lasofoxifene has been researched along with fulvestrant in 4 studies
| Studies (lasofoxifene) | Trials (lasofoxifene) | Recent Studies (post-2010) (lasofoxifene) | Studies (fulvestrant) | Trials (fulvestrant) | Recent Studies (post-2010) (fulvestrant) |
|---|---|---|---|---|---|
| 88 | 14 | 24 | 2,712 | 207 | 1,196 |
| Protein | Taxonomy | lasofoxifene (IC50) | fulvestrant (IC50) |
|---|---|---|---|
| Estrogen receptor | Homo sapiens (human) | 0.0061 | |
| Estrogen receptor | Rattus norvegicus (Norway rat) | 0.0059 | |
| Progesterone receptor | Homo sapiens (human) | 0.0002 | |
| Steroid hormone receptor ERR1 | Homo sapiens (human) | 0.002 | |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | 0.006 | |
| Estrogen receptor beta | Homo sapiens (human) | 0.0104 | |
| Bile acid receptor | Homo sapiens (human) | 0.79 | |
| NAD-dependent protein deacylase sirtuin-5, mitochondrial | Homo sapiens (human) | 2.6 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Balogh, I; Kim, HY; Koczok, K; Korade, Z; Liu, W; Mirnics, K; Porter, NA; Tallman, KA; Xu, L | 1 |
| Gutgesell, LM; Karumudi, B; Lee, S; Lu, Y; Thatcher, GR; Tonetti, DA; Wang, Y; Xiong, R; Zhao, H; Zhao, J | 1 |
| Andersson, A; Börjesson, AE; Carlsten, H; Farman, HH; Gustafsson, JÅ; Lagerquist, MK; Movérare-Skrtic, S; Ohlsson, C; Sjögren, K; Stubelius, A; Windahl, SH | 1 |
| Chang, YF; Fanning, SW; Green, B; Greene, GL; Greene, ME; Komm, B; Kurleto, JD; Lainé, M; Phung, L | 1 |
4 other study(ies) available for lasofoxifene and fulvestrant
| Article | Year |
|---|---|
The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts.
Topics: Animals; Cell Line; Dehydrocholesterols; Dose-Response Relationship, Drug; Fibroblasts; Homeostasis; Humans; Mice; Molecular Conformation; Neurons; Oxidoreductases Acting on CH-CH Group Donors; Small Molecule Libraries; Sterols; Structure-Activity Relationship | 2016 |
Novel Selective Estrogen Receptor Downregulators (SERDs) Developed against Treatment-Resistant Breast Cancer.
Topics: Animals; Antineoplastic Agents, Hormonal; Breast; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Mice, Nude; Models, Molecular; Neoplasms, Hormone-Dependent; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Thiophenes | 2017 |
The estrogen receptor antagonist ICI 182,780 can act both as an agonist and an inverse agonist when estrogen receptor α AF-2 is modified.
Topics: Adipose Tissue; Animals; Bone and Bones; Bone Marrow Cells; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Female; Fulvestrant; Insulin-Like Growth Factor I; Ligands; Mice; Mutation; Organ Size; Protein Structure, Tertiary; Pyrrolidines; Raloxifene Hydrochloride; Receptors, Estrogen; Tetrahydronaphthalenes; Thymus Gland; Tissue Distribution; Tomography, X-Ray Computed; Uterus; X-Ray Microtomography | 2014 |
Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease Models, Animal; Estrogen Receptor alpha; Female; Fulvestrant; Humans; MCF-7 Cells; Mice; Mutation; Neoplasm Metastasis; Piperazines; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Pyridines; Pyrrolidines; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Treatment Outcome | 2021 |