Compounds > lapatinib
Page last updated: 2024-09-05

lapatinib and ceritinib

lapatinib has been researched along with ceritinib in 3 studies

Compound Research Comparison

Studies
(lapatinib)		Trials
(lapatinib)		Recent Studies (post-2010)
(lapatinib)		Studies
(ceritinib)		Trials
(ceritinib)		Recent Studies (post-2010) (ceritinib)
1,9193051,44232935322

Protein Interaction Comparison

ProteinTaxonomylapatinib (IC50)ceritinib (IC50)
Tyrosine-protein kinase JAK2Homo sapiens (human)1.385
Rho-associated protein kinase 2Homo sapiens (human)1.27
Serine/threonine-protein kinase/endoribonuclease IRE1Homo sapiens (human)3.7
Tyrosine-protein kinase ABL1Homo sapiens (human)1.25
Epidermal growth factor receptorHomo sapiens (human)0.7757
High affinity nerve growth factor receptorHomo sapiens (human)2.727
Insulin receptorHomo sapiens (human)0.1525
Tyrosine-protein kinase LckHomo sapiens (human)0.616
NucleophosminHomo sapiens (human)0.026
Tyrosine-protein kinase LynHomo sapiens (human)1.573
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)1.352
Insulin-like growth factor 1 receptorHomo sapiens (human)0.209
Hepatocyte growth factor receptorHomo sapiens (human)1.5933
Cytochrome P450 3A4Homo sapiens (human)3.36
Proto-oncogene tyrosine-protein kinase ROSHomo sapiens (human)0.2697
Tyrosine-protein kinase FgrHomo sapiens (human)1.947
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 22.86
Mast/stem cell growth factor receptor KitHomo sapiens (human)2.0675
Cyclin-dependent kinase 4Homo sapiens (human)4.72
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)1.694
Platelet-derived growth factor receptor alphaHomo sapiens (human)1.14
Fibroblast growth factor receptor 2Homo sapiens (human)0.26
Fibroblast growth factor receptor 4Homo sapiens (human)0.95
Fibroblast growth factor receptor 3Homo sapiens (human)0.43
Tyrosine-protein kinase JAK1Homo sapiens (human)3.73
Cyclin-dependent kinase 2Homo sapiens (human)3.97
Vascular endothelial growth factor receptor 2Homo sapiens (human)4.21
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)1.0965
Transcription factor ETV6Homo sapiens (human)3.25
Tyrosine-protein kinase ZAP-70Homo sapiens (human)9.7
Tyrosine-protein kinase SYKHomo sapiens (human)3.05
Tyrosine-protein kinase JAK3Homo sapiens (human)7.92
Tyrosine-protein kinase BTKHomo sapiens (human)3.36
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.25
BDNF/NT-3 growth factors receptorHomo sapiens (human)1.829
Testis-specific serine/threonine-protein kinase 1Homo sapiens (human)0.023
MAP kinase-interacting serine/threonine-protein kinase 2Homo sapiens (human)2.24
Echinoderm microtubule-associated protein-like 4Homo sapiens (human)0.5935
ALK tyrosine kinase receptorHomo sapiens (human)0.1102

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Aiche, S; Bassermann, F; Becker, W; Canevari, G; Casale, E; Depaolini, SR; Ehrlich, HC; Felder, ER; Feuchtinger, A; Garz, AK; Gohlke, BO; Götze, K; Greif, PA; Hahne, H; Heinzlmeir, S; Helm, D; Huenges, J; Jeremias, I; Kayser, G; Klaeger, S; Koch, H; Koenig, PA; Kramer, K; Kuster, B; Médard, G; Meng, C; Petzoldt, S; Polzer, H; Preissner, R; Qiao, H; Reinecke, M; Reiter, K; Rueckert, L; Ruland, J; Ruprecht, B; Schlegl, J; Schmidt, T; Schneider, S; Schoof, M; Spiekermann, K; Tõnisson, N; Vick, B; Vooder, T; Walch, A; Wilhelm, M; Wu, Z; Zecha, J; Zolg, DP1
Egbert, M; Keserű, GM; Vajda, S; Whitty, A1
Chen, J; Li, W; Ouyang, L; Shuai, W; Tan, L; Wang, C; Wang, G; Wang, X; Wang, Y; Zhang, J; Zhang, Z1

Other Studies

3 other study(ies) available for lapatinib and ceritinib

ArticleYear
The target landscape of clinical kinase drugs.
    Science (New York, N.Y.), 2017, 12-01, Volume: 358, Issue:6367

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Drug Discovery; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Mice; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteomics; Xenograft Model Antitumor Assays

2017
Why Some Targets Benefit from beyond Rule of Five Drugs.
    Journal of medicinal chemistry, 2019, 11-27, Volume: 62, Issue:22

    Topics: Binding Sites; Drug Discovery; Ligands; Molecular Weight; Protein Binding

2019
Development of Dual Inhibitors Targeting Epidermal Growth Factor Receptor in Cancer Therapy.
    Journal of medicinal chemistry, 2022, 04-14, Volume: 65, Issue:7

    Topics: Aniline Compounds; Carcinoma, Non-Small-Cell Lung; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Lung Neoplasms; Mutation; Protein Kinase Inhibitors

2022