Page last updated: 2024-09-05

lapatinib and gdc 0449

lapatinib has been researched along with gdc 0449 in 2 studies

Compound Research Comparison

Studies
(lapatinib)
Trials
(lapatinib)
Recent Studies (post-2010)
(lapatinib)
Studies
(gdc 0449)
Trials
(gdc 0449)
Recent Studies (post-2010) (gdc 0449)
1,9193051,44266668611

Protein Interaction Comparison

ProteinTaxonomylapatinib (IC50)gdc 0449 (IC50)
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)0.02
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.02
Smoothened homologMus musculus (house mouse)0.07
Sonic hedgehog proteinHomo sapiens (human)0.8825
Sonic hedgehog proteinMus musculus (house mouse)0.0077
Smoothened homologHomo sapiens (human)0.0222
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.4

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's1 (50.00)2.80

Authors

AuthorsStudies
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF1

Reviews

1 review(s) available for lapatinib and gdc 0449

ArticleYear
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.
    European journal of medicinal chemistry, 2022, Jul-05, Volume: 237

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells

2022

Other Studies

1 other study(ies) available for lapatinib and gdc 0449

ArticleYear
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013