Page last updated: 2024-09-05

lapatinib and nutlin-3a

lapatinib has been researched along with nutlin-3a in 3 studies

Compound Research Comparison

Studies
(lapatinib)
Trials
(lapatinib)
Recent Studies (post-2010)
(lapatinib)
Studies
(nutlin-3a)
Trials
(nutlin-3a)
Recent Studies (post-2010) (nutlin-3a)
1,9193051,4426981504

Protein Interaction Comparison

ProteinTaxonomylapatinib (IC50)nutlin-3a (IC50)
Protein Mdm4Homo sapiens (human)4.6273
Cellular tumor antigen p53Homo sapiens (human)1.0388
Cytochrome P450 2C19Homo sapiens (human)0.07
E3 ubiquitin-protein ligase Mdm2Homo sapiens (human)0.1832

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Dewhirst, MW; Geradts, J; Henao, R; Kim, J; Kim, WJ; Kornbluth, S; Kurokawa, M; Liu, L; Lucas, JE; Matsuura, K; Ran, X; Ribar, TJ; Spector, NL; Wang, S; Xia, W1
Fu, Y; He, Q; Lin, G; Lou, J; Ma, J; Wu, Y; Yang, B; Zheng, L; Zhu, H1
Brors, B; Haibe-Kains, B; Kurilov, R1

Other Studies

3 other study(ies) available for lapatinib and nutlin-3a

ArticleYear
A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.
    Science signaling, 2013, May-07, Volume: 6, Issue:274

    Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Imidazoles; Immunoblotting; Lapatinib; Mice; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Nuclear Proteins; Phosphoprotein Phosphatases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-mdm2; Quinazolines; Receptor, ErbB-2; RNA Interference; Signal Transduction; Substrate Specificity; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Xenograft Model Antitumor Assays

2013
Nutlin-3 inhibits epithelial-mesenchymal transition by interfering with canonical transforming growth factor-β1-Smad-Snail/Slug axis.
    Cancer letters, 2014, Jan-01, Volume: 342, Issue:1

    Topics: Antigens, CD; Antineoplastic Agents; Cadherins; Cell Line, Tumor; Cell Movement; Drug Evaluation, Preclinical; Drug Synergism; Epithelial-Mesenchymal Transition; ErbB Receptors; Gefitinib; Gene Expression; Humans; Imidazoles; Lapatinib; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Quinazolines; RNA, Messenger; Signal Transduction; Smad Proteins; Snail Family Transcription Factors; Transcription Factors; Transforming Growth Factor beta1; Up-Regulation

2014
Assessment of modelling strategies for drug response prediction in cell lines and xenografts.
    Scientific reports, 2020, 02-18, Volume: 10, Issue:1

    Topics: Animals; Biomarkers, Pharmacological; Cell Line, Tumor; Erlotinib Hydrochloride; Humans; Imidazoles; Indoles; Lapatinib; Machine Learning; Mice; Neoplasms; Organ Specificity; Paclitaxel; Piperazines; Prognosis; Pyrimidines; Sorafenib; Sulfonamides; Xenograft Model Antitumor Assays

2020