lamivudine has been researched along with 2'-deoxycytidine 5'-triphosphate in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 9 (64.29) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amblard, F; Bassit, L; Bondada, L; Coats, SJ; Detorio, M; Grier, J; Hernandez-Santiago, BI; Koontz, D; Mellors, JW; Rapp, KL; Schinazi, RF; Sluis-Cremer, N | 1 |
| Cox, S; Palmer, S | 1 |
| Anderson, KS; Feng, JY | 2 |
| Arnold, E; Boyer, PL; Gao, HQ; Hughes, SH; Sarafianos, SG | 1 |
| Back, DJ; Hoggard, PG; Johnson, MA; Kewn, S; Sales, SD | 1 |
| Anderson, KS; Feng, JY; Johnson, AA; Johnson, KA | 1 |
| Clayette, P; Dereuddre-Bosquet, N; Foucault, G; Lepoivre, M; Routledge, K; Roy, B | 1 |
| Back, DJ; Beijnen, JH; Crommentuyn, KM; Hoggard, PG; Huitema, AD; Kewn, S; Lange, JM; Prins, JM; Sankatsing, SU; Sparidans, RW | 1 |
| Daikoku, M; Koga, M | 1 |
| Chatterjee, DK; Eisenhauer, BM; Gotte, M; Hecht, SM; Klarmann, GJ; Le Grice, SF; Pata, JD; Zhang, Y | 1 |
| Kisic, M; Martínez, MA; Martinez-Picado, J; Mendieta, J; Menéndez-Arias, L; Parera, M; Puertas, MC | 1 |
| Efthimiopoulos, G; Feng, JY; Fowler, JD; Gaur, V; Suo, Z; Vyas, R | 1 |
| Raper, AT; Reed, AJ; Suo, Z; Vyas, R; Wallenmeyer, PC; Zahurancik, WJ | 1 |
1 review(s) available for lamivudine and 2'-deoxycytidine 5'-triphosphate
| Article | Year |
|---|---|
[Lamivudine therapy for chronic hepatitis B].
Topics: Amino Acid Motifs; Anti-HIV Agents; Biomarkers; Deoxycytosine Nucleotides; Depression, Chemical; DNA Replication; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Virus Replication | 2004 |
1 trial(s) available for lamivudine and 2'-deoxycytidine 5'-triphosphate
| Article | Year |
|---|---|
Effect of mycophenolate mofetil on the pharmacokinetics of antiretroviral drugs and on intracellular nucleoside triphosphate pools.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Retroviral Agents; Cytidine Triphosphate; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Dideoxynucleotides; Drug Interactions; HIV-1; Humans; Lamivudine; Male; Metabolic Clearance Rate; Middle Aged; Mycophenolic Acid | 2004 |
12 other study(ies) available for lamivudine and 2'-deoxycytidine 5'-triphosphate
| Article | Year |
|---|---|
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Topics: Anti-HIV Agents; Cell Line, Tumor; Cell Survival; Cells, Cultured; Dideoxynucleosides; HIV Infections; HIV-1; Humans; Molecular Structure; Reverse Transcriptase Inhibitors | 2009 |
Increased activation of the combination of 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine in the presence of hydroxyurea.
Topics: Anti-HIV Agents; Cell Line; Deoxycytosine Nucleotides; Drug Synergism; Hydroxyurea; Lamivudine; Phosphorylation; Thymine Nucleotides; Zidovudine | 1997 |
Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase.
Topics: Anti-HIV Agents; Binding Sites; Deoxycytidine Monophosphate; Deoxycytosine Nucleotides; Deoxyribonucleosides; Dideoxynucleotides; DNA Primers; DNA, Viral; HIV Reverse Transcriptase; Hydrolysis; Kinetics; Lamivudine; Models, Molecular; Ribonuclease H; RNA, Viral; Stereoisomerism; Templates, Genetic | 1999 |
Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase.
Topics: Amino Acid Substitution; Deoxycytidine Monophosphate; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Dideoxynucleotides; DNA Primers; DNA, Viral; Drug Resistance, Microbial; HIV Reverse Transcriptase; Humans; Kinetics; Lamivudine; RNA, Viral; Templates, Genetic; Thermodynamics; Valine | 1999 |
The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.
Topics: Amino Acid Substitution; Anti-HIV Agents; Binding Sites; Catalysis; Deoxycytosine Nucleotides; Deoxyribonucleotides; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Lamivudine; Models, Molecular; Mutation; Nuclease Protection Assays; Oligodeoxyribonucleotides; Protein Binding; Protein Conformation; Reverse Transcriptase Inhibitors; Ribonuclease H; RNA; RNA-Binding Proteins; Salts; Static Electricity; Templates, Genetic; Transcription, Genetic | 2000 |
The intracellular activation of lamivudine (3TC) and determination of 2'-deoxycytidine-5'-triphosphate (dCTP) pools in the presence and absence of various drugs in HepG2 cells.
Topics: Anti-HIV Agents; Cell Survival; Cytidine Triphosphate; Deoxycytosine Nucleotides; Dideoxynucleotides; Drug Interactions; Humans; Hydroxyurea; Lamivudine; Methotrexate; Phosphorylation; Tumor Cells, Cultured; Vidarabine | 2000 |
Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Cytidine Triphosphate; Deoxycytosine Nucleotides; Dideoxynucleotides; DNA; DNA Polymerase gamma; DNA Replication; DNA-Directed DNA Polymerase; DNA, Mitochondrial; Exodeoxyribonucleases; Humans; Kinetics; Lamivudine; Mitochondria; Nucleic Acid Synthesis Inhibitors; Reverse Transcriptase Inhibitors; Zalcitabine | 2001 |
Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells.
Topics: Anti-HIV Agents; Antimetabolites; Deoxycytosine Nucleotides; Drug Synergism; HIV-1; Humans; Isoxazoles; Lamivudine; Leukocytes, Mononuclear; Phytohemagglutinins; Virus Replication | 2004 |
Investigating the "steric gate" of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids.
Topics: Amino Acid Substitution; Binding Sites; Cell-Free System; Cytidine Triphosphate; Deoxycytosine Nucleotides; Dideoxynucleotides; DNA; Escherichia coli; HIV Reverse Transcriptase; HIV-1; Hydrogen Bonding; Kinetics; Lamivudine; Models, Molecular; Protein Biosynthesis; Protein Engineering; Reverse Transcriptase Inhibitors; Transcription, Genetic; Tyrosine | 2007 |
Mechanistic basis of zidovudine hypersusceptibility and lamivudine resistance conferred by the deletion of codon 69 in the HIV-1 reverse transcriptase coding region.
Topics: Amino Acid Sequence; Anti-HIV Agents; Codon; Crystallography, X-Ray; Deoxycytosine Nucleotides; DNA, Viral; Drug Resistance, Multiple, Viral; Foscarnet; HIV Infections; HIV Reverse Transcriptase; Humans; Lamivudine; Models, Molecular; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Protein Conformation; Reverse Transcriptase Inhibitors; Sequence Alignment; Sequence Deletion; Zidovudine | 2008 |
Structural and kinetic insights into binding and incorporation of L-nucleotide analogs by a Y-family DNA polymerase.
Topics: Catalytic Domain; Deoxycytidine; Deoxycytosine Nucleotides; DNA; DNA Polymerase beta; Drug Resistance, Viral; Emtricitabine; Kinetics; Lamivudine; Models, Molecular; Reverse Transcriptase Inhibitors; Stereoisomerism; Sulfolobus solfataricus | 2014 |
Structural basis for the D-stereoselectivity of human DNA polymerase β.
Topics: Catalysis; Catalytic Domain; Crystallography, X-Ray; Deoxycytosine Nucleotides; DNA Polymerase beta; Emtricitabine; Humans; Kinetics; Lamivudine; Models, Molecular; Molecular Conformation; Mutation, Missense; Protein Binding; Protein Conformation; Protein Domains; Recombinant Proteins; Reverse Transcriptase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2017 |