lapachol and naphthoquinones

lapachol has been researched along with naphthoquinones in 118 studies

Research

Studies (118)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (8.47)	18.7374
1990's	9 (7.63)	18.2507
2000's	31 (26.27)	29.6817
2010's	53 (44.92)	24.3611
2020's	15 (12.71)	2.80

Authors

Authors	Studies
Otten, S; Rosazza, JP	1
da Consolação, M; de Oliveira, MM; Linardi, F; Sampaio, MR	1
Chaves, CG; Gleye, J; Grazziotin, JD; Henriques, AT; Schapoval, EE	1
da Silva Filho, AA; de Almeida, ER; dos Santos, ER; Lopes, CA	1
Biswas, M; Goel, RK; Pandey, VB; Pathak, NK; Sanyal, AK	1
Carvalho, LH; Krettli, AU; Oliveira, AB; Raslan, DS; Rocha, EM	1
Preusch, PC	1
Douglas, KT; Gohel, DI; Nadvi, IN; Quilter, AJ; Seddon, AP	1
Preusch, PC; Suttie, JW	1
Czerniak, R; Moore, HW	1
Otten, SL; Rosazza, JP	1
Campos-Takaki, GM; Guiraud, P; Seigle-Murandi, F; Simeon de Buochberg, M; Steiman, R	1
Browning, M; Houghton, PJ; Jackson, SJ; Photiou, A; Retsas, S; Shah, P; Uddin, S	1
Adesogan, KE; Binutu, OA; Okogun, JI	1
de Martínez, NR; de Sandoval, NA; Rodríguez, CP	1
Chatterjee, I; Kiema, G; McDermott, MT; Rothery, RA; Weiner, JH	1
Müller, K; Sellmer, A; Wiegrebe, W	1
Brandão, MA; Guerra, MO; Mazoni, AS; Peters, VM	1
Furukawa, H; Ito, C; Katsuno, S; Kondo, Y; Tan, HT	1
dos Santos, AF; Ferraz, PA; Goulart, MO; Pinto M do, C; Pinto, AV; Sant'Ana, AE	1
Coêlho, IC; de Almeida, YM; Holanda Filha, JG; Pompeu, MM; Prata, JR; Rao, VS; Rodrigues, TP; Teixeira, MJ; Viana, JR	1
Chiari, E; de Abreu, FC; Ferraz, PA; Goulart, MO; Sant'Ana, AE; Santos, AF	1
Brandão, MA; Guerra, Mde O; Mazoni, AS; Peters, VM	1
Aurelian, L; Brito, FV; Buarque, CD; Caruso, RR; Castro, NG; Costa, PR; da Silva, AJ; Hickey, RJ; Lopes, DV; Macedo, LF; Malkas, LH; Melo, PA; Murakami, YL; Noël, F; Silva, NM	1
dos Santos, AF; Goulart, MO; Lima, NM; Porfírio, Z; Sant'Ana, AE	1
Braz-Filho, R; de Mattos, MC; Lemos, TG; Oliveira, MF; Santiago, GM; Segundo, TA	1
Bombardieri, S; Colangelo, WI; Jones, AS; Lamont, BB; Ward, DJ	1
Brandão, MA; Chang, CV; Felício, AC; Guerra, Mde O; Peters, VM	1
Estévez-Braun, A; Ferro, EA; Mukainaka, T; Nishino, H; Ravelo, AG; Sacau, EP; Tokuda, H	1
Falkowski, P; Goulart, MO; Liwo, A; Ossowski, T	1
Bhuyan, R; Saikia, CN	1
de Vries, S; Heering, HA	1
Barbosa, TP; Camara, CA; da Cunha, LC; Pinto, AC; Silva, TM; Soares, AZ; Vargas, MD	1
Balassiano, IT; Cabral, MC; da Gloria da Costa Carvalho, M; De Paulo, SA; Henriques Silva, N	1
Correia, CS; Goulart, MO; Leon, LL; Lima, NM; Machado, GM; Madeira, Mde F; Santana, AE	1
Agra, MF; Barbosa-Filho, JM; Braz-Filho, R; Da-Cunha, EV; De Amorim, EL; De Araújo, CF; Lima, CS; Nascimento, SC; Silva, MS; Vieira, IJ	1
Ahn, YJ; Kim, JH; Kim, JR; Kim, KS; Lee, SE; Park, BS; Takeoka, GR	1
Beconi, MT; Beorlegui, N; Breininger, E; O'Flaherty, C	1
de Paula, JE; Espíndola, LS; Fournet, A; Roblot, F; Rodrigues, AM	1
Arya, K; Dandia, A; Jain, S; Natani, K; Singh, P	1
Estévez-Braun, A; Giménez Turba, A; Gutiérrez Yapu, D; Pérez-Sacau, E; Ravelo, AG	1
Aperis, G; Ausubel, FM; Breger, J; Fuchs, BB; Moy, TI; Mylonakis, E	1
Brum, TB; Leitão, GG; Lobato, AP; Pinto, AV; Pinto, Mdo C; Silva, RS	1
de Cássia da Silveira E Sá, R; de Oliveira Guerra, M	1
Câmara, CA; Echevarria, A; Esteves, A; Esteves-Souza, A; Figueiredo, DV; Pinto, AC; Vargas, MD	1
Armstrong, V; Ciudad, K; Ferreira, J; Kemmerling, U; Maya, JD; Morello, A; Orellana, M; Salas, C; Tapia, RA	1
Maeda, M; Murakami, M; Ota, T; Takegami, T	1
Albuquerque, MM; Carvalho, AL; Lira, AA; Santana, DP; Sester, EA; Strattmann, RR; Wanderley, AG	1
Baskaran, S; Eyong, KO; Folefoc, GN; Kuete, V; Kumar, PS; Nkengfack, EA	1
GATES, M; MOESTA, DL	1
Bacelar, TS; Buarque, CD; Castro, CP; Costa, PR; da Silva, AJ; Fernandes, RF; Maia, RC; Netto, CD; Rumjanek, VM; Salustiano, EJ	1
Goswami, D; Gurule, S; Khuroo, AH; Monif, T	1
Estévez-Braun, A; Hernández-Molina, R; López-Arencibia, A; Lorenzo-Morales, J; Martín-Navarro, CM; Oramas-Royo, S; Piñero, JE; Ravelo, AG; Valladares, B	1
Andrade, SF; Fernandes, DM; Maistro, EL; Pereira, FM	1
Bonifazi, EL; Burton, G; León, LG; Misico, RI; Padrón, JM; Ríos-Luci, C	1
Emery, FS; Galembeck, SE; Lopes, NP; Vessecchi, R	2
Azevedo-Ximenes, E; Garcia, RC; Luzzati, R; Oliveira, RA	1
Blatch, GL; Clark, PG; Cockburn, IL; Davies-Coleman, MT; Keyzers, RA; Pesce, ER; Pryzborski, JM; Stephens, LL	1
Furukawa, H; Ito, C; Itoigawa, M; Matsui, T; Oda, M; Okada, T; Yokoo, K	1
Andrade, SP; Beraldo, H; Campos, PP; Duarte, LP; Parrilha, GL; Silva, GD; Vieira, RP	1
Afonso, Mdel M; Droguett, D; González, P; Monsalve, F; Palenzuela, JA; Pertino, MW; Schmeda-Hirschmann, G; Theoduloz, C; Yesilada, E	1
Demicheli, C; Donnici, CL; Frézard, F; Oliveira, LG; Paula, FC; Pereira-Maia, EC; Silva, EN; Silva, MM; Simone, CA	1
Costa, WF; Nepomuceno, JC; Oliveira, AB	1
Kiage-Mokua, BN; Roos, N; Schrezenmeir, J	1
Aucélio, RQ; da Silva, AR; Esteva Guas, AM; Ferreira, AB; Peréz-Cordovés, AI; Xavier Lima, JL	1
Correia-Oliveira, J; Garcia, RC; Oliveira, RA; Tang, LJ	1
Assis, Md; Barros, VP; Dias-Baruffi, M; Emery, Fda S; Lopes, NP; Niehues, M	1
Bao, JL; Chen, XP; Huang, MQ; Lu, JJ; Wang, YT; Wu, GS; Xu, WS	1
Carrión, IB; Pertino, MW; Schmeda-Hirschmann, G; Theoduloz, C; Valenzuela, D	1
Baskaran, S; Eyong, KO; Folefoc, GN; Kumar, PS; Lamshöft, M; Puppala, M; Spiteller, M	1
da Rocha, DR; Ferreira, VF; Garcia, CR; Gaur, P; Santos, IO; Sharma, A	1
Caira, MR; da Silva Júnior, EN; Davies-Coleman, MT; de la Mare, JA; Edkins, AL; Hendricks, DT; Osoniyi, O; Pinto, AV; Shunmoogam-Gounden, N; Sunassee, SN; Veale, CG	1
Balsano, E; Berger, W; Göschl, S; Hartinger, CG; Jakupec, MA; Jungwirth, U; Kandioller, W; Keppler, BK; Meier, SM; Roller, A	1
Alves, TM; Beraldo, H; Campos, FF; Cisalpino, PS; de Sá, NP; Johann, S; Lima, LA; Mendes, IC; Rosa, CA; Souza, MA; Souza-Fagundes, EM; Zani, CL	1
Bai, L; Han, Y; Li, X; Li, Y; Xu, P; Xue, M; Yao, J	1
Gupta, MP; Ríos, MI; Rodríguez, MV; Solano, G; Tamayo-Castillo, G; Vásquez, V; Zacchino, S	1
Bruyère, C; Epifano, F; Fiorito, S; Genovese, S; Kiss, R; Mathieu, V	1
Okumura, N; Uno, B; Wakamatsu, S	1
Alves dos Santos, R; Cruz de Carvalho, T; Jacometti Cardoso Furtado, NA; Oliveira Silva, E; Parshikov, IA; Silva Emery, F	1
Barbero, A; Bartolucci, GB; Carrieri, M; Harper, M; Lee, T	1
Barbosa, MI; Barbosa-Filho, JM; Batista, AA; Corrêa, RS; de Oliveira, KM; Ellena, J; Macedo, TS; Nascimento, OR; Nonato, FR; Rocha, VP; Rodrigues, C; Soares, MB	1
Barbosa-Filho, JM; Camara, CA; da Silva, KN; da Silva, TM; de Sá, MS; dos Santos, RR; Goulart, MO; Guimaraes, ET; Macedo, TS; Maia, GL; Menezes, MN; Moreira, DR; Reys, JR; Santana, AE; Silva, TL; Soares, MB	1
Castelli, S; D'Annessa, I; Desideri, A	1
Brun, R; Ellendorff, T; Kaiser, M; Schmidt, TJ; Sendker, J	1
Inagaki, R; Koketsu, M; Ninomiya, M; Tanaka, K	1
Epifano, F; Fiorito, S; Genovese, S; Taddeo, VA	1
Aleu, J; Collado, IG; dos Santos, RA; Furtado, NA; Ruano-González, A; Sánchez-Maestre, R; Silva, EO	1
Niu, B; Qu, Y; Zhang, C	1
Bai, L; Chen, Q; Li, X; Wang, H; Xu, H; Xu, P; Xue, M; Yuan, R	1
Chiniforoshan, H; Tabrizi, L; Talaie, F	1
Alves-Filho, JC; Buqui, G; Cecilio, NT; Costa, TD; Cunha, FQ; Cunha, TM; Emery, FS; Jabor, VA; Lopes, NP; Louzada-Júnior, P; Niehues, M; Nonato, MC; Peres, RS; Ramalho, FS; Santos, GB; Silva, CH; Torres, BG	1
Green, IR; Hussain, H	1
Arantes, LM; Braga de Oliveira, A; Brandão, GC; Doerksen, RJ; Pereira, GR; Rocha Missias, FC; Roy, KK; Soares, LF	1
Hato, T; Lakhter, AJ; Mahanta, S; Naidu, SR; Paul, S; Shankar Babu, M	1
Khandelwal, P; Vyas, P; Yadav, DK	1
do Canto, VP; Follmer, C; Moura-Neto, V; Netz, PA; Pinto, ÂC; Romão, L	1
de Andrade, ARB; de Santana, DP; Leal, LB; Lira, AAM; Sarmento, VHV; Tabosa, MAM	1
Alves, TMA; Barbeira, PJS; Bertollo, CM; Cisalpino, PS; de Sá, NP; de Souza, DDG; Johann, S; Rosa, CA; Santos, PC; Zani, CL	1
Cons, BL; Costa, PRR; da Silva, AJM; Gomes, SLS; Melo, PA; Monteiro-Machado, M; Nogueira-Souza, PD; Patrão-Neto, FC; Schaeffer, E; Strauch, MA; Tavares-Henriques, MDS; Teixeira-Cruz, JDM; Tomaz, MA	1
Alves, CL; Araújo, IAC; de Paula, RC; Dias, EMFA; Faria, KF; Mendes, GG; Oliveira, AB; Oliveira, MM; Ribeiro, RR; Silva, SMD	1
Barbosa Coitinho, L; Cabral, H; da Rosa-Garzon, NG; da Silva Emery, F; Fumagalli, F	1
Castro, FAV; de Souza, GFM; Pereira, MD	1
Bode, AM; Dong, Z; Kim, DJ; Liu, K; Xie, X; Zhang, Y; Zu, X	1
Araújo, CRM; da Costa, MM; de Oliveira, HP; Dos Anjos Santos, VL; Fernandes, AWC	1
Alves, RJ; de Sousa, FS; de Victo, NC; Holzer, AK; Kisitu, J; Leist, M; Marques, LB; Ottoni, FM; Pinto, MCX; Ribeiro, JM; Souza-Fagundes, EM; Weinlich, R	1
Camara, CA; Coutinho, HDM; de Farias, PAM; Figueredo, FG; Fonteles, MMF; Oliveira-Tintino, CDM; Paz, JA; Ramos, ITL; Relison Tintino, S; Silva, TMS	1
Câmara, CA; Coutinho, HDM; de Farias, PAM; de Morais Oliveira-Tintino, CD; Figueredo, FG; Fonteles, MMF; Menezes, IRA; Paz, JA; Ramos, ITL; Silva, TMS; Tintino, SR	1
Borgati, TF; de Oliveira, AB; de Souza, LCR; do Nascimento, MFA; Tagliati, CA	1
Carranza-Rosales, P; Coronel, C; F de la Torre, A; Leal López, K; Pertino, MW; Rojas de Arias, A; Rolón, M; Schmeda-Hirschmann, G; Vega, C; Viveros Valdez, E	1
Ahmadi, ES; Asili, J; Iranshahy, M; Kretschmer, N; Sahebkar, A; Shakeri, A; Tajbakhsh, A	1
Kim, J; Kim, MM	1
Foulkes, MJ; Henry, KM; Jones, S; Renshaw, SA; Tolliday, FH	1
Batista, AA; Cominetti, MR; Correa, RS; Demidoff, FC; Honorato, J; Netto, CD; Oliveira, KM; Schultz, MS	1
Alcântara Lemos, J; Alves, RJ; Cassali, GD; de Barros, ALB; Fernandes, RS; Ferreira, LAM; Mendes Miranda, SE; Ottoni, FM; Rubello, D; Silva, JO; Townsend, DM	1
Aguiar, RS; Jardim, ACG; José, DP; Junior, NN; Lapa, IR; Meireles, BA; Nicolau, MSP; Santos, IA	1
Camara, CA; Cavalcante-Figueredo, MR; Coutinho, HDM; da Silva, RLP; de Morais Oliveira-Tintino, CD; Ferreira Matias, EF; Figueiredo, JG; Figueredo, FG; Fonteles, MMF; Parente, RELT; Silva, TMS; Tintino, SR	1
Brustolin, AÁ; Caetano, W; Campanholi, KSS; Demarchi, IG; Lera-Nonose, DSSL; Lonardoni, MVC; Oyama, J; Ramos-Milaré, ÁCFH; Silva, EL; Silveira, TGV; Sydor, BG	1

Reviews

6 review(s) available for lapachol and naphthoquinones

Article	Year
Naturally occurring quinones as potential bioreductive alkylating agents. Medicinal research reviews, 1981,Fall, Volume: 1, Issue:3 Topics: Alkylating Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Chemical Phenomena; Chemistry; Doxorubicin; Mitomycin; Mitomycins; Naphthacenes; Naphthoquinones; Oxidation-Reduction; Quinones; Stereoisomerism	1981
Quinones derived from plant secondary metabolites as anti-cancer agents. Anti-cancer agents in medicinal chemistry, 2013, Volume: 13, Issue:3 Topics: Anthraquinones; Antineoplastic Agents, Phytogenic; Benzoquinones; Cell Line, Tumor; Cell Survival; Humans; Naphthoquinones; Neoplasms; Plant Extracts	2013
Topoisomerase 1B as a target against leishmaniasis. Mini reviews in medicinal chemistry, 2015, Volume: 15, Issue:3 Topics: Antiprotozoal Agents; Camptothecin; DNA Topoisomerases, Type I; Humans; Indoles; Isoquinolines; Leishmania; Leishmaniasis; Naphthoquinones; Protozoan Proteins; Quercetin	2015
Lapachol and lapachone analogs: a journey of two decades of patent research(1997-2016). Expert opinion on therapeutic patents, 2017, Volume: 27, Issue:10 Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Design; Humans; Naphthoquinones; Neoplasms; Patents as Topic; Tabebuia	2017
Natural product research, 2019, Volume: 33, Issue:16 Topics: Animals; Antioxidants; Humans; Lamiaceae; Naphthoquinones; Phytochemicals; Plant Extracts; Quinones; Wound Healing	2019
Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity. Mini reviews in medicinal chemistry, 2020, Volume: 20, Issue:19 Topics: Anti-Infective Agents; Apoptosis; Drug Screening Assays, Antitumor; Fungi; Humans; Naphthoquinones; Neoplasms; Plants; Structure-Activity Relationship	2020

Other Studies

112 other study(ies) available for lapachol and naphthoquinones

Article	Year
Microbial transformations of natural antitumor agents: conversion of lapachol to dehydro-alpha-lapachone by Curvularia lunata. Applied and environmental microbiology, 1979, Volume: 38, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Biotransformation; Chemical Phenomena; Chemistry; Mitosporic Fungi; Naphthoquinones	1979
A lapachol derivative active against mouse lymphocytic leukemia P-388. Journal of medicinal chemistry, 1975, Volume: 18, Issue:11 Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Leukemia, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Naphthoquinones; Rats	1975
Phytochemical and analgesic investigation of Tabebuia chrysotricha. Journal of ethnopharmacology, 1992, Volume: 36, Issue:3 Topics: Alcohols; Analgesics; Animals; Chromatography, Thin Layer; Injections, Intraperitoneal; Male; Mice; Naphthoquinones; Plant Extracts; Plants, Medicinal	1992
Antiinflammatory action of lapachol. Journal of ethnopharmacology, 1990, Volume: 29, Issue:2 Topics: Abscess; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Foot; Male; Naphthoquinones; Phenylbutazone; Rats; Rats, Inbred Strains	1990
Effect of lapachol, a naphthaquinone isolated from Tectona grandis, on experimental peptic ulcer and gastric secretion. The Journal of pharmacy and pharmacology, 1987, Volume: 39, Issue:2 Topics: Animals; Female; Gastric Juice; Gastric Mucosa; Guinea Pigs; Male; Naphthoquinones; Peptic Ulcer; Proteins; Rats; Rats, Inbred Strains	1987
In vitro activity of natural and synthetic naphthoquinones against erythrocytic stages of Plasmodium falciparum. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1988, Volume: 21, Issue:3 Topics: Animals; Chloroquine; Drug Resistance; In Vitro Techniques; Naphthoquinones; Plant Extracts; Plasmodium falciparum	1988
Lapachol inhibition of DT-diaphorase (NAD(P)H:quinone dehydrogenase). Biochemical and biophysical research communications, 1986, Jun-13, Volume: 137, Issue:2 Topics: Animals; Chromatography, Affinity; Cytosol; In Vitro Techniques; Microsomes, Liver; NAD; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Oxidation-Reduction; Quinone Reductases; Rats	1986
Partial transition-state inhibitors of glyoxalase I from human erythrocytes, yeast and rat liver. Biochimica et biophysica acta, 1985, May-20, Volume: 829, Issue:1 Topics: Animals; Binding Sites; Erythrocytes; Humans; In Vitro Techniques; Kinetics; Lactoylglutathione Lyase; Liver; Lyases; Naphthoquinones; Pyrones; Quercetin; Rats; Saccharomyces cerevisiae	1985
Lapachol inhibition of vitamin K epoxide reductase and vitamin K quinone reductase. Archives of biochemistry and biophysics, 1984, Nov-01, Volume: 234, Issue:2 Topics: Animals; Anticoagulants; Dithiothreitol; Drug Resistance; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; NADH, NADPH Oxidoreductases; Naphthoquinones; Oxidation-Reduction; Quinone Reductases; Rats; Vitamin K Epoxide Reductases; Warfarin	1984
Oxidative ring fission of the naphthoquinones lapachol and dichloroallyl lawsone by Penicillium notatum. The Journal of biological chemistry, 1983, Feb-10, Volume: 258, Issue:3 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Mass Spectrometry; Naphthoquinones; Oxidation-Reduction; Penicillium; Species Specificity	1983
Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone. Planta medica, 1994, Volume: 60, Issue:4 Topics: Anti-Infective Agents; Antifungal Agents; Microbial Sensitivity Tests; Molecular Structure; Naphthoquinones	1994
Activity of extracts of Kigelia pinnata against melanoma and renal carcinoma cell lines. Planta medica, 1994, Volume: 60, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Renal Cell; Cell Line; Humans; Kidney Neoplasms; Melanoma; Naphthoquinones; Plants, Medicinal; Tissue Extracts; Tumor Cells, Cultured; Vincristine	1994
Antibacterial and antifungal compounds from Kigelia pinnata. Planta medica, 1996, Volume: 62, Issue:4 Topics: Anthraquinones; Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Bacteria; Bridged-Ring Compounds; Caffeic Acids; Coumaric Acids; Fungi; Furans; Microbial Sensitivity Tests; Naphthoquinones; Plant Extracts; Plant Roots; Plants, Medicinal	1996
[Tumors caused by methylcholanthrene and lapachol. Follow-up of development with cytology]. Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia, 1996, Volume: 46, Issue:4 Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Methylcholanthrene; Naphthoquinones; Neoplasms; Rats; Rats, Sprague-Dawley	1996
Hydroxylated naphthoquinones as substrates for Escherichia coli anaerobic reductases. The Biochemical journal, 1998, May-15, Volume: 332 ( Pt 1) Topics: Anaerobiosis; Binding Sites; Electrochemistry; Electron Transport Complex IV; Enzyme Inhibitors; Escherichia coli; Hydroxyquinolines; Kinetics; Molecular Structure; Naphthoquinones; Oxidoreductases; Spectrophotometry; Substrate Specificity	1998
Potential antipsoriatic agents: lapacho compounds as potent inhibitors of HaCaT cell growth. Journal of natural products, 1999, Volume: 62, Issue:8 Topics: Administration, Topical; Anthralin; Anti-Inflammatory Agents; Cell Division; Cell Line; Humans; Keratinocytes; Keratolytic Agents; L-Lactate Dehydrogenase; Naphthoquinones; Psoriasis; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet	1999
Interceptive effect of Lapachol in rats. Contraception, 1999, Volume: 60, Issue:5 Topics: Animals; Antimalarials; Body Weight; Eating; Embryo Implantation; Female; Fetal Death; Fetal Resorption; Naphthoquinones; Pregnancy; Rats; Rats, Wistar; Time Factors; Trypanocidal Agents	1999
Chemical constituents of Avicennia alba. Isolation and structural elucidation of new naphthoquinones and their analogues. Chemical & pharmaceutical bulletin, 2000, Volume: 48, Issue:3 Topics: Magnetic Resonance Spectroscopy; Naphthoquinones; Plant Epidermis; Plants, Medicinal; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet	2000
Molluscicidal activity of 2-hydroxy-3-alkyl-1,4-naphthoquinones and derivatives. International journal for parasitology, 2000, Volume: 30, Issue:11 Topics: Animals; Anti-Infective Agents; Biological Assay; Brazil; Molluscacides; Naphthoquinones; Snails	2000
In vitro and in vivo Leishmanicidal activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol). Phytotherapy research : PTR, 2001, Volume: 15, Issue:1 Topics: Animals; Antimony Sodium Gluconate; Antiprotozoal Agents; Cricetinae; Disease Models, Animal; Female; Leishmania braziliensis; Leishmaniasis, Cutaneous; Macrophages, Peritoneal; Male; Mesocricetus; Mice; Naphthoquinones; Plants, Medicinal	2001
Molluscicidal and trypanocidal activities of lapachol derivatives. Planta medica, 2001, Volume: 67, Issue:1 Topics: Animals; Antiprotozoal Agents; Naphthoquinones; Snails; Trypanosoma cruzi	2001
Toxicology of Lapachol in rats: embryolethality. Brazilian journal of biology = Revista brasleira de biologia, 2001, Volume: 61, Issue:1 Topics: Animals; Anti-Infective Agents; Body Weight; Chi-Square Distribution; Corpus Luteum; Female; Fetal Death; Naphthoquinones; Organ Size; Pregnancy; Rats; Rats, Wistar; Toxicity Tests	2001
Synthesis and preliminary pharmacological evaluation of new (+/-) 1,4-naphthoquinones structurally related to lapachol. Bioorganic & medicinal chemistry, 2002, Volume: 10, Issue:8 Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Division; Crotalid Venoms; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; GABA-A Receptor Antagonists; Herpesvirus 2, Human; Humans; Naphthoquinones; Neurotoxins; Rats; Structure-Activity Relationship; Tumor Cells, Cultured	2002
Toxicity of lapachol and isolapachol and their potassium salts against Biomphalaria glabrata, Schistosoma mansoni cercariae, Artemia salina and Tilapia nilotica. Acta tropica, 2002, Volume: 83, Issue:1 Topics: Animals; Anthelmintics; Artemia; Biomphalaria; Confidence Intervals; Molluscacides; Naphthoquinones; Parasitic Sensitivity Tests; Schistosoma mansoni; Structure-Activity Relationship; Tilapia	2002
New enamine derivatives of lapachol and biological activity. Anais da Academia Brasileira de Ciencias, 2002, Volume: 74, Issue:2 Topics: Aedes; Amines; Animals; Antineoplastic Agents, Phytogenic; Artemia; Breast Neoplasms; Drug Evaluation, Preclinical; Female; Humans; Magnetic Resonance Spectroscopy; Naphthoquinones; Tumor Cells, Cultured	2002
The anatomy and chemistry of the colour bands of grasstree stems (Xanthorrhoea preissii) used for plant age and fire history determination. Annals of botany, 2002, Volume: 89, Issue:5 Topics: Chromatography, Gas; Fires; Hydrolyzable Tannins; Magnoliopsida; Naphthoquinones; Pigmentation; Plant Stems; Resins, Plant; Time Factors	2002
Fetal growth in rats treated with lapachol. Contraception, 2002, Volume: 66, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Eating; Embryonic and Fetal Development; Female; Fetal Growth Retardation; Fetal Weight; Gestational Age; Naphthoquinones; Organ Size; Ovary; Placenta; Pregnancy; Rats; Rats, Wistar	2002
Inhibitory effects of lapachol derivatives on epstein-barr virus activation. Bioorganic & medicinal chemistry, 2003, Feb-20, Volume: 11, Issue:4 Topics: Acylation; Antigens, Viral; Antiviral Agents; Cell Line; Cyclization; Herpesvirus 4, Human; Hydroxylation; Naphthoquinones; Polycyclic Compounds; Structure-Activity Relationship	2003
Electrochemical study of oxygen interaction with lapachol and its radical anions. Bioelectrochemistry (Amsterdam, Netherlands), 2003, Volume: 59, Issue:1-2 Topics: Carbon; Electrochemistry; Electrodes; Naphthoquinones; Oxidation-Reduction; Oxygen; Reactive Oxygen Species	2003
Isolation of colour components from native dye-bearing plants in northeastern India. Bioresource technology, 2005, Volume: 96, Issue:3 Topics: Anthraquinones; Azo Compounds; Colorimetry; Cotton Fiber; India; Magnetic Resonance Spectroscopy; Naphthoquinones; Pigmentation; Pigments, Biological; Plant Extracts; Plants; Quercetin; Silk; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Textiles	2005
NO reductase from Bacillus azotoformans is a bifunctional enzyme accepting electrons from menaquinol and a specific endogenous membrane-bound cytochrome c551. Biochemistry, 2004, Oct-26, Volume: 43, Issue:42 Topics: Amino Acid Sequence; Bacillus; Bacterial Proteins; Cytochrome c Group; Electrochemistry; Electron Transport; Intracellular Membranes; Kinetics; Membrane Proteins; Molecular Sequence Data; Multienzyme Complexes; Naphthoquinones; Nitric Oxide; Oxidation-Reduction; Oxidoreductases; Protein Subunits	2004
Molluscicidal activity of synthetic lapachol amino and hydrogenated derivatives. Bioorganic & medicinal chemistry, 2005, Jan-03, Volume: 13, Issue:1 Topics: Amines; Animals; Hydrogen; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mollusca; Naphthoquinones	2005
Demonstration of the lapachol as a potential drug for reducing cancer metastasis. Oncology reports, 2005, Volume: 13, Issue:2 Topics: Antineoplastic Agents, Phytogenic; HeLa Cells; Humans; Naphthoquinones; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms	2005
Antileishmanial activity of lapachol analogues. Memorias do Instituto Oswaldo Cruz, 2004, Volume: 99, Issue:7 Topics: Animals; Antiprotozoal Agents; Leishmania braziliensis; Macrophages, Peritoneal; Mice; Naphthoquinones; Parasitic Sensitivity Tests; Time Factors	2004
Cytotoxic pyranonaphthoquinones from Melloa quadrival vis (Bignoniaceae). Natural product research, 2005, Volume: 19, Issue:3 Topics: Antineoplastic Agents, Phytogenic; Bignoniaceae; Carcinoma, Hepatocellular; Drug Screening Assays, Antitumor; Liver Neoplasms; Naphthoquinones; Plant Bark; Plant Extracts; Tumor Cells, Cultured	2005
Selective growth-inhibiting effects of compounds identified in Tabebuia impetiginosa inner bark on human intestinal bacteria. Journal of agricultural and food chemistry, 2005, Feb-23, Volume: 53, Issue:4 Topics: Anthraquinones; Bacteria; Growth Inhibitors; Humans; Intestines; Naphthoquinones; Plant Bark; Structure-Activity Relationship; Tabebuia	2005
Acrosome reaction in bovine spermatozoa: role of reactive oxygen species and lactate dehydrogenase C4. Biochimica et biophysica acta, 2005, Oct-30, Volume: 1726, Issue:1 Topics: Acrosome; Acrosome Reaction; Analysis of Variance; Animals; Biphenyl Compounds; Catalase; Cattle; Cyclic AMP-Dependent Protein Kinases; Hydrogen Peroxide; Isoenzymes; L-Lactate Dehydrogenase; Lysophosphatidylcholines; Male; Naphthoquinones; Onium Compounds; Protein Kinase C; Protein-Tyrosine Kinases; Reactive Oxygen Species; Sperm Capacitation; Spermatozoa; Superoxide Dismutase; Triazines	2005
Larvicidal activity of Cybistax antisyphilitica against Aedes aegypti larvae. Fitoterapia, 2005, Volume: 76, Issue:7-8 Topics: Aedes; Animals; Bignoniaceae; Insecticides; Larva; Naphthoquinones; Plant Stems	2005
Microwave-assisted rapid cyclization of lapachol, a main constituent of Heterophragma adenophyllum. Natural product research, 2006, Volume: 20, Issue:2 Topics: Bignoniaceae; Cyclization; Microwaves; Molecular Structure; Naphthoquinones; Spectrum Analysis	2006
Antiplasmodial activity of naphthoquinones related to lapachol and beta-lapachone. Chemistry & biodiversity, 2005, Volume: 2, Issue:2 Topics: Animals; Antimalarials; Molecular Structure; Naphthoquinones; Plasmodium falciparum	2005
Antifungal chemical compounds identified using a C. elegans pathogenicity assay. PLoS pathogens, 2007, Volume: 3, Issue:2 Topics: Animals; Antifungal Agents; Biofilms; Caenorhabditis elegans; Caffeic Acids; Candida; Enoxacin; Female; Fluconazole; Intestines; Mice; Mice, Inbred BALB C; Naphthoquinones; NF-kappa B; Phenylethyl Alcohol	2007
Applications of counter-current chromatography in organic synthesis purification of heterocyclic derivatives of lapachol. Journal of chromatography. A, 2007, Jun-01, Volume: 1151, Issue:1-2 Topics: Activating Transcription Factor 6; Chromatography, Thin Layer; Countercurrent Distribution; Cyclization; Imidazoles; Molecular Structure; Naphthoquinones; Oxazoles; Quinoxalines	2007
Reproductive toxicity of lapachol in adult male Wistar rats submitted to short-term treatment. Phytotherapy research : PTR, 2007, Volume: 21, Issue:7 Topics: Animals; Anti-Infective Agents; Male; Naphthoquinones; Organ Size; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Seminal Vesicles; Spermatozoa; Tabebuia	2007
Cytotoxic and DNA-topoisomerase effects of lapachol amine derivatives and interactions with DNA. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2007, Volume: 40, Issue:10 Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Carcinoma, Ehrlich Tumor; Cell Survival; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; K562 Cells; Mice; Naphthoquinones; Quercetin; Topoisomerase II Inhibitors; Vincristine	2007
Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms. Bioorganic & medicinal chemistry, 2008, Jan-15, Volume: 16, Issue:2 Topics: Animals; Molecular Structure; Naphthoquinones; Oxidation-Reduction; Stereoisomerism; Trypanocidal Agents; Trypanosoma cruzi	2008
Promotion or suppression of experimental metastasis of B16 melanoma cells after oral administration of lapachol. Toxicology and applied pharmacology, 2008, Jun-01, Volume: 229, Issue:2 Topics: Administration, Oral; Animals; Male; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Naphthoquinones; Neoplasm Metastasis; Vitamin K	2008
Development of lapachol topical formulation: anti-inflammatory study of a selected formulation. AAPS PharmSciTech, 2008, Volume: 9, Issue:1 Topics: Administration, Topical; Animals; Anti-Infective Agents; Diffusion; Drug Carriers; Drug Compounding; Drug Evaluation, Preclinical; Inflammation; Materials Testing; Naphthoquinones; Rats; Rats, Wistar	2008
Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol. Bioorganic & medicinal chemistry letters, 2008, Oct-15, Volume: 18, Issue:20 Topics: Aldehydes; Antineoplastic Agents; Cell Line, Tumor; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Furans; Humans; Models, Chemical; Naphthoquinones; Neoplasms; Ozone; Plant Extracts; Quinones	2008
Syntheses in the lapachol series. Journal of the American Chemical Society, 1948, Volume: 70, Issue:2 Topics: Humans; Naphthoquinones	1948
Comparison of the cytotoxic effect of lapachol, alpha-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells. Investigational new drugs, 2010, Volume: 28, Issue:2 Topics: Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Leukemia; Leukocytes, Mononuclear; Mitomycin; Naphthoquinones	2010
LC-APCI mass spectrometric method development and validation for the determination of atovaquone in human plasma. Biomedical chromatography : BMC, 2010, Volume: 24, Issue:5 Topics: Anti-Infective Agents; Atovaquone; Chromatography, Liquid; Humans; Naphthoquinones; Reference Standards; Sensitivity and Specificity; Tandem Mass Spectrometry	2010
Acanthamoeba castellanii Neff: In vitro activity against the trophozoite stage of a natural sesquiterpene and a synthetic cobalt(II)-lapachol complex. Experimental parasitology, 2010, Volume: 126, Issue:1 Topics: Acanthamoeba castellanii; Antiprotozoal Agents; Celastraceae; Cobalt; Humans; Naphthoquinones; Plant Extracts; Plant Roots; Sesquiterpenes	2010
Lapachol induces clastogenic effects in rats. Planta medica, 2010, Volume: 76, Issue:9 Topics: Animals; Bone Marrow Cells; Chromosome Aberrations; Erythrocytes; Male; Micronucleus Tests; Mutagenicity Tests; Mutagens; Naphthoquinones; Plant Extracts; Rats; Rats, Wistar; Tabebuia; Wood	2010
Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol. Bioorganic & medicinal chemistry, 2010, Apr-01, Volume: 18, Issue:7 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Lipids; Magnetic Resonance Spectroscopy; Naphthoquinones; Prenylation; Structure-Activity Relationship	2010
Fragmentation studies and electrospray ionization mass spectrometry of lapachol: protonated, deprotonated and cationized species. Rapid communications in mass spectrometry : RCM, 2010, Jul-30, Volume: 24, Issue:14 Topics: Models, Chemical; Naphthoquinones; Phase Transition; Spectrometry, Mass, Electrospray Ionization	2010
The hydroxy-naphthoquinone lapachol arrests mycobacterial growth and immunomodulates host macrophages. International immunopharmacology, 2010, Volume: 10, Issue:11 Topics: Anti-Bacterial Agents; Antigens, CD; B7-1 Antigen; B7-2 Antigen; CD83 Antigen; Cell Line; Histocompatibility Antigens Class II; Humans; Immunoglobulins; Immunologic Factors; Immunomodulation; Interferon gamma Receptor; Interferon-gamma; Interleukin-10; Macrophages; Membrane Glycoproteins; Mycobacterium avium; Naphthoquinones; Nitrogen; Oxidative Stress; Oxygen; Receptors, Interferon; Toll-Like Receptor 2; Tumor Necrosis Factor-alpha; Up-Regulation	2010
Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1. Biological chemistry, 2011, Volume: 392, Issue:5 Topics: Alkaloids; Antimalarials; HSP72 Heat-Shock Proteins; Inhibitory Concentration 50; Naphthoquinones; Plasmodium falciparum	2011
Lapachol suppresses cell proliferation and secretion of interleukin-6 and plasminogen activator inhibitor-1 of fibroblasts derived from hypertrophic scars. The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:7 Topics: Avicennia; Biopsy; Cell Cycle; Cell Proliferation; Cells, Cultured; Cicatrix, Hypertrophic; Collagen Type I; Collagen Type I, alpha 1 Chain; Fibroblasts; Gene Expression Regulation; Humans; Interleukin-6; Lactate Dehydrogenases; Naphthoquinones; Osmolar Concentration; Plant Bark; Plant Stems; Plasminogen Activator Inhibitor 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin	2011
Coordination of lapachol to bismuth(III) improves its anti-inflammatory and anti-angiogenic activities. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2012, Volume: 25, Issue:1 Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Bismuth; Implants, Experimental; Inflammation; Male; Mice; Molecular Structure; Naphthoquinones	2012
Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives. Molecules (Basel, Switzerland), 2011, Oct-13, Volume: 16, Issue:10 Topics: Animals; Anti-Ulcer Agents; Cell Line, Tumor; Diterpene Alkaloids; Diterpenes; Gastric Mucosa; Humans; Liver; Lung; Male; Mice; Naphthoquinones; Stomach; Stomach Ulcer; Tabebuia	2011
Antimony(V) and bismuth(V) complexes of lapachol: synthesis, crystal structure and cytotoxic activity. Molecules (Basel, Switzerland), 2011, Dec-13, Volume: 16, Issue:12 Topics: Antimony; Bismuth; Cell Death; Cell Proliferation; Crystallography, X-Ray; Female; Humans; K562 Cells; Magnetic Resonance Spectroscopy; Middle Aged; Molecular Conformation; Naphthoquinones	2011
Lapachol as an epithelial tumor inhibitor agent in Drosophila melanogaster heterozygote for tumor suppressor gene wts. Genetics and molecular research : GMR, 2011, Dec-22, Volume: 10, Issue:4 Topics: Animals; Antineoplastic Agents, Phytogenic; Crosses, Genetic; Dose-Response Relationship, Drug; Doxorubicin; Drosophila melanogaster; Drosophila Proteins; Female; Heterozygote; Humans; Larva; Male; Naphthoquinones; Neoplasms, Experimental; Neoplasms, Glandular and Epithelial; Plant Extracts; Protein Kinases; Tabebuia	2011
Lapacho tea (Tabebuia impetiginosa) extract inhibits pancreatic lipase and delays postprandial triglyceride increase in rats. Phytotherapy research : PTR, 2012, Volume: 26, Issue:12 Topics: Animals; Enzyme Inhibitors; Lipase; Lipoprotein Lipase; Male; Naphthoquinones; Plant Bark; Plant Extracts; Postprandial Period; Rats; Rats, Wistar; Tabebuia; Triglycerides	2012
Determination of lapachol in the presence of other naphthoquinones using 3MPA-CdTe quantum dots fluorescent probe. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2013, Jan-01, Volume: 100 Topics: 3-Mercaptopropionic Acid; Absorption; Cadmium Compounds; Fluorescent Dyes; Humans; Naphthoquinones; Quantum Dots; Spectrometry, Fluorescence; Tellurium	2013
A proteomic insight into the effects of the immunomodulatory hydroxynaphthoquinone lapachol on activated macrophages. International immunopharmacology, 2012, Volume: 14, Issue:1 Topics: Anti-Bacterial Agents; Cell Line, Tumor; Cell Movement; Cytosol; Endoplasmic Reticulum Chaperone BiP; Humans; Interferon-gamma; Macrophage Activation; Macrophages; Membrane Proteins; Naphthoquinones; Phagocytosis; Proteolysis; Proteomics; Toll-Like Receptor 2	2012
Biomimetic in vitro oxidation of lapachol: a model to predict and analyse the in vivo phase I metabolism of bioactive compounds. European journal of medicinal chemistry, 2012, Volume: 54 Topics: Animals; Biomimetics; Ethylenediamines; Female; Models, Biological; Naphthoquinones; Organometallic Compounds; Oxidants; Oxidation-Reduction; Rats; Rats, Wistar	2012
Potential gastroprotective effect of novel cyperenoic acid/quinone derivatives in human cell cultures. Planta medica, 2012, Volume: 78, Issue:17 Topics: Anti-Ulcer Agents; Cells, Cultured; Epithelial Cells; Fibroblasts; Gastric Mucosa; Humans; Jatropha; Naphthoquinones; Paraguay; Plant Bark; Plant Extracts; Plant Stems; Protective Agents; Rhizome; Sesquiterpenes; Stomach Ulcer; Tabebuia	2012
A mechanistic study on the Hooker oxidation: synthesis of novel indane carboxylic acid derivatives from lapachol. Organic & biomolecular chemistry, 2013, Jan-21, Volume: 11, Issue:3 Topics: Carboxylic Acids; Indans; Models, Molecular; Molecular Structure; Naphthoquinones; Oxidation-Reduction	2013
Addition of thiols to o-quinone methide: new 2-hydroxy-3-phenylsulfanylmethyl[1,4]naphthoquinones and their activity against the human malaria parasite Plasmodium falciparum (3D7). European journal of medicinal chemistry, 2013, Volume: 59 Topics: Antimalarials; Cells, Cultured; Flow Cytometry; Humans; Indolequinones; Malaria, Falciparum; Molecular Structure; Naphthoquinones; Plasmodium falciparum; Sulfhydryl Compounds	2013
Gas-phase reactivity of 2-hydroxy-1,4-naphthoquinones: a computational and mass spectrometry study of lapachol congeners. Journal of mass spectrometry : JMS, 2012, Volume: 47, Issue:12 Topics: Computer Simulation; Ions; Models, Molecular; Naphthoquinones; Protons; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Thermodynamics	2012
Cytotoxicity of lapachol, β-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells. European journal of medicinal chemistry, 2013, Volume: 62 Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Esophageal Neoplasms; Humans; Mice; Models, Molecular; Molecular Structure; Naphthoquinones; NIH 3T3 Cells; Structure-Activity Relationship	2013
Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity. Chemical communications (Cambridge, England), 2013, Apr-25, Volume: 49, Issue:32 Topics: Amino Acids; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Coordination Complexes; Guanine; Humans; Naphthoquinones; Osmium; Reactive Oxygen Species; Rhodium; Ruthenium	2013
The antimicrobial activity of lapachol and its thiosemicarbazone and semicarbazone derivatives. Memorias do Instituto Oswaldo Cruz, 2013, Volume: 108, Issue:3 Topics: Anti-Bacterial Agents; Antifungal Agents; Cryptococcus gattii; Enterococcus faecalis; Microbial Sensitivity Tests; Naphthoquinones; Paracoccidioides; Semicarbazones; Staphylococcus aureus; Thiosemicarbazones	2013
Structural elucidation of the metabolites of lapachol in rats by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Jan-01, Volume: 944 Topics: Animals; Bile; Chromatography, Liquid; Male; Models, Molecular; Naphthoquinones; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2014
Isolation of major components from the roots of Godmania aesculifolia and determination of their antifungal activities. Planta medica, 2013, Volume: 79, Issue:18 Topics: Allylbenzene Derivatives; Anisoles; Antifungal Agents; Aspergillus; Bignoniaceae; Candida; Cryptococcus neoformans; Glycosides; Humans; Microbial Sensitivity Tests; Microsporum; Molecular Structure; Naphthoquinones; Plant Extracts; Plant Roots; Trichophyton	2013
Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives. Bioorganic & medicinal chemistry letters, 2014, Jan-15, Volume: 24, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Colorimetry; Growth Inhibitors; Humans; Naphthoquinones; Neoplasms; Plant Extracts	2014
Electrochemical analysis in a liposome suspension using lapachol as a hydrophobic electro active species. Chemical & pharmaceutical bulletin, 2014, Volume: 62, Issue:1 Topics: Electrochemistry; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Liposomes; Naphthoquinones; Quinones; Solvents; Suspensions	2014
Cytotoxicity of lapachol metabolites produced by probiotics. Letters in applied microbiology, 2014, Volume: 59, Issue:1 Topics: Antineoplastic Agents; Bifidobacterium; Biotransformation; Cell Line, Tumor; Doxorubicin; Drug Screening Assays, Antitumor; Female; Humans; Indenes; Inhibitory Concentration 50; Lactobacillus acidophilus; Naphthoquinones; Probiotics	2014
Chemical markers of occupational exposure to teak wood dust. The Annals of occupational hygiene, 2014, Volume: 58, Issue:5 Topics: Air Pollutants, Occupational; Chromatography, High Pressure Liquid; Dust; Environmental Monitoring; Humans; Naphthoquinones; Occupational Exposure; Wood	2014
Antiparasitic activities of novel ruthenium/lapachol complexes. Journal of inorganic biochemistry, 2014, Volume: 136 Topics: Animals; Antimalarials; Cell Line, Tumor; Coordination Complexes; Crystallography, X-Ray; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Leishmania; Mice; Models, Molecular; Molecular Conformation; Naphthoquinones; Plasmodium falciparum; Ruthenium; Trypanocidal Agents	2014
Evaluation of naphthoquinones identified the acetylated isolapachol as a potent and selective antiplasmodium agent. Journal of enzyme inhibition and medicinal chemistry, 2015, Volume: 30, Issue:4 Topics: Acetylation; Animals; Antimalarials; Mice; Mice, Inbred BALB C; Micronucleus Tests; Naphthoquinones; Plasmodium berghei; Plasmodium falciparum	2015
PLS-Prediction and Confirmation of Hydrojuglone Glucoside as the Antitrypanosomal Constituent of Juglans Spp. Molecules (Basel, Switzerland), 2015, May-29, Volume: 20, Issue:6 Topics: Antiprotozoal Agents; Chromatography, Liquid; Inhibitory Concentration 50; Juglans; Least-Squares Analysis; Leishmania donovani; Mass Spectrometry; Naphthoquinones; Plant Extracts; Trypanosoma brucei rhodesiense; Trypanosoma cruzi	2015
Synthesis, Characterization, and Antileukemic Properties of Naphthoquinone Derivatives of Lawsone. ChemMedChem, 2015, Volume: 10, Issue:8 Topics: Alkenes; Antineoplastic Agents; Cell Proliferation; Crystallography, X-Ray; Dimerization; Glutathione; HL-60 Cells; Humans; Molecular Conformation; Naphthoquinones; Structure-Activity Relationship	2015
Complexes of Lapachol and Lawsone with Lanthanides. Natural product communications, 2015, Volume: 10, Issue:11 Topics: Lanthanoid Series Elements; Naphthoquinones	2015
Antifungal and Cytotoxic Assessment of Lapachol Derivatives Produced by Fungal Biotransformation. Natural product communications, 2016, Volume: 11, Issue:1 Topics: Antifungal Agents; Antineoplastic Agents; Biotransformation; Botrytis; Cell Line; Fungi; Humans; Molecular Structure; Naphthoquinones	2016
Design, synthesis and biological evaluation of lapachol derivatives possessing indole scaffolds as topoisomerase I inhibitors. Bioorganic & medicinal chemistry, 2016, 11-15, Volume: 24, Issue:22 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Structure; Naphthoquinones; Structure-Activity Relationship; Topoisomerase I Inhibitors	2016
Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II. Journal of experimental & clinical cancer research : CR, 2016, 11-16, Volume: 35, Issue:1 Topics: Animals; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Damage; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Glioma; Molecular Docking Simulation; Naphthoquinones; Rats; Rats, Wistar; Topoisomerase Inhibitors; Xenograft Model Antitumor Assays	2016
Copper(II), cobalt(II) and nickel(II) complexes of lapachol: synthesis, DNA interaction, and cytotoxicity. Journal of biomolecular structure & dynamics, 2017, Volume: 35, Issue:15 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cobalt; Coordination Complexes; Copper; DNA Cleavage; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Naphthoquinones; Nickel; Plasmids	2017
Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis. Arthritis research & therapy, 2017, 03-07, Volume: 19, Issue:1 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Cell Proliferation; Dihydroorotate Dehydrogenase; Humans; Immunosuppressive Agents; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Docking Simulation; Naphthoquinones; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Wistar	2017
Antimalarial naphthoquinones. Synthesis via click chemistry, in vitro activity, docking to PfDHODH and SAR of lapachol-based compounds. European journal of medicinal chemistry, 2018, Feb-10, Volume: 145 Topics: Antimalarials; Cell Survival; Chloroquine; Click Chemistry; Dose-Response Relationship, Drug; Drug Resistance; Hep G2 Cells; Humans; Models, Molecular; Molecular Structure; Naphthoquinones; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship	2018
Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2. PloS one, 2018, Volume: 13, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Glycolysis; Humans; Melanoma; Mitochondria; Models, Molecular; Naphthoquinones; Oxygen Consumption; Pyruvate Kinase	2018
Conjugation with polyamines enhances the antitumor activity of naphthoquinones against human glioblastoma cells. Anti-cancer drugs, 2018, Volume: 29, Issue:6 Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Astrocytes; Binding Sites; Brain Neoplasms; Cell Line, Tumor; Cerebral Cortex; DNA Topoisomerases, Type II; Glioblastoma; Humans; Mice; Naphthoquinones; Polyamines; Primary Cell Culture	2018
Microemulsion Formulations for the Transdermal Delivery of Lapachol. AAPS PharmSciTech, 2018, Volume: 19, Issue:4 Topics: Administration, Cutaneous; Animals; Drug Carriers; Drug Compounding; Drug Delivery Systems; Emulsions; Excipients; Naphthoquinones; Organ Culture Techniques; Skin; Skin Absorption; Surface-Active Agents; Swine	2018
Thiosemicarbazone of lapachol acts on cell membrane in Paracoccidioides brasiliensis. Medical mycology, 2019, Apr-01, Volume: 57, Issue:3 Topics: Animals; Antifungal Agents; Cell Membrane; Ergosterol; Macrophages; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Naphthoquinones; Paracoccidioides; Paracoccidioidomycosis; Phagocytosis; Thiosemicarbazones	2019
Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms. PloS one, 2019, Volume: 14, Issue:1 Topics: Animals; Blood Coagulation; Bothrops; Collagenases; Mice; Naphthoquinones; Neurotoxins; Phospholipases A2; Snake Venoms	2019
Efficacy of lapachol on treatment of cutaneous and visceral leishmaniasis. Experimental parasitology, 2019, Volume: 199 Topics: Amphotericin B; Animals; Antiprotozoal Agents; Disease Models, Animal; Female; Flow Cytometry; Hep G2 Cells; Humans; Inhibitory Concentration 50; Leishmania infantum; Leishmania mexicana; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Liver; Mice; Mice, Inbred BALB C; Naphthoquinones; Parasite Load; Plant Extracts; Random Allocation; RAW 264.7 Cells; Skin; Spleen; Tabebuia	2019
Lapachol biotransformation by filamentous fungi yields bioactive quinone derivatives and lapachol-stimulated secondary metabolites. Preparative biochemistry & biotechnology, 2019, Volume: 49, Issue:5 Topics: Biotransformation; Fungi; Gas Chromatography-Mass Spectrometry; Naphthoquinones	2019
Characterization of lapachol cytotoxicity: contribution of glutathione depletion for oxidative stress in Saccharomyces cerevisiae. Folia microbiologica, 2020, Volume: 65, Issue:1 Topics: Alkylation; Glutamate-Cysteine Ligase; Glutathione; Lipid Peroxidation; Mitochondria; Mutation; Naphthoquinones; Oxidative Stress; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Superoxide Dismutase-1	2020
Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells. Phytotherapy research : PTR, 2019, Volume: 33, Issue:9 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Esophageal Squamous Cell Carcinoma; Humans; Naphthoquinones; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction	2019
Anti-biofilm Effect of β-Lapachone and Lapachol Oxime Against Isolates of Staphylococcus aureus. Current microbiology, 2020, Volume: 77, Issue:2 Topics: Anti-Bacterial Agents; Biofilms; Blood Culture; Microbial Sensitivity Tests; Naphthoquinones; Oximes; Staphylococcus aureus	2020
Lapachol acetylglycosylation enhances its cytotoxic and pro-apoptotic activities in HL60 cells. Toxicology in vitro : an international journal published in association with BIBRA, 2020, Volume: 65 Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Survival; Glycosylation; HL-60 Cells; Humans; Naphthoquinones	2020
In silico evaluation of the antibacterial and modulatory activity of lapachol and nor-lapachol derivates. Microbial pathogenesis, 2020, Volume: 144 Topics: Anti-Bacterial Agents; Bacteria; Computer Simulation; DNA Helicases; Microbial Sensitivity Tests; Models, Molecular; Naphthoquinones; Rec A Recombinases	2020
Effect of hydroxyamines derived from lapachol and norlachol against Staphylococcus aureus strains carrying the NorA efflux pump. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2020, Volume: 84 Topics: Anti-Bacterial Agents; Bacterial Proteins; Computer Simulation; Drug Evaluation, Preclinical; Microbial Sensitivity Tests; Molecular Docking Simulation; Multidrug Resistance-Associated Proteins; Naphthoquinones; Norfloxacin; Staphylococcus aureus	2020
In silico, in vitro and in vivo evaluation of natural Bignoniaceous naphthoquinones in comparison with atovaquone targeting the selection of potential antimalarial candidates. Toxicology and applied pharmacology, 2020, 08-15, Volume: 401 Topics: A549 Cells; Animals; Antimalarials; Atovaquone; Caco-2 Cells; Computer Simulation; Dogs; Drug Delivery Systems; Drug Evaluation, Preclinical; Female; Hep G2 Cells; Humans; LLC-PK1 Cells; Madin Darby Canine Kidney Cells; Mice; Naphthoquinones; Plasmodium falciparum; Swine	2020
Synthesis, trypanocidal and anti-leishmania activity of new triazole-lapachol and nor-lapachol hybrids. Bioorganic chemistry, 2020, Volume: 103 Topics: Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Cell Line; Dose-Response Relationship, Drug; Gram-Negative Bacteria; Gram-Positive Bacteria; Leishmania; Mice; Microbial Sensitivity Tests; Molecular Structure; Naphthoquinones; Parasitic Sensitivity Tests; Structure-Activity Relationship; Triazoles; Trypanosoma cruzi	2020
Effect of Lapachol on the Inhibition of Matrix Metalloproteinase Related to the Invasion of Human Fibrosarcoma Cells. Current molecular pharmacology, 2021, 10-25, Volume: 14, Issue:4 Topics: Cell Line, Tumor; Fibrosarcoma; Humans; Matrix Metalloproteinases; Naphthoquinones; NF-kappa B	2021
Evaluation of the anti-inflammatory effects of synthesised tanshinone I and isotanshinone I analogues in zebrafish. PloS one, 2020, Volume: 15, Issue:10 Topics: Abietanes; Animals; Animals, Genetically Modified; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Humans; Inflammation; Molecular Structure; Naphthoquinones; Neutrophil Infiltration; Zebrafish	2020
Lapachol in the Design of a New Ruthenium(II)-Diphosphine Complex as a Promising Anticancer Metallodrug. Journal of inorganic biochemistry, 2021, Volume: 214 Topics: A549 Cells; Antineoplastic Agents; Coordination Complexes; Humans; MCF-7 Cells; Naphthoquinones; Neoplasms; Phosphines; Ruthenium	2021
Enhanced antitumor efficacy of lapachol-loaded nanoemulsion in breast cancer tumor model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 133 Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Drug Compounding; Drug Liberation; Drug Stability; Emulsions; Female; Humans; Mice, Inbred BALB C; Nanoparticles; Naphthoquinones; Tumor Burden	2021
In silico evaluation of lapachol derivatives binding to the Nsp9 of SARS-CoV-2. Journal of biomolecular structure & dynamics, 2022, Volume: 40, Issue:13 Topics: COVID-19 Drug Treatment; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Naphthoquinones; RNA; SARS-CoV-2; Viral Proteins	2022
Inhibition of Staphylococcus aureus TetK and MsrA efflux pumps by hydroxyamines derived from lapachol and norlachol. Journal of bioenergetics and biomembranes, 2021, Volume: 53, Issue:2 Topics: Anti-Bacterial Agents; Naphthoquinones; Staphylococcus aureus	2021
In vitro effects of lapachol and β-lapachone against Leishmania amazonensis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2023, Volume: 56 Topics: Animals; Antiprotozoal Agents; Humans; Leishmania mexicana; Mice; Mice, Inbred BALB C; Naphthoquinones	2023