Compounds > lapatinib
Page last updated: 2024-09-05

lapatinib and pd 153035

lapatinib has been researched along with pd 153035 in 5 studies

Compound Research Comparison

Studies
(lapatinib)		Trials
(lapatinib)		Recent Studies (post-2010)
(lapatinib)		Studies
(pd 153035)		Trials
(pd 153035)		Recent Studies (post-2010) (pd 153035)
1,9193051,442232261

Protein Interaction Comparison

ProteinTaxonomylapatinib (IC50)pd 153035 (IC50)
Cyclin-G-associated kinaseHomo sapiens (human)0.26
Mitogen-activated protein kinase 13Homo sapiens (human)6.3
Dihydrofolate reductaseHomo sapiens (human)0.2
Dihydrofolate reductaseMus musculus (house mouse)0.2
Tyrosine-protein kinase ABL1Homo sapiens (human)0.03
Tyrosine-protein kinase transforming protein AblAbelson murine leukemia virus0.4787
Epidermal growth factor receptorHomo sapiens (human)0.1416
Protein kinase C alpha typeBos taurus (cattle)0.4787
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.735
Cyclin-dependent kinase 1Homo sapiens (human)0.4787
Fructose-1,6-bisphosphatase 1Homo sapiens (human)1
Platelet-derived growth factor receptor betaHomo sapiens (human)0.2
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.709
G2/mitotic-specific cyclin-B1Homo sapiens (human)0.4787
Dihydrofolate reductasePneumocystis carinii0.2
Potassium-transporting ATPase subunit betaSus scrofa (pig)0.03
Potassium-transporting ATPase alpha chain 1Sus scrofa (pig)0.03
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.8445
Mitogen-activated protein kinase 12Homo sapiens (human)6.3
Mitogen-activated protein kinase 11Homo sapiens (human)6.3
Mitogen-activated protein kinase 14Homo sapiens (human)6.3
Dihydrofolate reductaseRattus norvegicus (Norway rat)0.2
MAP kinase-interacting serine/threonine-protein kinase 1Homo sapiens (human)0.63
Histamine H3 receptorRattus norvegicus (Norway rat)1
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)2.025

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abou El Ella, DA; Aly, RM; El-Motwally, AM; Ibrahim, DA1
Guo, Y; He, J; Li, Y; Liu, M; Liu, Y; Xiao, J; Yu, W; Zhang, Q1
Das, D; Hong, J1
Asquith, CRM; Drewry, DH; East, MP; Havener, TM; Johnson, GL; Laitinen, T; Morris, DC; Naegeli, KM; Wells, CI; Zuercher, WJ1
Asquith, CRM; Crona, DJ; Fleck, N; Grundner, C; Torrice, CD; Zuercher, WJ1

Reviews

2 review(s) available for lapatinib and pd 153035

ArticleYear
The association between anti-tumor potency and structure-activity of protein-kinases inhibitors based on quinazoline molecular skeleton.
    Bioorganic & medicinal chemistry, 2019, 02-01, Volume: 27, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Humans; Neoplasms; Protein Kinase Inhibitors; Protein Kinases; Quinazolines

2019
Recent advancements of 4-aminoquinazoline derivatives as kinase inhibitors and their applications in medicinal chemistry.
    European journal of medicinal chemistry, 2019, May-15, Volume: 170

    Topics: Animals; Antineoplastic Agents; Chemistry Techniques, Synthetic; Humans; Neoplasms; Protein Kinase Inhibitors; Quinazolines

2019

Other Studies

3 other study(ies) available for lapatinib and pd 153035

ArticleYear
Molecular design and synthesis of certain new quinoline derivatives having potential anticancer activity.
    European journal of medicinal chemistry, 2015, Sep-18, Volume: 102

    Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; MCF-7 Cells; Molecular Structure; Protein Kinase Inhibitors; Quinolines; Structure-Activity Relationship

2015
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma.
    Journal of medicinal chemistry, 2019, 05-09, Volume: 62, Issue:9

    Topics: Aminoquinolines; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chordoma; Drug Design; ErbB Receptors; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Molecular Docking Simulation; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines

2019
Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines.
    Bioorganic & medicinal chemistry letters, 2019, 09-15, Volume: 29, Issue:18

    Topics: Aniline Compounds; Antitubercular Agents; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Quinazolines; Quinolines; Structure-Activity Relationship

2019