Page last updated: 2024-09-05

lapatinib and cysteine

lapatinib has been researched along with cysteine in 3 studies

Compound Research Comparison

Studies (lapatinib)	Trials (lapatinib)	Recent Studies (post-2010) (lapatinib)	Studies (cysteine)	Trials (cysteine)	Recent Studies (post-2010) (cysteine)
1,919	305	1,442	31	0	11
1,919	305	1,442	40,132	418	11,457

Protein Interaction Comparison

Protein	Taxonomy	lapatinib (IC50)	cysteine (IC50)
Excitatory amino acid transporter 1	Homo sapiens (human)		376
Excitatory amino acid transporter 3	Homo sapiens (human)		161

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Hardy, KD; Nelson, SD; Papageorgiou, I; Rettie, AE; Unadkat, JD; Wahlin, MD	1
Dai, C; He, S; Hu, H; Lou, Q; Wang, L; Wu, J; You, X; Zhang, J; Zhao, M	1

Reviews

1 review(s) available for lapatinib and cysteine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

2 other study(ies) available for lapatinib and cysteine

Article	Year
Studies on the role of metabolic activation in tyrosine kinase inhibitor-dependent hepatotoxicity: induction of CYP3A4 enhances the cytotoxicity of lapatinib in HepaRG cells. Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:1 Topics: Biotransformation; Cell Line, Tumor; Cell Survival; Cysteine; Cytochrome P-450 CYP3A; Dexamethasone; Glutathione; Hepatocytes; Humans; Lapatinib; Liver; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Rifampin	2014
Cysteine-based redox-responsive nanoparticles for small-molecule agent delivery. Biomaterials science, 2019, Oct-01, Volume: 7, Issue:10 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Survival; Cysteine; Drug Delivery Systems; Drug Liberation; Erythrocytes; Female; Hydrogen-Ion Concentration; Lapatinib; Mammary Neoplasms, Experimental; Mice, Inbred BALB C; Nanoparticles; Oxidation-Reduction; Rats, Sprague-Dawley; Tissue Distribution	2019

Article

Year

Studies on the role of metabolic activation in tyrosine kinase inhibitor-dependent hepatotoxicity: induction of CYP3A4 enhances the cytotoxicity of lapatinib in HepaRG cells.

Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:1

Topics: Biotransformation; Cell Line, Tumor; Cell Survival; Cysteine; Cytochrome P-450 CYP3A; Dexamethasone; Glutathione; Hepatocytes; Humans; Lapatinib; Liver; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Rifampin

2014

Cysteine-based redox-responsive nanoparticles for small-molecule agent delivery.

Biomaterials science, 2019, Oct-01, Volume: 7, Issue:10

Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Survival; Cysteine; Drug Delivery Systems; Drug Liberation; Erythrocytes; Female; Hydrogen-Ion Concentration; Lapatinib; Mammary Neoplasms, Experimental; Mice, Inbred BALB C; Nanoparticles; Oxidation-Reduction; Rats, Sprague-Dawley; Tissue Distribution

2019