Page last updated: 2024-09-05

lapatinib and crizotinib

lapatinib has been researched along with crizotinib in 11 studies

Compound Research Comparison

Studies
(lapatinib)
Trials
(lapatinib)
Recent Studies (post-2010)
(lapatinib)
Studies
(crizotinib)
Trials
(crizotinib)
Recent Studies (post-2010) (crizotinib)
1,9193051,4421,7801121,718

Protein Interaction Comparison

ProteinTaxonomylapatinib (IC50)crizotinib (IC50)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2Homo sapiens (human)5.5
Tyrosine-protein kinase JAK2Homo sapiens (human)0.027
Sodium-dependent phosphate transport protein 2BHomo sapiens (human)0.051
Tyrosine-protein kinase ABL1Homo sapiens (human)0.5915
Tyrosine-protein kinase ABL1Mus musculus (house mouse)1.159
Epidermal growth factor receptorHomo sapiens (human)0.681
HLA class II histocompatibility antigen gamma chainHomo sapiens (human)0.0039
High affinity nerve growth factor receptorHomo sapiens (human)0.2905
Insulin receptorHomo sapiens (human)1.0966
Tyrosine-protein kinase LckHomo sapiens (human)1.8277
NucleophosminHomo sapiens (human)0.051
Insulin-like growth factor 1 receptorHomo sapiens (human)0.143
Hepatocyte growth factor receptorHomo sapiens (human)0.0057
Proto-oncogene tyrosine-protein kinase ROSHomo sapiens (human)0.5458
Tyrosine-protein kinase JAK1Homo sapiens (human)0.563
Non-receptor tyrosine-protein kinase TYK2Homo sapiens (human)1.269
Tyrosine-protein kinase receptor UFOHomo sapiens (human)0.2223
Tyrosine-protein kinase JAK3Homo sapiens (human)1.36
ALK tyrosine kinase receptorMus musculus (house mouse)0.08
Angiopoietin-1 receptorHomo sapiens (human)0.2265
Angiopoietin-1 receptorMus musculus (house mouse)0.448
Macrophage-stimulating protein receptorHomo sapiens (human)0.25
BDNF/NT-3 growth factors receptorHomo sapiens (human)0.2005
Macrophage-stimulating protein receptorMus musculus (house mouse)0.08
Mitogen-activated protein kinase kinase kinase kinase 3Homo sapiens (human)0.8745
Echinoderm microtubule-associated protein-like 4Homo sapiens (human)0.6542
ALK tyrosine kinase receptorHomo sapiens (human)0.4828

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's8 (72.73)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Bullock, AN; Canning, P; Choi, S; Cuny, GD; Mohedas, AH; Sanvitale, CE; Wang, Y; Xing, X; Yu, PB1
Aiche, S; Bassermann, F; Becker, W; Canevari, G; Casale, E; Depaolini, SR; Ehrlich, HC; Felder, ER; Feuchtinger, A; Garz, AK; Gohlke, BO; Götze, K; Greif, PA; Hahne, H; Heinzlmeir, S; Helm, D; Huenges, J; Jeremias, I; Kayser, G; Klaeger, S; Koch, H; Koenig, PA; Kramer, K; Kuster, B; Médard, G; Meng, C; Petzoldt, S; Polzer, H; Preissner, R; Qiao, H; Reinecke, M; Reiter, K; Rueckert, L; Ruland, J; Ruprecht, B; Schlegl, J; Schmidt, T; Schneider, S; Schoof, M; Spiekermann, K; Tõnisson, N; Vick, B; Vooder, T; Walch, A; Wilhelm, M; Wu, Z; Zecha, J; Zolg, DP1
Lou, L; Quan, H; Wang, L; Wang, Q; Xie, C; Zhao, J1
Gavine, P; Gu, Y; Liu, C; Liu, YJ; Lv, J; Ni, X; Qian, J; Qian, Z; Shen, D; Su, X; Sun, Y; Xu, Y; Yin, X; Zhan, P; Zhang, J; Zhang, T1
Axel, U; Baska, F; Greff, Z; Gyulavári, P; Ibolya, K; Kéri, G; Orfi, L; Peták, I; Szántai, KC; Szokol, B; Vantus, T; Zoltán, O1
Anderson, JC; Arafat, W; Bonner, JA; Denton, AJ; Dobelbower, MC; Dussaq, AM; Gilbert, AN; Minnich, DJ; Rohrbach, TD; Welaya, K; Willey, CD1
Al-Husein, BA; Alkhalifa, AE; Ayoub, NM; Ibrahim, DR1
Lucia, F; Nicolas, E1
Feng, M; Li, Q; Liao, W; Qian, Z; Wen, F; Wu, Q; Yang, Y1

Reviews

1 review(s) available for lapatinib and crizotinib

ArticleYear
[Radiation therapy and targeted therapies: Risks and opportunities].
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2022, Volume: 26, Issue:6-7

    Topics: Ado-Trastuzumab Emtansine; Antineoplastic Agents; Cetuximab; Crizotinib; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Lapatinib; Mitogen-Activated Protein Kinase Kinases; Molecular Targeted Therapy; Panitumumab; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Radiotherapy; Receptor Protein-Tyrosine Kinases; Trastuzumab

2022

Other Studies

10 other study(ies) available for lapatinib and crizotinib

ArticleYear
Comprehensive analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2011, Oct-30, Volume: 29, Issue:11

    Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity

2011
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants.
    Journal of medicinal chemistry, 2014, Oct-09, Volume: 57, Issue:19

    Topics: Activin Receptors, Type I; Aminopyridines; Humans; Mutation; Myositis Ossificans; Phenols; Protein Kinase Inhibitors; Structure-Activity Relationship

2014
The target landscape of clinical kinase drugs.
    Science (New York, N.Y.), 2017, 12-01, Volume: 358, Issue:6367

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Drug Discovery; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Mice; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteomics; Xenograft Model Antitumor Assays

2017
RON confers lapatinib resistance in HER2-positive breast cancer cells.
    Cancer letters, 2013, Oct-28, Volume: 340, Issue:1

    Topics: Anilides; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Crizotinib; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Gene Knockdown Techniques; Humans; Inhibitory Concentration 50; Lapatinib; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyridines; Quinazolines; Quinolines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Signal Transduction; Trastuzumab

2013
HER2, MET and FGFR2 oncogenic driver alterations define distinct molecular segments for targeted therapies in gastric carcinoma.
    British journal of cancer, 2014, Mar-04, Volume: 110, Issue:5

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Crizotinib; Female; Humans; Lapatinib; Male; Mice; Mice, Nude; Middle Aged; Molecular Targeted Therapy; Proto-Oncogene Proteins c-met; Pyrazoles; Pyridines; Pyrimidines; Quinazolines; Random Allocation; Receptor, ErbB-2; Receptor, Fibroblast Growth Factor, Type 2; Stomach Neoplasms; Xenograft Model Antitumor Assays

2014
[Development and biochemical characterization of EGFR/c-Met dual inhibitors].
    Acta pharmaceutica Hungarica, 2013, Volume: 83, Issue:4

    Topics: Afatinib; Aminopyridines; Anilides; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Computer Simulation; Crizotinib; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Imidazoles; Lapatinib; Lung Neoplasms; Molecular Structure; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-met; Pyrazines; Pyrazoles; Pyridines; Pyridones; Quinazolines; Quinolines

2013
Kinomic profiling of electromagnetic navigational bronchoscopy specimens: a new approach for personalized medicine.
    PloS one, 2014, Volume: 9, Issue:12

    Topics: Aged; Aged, 80 and over; Bronchoscopy; Crizotinib; Electromagnetic Phenomena; Erlotinib Hydrochloride; Female; Gene Expression Profiling; Humans; Lapatinib; Lung Neoplasms; Male; Middle Aged; Phosphotransferases; Precision Medicine; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Quinazolines

2014
Crizotinib induced antitumor activity and synergized with chemotherapy and hormonal drugs in breast cancer cells via downregulating MET and estrogen receptor levels.
    Investigational new drugs, 2021, Volume: 39, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Crizotinib; Dose-Response Relationship, Drug; Drug Synergism; Estrogen Antagonists; Humans; Inhibitory Concentration 50; Lapatinib; Proto-Oncogene Proteins c-met; Receptor, ErbB-2; Receptors, Estrogen

2021
Study on the prognosis, immune and drug resistance of m6A-related genes in lung cancer.
    BMC bioinformatics, 2022, Oct-19, Volume: 23, Issue:1

    Topics: Adenosine; Afatinib; Crizotinib; Dasatinib; Drug Resistance; Erlotinib Hydrochloride; Etoposide; Humans; Lapatinib; Lung Neoplasms; Tumor Microenvironment; Ubiquitin-Protein Ligases

2022