Compounds > lapatinib
Page last updated: 2024-09-05

lapatinib and pentamidine

lapatinib has been researched along with pentamidine in 4 studies

Compound Research Comparison

Studies
(lapatinib)		Trials
(lapatinib)		Recent Studies (post-2010)
(lapatinib)		Studies
(pentamidine)		Trials
(pentamidine)		Recent Studies (post-2010) (pentamidine)
1,9193051,4422,411136477

Protein Interaction Comparison

ProteinTaxonomylapatinib (IC50)pentamidine (IC50)
Solute carrier family 22 member 2Homo sapiens (human)1.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)3.278
Protein tyrosine phosphatase type IVA 3Homo sapiens (human)0.3
Solute carrier family 22 member 3Homo sapiens (human)9.5
PlasminogenHomo sapiens (human)7.3333
Urokinase-type plasminogen activatorHomo sapiens (human)10
Trypsin-1Homo sapiens (human)10
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.214
Muscarinic acetylcholine receptor M2Homo sapiens (human)1.425
Muscarinic acetylcholine receptor M4Homo sapiens (human)1.58
Muscarinic acetylcholine receptor M5Homo sapiens (human)2.885
Alpha-2A adrenergic receptorHomo sapiens (human)1.375
Cytochrome P450 2D6Homo sapiens (human)10
Amine oxidase [flavin-containing] AHomo sapiens (human)0.793
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.214
5-hydroxytryptamine receptor 2AHomo sapiens (human)1.639
5-hydroxytryptamine receptor 2CHomo sapiens (human)3.278
D(3) dopamine receptorHomo sapiens (human)3.998
Sodium-dependent dopamine transporter Homo sapiens (human)3.159
Glutamate receptor ionotropic, NMDA 1Homo sapiens (human)0.72
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)10
Glutamate receptor ionotropic, NMDA 2AHomo sapiens (human)0.72
Protein tyrosine phosphatase type IVA 2Homo sapiens (human)0.3
Multidrug and toxin extrusion protein 2Homo sapiens (human)2.7
Protein tyrosine phosphatase type IVA 1Homo sapiens (human)0.3
Multidrug and toxin extrusion protein 1Homo sapiens (human)1.7033

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Behera, R; Edwards, P; Guyett, PJ; Karver, CE; Mensa-Wilmot, K; Patel, G; Pollastri, MP; Roncal, NE; Sullenberger, C1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1

Reviews

1 review(s) available for lapatinib and pentamidine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

3 other study(ies) available for lapatinib and pentamidine

ArticleYear
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis.
    Journal of medicinal chemistry, 2013, May-23, Volume: 56, Issue:10

    Topics: Animals; Cell Cycle; Cell Line, Tumor; Cell Survival; Coloring Agents; Drug Design; Drug Discovery; ErbB Receptors; Humans; Indicators and Reagents; Lapatinib; Morpholines; Neglected Diseases; Phosphotransferases; Quinazolines; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

2013