laquinimod and roquinimex

laquinimod has been researched along with roquinimex* in 1 studies

Other Studies

1 other study(ies) available for laquinimod and roquinimex

ArticleYear
Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship.
    Journal of medicinal chemistry, 2004, Apr-08, Volume: 47, Issue:8

    Roquinimex-related 3-quinolinecarboxamide derivatives were prepared and evaluated for treatment of autoimmune disorders. The compounds were tested in mice for their inhibitory effects on disease development in the acute experimental autoimmune encephalomyelitis model and selected compounds in the beagle dog for induction of proinflammatory reaction. Structure-activity relationships are discussed. Compound 8c, laquinimod, showed improved potency and superior toxicological profile compared to the lead compound roquinimex (1b, Linomide) and was selected for clinical studies (currently in phase II).

    Topics: Adjuvants, Immunologic; Animals; Autoimmune Diseases; Dogs; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxyquinolines; Mice; Mice, Inbred C57BL; Quinolones; Structure-Activity Relationship

2004