lamotrigine 2-n-glucuronide has been researched along with lamotrigine in 8 studies
| Studies (lamotrigine 2-n-glucuronide) | Trials (lamotrigine 2-n-glucuronide) | Recent Studies (post-2010) (lamotrigine 2-n-glucuronide) | Studies (lamotrigine) | Trials (lamotrigine) | Recent Studies (post-2010) (lamotrigine) |
|---|---|---|---|---|---|
| 8 | 1 | 4 | 3,550 | 501 | 1,351 |
| Protein | Taxonomy | lamotrigine 2-n-glucuronide (IC50) | lamotrigine (IC50) |
|---|---|---|---|
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | 10 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Remmel, RP; Sinz, MW | 1 |
| Dickinson, RG; Elliot, DJ; Mackenzie, PI; Miners, JO; Rowland, A; Williams, JA | 1 |
| Amore, M; Bugamelli, F; Conti, M; Raggi, MA; Saracino, MA | 1 |
| Beck, O; Ohman, I; Tomson, T; Vitols, S | 1 |
| Bråthen, G; Brodtkorb, E; Helde, G; Reimers, A | 1 |
| Andreassen, T; Esmurziev, AM; Hoff, BH; Reimers, A; Simic, N; Sundby, E | 1 |
| Barceló, D; Pérez, S; Zonja, B | 1 |
| Dolžan, V; Grabnar, I; Kastelic, M; Lorber, B; Milosheska, D; Vovk, T | 1 |
1 trial(s) available for lamotrigine 2-n-glucuronide and lamotrigine
| Article | Year |
|---|---|
Pharmacokinetics of lamotrigine and its metabolite N-2-glucuronide: Influence of polymorphism of UDP-glucuronosyltransferases and drug transporters.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Epilepsy; Female; Genotype; Glucuronosyltransferase; Humans; Lamotrigine; Male; Middle Aged; Models, Biological; Organic Cation Transporter 1; Prospective Studies; Tissue Distribution; Triazines; Young Adult | 2016 |
7 other study(ies) available for lamotrigine 2-n-glucuronide and lamotrigine
| Article | Year |
|---|---|
Analysis of lamotrigine and lamotrigine 2-N-glucuronide in guinea pig blood and urine by reserved-phase ion-pairing liquid chromatography.
Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Guinea Pigs; Lamotrigine; Male; Triazines | 1991 |
In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction.
Topics: Anticonvulsants; Area Under Curve; Cell Line; Drug Interactions; Enzyme Inhibitors; Fluconazole; Glucuronosyltransferase; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Lamotrigine; Microsomes, Liver; Models, Biological; Recombinant Proteins; Sapogenins; Serum Albumin, Bovine; Triazines; Valproic Acid; Zidovudine | 2006 |
Rapid HPLC analysis of the antiepileptic lamotrigine and its metabolites in human plasma.
Topics: Anticonvulsants; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Humans; Lamotrigine; Solid Phase Extraction; Triazines | 2007 |
Plasma concentrations of lamotrigine and its 2-N-glucuronide metabolite during pregnancy in women with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; Humans; Inactivation, Metabolic; Lamotrigine; Metabolic Clearance Rate; Middle Aged; Pregnancy; Pregnancy Complications; Pregnancy Trimesters; Reference Values; Triazines | 2008 |
Lamotrigine and its N2-glucuronide during pregnancy: the significance of renal clearance and estradiol.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Estradiol; Female; Humans; Lamotrigine; Outpatients; Postpartum Period; Pregnancy; Prospective Studies; Renal Circulation; Triazines; Young Adult | 2011 |
Benzoylated uronic acid building blocks and synthesis of N-uronate conjugates of lamotrigine.
Topics: Benzene; Candida; Ethanol; Lamotrigine; Magnetic Resonance Spectroscopy; Triazines; Uronic Acids | 2012 |
Human Metabolite Lamotrigine-N(2)-glucuronide Is the Principal Source of Lamotrigine-Derived Compounds in Wastewater Treatment Plants and Surface Water.
Topics: Humans; Lamotrigine; Triazines; Wastewater; Water Pollutants, Chemical; Water Purification | 2016 |