM; Van Coster, R; von Bergmann, K1
Laaksonen, R; Lehtimäki, T; Lütjohann, D; Päivä, H; Thelen, KM1
Berthold, HK; Di Mauro, S; Gouni-Berthold, I; Gylling, H; Hallikainen, M; Krone, W; Naini, A1
Laaksonen, R; Lehtimäki, T; Luomala, M; Lütjohann, D; Päivä, H; Peltonen, N; Thelen, K1
Baker, SP; Caselli, R; Evans, BA; Evans, JE; Hinerfeld, D; Kane, K; Moonis, M; Pollen, DA; Rogaeva, E; St George-Hyslop, P; Swearer, J1
Gylling, H; Miettinen, TA; Miettinen, TE; Nissinen, MJ1
Groen, AK; Hutten, BA; Jakulj, L; Kastelein, JJ; Lutjohann, D; Veltri, EP; Vissers, MN1
Lütjohann, D; Stellaard, F; Sudhop, T; von Bergmann, K1
Bederman, IR; Mast, N; Pikuleva, IA1

Trials

13 trial(s) available for lathosterol and simvastatin

ArticleYear
The effect of dietary fat content on plasma noncholesterol sterol concentrations in patients with familial hypercholesterolemia treated with simvastatin.
    Metabolism: clinical and experimental, 1994, Volume: 43, Issue:3

    Topics: Adult; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Combined Modality Therapy; Dietary Fats; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Simvastatin; Sterols

1994
Comparative effects of simvastatin and pravastatin on cholesterol synthesis in patients with primary hypercholesterolemia.
    Atherosclerosis, 1995, Volume: 118, Issue:2

    Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Apolipoproteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Liver; Lovastatin; Male; Mevalonic Acid; Middle Aged; Pravastatin; Simvastatin; Treatment Outcome; Triglycerides

1995
Inhibition of cholesterogenesis decreases hepatic secretion of apoB-100 in normolipidemic subjects.
    The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 1

    Topics: Adult; Apolipoprotein B-100; Apolipoproteins B; Carbon Isotopes; Cholesterol; Double-Blind Method; Enzyme Inhibitors; Gas Chromatography-Mass Spectrometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isomerism; Leucine; Lipoproteins; Liver; Lovastatin; Male; Middle Aged; Random Allocation; Reference Values; Regression Analysis; Simvastatin

1997
Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol.
    Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:5

    Topics: Anticholesteremic Agents; Body Weight; Cholestanol; Cholesterol; Coronary Disease; Desmosterol; Humans; Phytosterols; Placebos; Simvastatin; Sitosterols; Sterols

2000
The rebound of lipoproteins after LDL-apheresis. Kinetics and estimation of mean lipoprotein levels.
    Atherosclerosis, 2000, Volume: 152, Issue:2

    Topics: Adult; Aged; Anticholesteremic Agents; Apolipoproteins B; Blood Component Removal; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoprotein(a); Lipoproteins, LDL; Male; Middle Aged; Simvastatin; Sitosterols; Triglycerides

2000
Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration.
    Journal of lipid research, 2001, Volume: 42, Issue:3

    Topics: Aged; Anticholesteremic Agents; Cholagogues and Choleretics; Cholesterol; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxycholesterols; Hypercholesterolemia; Liver Cirrhosis, Biliary; Male; Middle Aged; Simvastatin; Ursodeoxycholic Acid

2001
Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL.
    Journal of lipid research, 2003, Volume: 44, Issue:4

    Topics: Antioxidants; Cholesterol; Constriction, Pathologic; Coronary Artery Disease; Desmosterol; Drug Therapy, Combination; Female; Humans; Hypolipidemic Agents; Lipoproteins, HDL; Male; Middle Aged; Niacin; Simvastatin; Sitosterols

2003
Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins.
    The Journal of laboratory and clinical medicine, 2003, Volume: 141, Issue:2

    Topics: Anticholesteremic Agents; Atorvastatin; Cholestanol; Cholesterol; Coronary Disease; Female; Heptanoic Acids; Humans; Male; Middle Aged; Phytosterols; Pyrroles; Simvastatin; Sitosterols; Squalene; Sterols

2003
High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial.
    Clinical pharmacology and therapeutics, 2005, Volume: 78, Issue:1

    Topics: Adult; Age Factors; Aged; Atorvastatin; Biopsy; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Citrate (si)-Synthase; Dose-Response Relationship, Drug; Double-Blind Method; Electron Transport; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Muscles; Patient Selection; Phytosterols; Pyrroles; Sex Factors; Simvastatin; Sitosterols; Succinate Cytochrome c Oxidoreductase; Time Factors; Ubiquinone

2005
Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial.
    Drug safety, 2006, Volume: 29, Issue:8

    Topics: Adult; Anticholesteremic Agents; Azetidines; Cholestanol; Cholesterol; Cholesterol, LDL; Coenzymes; Drug Combinations; Ezetimibe, Simvastatin Drug Combination; Humans; Lipid Metabolism; Logistic Models; Male; Middle Aged; Reference Values; Simvastatin; Ubiquinone

2006
Plasma-soluble CD40 is related to cholesterol metabolism in patients with moderate hypercholesterolemia.
    Scandinavian cardiovascular journal : SCJ, 2006, Volume: 40, Issue:5

    Topics: Anticholesteremic Agents; Atorvastatin; Biomarkers; CD40 Antigens; Cholesterol; Cholesterol, Dietary; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Male; Pyrroles; Severity of Illness Index; Simvastatin; Solubility

2006
Applicability of non-cholesterol sterols in predicting response in cholesterol metabolism to simvastatin and fluvastatin treatment among hypercholesterolemic men.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2010, Volume: 20, Issue:5

    Topics: Cholestanol; Cholesterol; Desmosterol; Double-Blind Method; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lipids; Male; Middle Aged; Simvastatin; Sterols

2010
Baseline cholesterol absorption and the response to ezetimibe/simvastatin therapy: a post-hoc analysis of the ENHANCE trial.
    Journal of lipid research, 2010, Volume: 51, Issue:4

    Topics: Adult; Aged; Anticholesteremic Agents; Azetidines; Biomarkers; Cholesterol; Cholesterol, LDL; Double-Blind Method; Drug Therapy, Combination; Ezetimibe; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemia Type II; Intestinal Absorption; Male; Middle Aged; Phytosterols; Simvastatin; Sitosterols; Statistics as Topic

2010

Other Studies

11 other study(ies) available for lathosterol and simvastatin

ArticleYear
Effect of simvastatin on plasma lipid and lipoprotein concentrations and low-density lipoprotein metabolism in the nephrotic syndrome.
    Clinical science (London, England : 1979), 1992, Volume: 82, Issue:6

    Topics: Adult; Aged; Apolipoproteins B; Cholesterol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Lipoproteins; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Nephrotic Syndrome; Simvastatin

1992
Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans.
    Journal of lipid research, 1988, Volume: 29, Issue:9

    Topics: Anticholesteremic Agents; Biomarkers; Cholesterol; Female; Humans; Hyperlipoproteinemia Type II; Isomerism; Lovastatin; Male; Simvastatin

1988
Determination of changes in serum lathosterol during treatment with simvastatin to evaluate the role of lathosterol as a parameter for whole body cholesterol synthesis.
    Clinica chimica acta; international journal of clinical chemistry, 1993, Oct-15, Volume: 219, Issue:1-2

    Topics: Adult; Anticholesteremic Agents; Cholesterol; Chromatography, Gas; Female; Half-Life; Humans; Isomerism; Kinetics; Lovastatin; Male; Mevalonic Acid; Simvastatin

1993
Use of cholesterol precursors to assess changes in cholesterol synthesis under non-steady-state conditions.
    European journal of clinical investigation, 1998, Volume: 28, Issue:6

    Topics: Acyl Coenzyme A; Adult; Analysis of Variance; Anticholesteremic Agents; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Meglutol; Mevalonic Acid; Simvastatin

1998
Isotopomer spectral analysis of intermediates of cholesterol synthesis in human subjects and hepatic cells.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 282, Issue:6

    Topics: Acetates; Acetyl Coenzyme A; Carbon Isotopes; Carcinoma, Hepatocellular; Cholesterol; Duodenum; Gas Chromatography-Mass Spectrometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isotope Labeling; Kinetics; Liver; Liver Neoplasms; Models, Biological; Pravastatin; Simvastatin; Tumor Cells, Cultured

2002
Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients.
    Atherosclerosis, 2002, Volume: 164, Issue:1

    Topics: Cholestanol; Cholesterol; Desmosterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Simvastatin; Sitosterols

2002
LDL cholesterol lowering by bile acid malabsorption during inhibited synthesis and absorption of cholesterol in hypercholesterolemic coronary subjects.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2002, Volume: 12, Issue:1

    Topics: Aged; Anticholesteremic Agents; Bile Acids and Salts; Cholesterol; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Cholestyramine Resin; Coronary Artery Disease; Diet, Fat-Restricted; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Intestinal Absorption; Male; Simvastatin; Sitosterols; Treatment Outcome

2002
High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:7

    Topics: Adult; Aged; Atorvastatin; Biomarkers; Brain; Cholesterol; Female; Heptanoic Acids; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin

2006
Long-term statin therapy and CSF cholesterol levels: implications for Alzheimer's disease.
    Dementia and geriatric cognitive disorders, 2009, Volume: 27, Issue:6

    Topics: Adult; Aged; Alzheimer Disease; Apolipoproteins E; Atorvastatin; Cholesterol; Female; Heptanoic Acids; Heterozygote; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Mutation; Pilot Projects; Presenilin-1; Pyrroles; Simvastatin

2009
The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies.
    The Journal of steroid biochemistry and molecular biology, 2017, Volume: 169

    Topics: Adult; Azetidines; Bile Acids and Salts; Biomarkers; Cholesterol; Diet, Vegan; Drug Therapy, Combination; Feces; Female; Humans; Hydroxycholesterols; Hypolipidemic Agents; Lipid Metabolism; Male; Middle Aged; Phytosterols; Reproducibility of Results; Retrospective Studies; Simvastatin; Up-Regulation

2017
Retinal Cholesterol Content Is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol.
    Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:11

    Topics: Animals; Cholesterol; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Macular Degeneration; Male; Mice; Mice, Inbred C57BL; Retina; Simvastatin; Up-Regulation

2018