lamotrigine has been researched along with clozapine in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.04) | 18.2507 |
| 2000's | 27 (55.10) | 29.6817 |
| 2010's | 21 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Boysen, G; Dhakal, IB; Edavana, VK; Kadlubar, S; Penney, R; Williams, S; Yao-Borengasser, A | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Dursun, SM; McIntosh, D; Milliken, H | 1 |
| Calabrese, JR; Gajwani, P | 1 |
| Nemeroff, CB | 1 |
| Devarajan, S; Dursun, SM | 1 |
| Kahn, RS; Kossen, M; Selten, JP | 1 |
| Deakin, JF; Dursun, SM | 1 |
| Benadhira, R; Degrassat, K; Dumortier, G; Glikman, J; Januel, D; Kalalou, K; Saba, G | 1 |
| Freeman, MP; Gelenberg, AJ; Gnanadesikan, M | 1 |
| Eronen, M; Hallikainen, T; Kotilainen, I; Putkonen, A; Repo-Tiihonen, E; Ryynänen, OP; Tiihonen, J; Toivonen, P; Wahlbeck, K | 1 |
| Idris, NF; Large, CH; Neill, JC; Repeto, P | 1 |
| Beyazyürek, M; Kalyoncu, A; Mirsal, H; Pektas, O; Tan, D; Unsalan, N | 1 |
| Chan, YC; Hankins, MB; Miller, KM; Shaheen, N; Votolato, NA | 1 |
| de Groot, IW; Heck, AH; van Harten, PN | 1 |
| Dursun, SM; Robertson, H; Williams, HJ; Zamzow, CR | 1 |
| D'Amico, G; D'Arrigo, C; Micò, U; Migliardi, G; Muscatello, MR; Perucca, E; Santoro, V; Spina, E | 1 |
| Bruno, A; Cambria, R; Meduri, M; Micò, U; Muscatello, MR; Spina, E; Zoccali, R | 1 |
| Bajbouj, M; Danker-Hopfe, H; Gallinat, J; Hellen, F; Lang, UE; Lisanby, SH; Neu, P; Vesper, J | 1 |
| Cilia, J; Hatcher, P; Jones, DN; Reavill, C | 1 |
| Citrome, L; Davy, K; Goff, DC; Keefe, R; Krystal, JH; Large, C; Thompson, TR; Volavka, J; Webster, EL | 1 |
| Pavlovic, ZM | 1 |
| Kiviniemi, V; Tiihonen, J; Wahlbeck, K | 1 |
| Egger, C; Grohmann, R; Muehlbacher, M; Stuppaeck, C | 1 |
| Bastiampillai, TJ; Dhillon, R; Reid, CE | 1 |
| Grosić, V; Mihanović, M; Presecki, P; Silić, A | 1 |
| Gala, G; Kahn, DA; Muzyk, A | 1 |
| Begemann, MJ; Leucht, S; Sommer, IE; Temmerman, A | 1 |
| Damkier, P; Lublin, H; Nielsen, J; Taylor, D | 1 |
| Margolese, HC; Tourian, L | 1 |
| Anıl Yağcıoğlu, AE; Gürel, SC; Karahan, S; Karcı, O; Vayısoğlu, S; Yağcıoğlu, S; Yazıcı, MK | 1 |
| Jalenques, I; Kernisant, M; Legrand, G; May, R; Richard, B | 1 |
| Smith, JM; Szmulewicz, AG; Valerio, MP | 1 |
| Cubała, WJ; Krysta, K; Landowski, J; Urban, AE; Wiglusz, MS | 1 |
| Aebischer, B; Akboga, MK; Akdamar, G; Alcalay, RN; Álvarez-Pérez, S; Aydogdu, S; Balci, KG; Barcaro, G; Bišová, K; Blanco, JL; Brewer, SH; Caruthers, SD; Ceylan, O; Chadwick, JA; Chang, DD; Che, JM; Chen, QQ; Chen, W; Chen, Z; Chung, M; Chung, W; Colecraft, HM; Coteli, E; Dogan, H; Dong, S; Elsig, S; Fahn, S; Fang, XJ; Feng, MG; Fenlon, EE; Floyd, KT; Fokdal, L; Ford, B; Fortunelli, A; Freudenberg, R; Gan-Or, Z; García, ME; Gillham, C; Giovannelli, D; Goertz, RS; Gulati, V; Haie-Meder, C; Hao, YY; Hatano, K; Hines, KJ; Hines, SM; Hirakawa, H; Hoskin, P; Hu, JH; Huang, P; Huang, Y; Hubicka, U; Inoue, Y; Ishii, N; Janssen, PM; Jin, Z; Johnson, A; Jürgenliemk-Schultz, I; Kaineder, K; Kamei, K; Kang, U; Karatas, F; Kash, TL; Katayama, Y; Keupp, J; Kirisits, C; Kisacik, H; Kodama, K; Kotzerke, J; Kryczyk, A; Kuhness, D; Kuo, S; Lanza, GM; Le Bris, N; Levin, DE; Levy, OA; Li, B; Li, H; Li, X; Liang, GD; Liang, Y; Liao, RQ; Lin, JT; Lindegaard, JC; Liong, C; Liu, B; Liu, C; Liu, GH; Liu, L; Liu, Q; Liu, X; Lowe, J; Lowery-Gionta, EG; Ma, YH; Maden, O; Mankad, V; Marder, KS; Marshall, SA; Martínez-Nevado, E; Maucksch, U; Mazeron, R; Mazzone, CM; Mazzoni, P; Mezricky, D; Mizokami, Y; Naumann, A; Navarro, M; Netzer, FP; Neurath, MF; Nie, Q; Oliva, P; Ozeke, O; Peláez, T; Pfeifer, L; Pleil, KE; Pomp, S; Pötter, R; Puckerin, AA; Rafael-Fortney, JA; Raman, SV; Rastogi, N; Řezanka, M; Řezanka, T; Rinker, JA; Rouleau, GA; Runge, R; Sahin, MD; Sakai, A; Schmieder, AH; Schmitz, AJ; Schultz, EJ; Šegedin, B; Sementa, L; Shen, Y; Shiotsuki, I; Shirahama, M; Staley, J; Starovoytov, V; Sterrer, M; Strobel, D; Sturdza, A; Subramanyam, P; Surnev, S; Swager, SA; Taeymans, J; Tan, H; Tan, LT; Tanderup, K; Temizhan, A; Terao, T; Thiele, TE; Tran, T; Tucker, MJ; Vetriani, C; Vítová, M; Wang, JP; Wang, L; Wang, M; Wang, X; Waters, CH; Weng, SX; Wickline, SA; Wildner, D; Wodarcyk, AJ; Wolf, P; Wu, L; Wu, YL; Wunderlich, G; Xiong, L; Xu, P; Yang, GS; Yang, XN; Yang, Y; Yayla, C; Ying, SH; Zachleder, V; Zhang, XG; Zhang, XK; Zhang, Y; Zheng, JY; Zhong, WZ; Zhu, J; Zhu, YJ; Żmudzki, P | 1 |
| Lin, JW; Tsai, LH | 1 |
8 review(s) available for lamotrigine and clozapine
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
An ever-increasing pharmacopoeia for the management of patients with bipolar disorder.
Topics: Acetates; Amines; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Carbamazepine; Clozapine; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Electroconvulsive Therapy; Electromagnetic Phenomena; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Lithium; Olanzapine; Pirenzepine; Risperidone; Topiramate; Treatment Outcome; Triazines; Valproic Acid | 2000 |
Alternatives to lithium and divalproex in the maintenance treatment of bipolar disorder.
Topics: Acetates; Amines; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Calcium Channel Blockers; Carbamazepine; Clozapine; Cyclohexanecarboxylic Acids; Dibenzothiazepines; Donepezil; Fatty Acids, Omega-3; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Indans; Lamotrigine; Lithium Carbonate; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quetiapine Fumarate; Risperidone; Thiazoles; Topiramate; Treatment Outcome; Triazines; Valproic Acid | 2003 |
The efficacy of lamotrigine in clozapine-resistant schizophrenia: a systematic review and meta-analysis.
Topics: Age Factors; Anticonvulsants; Antipsychotic Agents; Clozapine; Cognition Disorders; Drug Resistance; Drug Therapy, Combination; Humans; Lamotrigine; Outcome Assessment, Health Care; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; Triazines | 2009 |
Pharmacological augmentation strategies for schizophrenia patients with insufficient response to clozapine: a quantitative literature review.
Topics: Antipsychotic Agents; Brief Psychiatric Rating Scale; Citalopram; Clozapine; Dioxoles; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Fructose; Humans; Lamotrigine; Piperidines; Psychiatric Status Rating Scales; Psychotropic Drugs; Randomized Controlled Trials as Topic; Schizophrenia; Schizophrenic Psychology; Sulpiride; Topiramate; Treatment Outcome; Triazines | 2012 |
Optimizing clozapine treatment.
Topics: Antipsychotic Agents; Calcium Channel Blockers; Central Nervous System Diseases; Clozapine; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Electroconvulsive Therapy; Heart Diseases; Humans; Lamotrigine; Schizophrenia; Treatment Outcome; Triazines | 2011 |
Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; Animals; Animals, Zoo; Anti-Bacterial Agents; Anticoagulants; Antifungal Agents; Antimanic Agents; Antioxidants; Aortic Valve; Area Under Curve; ATP Binding Cassette Transporter, Subfamily G, Member 2; Bacillus; Bacterial Toxins; Bacterial Typing Techniques; Base Composition; Beauveria; Binge Drinking; Biomarkers; Bipolar Disorder; Blood Coagulation; Blotting, Western; Brachytherapy; Calcium Channels, L-Type; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Wall; Cells, Cultured; Ceramics; Chi-Square Distribution; China; Chlorophyll; Chlorophyta; Chloroplasts; Cholesterol, HDL; Chromatography, High Pressure Liquid; Chromobacterium; Clostridium perfringens; Clozapine; Constriction, Pathologic; Coronary Artery Bypass; Corticotropin-Releasing Hormone; Cross-Sectional Studies; Cytochrome P-450 CYP2C9; Dental Porcelain; Dental Restoration Failure; Dental Stress Analysis; Designer Drugs; Diaminopimelic Acid; DNA Fingerprinting; DNA, Bacterial; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Dosage Calculations; Drug Evaluation, Preclinical; Drug Resistance, Bacterial; Elasticity Imaging Techniques; Epsilonproteobacteria; Equipment Design; Ericaceae; Excitatory Amino Acid Antagonists; False Negative Reactions; Fatty Acids; Female; Food Analysis; Fresh Water; Gene Expression Regulation, Neoplastic; Glutathione; Graft Occlusion, Vascular; Heart Valve Prosthesis Implantation; Heart Ventricles; HEK293 Cells; Hemolymph; Humans; Hyaluronan Receptors; Hydrogen Peroxide; Hydrothermal Vents; Indoles; Inflammation Mediators; Inhibitory Concentration 50; Insecta; International Normalized Ratio; Isotope Labeling; Itraconazole; Kidney; Kinetics; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lamotrigine; Lanthanoid Series Elements; Limit of Detection; Linear Models; Lipid Peroxidation; Liver; Liver Cirrhosis; Logistic Models; Lung Neoplasms; Lymph Node Excision; Lymphatic Metastasis; Male; Malondialdehyde; Mediastinum; Metronidazole; Mice; Mice, Nude; Mice, Transgenic; Microbial Sensitivity Tests; Microscopy, Fluorescence; Middle Aged; Monocytes; Monomeric GTP-Binding Proteins; Multivariate Analysis; Myocytes, Cardiac; Neoplasm Staging; Neoplastic Stem Cells; Neural Pathways; Nitrates; Nucleic Acid Hybridization; Octamer Transcription Factor-3; Odds Ratio; Oxidation-Reduction; Oxidative Stress; Peptidoglycan; Phantoms, Imaging; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Phospholipids; Photolysis; Photosynthesis; Phylogeny; Plant Extracts; Polychaeta; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Positron Emission Tomography Computed Tomography; Predictive Value of Tests; Preoperative Care; Prostatic Neoplasms; Pseudomonas aeruginosa; Pyrimidines; Pyrroles; Quorum Sensing; Radiology, Interventional; Radiopharmaceuticals; Radiotherapy Dosage; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Reference Values; Regression Analysis; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Rhizosphere; Risk Factors; RNA, Ribosomal, 16S; ROC Curve; Rutin; Saphenous Vein; Seawater; Selenium; Semen Preservation; Sensitivity and Specificity; Septal Nuclei; Sequence Analysis, DNA; Serum Albumin; Serum Albumin, Human; Shear Strength; Sodium Pertechnetate Tc 99m; Sodium-Hydrogen Exchangers; Soil Microbiology; SOXB1 Transcription Factors; Spain; Species Specificity; Sperm Motility; Spermatozoa; Spheroids, Cellular; Spores, Fungal; Stroke; Superoxide Dismutase; Swine; Tandem Mass Spectrometry; Technetium Compounds; Technetium Tc 99m Exametazime; Technetium Tc 99m Sestamibi; Temperature; Thiosulfates; Thrombosis; Thyroid Neoplasms; Transducers; Transfection; Transplantation, Heterologous; Treatment Outcome; Triazines; Tumor Burden; Urocortins; Uterine Cervical Neoplasms; Vacuoles; Valproic Acid; Ventral Tegmental Area; Vitamin K 2; Vitamin K Epoxide Reductases; Warfarin; Water Microbiology; Young Adult | 2016 |
9 trial(s) available for lamotrigine and clozapine
| Article | Year |
|---|---|
Clozapine plus lamotrigine in treatment-resistant schizophrenia.
Topics: Adult; Ambulatory Care; Anticonvulsants; Antipsychotic Agents; Clozapine; Female; Humans; Lamotrigine; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; Triazines | 1999 |
Augmenting antipsychotic treatment with lamotrigine or topiramate in patients with treatment-resistant schizophrenia: a naturalistic case-series outcome study.
Topics: Adult; Antipsychotic Agents; Clozapine; Drug Resistance; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Female; Fructose; Humans; Lamotrigine; Male; Middle Aged; Neuroprotective Agents; Psychiatric Status Rating Scales; Schizophrenia; Topiramate; Treatment Outcome; Triazines | 2001 |
[Lamotrigine in clozapine treatment-resistant schizophrenia].
Topics: Antipsychotic Agents; Clozapine; Drug Resistance; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lamotrigine; Male; Risk Assessment; Schizophrenia; Severity of Illness Index; Treatment Outcome; Triazines | 2004 |
Addition of lamotrigine to clozapine in inpatients with chronic psychosis.
Topics: Anticonvulsants; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Humans; Lamotrigine; Middle Aged; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; Triazines | 2005 |
Effect of adjunctive lamotrigine treatment on the plasma concentrations of clozapine, risperidone and olanzapine in patients with schizophrenia or bipolar disorder.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Clozapine; Drug Interactions; Female; Humans; Lamotrigine; Male; Middle Aged; Olanzapine; Risperidone; Schizophrenia; Triazines | 2006 |
The effect of lamotrigine augmentation of clozapine in a sample of treatment-resistant schizophrenic patients: a double-blind, placebo-controlled study.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Attention; Brief Psychiatric Rating Scale; Clozapine; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Humans; Lamotrigine; Male; Middle Aged; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; Triazines | 2007 |
Motor cortex excitability after vagus nerve stimulation in major depression.
Topics: Adult; Benzodiazepines; Citalopram; Clomipramine; Clozapine; Depressive Disorder; Doxepin; Drug Therapy, Combination; Electric Stimulation; Female; Humans; Lamotrigine; Lithium Carbonate; Male; Mianserin; Middle Aged; Mirtazapine; Morpholines; Motor Cortex; Neural Conduction; Neural Inhibition; Olanzapine; Paroxetine; Psychiatric Status Rating Scales; Reboxetine; Tranylcypromine; Triazines; Vagus Nerve; Valproic Acid | 2007 |
Lamotrigine as add-on therapy in schizophrenia: results of 2 placebo-controlled trials.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Clozapine; Diagnostic and Statistical Manual of Mental Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Female; Humans; Lamotrigine; Male; Middle Aged; Patient Compliance; Patient Dropouts; Psychiatric Status Rating Scales; Schizophrenia; Severity of Illness Index; Suicide, Attempted; Treatment Outcome; Triazines | 2007 |
Lamotrigine augmentation in patients with schizophrenia who show partial response to clozapine treatment.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Antipsychotic Agents; Calcium Channel Blockers; Chi-Square Distribution; Clozapine; Cognition Disorders; Double-Blind Method; Drug Synergism; Electroencephalography; Evoked Potentials, Auditory; Female; Humans; Lamotrigine; Male; Middle Aged; Neuropsychological Tests; Prospective Studies; Psychiatric Status Rating Scales; Schizophrenia; Severity of Illness Index; Triazines; Young Adult | 2013 |
32 other study(ies) available for lamotrigine and clozapine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery.
Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats | 2007 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics.
Topics: Anastrozole; Anticonvulsants; Aromatase Inhibitors; Gene Expression Regulation, Enzymologic; Genotype; Glucuronosyltransferase; Humans; In Vitro Techniques; Inactivation, Metabolic; Lamotrigine; Microsomes, Liver; Nitriles; Polymorphism, Single Nucleotide; Sapogenins; Triazines; Triazoles | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Lamotrigine and clozapine for bipolar disorder.
Topics: Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Clozapine; Drug Therapy, Combination; Humans; Lamotrigine; Male; Middle Aged; Treatment Outcome; Triazines; Valproic Acid | 2000 |
When treating patients with schizophrenia, what clinical points should be considered if lamotrigine is chosen to augment clozapine?
Topics: Antipsychotic Agents; Clozapine; Drug Administration Schedule; Drug Therapy, Combination; Humans; Lamotrigine; Practice Guidelines as Topic; Schizophrenia; Triazines | 2001 |
Elevated clozapine plasma level with lamotrigine.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Humans; Lamotrigine; Male; Schizophrenia; Triazines | 2001 |
Lamotrigine--clozapine combination in refractory schizophrenia: three cases.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Clozapine; Drug Resistance; Drug Therapy, Combination; Female; Humans; Lamotrigine; Male; Schizophrenia; Triazines | 2002 |
Investigation of the effects of lamotrigine and clozapine in improving reversal-learning impairments induced by acute phencyclidine and D-amphetamine in the rat.
Topics: Animals; Antimanic Agents; Antipsychotic Agents; Central Nervous System Stimulants; Clozapine; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Female; Hallucinogens; Haloperidol; Lamotrigine; Learning Disabilities; Phencyclidine; Rats; Reversal Learning; Triazines | 2005 |
Use of lamotrigine to augment clozapine in patients with resistant schizophrenia and comorbid alcohol dependence: a potent anti-craving effect?
Topics: Adult; Alcoholism; Antimanic Agents; Antipsychotic Agents; Clozapine; Diagnosis, Dual (Psychiatry); Drug Resistance; Drug Therapy, Combination; Humans; Lamotrigine; Male; Schizophrenia; Schizophrenic Psychology; Triazines | 2005 |
Worsening of psychotic symptoms in schizophrenia with addition of lamotrigine: a case report.
Topics: Adult; Antipsychotic Agents; Brain; Clozapine; Drug Therapy, Combination; Female; Humans; Lamotrigine; Lithium Carbonate; Magnetic Resonance Imaging; Psychotic Disorders; Schizophrenia; Severity of Illness Index; Triazines; Valproic Acid | 2005 |
Effects of clozapine plus lamotrigine on phencyclidine-induced hyperactivity.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Clozapine; Disease Models, Animal; Drug Interactions; Hyperkinesis; Lamotrigine; Male; Motor Activity; Phencyclidine; Rats; Rats, Sprague-Dawley; Time Factors; Triazines | 2006 |
(+/-) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics.
Topics: Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Ketamine; Lamotrigine; Male; Pyridines; Rats; Rats, Sprague-Dawley; Reflex, Startle; Risperidone; Schizophrenia; Sulfonamides; Thiophenes; Triazines | 2007 |
Augmentation of clozapine's antiagressive properties with lamotrigine in a patient with chronic disorganized schizophrenia.
Topics: Adult; Aggression; Anticonvulsants; Antipsychotic Agents; Chronic Disease; Clozapine; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Humans; Lamotrigine; Male; Schizophrenia, Disorganized; Triazines | 2008 |
Clozapine intoxication in a patient with lamotrigine-induced rash.
Topics: Analgesics; Antipsychotic Agents; Bipolar Disorder; Clozapine; Exanthema; Humans; Lamotrigine; Male; Triazines; Young Adult | 2010 |
The long-term effectiveness of clozapine and lamotrigine in a patient with treatment-resistant rapid-cycling bipolar disorder.
Topics: Antipsychotic Agents; Bipolar Disorder; Calcium Channel Blockers; Clozapine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lamotrigine; Middle Aged; Severity of Illness Index; Time Factors; Treatment Outcome; Triazines | 2010 |
Infection or idiosyncratic reaction to antiepileptic drugs?
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Clozapine; Diagnosis, Differential; Drug Therapy, Combination; Humans; Lamotrigine; Male; Pericarditis; Respiratory Insufficiency; Systemic Inflammatory Response Syndrome; Triazines; Valproic Acid | 2010 |
Use of lamotrigine in a patient with a clozapine-related seizure.
Topics: Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Humans; Lamotrigine; Lithium Carbonate; Male; Psychotic Disorders; Triazines; Young Adult | 2010 |
Late-onset agranulocytosis in a patient treated with clozapine and lamotrigine.
Topics: Adult; Agranulocytosis; Anticonvulsants; Antipsychotic Agents; Clozapine; Female; Humans; Lamotrigine; Schizophrenia, Paranoid; Time Factors; Triazines | 2011 |
A case report of partial bowel obstruction after aripiprazole addition to clozapine in a young male with schizophrenia.
Topics: Adult; Antipsychotic Agents; Aripiprazole; Clozapine; Defecation; Drug Substitution; Drug Therapy, Combination; Humans; Intestinal Obstruction; Lamotrigine; Male; Piperazines; Quinolones; Risk Factors; Schizophrenia; Treatment Outcome; Triazines | 2013 |
Obsessive-compulsive symptoms in adjunctive therapy with lamotrigine in clozapine-medicated patients.
Topics: Adult; Antipsychotic Agents; Clozapine; Cross-Sectional Studies; Drug Therapy, Combination; Female; Humans; Lamotrigine; Male; Obsessive-Compulsive Disorder; Prevalence; Psychiatric Status Rating Scales; Psychotic Disorders; Risk; Schizophrenia; Triazines | 2015 |
Rapid-onset agranulocytosis in a patient treated with clozapine and lamotrigine.
Topics: Agranulocytosis; Clozapine; Drug Therapy, Combination; Female; Humans; Lamotrigine; Leukocyte Count; Middle Aged; Neutrophils; Schizophrenia, Paranoid; Time Factors; Triazines | 2015 |
Use of clozapine for resolving lamotrigine-induced skin lesions caused by schizophrenia treatment.
Topics: Adult; Antipsychotic Agents; Clozapine; Exanthema; Female; Humans; Lamotrigine; Schizophrenia | 2019 |