lankacidins has been researched along with sedecamycin* in 1 studies
1 other study(ies) available for lankacidins and sedecamycin
| Article | Year |
|---|---|
Quinoprotein dehydrogenase functions at the final oxidation step of lankacidin biosynthesis in Streptomyces rochei 7434AN4.
Reinvestigation of the metabolite profile in a disruptant of the quinoprotein dehydrogenase (orf23) gene revealed that the Orf23 protein catalyzes dehydrogenation of the C23-C25 lactate moiety to pyruvate during lankacidin biosynthesis in Streptomyces rochei 7434AN4. The dehydrogenase activity was expressed and detected in a soluble fraction of the Streptomyces lividans recombinant harboring orf23. The Orf23 protein preferentially converts lankacidinol to lankacidin C in the presence of pyrroloquinoline quinone (PQQ). Other lankacidinol derivatives, lankacidinol A and iso-lankacidinol, were also converted to the corresponding C-24 keto compounds, lankacidin A (=sedecamycin) and iso-lankacidin C. Addition of various divalent metal cations, especially Ca Topics: Cations, Divalent; Macrolides; Metabolic Networks and Pathways; Oxidation-Reduction; Oxidoreductases; Streptomyces; Streptomyces lividans | 2018 |