largazole and pyridine

largazole has been researched along with pyridine* in 1 studies

Other Studies

1 other study(ies) available for largazole and pyridine

Article	Year
Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole. Bioorganic & medicinal chemistry, 2015, Aug-01, Volume: 23, Issue:15 The formation of a series of analogs containing a pyridine moiety in place of the natural thiazole heterocycle, based on the potent, naturally occurring HDAC inhibitor Largazole has been accomplished. The synthetic strategy was designed modularly to access multiple inhibitors with different aryl functionalities containing both the natural depsipeptide and peptide isostere variant of the macrocycle. The cytotoxicity and biochemical activity of the library of HDAC inhibitors is described herein. Topics: Binding Sites; Cell Line, Tumor; Cell Survival; Depsipeptides; Drug Design; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Molecular Docking Simulation; Protein Structure, Tertiary; Pyridines; Structure-Activity Relationship; Thiazoles	2015

Article

Year

Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.

Bioorganic & medicinal chemistry, 2015, Aug-01, Volume: 23, Issue:15

The formation of a series of analogs containing a pyridine moiety in place of the natural thiazole heterocycle, based on the potent, naturally occurring HDAC inhibitor Largazole has been accomplished. The synthetic strategy was designed modularly to access multiple inhibitors with different aryl functionalities containing both the natural depsipeptide and peptide isostere variant of the macrocycle. The cytotoxicity and biochemical activity of the library of HDAC inhibitors is described herein.

Topics: Binding Sites; Cell Line, Tumor; Cell Survival; Depsipeptides; Drug Design; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Molecular Docking Simulation; Protein Structure, Tertiary; Pyridines; Structure-Activity Relationship; Thiazoles

2015