lactose has been researched along with chloramphenicol in 54 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 51 (94.44) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (3.70) | 24.3611 |
2020's | 1 (1.85) | 2.80 |
Authors | Studies |
---|---|
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Hardisson, C; Sanchez, J | 1 |
Parsell, Z; Smith, HW | 1 |
Ambrosio, RE | 1 |
Blundell, M; Kennell, D; Schneider, E | 1 |
Chabbert, Y; Coynault, C; Gerbaud, G; Le Minor, L; Le Minor, S | 1 |
Schulz, G; Stodolsky, M | 1 |
Drasar, BS; Hill, MJ | 1 |
Hill, RJ; Lancaster, JR; Struve, WG | 1 |
Koch, E; Tronnier, H | 1 |
Bhatnagar, RK; Doull, JL; Vining, LC | 1 |
Cohen, SL; Koornhof, HJ; Sooka, A; Wylie, BA | 1 |
Magasanik, B; Silverstone, AE | 1 |
Dán, A; Szabó, G | 1 |
Traub, WH | 1 |
Pastan, I; Perlman, RL; Varmus, HE | 1 |
Dütting, D; Hübner, L | 1 |
Brenchley, JE; Magasanik, B | 1 |
Kennell, D; Pastushok, C | 1 |
Bernier, G; Filion, R; Malo, R; Phaneuf, JB | 1 |
Durr, IF; Hasan, N | 1 |
Delhalle, E; Fredericq, P | 1 |
Stein, WD; West, IC | 1 |
Maloney, PC; Wilson, TH | 1 |
Ou, JT; Wood, TH | 1 |
Coynault, C; Le Minor, L; Pessoa, G | 1 |
Bornside, BB; Bornside, GH; Cohn, I | 1 |
Ali, LM; Khalil, SA | 1 |
Allen, MJ | 1 |
Chuit, CF | 1 |
Ballesteros-Olmo, A; Goldberger, RF; Kovach, JS; Van Knippenberg, P | 1 |
Jacobson, LA | 1 |
Ciak, J; Hahn, FE | 1 |
Montefiore, D; Okubadejo, OA | 1 |
Autissier, F; Jaffe, A; Kepes, A | 1 |
Casas, IA; Zimmerman, LN | 1 |
Krofton, DV | 1 |
Majumdar, AC; Sharma, AK | 1 |
Alpers, DH; Tomkins, GM | 1 |
Horiuchi, T; Ohshima, Y | 1 |
Moses, V; Palmer, J | 1 |
Mainville, CA; Withey, RJ | 1 |
Feary, TW; Sturtevant, AB | 1 |
Kovalevskaia, AN | 1 |
Collins, EB; Moustafa, HH | 1 |
Chatterjee, S; Vining, LC | 1 |
McDonough, P; Shin, S; Taylor, DE; Timoney, JF | 1 |
GRANT, DJ; HINSHELWOOD, C | 2 |
BITO, Y | 1 |
SCHAFFER, G; SVENDSEN, IB | 1 |
SANDMANN, F | 1 |
Kleinebudde, P; Krueger, C; Thommes, M | 1 |
Aggarwal, RK; Narang, A | 1 |
54 other study(ies) available for lactose and chloramphenicol
Article | Year |
---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Induction of beta-galactosidase in Streptomyces violaceus.
Topics: Arabinose; beta-Galactosidase; Chloramphenicol; Enzyme Induction; Galactose; Galactosidases; Lactose; Methylgalactosides; Rifampin; Stereoisomerism; Streptomyces | 1979 |
A transmissible plasmid determining lactose fermentation and multiple antibiotic resistance in a strain of Klebsiella pneumoniae.
Topics: Ampicillin; Animals; Chickens; Chloramphenicol; Extrachromosomal Inheritance; Fermentation; Klebsiella pneumoniae; Lactose; Penicillin Resistance; Plasmids; Salmonella; Spectinomycin; Streptomycin; Sulfonamides; Tetracyclines | 1976 |
Influence of rec and pol genes on the maintenance of a Proteus plasmid (P-lac) in Escherichia coli.
Topics: Chloramphenicol; Conjugation, Genetic; DNA Replication; DNA, Bacterial; Escherichia coli; Extrachromosomal Inheritance; Genes; Lactose; Plasmids; Proteus mirabilis | 1977 |
Translation and mRNA decay.
Topics: Aminoglycosides; Anti-Bacterial Agents; Chloramphenicol; Escherichia coli; Genes; Lactose; Protein Biosynthesis; RNA, Bacterial; RNA, Messenger | 1978 |
[Compatibility groups of metabolic plasmids (author's transl)].
Topics: Chloramphenicol; Conjugation, Genetic; Drug Resistance, Microbial; Escherichia coli; Extrachromosomal Inheritance; Fermentation; Hemolysin Proteins; Lactose; Plasmids; Sucrose; Transduction, Genetic | 1976 |
Integration sites of foreign genes in the chromosome of coliphage P1: a finer resolution.
Topics: Chloramphenicol; Coliphages; DNA Restriction Enzymes; DNA, Viral; Drug Resistance, Microbial; Genes; Lactose; Molecular Weight; Plasmids; Recombination, Genetic | 1976 |
The normal colonic bacterial flora.
Topics: Ammonia; Bacteria; Bacteroides; Bile Acids and Salts; Carcinogens; Chloramphenicol; Clostridium; Colon; Colonic Neoplasms; Diet; Escherichia coli; Eubacterium; Feces; Glucuronates; Glucuronidase; Glycosides; Hepatic Encephalopathy; Humans; Hydrolysis; Lactobacillus; Lactose; Liver Diseases; Streptococcus; Urea | 1975 |
The characterization of energized and partially de-energized (respiration-independent) beta-galactoside transport into Escherichia coli.
Topics: Aerobiosis; Anaerobiosis; Biological Transport, Active; Chloramphenicol; Cyanides; Escherichia coli; Kinetics; Lactose; Mathematics; Oxygen Consumption | 1975 |
[The effect of local treatment on the epithelization of experimental defects in the human skin].
Topics: Chloramphenicol; Epithelium; Lactose; Methacrylates; Methylcellulose; Pregnadienetriols; Psoriasis; Radiation Effects; Talc; Ultraviolet Rays; Wound Healing; Zinc Oxide | 1975 |
Role of the carbon source in regulating chloramphenicol production by Streptomyces venezuelae: studies in batch and continuous cultures.
Topics: Carbon; Chloramphenicol; Culture Media; Glucose; Lactose; Multienzyme Complexes; Peptones; Streptomyces | 1988 |
Bacteremia caused by a lactose-fermenting, multiply resistant Salmonella typhi strain in a patient recovering from typhoid fever.
Topics: Adolescent; Ampicillin; Anti-Bacterial Agents; Bacteriophage Typing; Chloramphenicol; DNA, Bacterial; Female; Fermentation; Humans; Lactose; Penicillin Resistance; R Factors; Salmonella typhi; Sepsis; Serotyping; Tetracycline; Trimethoprim; Typhoid Fever | 1987 |
Polycistronic effects of catabolite repression on the lac operon.
Topics: Acetyltransferases; Chloramphenicol; Chromosome Mapping; Chromosomes, Bacterial; Coliphages; Dactinomycin; Edetic Acid; Enzyme Induction; Enzyme Repression; Escherichia coli; Galactose; Galactosidases; Glucose; Glucosephosphates; Glycosides; Lactose; Operon; Protein Biosynthesis; Rifampin; RNA, Messenger; Transcription, Genetic; Transduction, Genetic; Tryptophan | 1972 |
Induced production of beta-galactosidase in Streptomyces griseus.
Topics: Chloramphenicol; Culture Media; Dactinomycin; Disaccharides; Enzyme Induction; Fungal Proteins; Galactose; Galactosidases; Kinetics; Lactose; Streptomyces griseus; Thioglycosides | 1973 |
Isolation of an antibiotic-resistant, lactose-fermenting strain of Proteus rettgeri.
Topics: Agar; Ampicillin; Anti-Bacterial Agents; Cephalothin; Chloramphenicol; Fermentation; Gentamicins; Kanamycin; Lactose; Methenamine; Neomycin; Nitrofurantoin; Penicillin Resistance; Penicillins; Polymyxins; Proteus; Streptomycin; Sulfonamides; Tetracycline | 1970 |
Regulation of lac transcription in antibiotic-treated E. coli.
Topics: Adenine Nucleotides; Bacterial Proteins; Chloramphenicol; Cyclic AMP; Depression, Chemical; Escherichia coli; Galactosidases; Genetic Code; Glycosides; Lactose; Puromycin; Ribosomes; RNA, Messenger; Suppression, Genetic; Tritium; Uridine | 1971 |
The effect of antibiotics on the in vivo synthesis of messenger ribonucleic acid from the lactose operon of Escherichia coli.
Topics: Anti-Bacterial Agents; Chloramphenicol; Cyclic AMP; DNA, Bacterial; Escherichia coli; Genetic Code; Lactose; Nucleic Acid Hybridization; Operon; Peptide Biosynthesis; Puromycin; Ribosomes; RNA Nucleotidyltransferases; RNA, Bacterial; RNA, Messenger; Streptomycin | 1972 |
Klebsiella aerogenes strain carrying drug-resistance determinants and a lac plasmid.
Topics: Acridines; Adenine; Chloramphenicol; Conjugation, Genetic; Cyclic AMP; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Extrachromosomal Inheritance; Galactose; Galactosidases; Glucose; Klebsiella; Lactose; Mutation; Salmonella typhimurium; Sodium Dodecyl Sulfate; Streptomycin; Tetrazolium Salts; Transduction, Genetic; Transformation, Genetic | 1972 |
Residual polarity and transcription-translation coupling during recovery from chloramphenicol or fusidic acid.
Topics: Acetyltransferases; Anthranilate Synthase; Bacterial Proteins; Carbon Radioisotopes; Centrifugation, Density Gradient; Chloramphenicol; Cyclic AMP; Enzyme Induction; Escherichia coli; Fusidic Acid; Galactosidases; Lactose; Leucine; Nucleic Acid Hybridization; Operon; Peptide Biosynthesis; Protein Biosynthesis; RNA, Bacterial; RNA, Messenger; Transcription, Genetic; Tritium; Tryptophan; Tryptophan Synthase; Uracil | 1974 |
[Necrotic enteritis in broilers. II. Characteristics of the strains of Clostridium perfringens isolated].
Topics: Animals; Antitoxins; Chickens; Chloramphenicol; Clostridium perfringens; Culture Media; Enteritis; Glucose; Guinea Pigs; Hemolysin Proteins; Lactose; Mice; Necrosis; Nitrofurazone; Phospholipases; Poultry Diseases; Sucrose; Toxins, Biological | 1974 |
Induction of beta-galactosidase in Lactobacillus plantarum.
Topics: Acetates; Biotin; Carbon Radioisotopes; Cell-Free System; Chloramphenicol; Chromatography, Thin Layer; Dactinomycin; Enzyme Induction; Enzyme Repression; Fructose; Galactose; Galactosidases; Glucose; Lactobacillus; Lactose; Maltose; Mannitol; Mevalonic Acid; Mitomycins; Thioglycosides | 1974 |
[Recombinations between R and colicinogenic factors in Escherichia coli K12. I. Production of recombinants].
Topics: Chloramphenicol; Chromosomes, Bacterial; Colicins; Conjugation, Genetic; Drug Resistance, Microbial; Escherichia coli; Genes; Kanamycin; Lactose; Recombination, Genetic; Streptomycin; Tetracycline; Transduction, Genetic | 1972 |
The kinetics of induction of -galactoside permease.
Topics: Acetyltransferases; Chloramphenicol; Enzyme Induction; Escherichia coli; Galactose; Galactosidases; Glycosides; Half-Life; Kinetics; Lactose; Membrane Transport Proteins; Models, Biological; Operon; Spectrophotometry; Sulfur; Time Factors | 1973 |
Quantitative aspects of active transport by the lactose transport system of Escherichia coli.
Topics: Biological Transport, Active; Carbon Radioisotopes; Cell Membrane; Chloramphenicol; Chromatography, Paper; Enzyme Induction; Escherichia coli; Galactose; Galactosidases; Kinetics; Lactose; Mathematics; Mutation; Nitrophenols; Sulfhydryl Compounds; Thioglycosides; Time Factors | 1973 |
Kinetics of genetic recombination in Escheria coli K-12: competition between genetic integration and degradation.
Topics: Amino Acids; Cell Count; Cell Division; Chloramphenicol; Chromosomes, Bacterial; Culture Media; Escherichia coli; Glucose; Homozygote; Lactose; Mutation; Recombination, Genetic; Streptomycin; Succinates; Time Factors | 1973 |
[Plasmid determinants of the atypical "lactose positive" character in "S. typhi-murium" and "S. oranienburg" isolates from epidemic in Brasil, 1971-1973 (author's transl)].
Topics: Anti-Bacterial Agents; Brazil; Chloramphenicol; Drug Resistance, Microbial; Extrachromosomal Inheritance; Humans; Lactose; Salmonella; Salmonella Infections; Salmonella Phages; Salmonella typhimurium | 1974 |
Development of tetracycline-resistant Staphylococcus aureus in gnotobiotic mice.
Topics: Animals; Anti-Bacterial Agents; Carboxy-Lyases; Chloramphenicol; Coagulase; Drug Resistance, Microbial; Feces; Gelatin; Germ-Free Life; Glucose; Hydrolysis; Intestines; Lactose; Lysine; Mannitol; Mice; Mice, Inbred Strains; Ornithine; Pigmentation; Staphylococcus; Sucrose; Tetracycline; Time Factors | 1972 |
Some formulation factors affecting disintegration and dissolution of chloramphenicol capsules.
Topics: Capsules; Chloramphenicol; Drug Compounding; Lactose; Lubrication; Magnesium; Solubility; Talc | 1972 |
The electrochemical aspects of some biochemical systems. 8. The induction of beta-galactosidase.
Topics: Chloramphenicol; Electrochemistry; Enzyme Induction; Escherichia coli; Galactosidases; Glucose; Lactose | 1967 |
[Respiration of Escherichia coli K 12 resistant to chloramphenicol or tetracycline].
Topics: Arabinose; Chloramphenicol; Culture Media; Drug Resistance, Microbial; Escherichia coli; Galactose; Glucose; Lactose; Oxygen Consumption; Pyruvates; Tetracycline | 1968 |
Kinetics of induction of the lactose operon on an episome in Samonellla typhimurium.
Topics: Acyltransferases; Adenine; Chloramphenicol; Enzyme Induction; Extrachromosomal Inheritance; Galactosidases; Genetics, Microbial; Histidine; Lactose; Methionine; Molecular Biology; Nucleosides; Operon; Salmonella typhimurium; Serine | 1969 |
Regulation of ribonucleic acid synthesis in Escherichia coli during diauxie lag: accumulation of heterogeneous ribonucleic acid.
Topics: Bacterial Proteins; Carbon Isotopes; Centrifugation, Density Gradient; Chloramphenicol; Culture Media; Dactinomycin; Escherichia coli; Glucose; Lactose; Leucine; Ribosomes; RNA, Bacterial; RNA, Messenger; RNA, Transfer; Sucrose; Tritium; Uracil | 1970 |
The problems of drug-resistant pathogenic bacteria. Elimination of bacterial episomes by DNA-complexing compounds.
Topics: Acridines; Carbon Isotopes; Centrifugation, Density Gradient; Cesium; Chloramphenicol; Chlorides; Chloroquine; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Genetics, Microbial; Kanamycin; Lactose; Methylene Blue; Phenanthridines; Quinacrine; Quinine; Rosaniline Dyes; Spermine; Thymidine | 1971 |
Organisms and their sensitivities among hospital patients. I. Ecology.
Topics: Anti-Bacterial Agents; Bacteria; Bacteriuria; Chloramphenicol; Cross Infection; Drug Resistance, Microbial; Ear Canal; Ecology; Enterobacteriaceae; Escherichia coli; Female; Fermentation; Genetics, Microbial; Hospitals; Humans; Lactose; Microbial Sensitivity Tests; Penicillin Resistance; Selection, Genetic; Staphylococcus; Streptomycin; Suppuration; Tetracycline; Time Factors; Uganda; Vagina; Wound Infection | 1970 |
Segregation of galactoside permease, a membrane marker during growth and cell division in Escherichia coli.
Topics: Cell Division; Cell Membrane; Chloramphenicol; Coliphages; Culture Media; Escherichia coli; Galactose; Genetics, Microbial; Genetics, Population; Lactose; Membrane Transport Proteins; Molecular Biology; Operon; Ribosomes; RNA, Bacterial; Time Factors | 1971 |
Dependence of protease secretion by Streptococcus faecalis var. liquefaciens on arginine and its possible relation to site of synthesis.
Topics: Adenosine Triphosphate; Arginine; Arsenicals; Chloramphenicol; Dactinomycin; Edetic Acid; Enterococcus faecalis; Fermentation; Lactose; Penicillin G; Peptide Hydrolases; Phosphates; Puromycin; Streptomycin; Zinc | 1969 |
[Chemotherapy of respiratory diseases].
Topics: Ampicillin; Anti-Bacterial Agents; Bacteria; Bronchiectasis; Bronchitis; Cephaloridine; Chloramphenicol; Chronic Disease; Cloxacillin; Erythromycin; Humans; Lactose; Methicillin; Oxytetracycline; Penicillin G; Penicillin Resistance; Pneumonia; Pneumonia, Staphylococcal; Pneumonia, Viral; Streptomycin; Tetracycline | 1971 |
Studies on the effect of some broad spectrum antibiotics on small intestinal oligosaccharidases and absorption of lactose.
Topics: Animals; Anti-Bacterial Agents; Blood Glucose; Chloramphenicol; Chlortetracycline; Galactosidases; Glucosidases; Glycoside Hydrolases; Hydrochloric Acid; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Lactose; Oxytetracycline; Rabbits; Rats; Sucrase; Swine | 1970 |
Sequential transcription of the genes of the lactose operon and its regulation by protein synthesis.
Topics: Acyltransferases; Bacterial Proteins; Chloramphenicol; Enzyme Induction; Escherichia coli; Fluorouracil; Galactosidases; Genetic Code; Kinetics; Lactose; Molecular Biology; Puromycin; RNA, Messenger | 1966 |
Inhibition of repressor formation in the lactose system of Escherichia coli by inhibitors of protein synthesis.
Topics: Antimetabolites; Chloramphenicol; DNA, Bacterial; Enzyme Repression; Escherichia coli; Fluorouracil; Galactosidases; Hot Temperature; Lactose; Mutation; Puromycin; RNA, Bacterial; Thymine; Uracil | 1966 |
Involvement of the lac regulatory genes in catabolite repression in Escherichia coli.
Topics: Alkaline Phosphatase; Bacteriological Techniques; Carbon Isotopes; Chloramphenicol; Enzyme Induction; Enzyme Repression; Escherichia coli; Galactosidases; Genes; Glucose; Kinetics; Lactose; Lyases; Mutation; Pentosephosphates | 1967 |
A critical analysis of a capsule dissolution test.
Topics: Capsules; Chloramphenicol; Lactose; Methods; Pharmacopoeias as Topic; Solubility; Spectrophotometry; Time Factors; Ultraviolet Rays | 1969 |
Incidence of infectious drug resistance among lactose-fermenting bacteria isolated from raw and treated sewage.
Topics: Anti-Bacterial Agents; Bacteria; Chloramphenicol; Drug Resistance, Microbial; Escherichia; Fermentation; Genetics, Microbial; Lactose; Microbial Sensitivity Tests; Sewage; Streptomycin; Tetracycline; Water Microbiology | 1969 |
[Variability of Flexner dysentery bacteria under the action of neomycin (mycerin) and levomycetin during continuous cultivation].
Topics: Chloramphenicol; Culture Media; Drug Resistance, Microbial; Lactose; Methods; Neomycin; Shigella; Sucrose | 1967 |
Role of galactose or glucose-1-phosphate in preventing the lysis of Streptococcus diacetilactis.
Topics: Bacterial Proteins; Bacteriolysis; Chloramphenicol; Galactose; Glucose; Hexosamines; Hexosephosphates; Hydrogen-Ion Concentration; Lactose; Maltose; Osmosis; Streptococcus; Temperature | 1968 |
Catabolite repression in Streptomyces venezuelae. Induction of beta-galactosidase, chloramphenicol production, and intracellular cyclic adenosine 3',5'-monophosphate concentrations.
Topics: beta-Galactosidase; Chloramphenicol; Culture Media; Cyclic AMP; Enzyme Induction; Galactosidases; Glucose; Lactose; Streptomyces | 1982 |
pJT2: unusual H1 plasmid in a highly virulent lactose-positive and chloramphenicol-resistant Salmonella typhimurium strain from calves.
Topics: Animals; Cattle; Cattle Diseases; Chloramphenicol; Drug Resistance, Microbial; Escherichia coli; Lactose; Plasmids; Salmonella Infections; Salmonella Infections, Animal; Salmonella typhimurium | 1980 |
STUDIES OF THE ENZYME ACTIVITY OF BACT. LACTIS AEROGENES. (AEROBACTER AEROGENES). I. THE EFFECTS OF CELLULAR DISRUPTION ON THE ACTIVITIES OF SOME TYPICAL ENZYMES.
Topics: Arabinose; Aspartate Aminotransferases; Benzene; Catalase; Chloramphenicol; Electron Transport Complex II; Enterobacter aerogenes; Galactose; Galactosidases; Glucose; Glucose Oxidase; Lactose; Maltose; Metabolism; Oxidoreductases; Pharmacology; Research; Succinate Dehydrogenase; Ultrasonics | 1964 |
STUDIES OF THE ENZYME ACTIVITY OF BACT. LACTIS AEROGENES. (AEROBACTER AEROGENES). II. THE EFFECTS OF VARIOUS ADAPTATIONS ON THE ENZYME BALANCE.
Topics: Acclimatization; Anti-Infective Agents, Local; Aspartate Aminotransferases; Carbohydrate Metabolism; Catalase; Chloramphenicol; Drug Resistance; Drug Resistance, Microbial; Electron Transport Complex II; Enterobacter aerogenes; Flavins; Galactosidases; Gentian Violet; Glucose; Glucose Oxidase; Lactose; Oxidoreductases; Pharmacology; Proteins; Research; Streptomycin; Succinate Dehydrogenase | 1964 |
BETA-GALACTOSIDASE SYNTHESIS BY CELL-FREE PREPARATIONS FROM A LACTOSE-NONFERMENTING MUTANT DEPENDENT UPON DEOXYRIBONUCLEIC ACID FROM A LACTOSE-FERMENTING STRAIN OF ESCHERICHIA COLI.
Topics: Adenosine Triphosphate; beta-Galactosidase; Carbon Isotopes; Chloramphenicol; Deoxyribonucleases; DNA; DNA, Bacterial; Escherichia coli; Fluorine; Galactosidases; Lactose; Mutation; Nucleotides; Phenylalanine; Proteins; Radiation Genetics; Radiometry; Research; Ribonucleases; Ultraviolet Rays | 1965 |
[Aureomycin and chloromycetin therapy of zoster].
Topics: Chloramphenicol; Chlortetracycline; Herpes Zoster; Lactose | 1951 |
[The state of the intestine in chloromycetin medication].
Topics: Child; Chloramphenicol; Gastrointestinal Diseases; Humans; Infant; Intestines; Lactobacillus; Lactose | 1952 |
Influence of MCC II fraction and storage conditions on pellet properties.
Topics: Cellulose; Chemistry, Pharmaceutical; Chloramphenicol; Drug Delivery Systems; Drug Implants; Drug Stability; Excipients; Humidity; Kinetics; Lactose; Particle Size; Porosity; Solubility; Surface Properties; Technology, Pharmaceutical; Tensile Strength; Theophylline; Water | 2013 |
Inducer exclusion, by itself, cannot account for the glucose-mediated lac repression of Escherichia coli.
Topics: Chloramphenicol; Escherichia coli; Glucose; Lac Operon; Lactose; Membrane Transport Proteins | 2022 |