Compounds > lapatinib
Page last updated: 2024-09-05

lapatinib and clotrimazole

lapatinib has been researched along with clotrimazole in 6 studies

Compound Research Comparison

Studies
(lapatinib)		Trials
(lapatinib)		Recent Studies (post-2010)
(lapatinib)		Studies
(clotrimazole)		Trials
(clotrimazole)		Recent Studies (post-2010) (clotrimazole)
1,9193051,4422,005299503

Protein Interaction Comparison

ProteinTaxonomylapatinib (IC50)clotrimazole (IC50)
Intermediate conductance calcium-activated potassium channel protein 4Homo sapiens (human)0.1667
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.59
Transient receptor potential cation channel subfamily M member 2Homo sapiens (human)3
Bile salt export pumpHomo sapiens (human)10
Glucocorticoid receptorHomo sapiens (human)3.258
ATP-dependent translocase ABCB1Mus musculus (house mouse)3.5
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)3.258
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)7.936
ATP-dependent translocase ABCB1Homo sapiens (human)4.9
Cytochrome P450 3A4Homo sapiens (human)0.0406
Adenosine receptor A3Homo sapiens (human)4.752
Muscarinic acetylcholine receptor M1Homo sapiens (human)6.869
AromataseHomo sapiens (human)0.0018
Cytochrome P450 2C9 Homo sapiens (human)0.016
Beta-3 adrenergic receptorHomo sapiens (human)7.208
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)4.752
Alpha-2B adrenergic receptorHomo sapiens (human)8.159
Potassium-transporting ATPase subunit betaSus scrofa (pig)5.2
Potassium-transporting ATPase alpha chain 1Sus scrofa (pig)5.2
Muscarinic acetylcholine receptor M3Homo sapiens (human)9.928
Glycine receptor subunit betaRattus norvegicus (Norway rat)3.258
ATP-dependent translocase ABCB1Mus musculus (house mouse)4.8
D(1A) dopamine receptorHomo sapiens (human)9.017
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)6
Voltage-dependent L-type calcium channel subunit alpha-1CRattus norvegicus (Norway rat)0.59
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)3.258
Sodium-dependent noradrenaline transporter Homo sapiens (human)7.936
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)3.258
Thromboxane-A synthase Homo sapiens (human)0.014
Histamine H2 receptorHomo sapiens (human)5.165
C-X-C chemokine receptor type 1Homo sapiens (human)5.9677
Vasopressin V2 receptorHomo sapiens (human)2.6059
Sodium-dependent serotonin transporterHomo sapiens (human)5.76
Cytochrome P450 2C19Homo sapiens (human)0.016
Mu-type opioid receptorHomo sapiens (human)1.802
D(3) dopamine receptorHomo sapiens (human)2.647
Delta-type opioid receptorHomo sapiens (human)4.978
Kappa-type opioid receptorHomo sapiens (human)6.303
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)4.752
C-C chemokine receptor type 4Homo sapiens (human)1.6
Transitional endoplasmic reticulum ATPaseHomo sapiens (human)1.4
Sodium-dependent dopamine transporter Homo sapiens (human)5.581
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)3.0199
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.59
Nuclear receptor subfamily 1 group I member 3 Homo sapiens (human)0.29
Lanosterol 14-alpha demethylaseHomo sapiens (human)0.13
Indoleamine 2,3-dioxygenase 2Mus musculus (house mouse)5.9
Bile acid receptorHomo sapiens (human)3.24

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Aleo, MD; Bonin, PD; Luo, Y; Potter, DM; Swiss, R; Will, Y1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1

Reviews

1 review(s) available for lapatinib and clotrimazole

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

5 other study(ies) available for lapatinib and clotrimazole

ArticleYear
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
    Hepatology (Baltimore, Md.), 2014, Volume: 60, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Chemical and Drug Induced Liver Injury; Humans; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Severity of Illness Index

2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016