Page last updated: 2024-09-05

lapatinib and berberine

lapatinib has been researched along with berberine in 3 studies

Compound Research Comparison

Studies
(lapatinib)
Trials
(lapatinib)
Recent Studies (post-2010)
(lapatinib)
Studies
(berberine)
Trials
(berberine)
Recent Studies (post-2010) (berberine)
1,9193051,4424,1061022,791

Protein Interaction Comparison

ProteinTaxonomylapatinib (IC50)berberine (IC50)
AcetylcholinesteraseElectrophorus electricus (electric eel)0.7827
Lysine-specific histone demethylase 1AHomo sapiens (human)6.97
CholinesteraseHomo sapiens (human)1.09
AcetylcholinesteraseHomo sapiens (human)0.4
Aldo-keto reductase family 1 member C3Homo sapiens (human)4.99
Aldo-keto reductase family 1 member C2 Homo sapiens (human)6.71
CholinesteraseEquus caballus (horse)9.4
Cytochrome P450 1B1Homo sapiens (human)0.9747

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Chen, S; Chen, X; Dou, K; Qiao, H; Wei, L; Zhang, J; Zhang, R1
Ismail, P; Jabbarzadeh Kaboli, P; Leong, MP; Ling, KH1
Chen, Y; Hin Cho, C; Imani, S; Jabbarzadeh Kaboli, P; Jomhori, M; Li, M; Luo, S; Shen, J; Wu, X; Wu, Z; Xiang, S; Xiao, Z; Zhao, Y1

Other Studies

3 other study(ies) available for lapatinib and berberine

ArticleYear
Berberine reverses lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS.
    Cancer biology & therapy, 2016, Volume: 17, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Berberine; Breast Neoplasms; Cell Line, Tumor; Drug Interactions; Drug Resistance, Neoplasm; Female; Humans; Lapatinib; NF-E2-Related Factor 2; Quinazolines; Reactive Oxygen Species; Receptor, ErbB-2; Signal Transduction

2016
Antitumor effects of berberine against EGFR, ERK1/2, P38 and AKT in MDA-MB231 and MCF-7 breast cancer cells using molecular modelling and in vitro study.
    Pharmacological reports : PR, 2019, Volume: 71, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Berberine; Breast Neoplasms; Catalytic Domain; Enzyme Stability; ErbB Receptors; Female; Humans; Lapatinib; MCF-7 Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Docking Simulation; Molecular Dynamics Simulation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Structure-Activity Relationship

2019
Pharmacotranscriptomic profiling of resistant triple-negative breast cancer cells treated with lapatinib and berberine shows upregulation of PI3K/Akt signaling under cytotoxic stress.
    Gene, 2022, Mar-30, Volume: 816

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Berberine; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase 6; DNA (Cytosine-5-)-Methyltransferase 1; Epigenesis, Genetic; ErbB Receptors; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Lapatinib; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Pyrimidines; Pyrroles; Signal Transduction; Transcriptome; Triple Negative Breast Neoplasms; Up-Regulation

2022