lapatinib has been researched along with berberine in 3 studies
| Studies (lapatinib) | Trials (lapatinib) | Recent Studies (post-2010) (lapatinib) | Studies (berberine) | Trials (berberine) | Recent Studies (post-2010) (berberine) |
|---|---|---|---|---|---|
| 1,919 | 305 | 1,442 | 4,106 | 102 | 2,791 |
| Protein | Taxonomy | lapatinib (IC50) | berberine (IC50) |
|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | 0.7827 | |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | 6.97 | |
| Cholinesterase | Homo sapiens (human) | 1.09 | |
| Acetylcholinesterase | Homo sapiens (human) | 0.4 | |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | 4.99 | |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | 6.71 | |
| Cholinesterase | Equus caballus (horse) | 9.4 | |
| Cytochrome P450 1B1 | Homo sapiens (human) | 0.9747 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, S; Chen, X; Dou, K; Qiao, H; Wei, L; Zhang, J; Zhang, R | 1 |
| Ismail, P; Jabbarzadeh Kaboli, P; Leong, MP; Ling, KH | 1 |
| Chen, Y; Hin Cho, C; Imani, S; Jabbarzadeh Kaboli, P; Jomhori, M; Li, M; Luo, S; Shen, J; Wu, X; Wu, Z; Xiang, S; Xiao, Z; Zhao, Y | 1 |
3 other study(ies) available for lapatinib and berberine
| Article | Year |
|---|---|
Berberine reverses lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS.
Topics: Antineoplastic Combined Chemotherapy Protocols; Berberine; Breast Neoplasms; Cell Line, Tumor; Drug Interactions; Drug Resistance, Neoplasm; Female; Humans; Lapatinib; NF-E2-Related Factor 2; Quinazolines; Reactive Oxygen Species; Receptor, ErbB-2; Signal Transduction | 2016 |
Antitumor effects of berberine against EGFR, ERK1/2, P38 and AKT in MDA-MB231 and MCF-7 breast cancer cells using molecular modelling and in vitro study.
Topics: Antineoplastic Agents, Phytogenic; Berberine; Breast Neoplasms; Catalytic Domain; Enzyme Stability; ErbB Receptors; Female; Humans; Lapatinib; MCF-7 Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Docking Simulation; Molecular Dynamics Simulation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Structure-Activity Relationship | 2019 |
Pharmacotranscriptomic profiling of resistant triple-negative breast cancer cells treated with lapatinib and berberine shows upregulation of PI3K/Akt signaling under cytotoxic stress.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Berberine; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase 6; DNA (Cytosine-5-)-Methyltransferase 1; Epigenesis, Genetic; ErbB Receptors; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Lapatinib; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Pyrimidines; Pyrroles; Signal Transduction; Transcriptome; Triple Negative Breast Neoplasms; Up-Regulation | 2022 |