Page last updated: 2024-09-05

lapatinib and ag 1879

lapatinib has been researched along with ag 1879 in 5 studies

Compound Research Comparison

Studies
(lapatinib)
Trials
(lapatinib)
Recent Studies (post-2010)
(lapatinib)
Studies
(ag 1879)
Trials
(ag 1879)
Recent Studies (post-2010) (ag 1879)
1,9193051,4425750215

Protein Interaction Comparison

ProteinTaxonomylapatinib (IC50)ag 1879 (IC50)
Chain A, Lck KinaseHomo sapiens (human)0.02
Chain A, Tyrosine-protein kinase LynMus musculus (house mouse)0.009
Chain A, Tyrosine-protein kinase LynMus musculus (house mouse)0.009
Receptor-interacting serine/threonine-protein kinase 2Homo sapiens (human)0.019
Proto-oncogene tyrosine-protein kinase SrcGallus gallus (chicken)0.036
Epidermal growth factor receptorHomo sapiens (human)0.48
Tyrosine-protein kinase LckHomo sapiens (human)0.004
Proto-oncogene tyrosine-protein kinase LCK Mus musculus (house mouse)0.031
Tyrosine-protein kinase FynHomo sapiens (human)0.0052
Tyrosine-protein kinase LynHomo sapiens (human)0.0005
Tyrosine-protein kinase HCKHomo sapiens (human)0.005
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)1.1814
Tyrosine-protein kinase CSKHomo sapiens (human)0.5
Casein kinase I isoform deltaHomo sapiens (human)0.041
Mitogen-activated protein kinase 14Homo sapiens (human)4.23

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB1
Debnath, B; Ding, J; Kazemi, R; Long, YQ; Neamati, N; Odde, S; Sanchez, TW; Wang, Y; Xie, H; Xu, S; Xu, ZL; Yang, LM; Zeng, LF; Zheng, YT1
Jadhav, A; Kerns, E; Nguyen, K; Shah, P; Sun, H; Xu, X; Yan, Z; Yu, KR1
Kabir, M; Kerns, E; Nguyen, K; Shah, P; Sun, H; Wang, Y; Xu, X; Yu, KR1
Kabir, M; Kerns, E; Neyra, J; Nguyen, K; Nguyễn, ÐT; Shah, P; Siramshetty, VB; Southall, N; Williams, J; Xu, X; Yu, KR1

Other Studies

5 other study(ies) available for lapatinib and ag 1879

ArticleYear
Navigating the kinome.
    Nature chemical biology, 2011, Volume: 7, Issue:4

    Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

2011
Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
    Journal of medicinal chemistry, 2012, Nov-26, Volume: 55, Issue:22

    Topics: Antineoplastic Agents; Drug Design; HIV Infections; HIV Integrase; HIV Integrase Inhibitors; HIV-1; Humans; Models, Molecular; Molecular Structure; Naphthyridines; Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured; Virus Integration

2012
Highly predictive and interpretable models for PAMPA permeability.
    Bioorganic & medicinal chemistry, 2017, 02-01, Volume: 25, Issue:3

    Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine

2017
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.
    Bioorganic & medicinal chemistry, 2019, 07-15, Volume: 27, Issue:14

    Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility

2019
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models.
    Scientific reports, 2020, 11-26, Volume: 10, Issue:1

    Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States

2020