Compounds > lapatinib
Page last updated: 2024-09-05

lapatinib and terfenadine

lapatinib has been researched along with terfenadine in 4 studies

Compound Research Comparison

Studies
(lapatinib)		Trials
(lapatinib)		Recent Studies (post-2010)
(lapatinib)		Studies
(terfenadine)		Trials
(terfenadine)		Recent Studies (post-2010) (terfenadine)
1,9193051,4421,751568346

Protein Interaction Comparison

ProteinTaxonomylapatinib (IC50)terfenadine (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.93
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)1.231
Epidermal growth factor receptorHomo sapiens (human)3.566
Tyrosine-protein kinase FynHomo sapiens (human)6.123
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.928
ATP-dependent translocase ABCB1Homo sapiens (human)1.8167
Cytochrome P450 3A4Homo sapiens (human)0.32
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.9
D(2) dopamine receptorHomo sapiens (human)6.167
Dipeptidyl peptidase 4Rattus norvegicus (Norway rat)0.35
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)2.34
Alpha-2C adrenergic receptorHomo sapiens (human)3.748
DRattus norvegicus (Norway rat)0.1288
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.1288
Substance-K receptorHomo sapiens (human)2.677
D(1A) dopamine receptorHomo sapiens (human)2.673
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.1288
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.1288
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)2.34
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.928
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)0.1288
Alpha-1D adrenergic receptorHomo sapiens (human)2.34
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.255
5-hydroxytryptamine receptor 2CHomo sapiens (human)1.231
Histamine H1 receptorCavia porcellus (domestic guinea pig)0.094
Alpha-1A adrenergic receptorHomo sapiens (human)2.34
Histamine H1 receptorHomo sapiens (human)0.0115
Alpha-1B adrenergic receptorHomo sapiens (human)2.34
D(3) dopamine receptorHomo sapiens (human)1.503
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.048
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)2.34
5-hydroxytryptamine receptor 6Homo sapiens (human)1.306
Cytochrome P450 2J2Homo sapiens (human)8.1
C-C chemokine receptor type 5Homo sapiens (human)1.103
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.93
Sodium-dependent dopamine transporter Homo sapiens (human)0.255
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.2233
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.93
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)1.125
Sodium channel protein type 5 subunit alphaHomo sapiens (human)0.971

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ekins, S; Williams, AJ; Xu, JJ1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Takai, N; Tanaka, Y1
Abe, K; Ando, O; Imaoka, T; Karibe, T1

Other Studies

4 other study(ies) available for lapatinib and terfenadine

ArticleYear
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Imaging of drug and metabolite distribution by MS: case studies.
    Bioanalysis, 2015, Volume: 7, Issue:20

    Topics: Animals; Autoradiography; Dogs; Fluoroquinolones; Lapatinib; Liver; Lung; Mice; Moxifloxacin; Pharmaceutical Preparations; Quinazolines; Rabbits; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Terfenadine; Tissue Distribution; Whole Body Imaging

2015
Curcumin as an In Vivo Selective Intestinal Breast Cancer Resistance Protein Inhibitor in Cynomolgus Monkeys.
    Drug metabolism and disposition: the biological fate of chemicals, 2018, Volume: 46, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Availability; Breast Neoplasms; Caco-2 Cells; Cell Line, Tumor; Curcumin; Cytochrome P-450 CYP3A; Female; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Lapatinib; Macaca fascicularis; Male; Midazolam; Neoplasm Proteins; Pantoprazole; Quinazolines; Rosuvastatin Calcium; Sulfasalazine; Terfenadine

2018