lactoferrin and trypanothione

lactoferrin has been researched along with trypanothione* in 1 studies

Other Studies

1 other study(ies) available for lactoferrin and trypanothione

Article	Year
Bioinorganic chemistry of bismuth and antimony: target sites of metallodrugs. Accounts of chemical research, 2007, Volume: 40, Issue:4 The biocoordination chemistry of antimony and bismuth has been extensively investigated due to the historical use of these metals in medicine. Structures of bismuth antiulcer agents and interactions of Bi3+ with proteins and enzymes, such as transferrin and lactoferrin, the histidine-rich protein Hpn, and urease, have been characterized. Sb5+ is a prodrug and is bioreduced or activated to its active form Sb3+ intracellularly. Antimony binds to biomolecules, such as glutathione, trypanothione, and nucleotides, and forms binary and ternary complexes, which may allow it to be trafficked in cells. These studies have improved our understanding of the mechanism of action of bismuth and antimony drugs, which in turn allows the future design of drugs. Topics: Antimony; Bismuth; Cations; Drug Design; Enzymes; Glutathione; Lactoferrin; Magnetic Resonance Spectroscopy; Molecular Structure; Nucleotides; Protein Binding; Proteins; Spectrometry, Mass, Electrospray Ionization; Spermidine; Time Factors; Transferrin; Urease	2007

Article

Year

Bioinorganic chemistry of bismuth and antimony: target sites of metallodrugs.

Accounts of chemical research, 2007, Volume: 40, Issue:4

The biocoordination chemistry of antimony and bismuth has been extensively investigated due to the historical use of these metals in medicine. Structures of bismuth antiulcer agents and interactions of Bi3+ with proteins and enzymes, such as transferrin and lactoferrin, the histidine-rich protein Hpn, and urease, have been characterized. Sb5+ is a prodrug and is bioreduced or activated to its active form Sb3+ intracellularly. Antimony binds to biomolecules, such as glutathione, trypanothione, and nucleotides, and forms binary and ternary complexes, which may allow it to be trafficked in cells. These studies have improved our understanding of the mechanism of action of bismuth and antimony drugs, which in turn allows the future design of drugs.

Topics: Antimony; Bismuth; Cations; Drug Design; Enzymes; Glutathione; Lactoferrin; Magnetic Resonance Spectroscopy; Molecular Structure; Nucleotides; Protein Binding; Proteins; Spectrometry, Mass, Electrospray Ionization; Spermidine; Time Factors; Transferrin; Urease

2007