lamotrigine and glutamic acid

lamotrigine has been researched along with glutamic acid in 72 studies

Research

Studies (72)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.39)	18.7374
1990's	24 (33.33)	18.2507
2000's	27 (37.50)	29.6817
2010's	18 (25.00)	24.3611
2020's	2 (2.78)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Meldrum, BS	3
Porter, RJ	1
Baumann, PA; Feldtrauer, JJ; Schmutz, M; Stierlin, C; Waldmeier, PC; Wicki, P	1
Boireau, A; Bordier, F; Doble, A; Dubédat, P	1
Beek, O; Cooper, BR; Dickerson, MC; Norton, R; Wiard, RP	1
Cameron, D; Eisen, A; Schulzer, M; Stewart, H	1
Halsey, MJ; Maclean, CJ; Meldrum, BS; Pearce, PC; Shergill, HK; Tindley, G; Ward, EM	1
Baas, H; Fischer, PA; Zipp, F	1
Adams, J; Collaço-Moraes, Y; de Belleroche, J	1
Bowery, NG; Fowler, LJ; Teoh, H	1
Hajak, G; Riederer, P; Riemann, H; Rüther, E; Staedt, J; Stoppe, G	1
Mary, V; Stutzmann, JM; Wahl, F	1
Howlett, W; Ijaz, S; Kanthan, R; Mahmood, RH; Miyashita, H; Murabit, MA; Shuaib, A; Wishart, T	1
Martin, P; Portet, C; Schmutz, M; Stöcklin, K; Waldmeier, PC	1
Bacher, A; Zornow, MH	1
Ebinger, G; Khan, GM; Manil, J; Michotte, Y; Smolders, I	1
Gernert, M; Löscher, W; Richter, A	1
Hölter, SM; Hundt, W; Spanagel, R	1
Attwell, PJ; Bradford, HF; Croucher, MJ; Jane, DE; Singh Kent, N	1
Godukhin, OV; Kalemenev, SV; Kosacheva, ES; Raevskiĭ, KS; Sem'ianov, AV	1
Black, D; Conroy, BP; Crumrine, RC; DeWitt, DS; Jenkins, LW; Johnston, WE; Lin, CY	1
Bernardi, G; Calabresi, P; Centonze, D; Marfia, GA; Pisani, A	1
Eriksson, AS; O'Connor, WT	1
Cahill, CM; Coderre, TJ; Fisher, K; Lefebvre, C	1
Cunningham, MO; Jones, RS	1
Gjerstad, L; Hassel, B; Taubøll, E	1
Koinig, H; Morimoto, Y; Zornow, MH	1
Behar, KL; Hyder, F; Kida, I	1
Gean, PW; Sihra, TS; Wang, SJ	1
Belsito, KM; Kirk, KS; Landa, RJ; Law, PA; Zimmerman, AW	1
Shim, SS	1
Kalkman, HO	1
Askmark, H; Persson, LI; Ryberg, H	1
Brody, SA; Conquet, F; Geyer, MA	1
Ahmad, S; Fowler, LJ; Whitton, PS	1
Goff, DC; Large, CH; Webster, EL	1
Kugaya, A; Sanacora, G	1
Kapaki, E; Limpitaki, G; Paraskevas, GP; Petropoulou, O; Triantafyllou, NI; Vassilopoulos, D	1
Bezprozvanny, I; Tang, T; Wu, J	1
Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS	1
Howland, RH	1
Banakar, S; Chirichigno, JW; Davanzo, P; Elman, S; Fischer, J; Frye, MA; Mintz, J; O'Neill, J; Thomas, MA; Tsuang, J; Ventura, J; Walot, I; Watzl, J	1
Cilia, J; Hatcher, P; Jones, DN; Reavill, C	1
Brown, ES; Osuji, IJ; Shad, MU; Vazquez, M; Wolfshohl, J	1
Han, J; Hong, SG; Kang, D; Kim, EJ; Kim, GT; La, JH; Lee, ES; Lee, JS; Park, JY	1
Deakin, JF; Dursun, SM; Hallak, JE; Lees, J; McKie, S; Williams, SR	1
Nair, J; Singh Ajit, S	1
Sümegi, A	1
Dursun, A; Ofluoglu, E; Ozogul, C; Oztanir, N; Pasaoglu, A; Pasaoglu, H; Tufan, K; Uzum, N	1
Brown, ES; Desai, S; Khanani, S; Shad, MU	1
Ali, F; Cavanna, AE; McCorry, D; Rickards, HE	1
Allen, G; Brown, ES; McColl, R; Ringe, WK; Vazquez, M; Zaidel, L	1
Abekawa, T; Inoue, T; Ito, K; Koyama, T; Nakato, Y	1
Aldana, BI; Chiu, LM; Guarneros, A; Sanchez-Tafolla, BM; Sitges, M	1
Anand, A; Barkay, G; Ghosh, S; Gunn, AD; Karne, HS; Mathew, SJ; Nurnberger, JI	1
Chuang, DM; Fessler, EB; Leng, Y	1
Deng, Y; He, N; Ma, C; Wang, M; Wang, W	1
Inagaki, M; Ohashi, M; Oka, J; Saitoh, A; Sugiyama, A; Suzuki, S; Tsukagoshi, M; Yamada, M	1
Chen, YJ; Huang, F; Li, Q; Song, F; Wan, ZY; Yang, Q; Zhang, M; Zhao, WF; Zhao, YJ	1
Aitta-aho, T; Korpi, ER; Maksimovic, M	1
Goff, DC	1
de Simoni, S; Doyle, O; Mehta, MA; Schwarz, AJ; Shcherbinin, S; Zelaya, FO	1
Alexander, SP; Fone, KC; Gaskin, PL; Toledo-Rodriguez, M	1
Chen, W; Huang, P; Sun, M; Wang, Y	1
Bargiotas, T; Cowen, PJ; Emir, UE; Godlewska, BR; Masaki, C	1
Brown, ES; Choi, C; Frol, AB; Holmes, T; Ivleva, EI; Khan, DA; Kulikova, A; McEwen, B; Nakamura, A; Roberts, J; Sayed, N; Sunderajan, P; Tustison, N; Van Enkevort, E; Vazquez, M; Yassa, MA	1
Forester, BP; Harper, DG; Jensen, E; Mellen, EJ; Ravichandran, C; Silveri, M	1
Beckmann, C; Carstens, L; Gärtner, M; Grimm, S; Hertrampf, R; Keicher, C; Meiering, MS; Mennes, M; Weigand, A; Weigner, D; Wunder, A	1
Costa, B; Vale, N	1

Reviews

12 review(s) available for lamotrigine and glutamic acid

Article	Year
Excitatory amino acid transmitters in epilepsy. Epilepsia, 1991, Volume: 32 Suppl 2 Topics: Anticonvulsants; Aspartic Acid; Epilepsy; Epilepsy, Temporal Lobe; Glutamates; Glutamic Acid; Humans; Ion Channels; Lamotrigine; Neurotransmitter Agents; Triazines	1991
Lamotrigine--a novel approach. Seizure, 1994, Volume: 3 Suppl A Topics: Anticonvulsants; Brain; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy; Glutamic Acid; Humans; Lamotrigine; Metabolic Clearance Rate; Sodium Channels; Triazines	1994
The role of glutamate in epilepsy and other CNS disorders. Neurology, 1994, Volume: 44, Issue:11 Suppl 8 Topics: Animals; Central Nervous System Diseases; Epilepsy; Glutamic Acid; Humans; Lamotrigine; Mice; N-Methylaspartate; Parkinson Disease; Piperazines; Pyrimidines; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Triazines	1994
Antischizophrenic activity independent of dopamine D2 blockade. Expert opinion on therapeutic targets, 2002, Volume: 6, Issue:5 Topics: Amino Acid Transport System X-AG; Animals; Antipsychotic Agents; Brain Chemistry; Dopamine D2 Receptor Antagonists; Drug Design; Drug Evaluation, Preclinical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Frontal Lobe; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Interneurons; Ketamine; Lamotrigine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, GABA; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Schizophrenia; Symporters; Triazines	2002
The potential role of lamotrigine in schizophrenia. Psychopharmacology, 2005, Volume: 181, Issue:3 Topics: Animals; Anticonvulsants; Antipsychotic Agents; Brain; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Glutamic Acid; Humans; Lamotrigine; Rats; Schizophrenia; Schizophrenic Psychology; Triazines	2005
Beyond monoamines: glutamatergic function in mood disorders. CNS spectrums, 2005, Volume: 10, Issue:10 Topics: Bipolar Disorder; Brain; Clinical Trials as Topic; Depressive Disorder, Major; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Lamotrigine; Magnetic Resonance Spectroscopy; Neuroglia; Receptors, Glutamate; Riluzole; Treatment Outcome; Triazines	2005
Glutamate-modulating drugs & the treatment of mental disorders. Journal of psychosocial nursing and mental health services, 2007, Volume: 45, Issue:1 Topics: Acamprosate; Amantadine; Cycloserine; Glutamic Acid; Humans; Ketamine; Lamotrigine; Memantine; Mental Disorders; Psychotropic Drugs; Riluzole; Taurine; Triazines	2007
The role of the glutamatergic system in posttraumatic stress disorder. CNS spectrums, 2008, Volume: 13, Issue:7 Topics: Animals; Calcium Channel Blockers; Corticotropin-Releasing Hormone; Glutamic Acid; Humans; Hypothalamo-Hypophyseal System; Lamotrigine; Pituitary-Adrenal System; Stress Disorders, Post-Traumatic; Stress, Physiological; Triazines	2008
[Mood stabilizers--past, present and future]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2008, Volume: 10, Issue:1 Topics: Affect; Antimanic Agents; Bipolar Disorder; Calcium; Carbamazepine; Depressive Disorder; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Lamotrigine; Lithium Compounds; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Mood Disorders; Triazines; Valproic Acid	2008
Behavioral and cognitive effects of anti-epileptic drugs. Discovery medicine, 2010, Volume: 9, Issue:45 Topics: Amines; Anticonvulsants; Antidepressive Agents; Behavior; Cognition; Cognition Disorders; Cyclohexanecarboxylic Acids; Epilepsy; Felbamate; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Lamotrigine; Neurotransmitter Agents; Nipecotic Acids; Phenylcarbamates; Propylene Glycols; Tiagabine; Triazines; Vigabatrin	2010
Drug development in schizophrenia: are glutamatergic targets still worth aiming at? Current opinion in psychiatry, 2015, Volume: 28, Issue:3 Topics: Excitatory Amino Acid Agents; Glutamic Acid; Humans; Lamotrigine; Receptors, AMPA; Receptors, Metabotropic Glutamate; Reproducibility of Results; Schizophrenia; Triazines	2015
Understanding Lamotrigine's Role in the CNS and Possible Future Evolution. International journal of molecular sciences, 2023, Mar-23, Volume: 24, Issue:7 Topics: Anticonvulsants; Central Nervous System; Depressive Disorder, Major; Epilepsy; Glutamic Acid; Humans; Ion Channels; Lamotrigine; Triazines	2023

Trials

13 trial(s) available for lamotrigine and glutamic acid

Article	Year
Anti-glutamate therapy in amyotrophic lateral sclerosis: a trial using lamotrigine. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1993, Volume: 20, Issue:4 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Anticonvulsants; Brain; Double-Blind Method; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Lamotrigine; Magnetics; Male; Middle Aged; Physical Stimulation; Triazines	1993
Lamotrigine in the treatment of nocturnal myoclonus syndrome (NMS): two case reports. Journal of neural transmission (Vienna, Austria : 1996), 1996, Volume: 103, Issue:3 Topics: Anticonvulsants; Glutamic Acid; Humans; Lamotrigine; Male; Middle Aged; Myoclonus; Polysomnography; Sleep Wake Disorders; Triazines	1996
Lamotrigine therapy for autistic disorder: a randomized, double-blind, placebo-controlled trial. Journal of autism and developmental disorders, 2001, Volume: 31, Issue:2 Topics: Analysis of Variance; Autistic Disorder; Child; Child Behavior; Child, Preschool; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Lamotrigine; Male; Psychiatric Status Rating Scales; Triazines	2001
A double-blind randomized clinical trial in amyotrophic lateral sclerosis using lamotrigine: effects on CSF glutamate, aspartate, branched-chain amino acid levels and clinical parameters. Acta neurologica Scandinavica, 2003, Volume: 108, Issue:1 Topics: Adult; Aged; Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Aspartic Acid; Cross-Over Studies; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Lamotrigine; Male; Middle Aged; Outcome Assessment, Health Care; Triazines	2003
Add-on lamotrigine treatment and plasma glutamate levels in epilepsy: relation to treatment response. Epilepsy research, 2006, Volume: 70, Issue:2-3 Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Glutamic Acid; Humans; Lamotrigine; Male; Time Factors; Triazines; Valproic Acid	2006
Attenuation of the effects of corticosteroids on declarative memory with lamotrigine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:10 Topics: Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Atrophy; Double-Blind Method; Drug Synergism; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Humans; Lamotrigine; Learning; Magnetic Resonance Imaging; Male; Memory; Memory Disorders; Middle Aged; Neuropsychological Tests; Nootropic Agents; Placebos; Treatment Outcome; Triazines	2008
Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study. Archives of general psychiatry, 2008, Volume: 65, Issue:2 Topics: Adult; Anticonvulsants; Awareness; Brain; Brief Psychiatric Rating Scale; Cross-Over Studies; Dissociative Disorders; Double-Blind Method; Excitatory Amino Acid Antagonists; Frontal Lobe; Glutamic Acid; Gyrus Cinguli; Humans; Image Enhancement; Image Processing, Computer-Assisted; Infusions, Intravenous; Ketamine; Lamotrigine; Magnetic Resonance Imaging; Male; Oxygen; Premedication; Psychoses, Substance-Induced; Receptors, N-Methyl-D-Aspartate; Statistics as Topic; Triazines	2008
Attenuation of amygdala atrophy with lamotrigine in patients receiving corticosteroid therapy. Journal of clinical psychopharmacology, 2009, Volume: 29, Issue:3 Topics: Adult; Affect; Amygdala; Analysis of Variance; Antimanic Agents; Female; Glucocorticoids; Glutamic Acid; Humans; Lamotrigine; Magnetic Resonance Imaging; Male; Middle Aged; Prednisone; Psychiatric Status Rating Scales; Triazines; Young Adult	2009
Effects of lamotrigine on hippocampal activation in corticosteroid-treated patients. Journal of affective disorders, 2010, Volume: 126, Issue:3 Topics: Adult; Anti-Inflammatory Agents; Anticonvulsants; Dominance, Cerebral; Double-Blind Method; Echo-Planar Imaging; Female; Glutamic Acid; Graft Rejection; Hippocampus; Humans; Image Processing, Computer-Assisted; Kidney Transplantation; Lamotrigine; Magnetic Resonance Imaging; Male; Memory, Short-Term; Middle Aged; Oxygen; Pattern Recognition, Visual; Prednisone; Triazines	2010
Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double-blind, randomized, placebo-controlled trial. Bipolar disorders, 2012, Volume: 14, Issue:1 Topics: Adult; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Depression; Dopamine Agents; Double-Blind Method; Drug Therapy, Combination; Female; Glutamic Acid; Humans; Lamotrigine; Male; Memantine; Middle Aged; Pilot Projects; Treatment Outcome; Triazines	2012
Modulatory effects of ketamine, risperidone and lamotrigine on resting brain perfusion in healthy human subjects. Psychopharmacology, 2015, Volume: 232, Issue:21-22 Topics: Adult; Brain; Dopamine Antagonists; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Healthy Volunteers; Humans; Ketamine; Lamotrigine; Male; Receptors, N-Methyl-D-Aspartate; Risperidone; Triazines; Young Adult	2015
A randomized, double-blind, placebo-controlled trial of lamotrigine for prescription corticosteroid effects on the human hippocampus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2019, Volume: 29, Issue:3 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Antipsychotic Agents; Double-Blind Method; Female; Functional Laterality; Glutamic Acid; Hippocampus; Humans; Lamotrigine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memory Disorders; Middle Aged; Young Adult	2019
Modulatory Effects of Ketamine and Lamotrigine on Cognition: Emotion Interaction in the Brain. Neuropsychobiology, 2023, Volume: 82, Issue:2 Topics: Anticonvulsants; Brain; Cognition; Emotions; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Lamotrigine	2023

Other Studies

47 other study(ies) available for lamotrigine and glutamic acid

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Mechanisms of action of new antiepileptic drugs. Epilepsia, 1989, Volume: 30 Suppl 1 Topics: Acetamides; Acetates; Amines; Aminocaproates; Aminopyridines; Anti-Anxiety Agents; Anticonvulsants; Aspartic Acid; Benzodiazepines; Benzodiazepinones; Clobazam; Cyclohexanecarboxylic Acids; Dibenzocycloheptenes; Dizocilpine Maleate; Epilepsy; Felbamate; Flumazenil; GABA Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Imidazoles; Lamotrigine; Phenylcarbamates; Propylene Glycols; Receptors, GABA-A; Triazines; Vigabatrin	1989
Similar potency of carbamazepine, oxcarbazepine, and lamotrigine in inhibiting the release of glutamate and other neurotransmitters. Neurology, 1995, Volume: 45, Issue:10 Topics: Animals; Anticonvulsants; Carbamazepine; Glutamic Acid; Lamotrigine; Male; Oxcarbazepine; Rats; Receptors, Dopamine; Receptors, GABA; Receptors, Glutamate; Triazines; Veratrine	1995
Methamphetamine and dopamine neurotoxicity: differential effects of agents interfering with glutamatergic transmission. Neuroscience letters, 1995, Jul-28, Volume: 195, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Dizocilpine Maleate; Dopamine; Dopamine Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Lamotrigine; Male; Methamphetamine; Mice; Mice, Inbred Strains; Neostriatum; Neurons; Riluzole; Sodium Channels; Synaptic Transmission; Thiazoles; Triazines	1995
Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. Stroke, 1995, Volume: 26, Issue:3 Topics: Animals; Anticonvulsants; Arterial Occlusive Diseases; Behavior, Animal; Brain Chemistry; Brain Ischemia; Carotid Artery Diseases; Cell Death; Cognition; Disease Models, Animal; Gerbillinae; Glutamic Acid; Hippocampus; Lamotrigine; Male; Memory; Nerve Degeneration; Neurons; Neuroprotective Agents; Pyramidal Cells; Reperfusion Injury; Triazines	1995
Lack of effect of lamotrigine against HPNS in rodent and primate models. Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:1 Topics: Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Female; Glutamates; Glutamic Acid; High Pressure Neurological Syndrome; Individuality; Lamotrigine; Male; Myoclonus; Papio; Rats; Rats, Sprague-Dawley; Tremor; Triazines	1994
Lamotrigine--antiparkinsonian activity by blockade of glutamate release? Journal of neural transmission. Parkinson's disease and dementia section, 1993, Volume: 5, Issue:1 Topics: Aged; Anticonvulsants; Antiparkinson Agents; Female; Glutamates; Glutamic Acid; Humans; Lamotrigine; Male; Middle Aged; Parkinson Disease; Triazines	1993
Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation. Journal of neurochemistry, 1996, Volume: 66, Issue:1 Topics: Animals; Base Sequence; Dexamethasone; Dizocilpine Maleate; Enzyme Induction; Glutamic Acid; Kainic Acid; Lamotrigine; Male; Molecular Sequence Data; Nerve Tissue Proteins; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-fos; Rats; Receptors, N-Methyl-D-Aspartate; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Substantia Innominata; Synaptic Transmission; Triazines	1996
Effect of lamotrigine on the electrically-evoked release of endogenous amino acids from slices of dorsal horn of the rat spinal cord. Neuropharmacology, 1995, Volume: 34, Issue:10 Topics: Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dose-Response Relationship, Drug; Evoked Potentials; Glutamic Acid; Lamotrigine; Male; Morphine; Rats; Rats, Wistar; Spinal Cord; Triazines	1995
Effect of riluzole on quinolinate-induced neuronal damage in rats: comparison with blockers of glutamatergic neurotransmission. Neuroscience letters, 1995, Dec-01, Volume: 201, Issue:1 Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Lamotrigine; Male; Neurons; Quinolinic Acid; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Riluzole; Synaptic Transmission; Thiazoles; Triazines	1995
Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histological, in vivo microdialysis and behavioral study. Brain research, 1995, Dec-08, Volume: 702, Issue:1-2 Topics: Animals; Anticonvulsants; Brain Ischemia; Gerbillinae; Glutamic Acid; Hippocampus; Lamotrigine; Male; Microdialysis; Reaction Time; Time Factors; Triazines	1995
Effect of carbamazepine, oxcarbazepine and lamotrigine on the increase in extracellular glutamate elicited by veratridine in rat cortex and striatum. Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 354, Issue:2 Topics: Animals; Anticonvulsants; Aspartic Acid; Carbamazepine; Cerebral Cortex; Corpus Striatum; Glutamic Acid; Lamotrigine; Male; Microdialysis; Oxcarbazepine; Rats; Triazines; Veratridine	1996
Lamotrigine inhibits extracellular glutamate accumulation during transient global cerebral ischemia in rabbits. Anesthesiology, 1997, Volume: 86, Issue:2 Topics: Animals; Glutamic Acid; Ischemic Attack, Transient; Lamotrigine; Rabbits; Sodium Channel Blockers; Triazines	1997
NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis. British journal of pharmacology, 1997, Volume: 121, Issue:6 Topics: Animals; Anticonvulsants; Atropine; Convulsants; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Lamotrigine; Male; Microdialysis; Pilocarpine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Triazines	1997
Prodystonic effects of riluzole in an animal model of idiopathic dystonia related to decreased total power in the red nucleus? European journal of pharmacology, 1997, Aug-06, Volume: 332, Issue:2 Topics: Animals; Antiparkinson Agents; Calcium Channel Blockers; Cricetinae; Disease Models, Animal; Dystonia; Electroencephalography; Excitatory Amino Acid Antagonists; Glutamic Acid; Lamotrigine; Neuroprotective Agents; Riluzole; Triazines	1997
Discriminative stimulus effects of glutamate release inhibitors in rats trained to discriminate ethanol. Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:3 Topics: Animals; Calcium Channel Blockers; Central Nervous System Depressants; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Glutamic Acid; Lamotrigine; Male; Rats; Rats, Wistar; Riluzole; Triazines	1998
Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV). Brain research, 1998, Sep-14, Volume: 805, Issue:1-2 Topics: Amygdala; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cyclopropanes; Glutamic Acid; Glycine; Kindling, Neurologic; Lamotrigine; Male; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Seizures; Synaptosomes; Triazines	1998
[Effect of anticonvulsants lamotrigine and carbamazepine on the synaptic transmission in CA1 field of the rat hippocampal slices]. Biulleten' eksperimental'noi biologii i meditsiny, 1998, Volume: 126, Issue:9 Topics: Action Potentials; Animals; Anticonvulsants; Axons; Carbamazepine; Glutamic Acid; Hippocampus; In Vitro Techniques; Lamotrigine; Male; Pyramidal Cells; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Triazines	1998
Lamotrigine attenuates cortical glutamate release during global cerebral ischemia in pigs on cardiopulmonary bypass. Anesthesiology, 1999, Volume: 90, Issue:3 Topics: Analgesics; Animals; Brain Ischemia; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Glutamic Acid; Lamotrigine; Oxygen; Swine; Triazines	1999
An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons. British journal of pharmacology, 1999, Volume: 126, Issue:3 Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Cerebral Cortex; Corpus Striatum; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Lamotrigine; Male; Membrane Potentials; Neurons; Phenytoin; Rats; Rats, Wistar; Triazines	1999
Analysis of CSF amino acids in young patients with generalised refractory epilepsy during an add-on study with lamotrigine. Epilepsy research, 1999, Volume: 34, Issue:1 Topics: Adolescent; Adult; Amino Acids; Anticonvulsants; Aspartic Acid; Child; Child, Preschool; Drug Resistance; Drug Therapy, Combination; Epilepsy, Generalized; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; Lamotrigine; Male; Treatment Outcome; Triazines	1999
Evidence that DHPG-induced nociception depends on glutamate release from primary afferent C-fibres. Neuroreport, 2000, Jun-05, Volume: 11, Issue:8 Topics: 4-Aminopyridine; Animals; Behavior, Animal; Capsaicin; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Lamotrigine; Male; Methoxyhydroxyphenylglycol; Nerve Fibers; Neurons, Afferent; Nociceptors; Proline; Propionates; Rats; Rats, Long-Evans; Riluzole; Triazines	2000
The anticonvulsant, lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vitro. Neuropharmacology, 2000, Aug-23, Volume: 39, Issue:11 Topics: Animals; Anticonvulsants; Entorhinal Cortex; gamma-Aminobutyric Acid; Glutamic Acid; Lamotrigine; Male; Rats; Rats, Wistar; Synaptic Transmission; Triazines	2000
Chronic lamotrigine treatment increases rat hippocampal GABA shunt activity and elevates cerebral taurine levels. Epilepsy research, 2001, Volume: 43, Issue:2 Topics: Amino Acids; Animals; Anticonvulsants; Body Weight; Brain; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Lamotrigine; Male; Nerve Tissue Proteins; Organ Size; Proteolipids; Rats; Rats, Wistar; Taurine; Time Factors; Triazines	2001
The combination of lamotrigine and mild hypothermia prevents ischemia-induced increase in hippocampal glutamate. Journal of neurosurgical anesthesiology, 2001, Volume: 13, Issue:2 Topics: Animals; Blood Gas Analysis; Body Temperature; Brain Ischemia; Extracellular Space; Female; Glutamic Acid; Hippocampus; Hypothermia, Induced; Lamotrigine; Male; Microdialysis; Rabbits; Triazines	2001
Inhibition of voltage-dependent sodium channels suppresses the functional magnetic resonance imaging response to forepaw somatosensory activation in the rodent. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2001, Volume: 21, Issue:5 Topics: Animals; Anticonvulsants; Blood Pressure; Brain; Electric Stimulation; Forelimb; Glutamic Acid; Kinetics; Lamotrigine; Magnetic Resonance Imaging; Male; Oxygen; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Somatosensory Cortex; Triazines	2001
Lamotrigine inhibition of glutamate release from isolated cerebrocortical nerve terminals (synaptosomes) by suppression of voltage-activated calcium channel activity. Neuroreport, 2001, Jul-20, Volume: 12, Issue:10 Topics: 4-Aminopyridine; Animals; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glutamic Acid; Lamotrigine; Male; Membrane Potentials; Rats; Rats, Sprague-Dawley; Synaptosomes; Triazines	2001
Is NMDA receptor hypofunction in schizophrenia associated with a primary hyperglutamatergic state? Archives of general psychiatry, 2002, Volume: 59, Issue:5 Topics: Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Ketamine; Lamotrigine; Models, Biological; Neurons; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission; Triazines	2002
Disruption of prepulse inhibition in mice lacking mGluR1. The European journal of neuroscience, 2003, Volume: 18, Issue:12 Topics: Acoustic Stimulation; Animals; Antimanic Agents; Brain; Disease Models, Animal; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Lamotrigine; Male; Mice; Mice, Knockout; Neural Inhibition; Receptors, Metabotropic Glutamate; Reflex, Startle; Schizophrenia; Synaptic Transmission; Triazines	2003
Effects of acute and chronic lamotrigine treatment on basal and stimulated extracellular amino acids in the hippocampus of freely moving rats. Brain research, 2004, Dec-10, Volume: 1029, Issue:1 Topics: Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain Chemistry; Dose-Response Relationship, Drug; Drug Administration Schedule; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Lamotrigine; Male; Microdialysis; Potassium Chloride; Rats; Rats, Wistar; Taurine; Triazines; Veratridine	2004
Evaluation of clinically relevant glutamate pathway inhibitors in in vitro model of Huntington's disease. Neuroscience letters, 2006, Oct-30, Volume: 407, Issue:3 Topics: Amines; Animals; Apoptosis; Cells, Cultured; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Folic Acid; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Huntington Disease; Lamotrigine; Male; Memantine; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; Riluzole; Triazines	2006
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. Journal of neurochemistry, 2007, Volume: 100, Issue:5 Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Lamotrigine; Male; Microdialysis; Pain; Pain Measurement; Peripheral Nervous System Diseases; Rats; Rats, Long-Evans; Riluzole; Spinal Cord; Touch; Triazines	2007
Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:12 Topics: Adult; Analysis of Variance; Antidepressive Agents; Bipolar Disorder; Creatine; Evaluation Studies as Topic; Female; Glutamic Acid; Gyrus Cinguli; Humans; Lamotrigine; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Protons; Triazines	2007
(+/-) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics. Journal of psychopharmacology (Oxford, England), 2007, Volume: 21, Issue:3 Topics: Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Ketamine; Lamotrigine; Male; Pyridines; Rats; Rats, Sprague-Dawley; Reflex, Startle; Risperidone; Schizophrenia; Sulfonamides; Thiophenes; Triazines	2007
Lamotrigine inhibits TRESK regulated by G-protein coupled receptor agonists. Biochemical and biophysical research communications, 2008, Mar-14, Volume: 367, Issue:3 Topics: Analgesics; Animals; Animals, Newborn; Cells, Cultured; Chlorocebus aethiops; COS Cells; Dose-Response Relationship, Drug; Fluoxetine; Ganglia, Spinal; Glutamic Acid; Lamotrigine; Mice; Neurons; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Triazines	2008
Ultrastructure protection and attenuation of lipid peroxidation after blockade of presynaptic release of glutamate by lamotrigine in experimental spinal cord injury. Neurosurgical focus, 2008, Volume: 25, Issue:5 Topics: Animals; Calcium Channel Blockers; Disease Models, Animal; Female; Glutamic Acid; Glutathione Peroxidase; Laminectomy; Lamotrigine; Lipid Peroxidation; Malondialdehyde; Microscopy, Electron, Transmission; Presynaptic Terminals; Random Allocation; Rats; Rats, Wistar; Spinal Cord; Spinal Cord Injuries; Superoxide Dismutase; Triazines	2008
Lamotrigine blocks apoptosis induced by repeated administration of high-dose methamphetamine in the medial prefrontal cortex of rats. Neuroscience letters, 2011, Mar-03, Volume: 490, Issue:3 Topics: Analysis of Variance; Animals; Anticonvulsants; Apoptosis; Central Nervous System Stimulants; Drug Administration Schedule; Drug Interactions; Glutamic Acid; In Situ Nick-End Labeling; Lamotrigine; Male; Methamphetamine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Triazines	2011
Vinpocetine inhibits glutamate release induced by the convulsive agent 4-aminopyridine more potently than several antiepileptic drugs. Epilepsy research, 2011, Volume: 96, Issue:3 Topics: 4-Aminopyridine; Animals; Anticonvulsants; Calcium; Carbamazepine; Drug Interactions; Epilepsy; Fructose; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Lamotrigine; Male; Nerve Endings; Oxcarbazepine; Phenytoin; Potassium Channel Blockers; Rats; Rats, Wistar; Sodium; Sodium Channel Blockers; Tetrodotoxin; Topiramate; Triazines; Tritium; Vinca Alkaloids	2011
Neuroprotective effects of the mood stabilizer lamotrigine against glutamate excitotoxicity: roles of chromatin remodelling and Bcl-2 induction. The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:3 Topics: Affect; Animals; Antimanic Agents; Cell Survival; Cells, Cultured; Cerebellum; Chromatin Assembly and Disassembly; Glutamic Acid; Lamotrigine; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Triazines	2013
Comparison and effects of acute lamotrigine treatment on extracellular excitatory amino acids in the hippocampus of PTZ-kindled epileptic and PTZ-induced status epilepticus rats. Neurochemical research, 2013, Volume: 38, Issue:3 Topics: Animals; Aspartic Acid; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kindling, Neurologic; Lamotrigine; Male; Neurotransmitter Agents; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Status Epilepticus; Triazines	2013
Activation of the prelimbic medial prefrontal cortex induces anxiety-like behaviors via N-Methyl-D-aspartate receptor-mediated glutamatergic neurotransmission in mice. Journal of neuroscience research, 2014, Volume: 92, Issue:8 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anxiety; Behavior, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Lamotrigine; Male; Mice; Mice, Inbred C57BL; Microdialysis; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Synaptic Transmission; Triazines; Veratrine	2014
Lamotrigine reverses masseter overactivity caused by stress maybe via Glu suppression. Physiology & behavior, 2014, Volume: 137 Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Dose-Response Relationship, Drug; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Lamotrigine; Male; Masseter Muscle; Muscle Tonus; Neuromuscular Agents; Random Allocation; Rats, Sprague-Dawley; Restraint, Physical; Stress, Psychological; Triazines; Trigeminal Motor Nucleus	2014
Reversal of novelty-induced hippocampal c-Fos expression in GluA1 subunit-deficient mice by chronic treatment targeting glutamatergic transmission. European journal of pharmacology, 2014, Dec-15, Volume: 745 Topics: Animals; CA3 Region, Hippocampal; Exploratory Behavior; Female; Fructose; Glutamic Acid; Hippocampus; Lamotrigine; Lithium Compounds; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neuroprotective Agents; Nitriles; Proto-Oncogene Proteins c-fos; Pyridones; Receptors, AMPA; Synaptic Transmission; Topiramate; Triazines; Valproic Acid	2014
Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia. The international journal of neuropsychopharmacology, 2016, Volume: 19, Issue:11 Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; GABAergic Neurons; Gene Expression Profiling; Gene Expression Regulation; Genetic Predisposition to Disease; Glutamic Acid; Hippocampus; Lamotrigine; Locomotion; Male; Oligonucleotide Array Sequence Analysis; Phencyclidine; Phenotype; Prepulse Inhibition; Rats, Inbred Strains; Recognition, Psychology; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Social Isolation; Sodium Channel Blockers; Synaptic Transmission; Time Factors; Triazines; Weaning	2016
Anticonvulsants lamotrigine and riluzole disrupt maternal behavior in postpartum female rats. Pharmacology, biochemistry, and behavior, 2018, Volume: 168 Topics: Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Female; Glutamic Acid; Lamotrigine; Maternal Behavior; Postpartum Period; Rats, Sprague-Dawley; Riluzole	2018
Changes in brain Glx in depressed bipolar patients treated with lamotrigine: A proton MRS study. Journal of affective disorders, 2019, 03-01, Volume: 246 Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Brain; Female; Glutamic Acid; Humans; Lamotrigine; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Treatment Outcome; Young Adult	2019
Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2019, Volume: 27, Issue:8 Topics: Aged; Aging; Antipsychotic Agents; Aspartic Acid; Biomarkers; Bipolar Disorder; Cerebral Cortex; Creatine; Depression; Energy Metabolism; Female; Follow-Up Studies; Glutamic Acid; Glutamine; Humans; Lamotrigine; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Severity of Illness Index; Treatment Outcome	2019