Page last updated: 2024-09-05

lapatinib and osimertinib

lapatinib has been researched along with osimertinib in 6 studies

Compound Research Comparison

Studies
(lapatinib)
Trials
(lapatinib)
Recent Studies (post-2010)
(lapatinib)
Studies
(osimertinib)
Trials
(osimertinib)
Recent Studies (post-2010) (osimertinib)
1,9193051,4421,3151341,282

Protein Interaction Comparison

ProteinTaxonomylapatinib (IC50)osimertinib (IC50)
Histone deacetylase 3Homo sapiens (human)1
Lysine-specific histone demethylase 1AHomo sapiens (human)3.98
Epidermal growth factor receptorHomo sapiens (human)0.1858
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)0.0274
Insulin receptorHomo sapiens (human)0.912
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 23.26
Receptor tyrosine-protein kinase erbB-3Homo sapiens (human)0.0268
von Hippel-Lindau disease tumor suppressorHomo sapiens (human)0.002
Histone deacetylase 4Homo sapiens (human)1
Fatty-acid amide hydrolase 1Rattus norvegicus (Norway rat)0.0395
Epidermal growth factor receptorMus musculus (house mouse)0.081
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.57
Histone deacetylase 1Homo sapiens (human)1
Receptor tyrosine-protein kinase erbB-4Homo sapiens (human)0.033
Histone deacetylase 7Homo sapiens (human)1
Histone deacetylase 2Homo sapiens (human)1
Polyamine deacetylase HDAC10Homo sapiens (human)1
Histone deacetylase 11 Homo sapiens (human)1
Histone deacetylase 8Homo sapiens (human)1
Histone deacetylase 6Homo sapiens (human)1
Histone deacetylase 9Homo sapiens (human)1
ALK tyrosine kinase receptorHomo sapiens (human)0.177
Histone deacetylase 5Homo sapiens (human)1

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (33.33)24.3611
2020's4 (66.67)2.80

Authors

AuthorsStudies
Aiche, S; Bassermann, F; Becker, W; Canevari, G; Casale, E; Depaolini, SR; Ehrlich, HC; Felder, ER; Feuchtinger, A; Garz, AK; Gohlke, BO; Götze, K; Greif, PA; Hahne, H; Heinzlmeir, S; Helm, D; Huenges, J; Jeremias, I; Kayser, G; Klaeger, S; Koch, H; Koenig, PA; Kramer, K; Kuster, B; Médard, G; Meng, C; Petzoldt, S; Polzer, H; Preissner, R; Qiao, H; Reinecke, M; Reiter, K; Rueckert, L; Ruland, J; Ruprecht, B; Schlegl, J; Schmidt, T; Schneider, S; Schoof, M; Spiekermann, K; Tõnisson, N; Vick, B; Vooder, T; Walch, A; Wilhelm, M; Wu, Z; Zecha, J; Zolg, DP1
Basetti, V; Keesara, M; Maiti, P; Mansour, TS; Moghudula, AG; Pallepati, RR; Potluri, V1
Abd El-Karim, SS; Ahmed, NS; Anwar, MM; El-Hallouty, SM; Srour, AM1
Bauer, S; Baumann, M; Becker, C; Grabe, T; Hardick, J; Hodson, L; Jeyakumar, K; Ketzer, J; Keul, M; Kirschner, T; Klövekorn, P; Lategahn, J; Müller, MP; Niggenaber, J; Rauh, D; Terheyden, S; Tumbrink, HL; Unger, A; van Otterlo, WAL; Weisner, J1
Abuo-Rahma, GEA; Badr, M; Bass, AKA; El-Zoghbi, MS; Mohamed, MFA; Nageeb, EM1
Chen, J; Li, W; Ouyang, L; Shuai, W; Tan, L; Wang, C; Wang, G; Wang, X; Wang, Y; Zhang, J; Zhang, Z1

Reviews

1 review(s) available for lapatinib and osimertinib

ArticleYear
Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors.
    European journal of medicinal chemistry, 2021, Jan-01, Volume: 209

    Topics: Androgen Antagonists; Animals; Antineoplastic Agents; Benzimidazoles; Cyclic Nucleotide Phosphodiesterases, Type 5; Daunorubicin; Doxorubicin; fms-Like Tyrosine Kinase 3; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Molecular Targeted Therapy; Morpholines; Nicotinamide Phosphoribosyltransferase; Nitric Oxide; Pyrimidines; Quinazolines; Structure-Activity Relationship; Transcription Factors

2021

Other Studies

5 other study(ies) available for lapatinib and osimertinib

ArticleYear
The target landscape of clinical kinase drugs.
    Science (New York, N.Y.), 2017, 12-01, Volume: 358, Issue:6367

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Drug Discovery; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Mice; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteomics; Xenograft Model Antitumor Assays

2017
Lead generation of 1,2-dithiolanes as exon 19 and exon 21 mutant EGFR tyrosine kinase inhibitors.
    Bioorganic & medicinal chemistry letters, 2019, 06-15, Volume: 29, Issue:12

    Topics: Exons; Humans; Mutation; Protein Kinase Inhibitors; Thioctic Acid

2019
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors.
    Bioorganic & medicinal chemistry, 2020, 09-15, Volume: 28, Issue:18

    Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Breast Neoplasms; Cell Proliferation; Drug Screening Assays, Antitumor; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; MCF-7 Cells; Molecular Docking Simulation; Protein Kinase Inhibitors; Quantitative Structure-Activity Relationship; Thiazoles

2020
Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
    Journal of medicinal chemistry, 2020, 10-22, Volume: 63, Issue:20

    Topics: Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Humans; Kinetics; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor, ErbB-2; Structure-Activity Relationship; Tumor Cells, Cultured

2020
Development of Dual Inhibitors Targeting Epidermal Growth Factor Receptor in Cancer Therapy.
    Journal of medicinal chemistry, 2022, 04-14, Volume: 65, Issue:7

    Topics: Aniline Compounds; Carcinoma, Non-Small-Cell Lung; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Lung Neoplasms; Mutation; Protein Kinase Inhibitors

2022