lapatinib has been researched along with trifluoperazine in 5 studies
| Studies (lapatinib) | Trials (lapatinib) | Recent Studies (post-2010) (lapatinib) | Studies (trifluoperazine) | Trials (trifluoperazine) | Recent Studies (post-2010) (trifluoperazine) |
|---|---|---|---|---|---|
| 1,919 | 305 | 1,442 | 3,696 | 157 | 198 |
| Protein | Taxonomy | lapatinib (IC50) | trifluoperazine (IC50) |
|---|---|---|---|
| Genome polyprotein | 0.7 | ||
| Ubiquitin carboxyl-terminal hydrolase 1 | Homo sapiens (human) | 8 | |
| Bile salt export pump | Homo sapiens (human) | 10 | |
| Lysozyme C-1 | Rattus norvegicus (Norway rat) | 9 | |
| Beta-glucuronidase | Rattus norvegicus (Norway rat) | 7.8 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 6.75 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 6.226 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.35 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 0.35 | |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | 1.4 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.35 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 0.016 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 6.226 | |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | 6.226 | |
| WD repeat-containing protein 48 | Homo sapiens (human) | 8 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
1 review(s) available for lapatinib and trifluoperazine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
4 other study(ies) available for lapatinib and trifluoperazine
| Article | Year |
|---|---|
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index | 2014 |