Page last updated: 2024-09-05

lapatinib and osu 03012

lapatinib has been researched along with osu 03012 in 2 studies

Compound Research Comparison

Studies (lapatinib)	Trials (lapatinib)	Recent Studies (post-2010) (lapatinib)	Studies (osu 03012)	Trials (osu 03012)	Recent Studies (post-2010) (osu 03012)
1,919	305	1,442	85	0	55

Protein Interaction Comparison

Protein	Taxonomy	lapatinib (IC50)	osu 03012 (IC50)
3-phosphoinositide-dependent protein kinase 1	Homo sapiens (human)		5

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Booth, L; Chen, CS; Cruickshanks, N; Dent, P; Grant, S; Ridder, T	1
Chalfant, CE; Garcia-Vargas, A; Park, MA; West, NW	1

Other Studies

2 other study(ies) available for lapatinib and osu 03012

Article	Year
OSU-03012 interacts with lapatinib to kill brain cancer cells. Cancer biology & therapy, 2012, Volume: 13, Issue:14 Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy-Related Protein 5; Beclin-1; Benzoquinones; Brain Neoplasms; Celecoxib; Cell Line, Tumor; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; ErbB Receptors; Genes, erbB-1; Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Lapatinib; Lipids; MAP Kinase Kinase 1; Membrane Proteins; Microtubule-Associated Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; PTEN Phosphohydrolase; Pyrazoles; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; RNA Interference; RNA, Small Interfering; Signal Transduction; Sulfonamides	2012
OSU-03012 sensitizes breast cancers to lapatinib-induced cell killing: a role for Nck1 but not Nck2. BMC cancer, 2013, May-24, Volume: 13 Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Immunoprecipitation; Lapatinib; Oncogene Proteins; Pyrazoles; Quinazolines; Signal Transduction; Sulfonamides; Transfection	2013

Article

Year

OSU-03012 interacts with lapatinib to kill brain cancer cells.

Cancer biology & therapy, 2012, Volume: 13, Issue:14

Topics: Apoptosis; Apoptosis Regulatory Proteins; Autophagy-Related Protein 5; Beclin-1; Benzoquinones; Brain Neoplasms; Celecoxib; Cell Line, Tumor; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; ErbB Receptors; Genes, erbB-1; Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Lapatinib; Lipids; MAP Kinase Kinase 1; Membrane Proteins; Microtubule-Associated Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; PTEN Phosphohydrolase; Pyrazoles; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; RNA Interference; RNA, Small Interfering; Signal Transduction; Sulfonamides

2012

OSU-03012 sensitizes breast cancers to lapatinib-induced cell killing: a role for Nck1 but not Nck2.

BMC cancer, 2013, May-24, Volume: 13

Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Immunoprecipitation; Lapatinib; Oncogene Proteins; Pyrazoles; Quinazolines; Signal Transduction; Sulfonamides; Transfection

2013