Compounds > lapatinib
Page last updated: 2024-09-05

lapatinib and cabozantinib

lapatinib has been researched along with cabozantinib in 5 studies

Compound Research Comparison

Studies
(lapatinib)		Trials
(lapatinib)		Recent Studies (post-2010)
(lapatinib)		Studies
(cabozantinib)		Trials
(cabozantinib)		Recent Studies (post-2010) (cabozantinib)
1,9193051,442731127716

Protein Interaction Comparison

ProteinTaxonomylapatinib (IC50)cabozantinib (IC50)
Epidermal growth factor receptorHomo sapiens (human)1.118
High affinity nerve growth factor receptorHomo sapiens (human)0.0723
Acyl-CoA desaturase 1Rattus norvegicus (Norway rat)0.0013
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)0.1699
Hepatocyte growth factor receptorHomo sapiens (human)0.0791
Mast/stem cell growth factor receptor KitHomo sapiens (human)0.0108
Fibroblast growth factor receptor 1Homo sapiens (human)0.0113
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.178
Vascular endothelial growth factor receptor 1 Homo sapiens (human)0.012
Tyrosine-protein kinase receptor UFOHomo sapiens (human)0.5617
Kinesin-1 heavy chainHomo sapiens (human)0.19
Vascular endothelial growth factor receptor 3Homo sapiens (human)0.006
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.3151
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.8877
Angiopoietin-1 receptorHomo sapiens (human)0.0143
Macrophage-stimulating protein receptorHomo sapiens (human)0.069
Coiled-coil domain-containing protein 6Homo sapiens (human)0.4615
SAFB-like transcription modulatorHomo sapiens (human)0.0013

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Jadhav, A; Kerns, E; Nguyen, K; Shah, P; Sun, H; Xu, X; Yan, Z; Yu, KR1
Aiche, S; Bassermann, F; Becker, W; Canevari, G; Casale, E; Depaolini, SR; Ehrlich, HC; Felder, ER; Feuchtinger, A; Garz, AK; Gohlke, BO; Götze, K; Greif, PA; Hahne, H; Heinzlmeir, S; Helm, D; Huenges, J; Jeremias, I; Kayser, G; Klaeger, S; Koch, H; Koenig, PA; Kramer, K; Kuster, B; Médard, G; Meng, C; Petzoldt, S; Polzer, H; Preissner, R; Qiao, H; Reinecke, M; Reiter, K; Rueckert, L; Ruland, J; Ruprecht, B; Schlegl, J; Schmidt, T; Schneider, S; Schoof, M; Spiekermann, K; Tõnisson, N; Vick, B; Vooder, T; Walch, A; Wilhelm, M; Wu, Z; Zecha, J; Zolg, DP1
Kabir, M; Kerns, E; Nguyen, K; Shah, P; Sun, H; Wang, Y; Xu, X; Yu, KR1
Kabir, M; Kerns, E; Neyra, J; Nguyen, K; Nguyễn, ÐT; Shah, P; Siramshetty, VB; Southall, N; Williams, J; Xu, X; Yu, KR1

Other Studies

5 other study(ies) available for lapatinib and cabozantinib

ArticleYear
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Highly predictive and interpretable models for PAMPA permeability.
    Bioorganic & medicinal chemistry, 2017, 02-01, Volume: 25, Issue:3

    Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine

2017
The target landscape of clinical kinase drugs.
    Science (New York, N.Y.), 2017, 12-01, Volume: 358, Issue:6367

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Drug Discovery; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Mice; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteomics; Xenograft Model Antitumor Assays

2017
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.
    Bioorganic & medicinal chemistry, 2019, 07-15, Volume: 27, Issue:14

    Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility

2019
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models.
    Scientific reports, 2020, 11-26, Volume: 10, Issue:1

    Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States

2020