lamotrigine and mexiletine

lamotrigine has been researched along with mexiletine in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (58.82)29.6817
2010's5 (29.41)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Strassburg, CP; Tukey, RH1
Topliss, JG; Yoshida, F1
Anger, T; Madge, DJ; Mulla, M; Riddall, D1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Atkinson, R; Carroll, W; Chapman, M; Chu, K; Drizin, I; Faltynek, CR; Gauvin, D; Gregg, R; Gross, M; Hakeem, A; Hernandez, G; Honore, P; Jarvis, MF; Johnson, M; Joshi, S; Kort, M; Krafte, DS; Krambis, M; Liu, D; Liu, Y; Marron, B; Marsh, K; Matulenko, M; McGaraughty, S; Mikusa, JP; Pai, M; Roeloffs, R; Scanio, M; Shi, L; Shieh, CC; Sullivan, JP; Thomas, J; Wade, C; Wagoner, PK; Zhang, XF; Zhong, C; Zhu, C1
Atkinson, RN; Carroll, WA; Chapman, ML; Drizin, I; Faltynek, CR; Gauvin, DM; Gregg, RJ; Gross, MF; Hernandez, G; Honore, P; Jarvis, MF; Johnson, MS; Joshi, S; Kort, ME; Krafte, DS; Krambis, MJ; Liu, D; Marron, BE; Marsh, KC; Mikusa, JP; Roeloffs, R; Scanio, MJ; Shi, L; Shieh, CC; Thomas, JB; Werness, S; Zhang, X; Zhu, CZ1
Campillo, NE; Guerra, A; Páez, JA1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Blackburn-Munro, G; Erichsen, HK; Hao, JX; Xu, XJ1
Maeda, K; Yasuda, H1
Abbadie, C; Köhler, MG; Lindia, JA; Martin, WJ1
Abbadie, C; Anderson, HA; Clapp, RH; Delaney, A; Fleetwood-Walker, SM; Garry, EM; Kinchington, PR; Krah, DL; Martin, WJ; Sirinathsinghji, EC1
Clouse, AK; Eisennagel, SH; Jugus, MJ; Laping, NJ; Thorneloe, KS; Westfall, TD1
Banach, M; Borowicz-Reutt, KK; Rudkowska, M; Wróblewska, D1
Arnold, WD; Barohn, RJ; Cannon, SC; Fontaine, B; Griggs, RC; Hanna, MG; LoRusso, S; Matthews, E; Meola, G; Sansone, VA; Statland, JM; Stunnenberg, BC; Trivedi, JR; van Engelen, BGM; Vicart, S1
Altamura, C; Desaphy, JF; Fontaine, B; Vicart, S1

Reviews

6 review(s) available for lamotrigine and mexiletine

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
Medicinal chemistry of neuronal voltage-gated sodium channel blockers.
    Journal of medicinal chemistry, 2001, Jan-18, Volume: 44, Issue:2

    Topics: Amyotrophic Lateral Sclerosis; Analgesics; Anticonvulsants; Epilepsy; Humans; Ion Channel Gating; Models, Molecular; Mutation; Nerve Tissue Proteins; Neuroprotective Agents; Protein Binding; Sodium Channel Blockers; Sodium Channels; Stroke

2001
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Symptomatic treatment of painful diabetic neuropathy].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 6

    Topics: Amines; Anti-Asthmatic Agents; Anticonvulsants; Antidepressive Agents; Antitussive Agents; Cyclohexanecarboxylic Acids; Dextromethorphan; Diabetic Neuropathies; Fructose; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; Humans; Lamotrigine; Mexiletine; Nerve Fibers; Posterior Horn Cells; Pregabalin; Selective Serotonin Reuptake Inhibitors; Sodium Channels; Topiramate; Triazines

2005
Guidelines on clinical presentation and management of nondystrophic myotonias.
    Muscle & nerve, 2020, Volume: 62, Issue:4

    Topics: Acetazolamide; Age of Onset; Carbonic Anhydrase Inhibitors; Chloride Channels; Electrodiagnosis; Electromyography; Fatigue; Genetic Testing; Humans; Lamotrigine; Mexiletine; Muscle Weakness; Muscle, Skeletal; Myalgia; Myotonia Congenita; Myotonic Disorders; NAV1.4 Voltage-Gated Sodium Channel; Practice Guidelines as Topic; Ranolazine; Sodium Channel Blockers; Voltage-Gated Sodium Channel Blockers

2020
Targeted Therapies for Skeletal Muscle Ion Channelopathies: Systematic Review and Steps Towards Precision Medicine.
    Journal of neuromuscular diseases, 2021, Volume: 8, Issue:3

    Topics: Channelopathies; Humans; Hypokalemic Periodic Paralysis; Lamotrigine; Mexiletine; Muscle, Skeletal; Mutation; Myasthenic Syndromes, Congenital; Myotonic Disorders; Precision Medicine; Randomized Controlled Trials as Topic; Sodium Channel Blockers

2021

Other Studies

11 other study(ies) available for lamotrigine and mexiletine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, May-15, Volume: 104, Issue:20

    Topics: Action Potentials; Analgesics; Aniline Compounds; Animals; Capsaicin; Evoked Potentials; Furans; Ganglia, Spinal; Humans; Inflammation; Kinetics; Male; Mononeuropathies; NAV1.8 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neurons; Pain; Pain Management; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sodium Channel Blockers; Sodium Channels

2007
Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain.
    Bioorganic & medicinal chemistry, 2008, Jun-15, Volume: 16, Issue:12

    Topics: Analgesics, Non-Narcotic; Animals; Ether-A-Go-Go Potassium Channels; Furans; Humans; Male; Mice; Neuralgia; Piperazines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Structure-Activity Relationship

2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain.
    European journal of pharmacology, 2003, Jan-05, Volume: 458, Issue:3

    Topics: Analgesics; Analysis of Variance; Anesthetics, Local; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hindlimb; Lamotrigine; Lidocaine; Male; Mexiletine; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Time Factors; Tocainide; Triazines

2003
Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats.
    Pain, 2005, Volume: 117, Issue:1-2

    Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Immunohistochemistry; Lamotrigine; Male; Mexiletine; NAV1.3 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neurons; Oligonucleotides; Pain; Pain Measurement; Peripheral Nerves; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Skin; Sodium Channels; Time Factors; Triazines; Up-Regulation

2005
Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs.
    Pain, 2005, Volume: 118, Issue:1-2

    Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models, Animal; Fluorescent Antibody Technique; Gabapentin; Galanin; gamma-Aminobutyric Acid; Ganglia, Spinal; Herpes Zoster; Herpesvirus 3, Human; Immediate-Early Proteins; Immunohistochemistry; Lamotrigine; Mexiletine; Neuralgia; Neuralgia, Postherpetic; Neurons, Afferent; Neuropeptide Y; Rats; Receptors, N-Methyl-D-Aspartate; Reflex; Sodium Channels; Trans-Activators; Triazines; Viral Envelope Proteins; Virus Latency

2005
Voltage-gated Na+ channel blockers reduce functional bladder capacity in the conscious spontaneously hypertensive rat.
    Urology, 2012, Volume: 79, Issue:6

    Topics: Amitriptyline; Animals; Carbamazepine; Female; Lamotrigine; Mexiletine; Rats; Rats, Inbred SHR; Receptors, Muscarinic; Sodium Channel Blockers; Sodium Channels; Triazines; Urinary Bladder, Overactive; Urodynamics

2012
Interactions of Mexiletine with Novel Antiepileptic Drugs in the Maximal Electroshock Test in Mice: An Isobolographic Analysis.
    Neurochemical research, 2018, Volume: 43, Issue:10

    Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Drug Interactions; Drug Therapy, Combination; Electroshock; Lamotrigine; Male; Memory, Long-Term; Mexiletine; Mice; Oxcarbazepine; Pregabalin; Topiramate

2018