Compounds > lapatinib
Page last updated: 2024-09-05

lapatinib and econazole

lapatinib has been researched along with econazole in 2 studies

Compound Research Comparison

Studies
(lapatinib)		Trials
(lapatinib)		Recent Studies (post-2010)
(lapatinib)		Studies
(econazole)		Trials
(econazole)		Recent Studies (post-2010) (econazole)
1,9193051,44261572136

Protein Interaction Comparison

ProteinTaxonomylapatinib (IC50)econazole (IC50)
Transient receptor potential cation channel subfamily M member 2Homo sapiens (human)3
Bile salt export pumpHomo sapiens (human)10
Cytochrome P450 1A2Homo sapiens (human)0.3
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)2.435
Muscarinic acetylcholine receptor M2Homo sapiens (human)3.256
Muscarinic acetylcholine receptor M4Homo sapiens (human)2.122
Cytochrome P450 3A4Homo sapiens (human)0.5026
Alpha-2A adrenergic receptorHomo sapiens (human)4.325
Adenosine receptor A3Homo sapiens (human)3.249
Cytochrome P450 2D6Homo sapiens (human)0.4
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.642
Cytochrome P450 2C9 Homo sapiens (human)0.2
Beta-3 adrenergic receptorHomo sapiens (human)6.15
Matrix metalloproteinase-9Homo sapiens (human)6.997
Indoleamine 2,3-dioxygenase 1Homo sapiens (human)4.6
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)3.249
Alpha-2B adrenergic receptorHomo sapiens (human)5.863
Muscarinic acetylcholine receptor M3Homo sapiens (human)1.789
Substance-K receptorHomo sapiens (human)6.033
D(1A) dopamine receptorHomo sapiens (human)9.225
D(4) dopamine receptorHomo sapiens (human)9.328
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.435
Thromboxane-A synthase Homo sapiens (human)0.029
Histamine H2 receptorHomo sapiens (human)1.592
Alpha-1D adrenergic receptorHomo sapiens (human)8.897
5-hydroxytryptamine receptor 2AHomo sapiens (human)4.034
Sodium-dependent serotonin transporterHomo sapiens (human)0.423
Cytochrome P450 2C19Homo sapiens (human)0.04
Mu-type opioid receptorHomo sapiens (human)5.693
D(3) dopamine receptorHomo sapiens (human)4.756
Delta-type opioid receptorHomo sapiens (human)1.442
Kappa-type opioid receptorHomo sapiens (human)8.616
5-hydroxytryptamine receptor 2BHomo sapiens (human)6.833
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)3.249
Sodium-dependent dopamine transporter Homo sapiens (human)0.835
Lanosterol 14-alpha demethylaseHomo sapiens (human)0.05
Indoleamine 2,3-dioxygenase 2Mus musculus (house mouse)7.6

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y1

Other Studies

2 other study(ies) available for lapatinib and econazole

ArticleYear
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
    Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index

2014