lasofoxifene has been researched along with raloxifene in 5 studies
| Studies (lasofoxifene) | Trials (lasofoxifene) | Recent Studies (post-2010) (lasofoxifene) | Studies (raloxifene) | Trials (raloxifene) | Recent Studies (post-2010) (raloxifene) |
|---|---|---|---|---|---|
| 88 | 14 | 24 | 128 | 0 | 61 |
| Protein | Taxonomy | lasofoxifene (IC50) | raloxifene (IC50) |
|---|---|---|---|
| Phospholipase D2 | Homo sapiens (human) | 6.1333 | |
| Aldehyde oxidase 1 | Mus musculus (house mouse) | 0.5 | |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | 2.08 | |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 1.178 | |
| Estrogen receptor | Homo sapiens (human) | 0.0416 | |
| Estrogen receptor | Rattus norvegicus (Norway rat) | 0.0032 | |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | 3.666 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.282 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 1.664 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 2 | |
| D(2) dopamine receptor | Homo sapiens (human) | 1.174 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 3.698 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.738 | |
| Substance-K receptor | Homo sapiens (human) | 3.989 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 3.864 | |
| Acetylcholinesterase | Homo sapiens (human) | 0.4 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.282 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.973 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 1.45 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 1.178 | |
| Adenosine receptor A2a | Homo sapiens (human) | 2.111 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 3.576 | |
| Mu-type opioid receptor | Homo sapiens (human) | 1.176 | |
| D(3) dopamine receptor | Homo sapiens (human) | 1.565 | |
| Delta-type opioid receptor | Homo sapiens (human) | 6.644 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 1.602 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.355 | |
| Aldehyde oxidase 1 | Oryctolagus cuniculus (rabbit) | 0.008 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 1.869 | |
| Aldehyde oxidase | Homo sapiens (human) | 0.0055 | |
| Platelet-activating factor acetylhydrolase | Homo sapiens (human) | 0.0003 | |
| Phospholipase D1 | Homo sapiens (human) | 4.9167 | |
| Aldehyde oxidase 1 | Macaca fascicularis (crab-eating macaque) | 0.5 | |
| Estrogen receptor beta | Rattus norvegicus (Norway rat) | 0.1584 | |
| Estrogen receptor beta | Homo sapiens (human) | 0.3051 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.681 | |
| Aldehyde oxidase 1 | Rattus norvegicus (Norway rat) | 1.1 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arriola, MW; Brown, TA; Cameron, KO; Cole, MJ; Crawford, DT; Da Silva Jardine, P; Ebbinghaus, CF; Elliott, NC; Gauthier, JW; Ke, HZ; Newhouse, BN; Nickerson, DF; Pan, LC; Pirie, CM; Qi, H; Reinhold, AR; Rosati, RL; Simmons, HA; Sweetnam, PM; Thompson, DD; Tjoa, CM; Tkalcevic, GT; Toler, SM | 1 |
| Bischoff, SF; Buhl, T; Floersheim, P; Fournier, B; Halleux, C; Kallen, J; Keller, H; Renaud, J; Schlaeppi, JM; Stark, W | 1 |
| Bischoff, SF; Buhl, T; Floersheim, P; Fournier, B; Geiser, M; Halleux, C; Kallen, J; Keller, H; Ramage, P; Renaud, J | 1 |
| Birzin, ET; Blizzard, TA; Chan, W; DaSilva, CA; Dininno, F; Hammond, ML; Hayes, EC; Morgan, JD; Mosley, RT; Pai, LY; Rohrer, SP; Yang, YT | 1 |
| Balogh, I; Kim, HY; Koczok, K; Korade, Z; Liu, W; Mirnics, K; Porter, NA; Tallman, KA; Xu, L | 1 |
5 other study(ies) available for lasofoxifene and raloxifene
| Article | Year |
|---|---|
Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene.
Topics: Administration, Oral; Animals; Biological Availability; Bone Density; Breast Neoplasms; Cell Division; Cholesterol; Estrogen Antagonists; Ethinyl Estradiol; Female; Humans; Hypolipidemic Agents; Neoplasms, Hormone-Dependent; Organ Size; Ovariectomy; Pyrrolidines; Rats; Receptors, Estrogen; Tetrahydronaphthalenes; Tumor Cells, Cultured; Uterus | 1998 |
Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands.
Topics: Administration, Oral; Animals; Binding Sites; Biological Availability; Cell Division; Crystallography, X-Ray; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; HeLa Cells; Humans; Isoquinolines; Ligands; Models, Molecular; Radioligand Assay; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Stereoisomerism; Structure-Activity Relationship; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
Selective estrogen receptor modulators with conformationally restricted side chains. Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands.
Topics: Animals; Biological Availability; Cell Line, Tumor; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Estrogen Receptor alpha; Female; Humans; Inhibitory Concentration 50; Isoquinolines; Ligands; Models, Molecular; Piperazines; Piperidines; Radioligand Assay; Rats; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Tetrahydroisoquinolines | 2005 |
Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms.
Topics: Animals; Estrogen Receptor alpha; Ligands; Oxathiins; Rats; Selective Estrogen Receptor Modulators | 2005 |
The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts.
Topics: Animals; Cell Line; Dehydrocholesterols; Dose-Response Relationship, Drug; Fibroblasts; Homeostasis; Humans; Mice; Molecular Conformation; Neurons; Oxidoreductases Acting on CH-CH Group Donors; Small Molecule Libraries; Sterols; Structure-Activity Relationship | 2016 |